The worldwide environmentally friendly trend has focused the last decade on emphasizing the value of energy conservation and reducing the carbon footprint in buildings, achieving zero energy buildings. Presently, viable building techniques, in developing countries, are insufficient to achieve zero energy buildings. Thus, authorities should implement policies mandating new developments and renovations to establish “energy-efficient buildings”; nevertheless, design solutions should be properly evaluated and assessed preceding execution. The conservation of energy without jeopardizing human comfortability is a huge challenge for any designer. Occupants are less interested in making a major investment to save some expenses over the next two decades, especially nowadays that energy is still affordable. Therefore, improved indoor environmental conditions are perhaps another important parameter toward energy-efficient buildings. Through dynamic simulations, this study examines the energy efficiency and thermal comfort achieved by integrating retrofitting strategies in an institutional building in three different American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE) hot climate zones represented by three cities of Egypt (Aswan, Cairo, and Alexandria). The built-up baseline model is validated using actual energy usage data. The validated baseline model is then subjected to local sensitivity analysis to determine the driving parameters influencing the building's energy demand. The study at hand focuses on a broader perspective on sustainability. With a multiapproach decision-making methodology based on the most recent measures, the study highlights the outcomes through an environmental–economic assessment and indoor thermal comfort depending on experts' weighting, responses, and recommendations. The outcomes postulate that the implementation of reflective paints solutions would achieve the highest percentages of whole-building energy savings with 21%, 19%, and 17% for Aswan, Cairo, and Alexandria, respectively, improving indoor thermal comfort levels.
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