The Government program "Affordable Medicines" is implemented in Ukraine to provide outpatients with chronic diseases with the essential medicines from April 2017. The e-prescriptions have implemented under the administration of the National Health Service of Ukraine (NHSU) since April 2019. was to analyze the dynamics of the regional distribution of e-prescriptions in the program for 2019-2020 according to criteria such as: prescribed and released e-prescriptions, gender and age of patients. Analysis of the NHSU database, statistical data of e-prescriptions, comparative analysis. According to statistics data of NHSU, 24605999 e-prescriptions were prescribed during the selected period, of which 21020508 were delivered. The increase e-prescriptions was + 20.2% in 2020, and the highest rates were in the Southern (+ 25.3%) and Western regions of Ukraine (+ 23.2%). Accordingly, the growth in e-prescriptions is + 20.5% with the highest rate in the Southern (+ 26.3%) and Western regions (+ 22.8%). The highest increase in e-prescriptions for patients depending on gender was found in the Southern region (women + 24.6%, men + 26.8%). By age distribution: 65+ patients had the highest increase in the Western region (+ 23.4%); 40-64 (+ 26.5%), 18-39 (+ 30.1%), 6-17 (+ 30%) in the Southern region; 0-5% (+ 16.2%) in the Central region. After analyzing the sample of e-prescriptions in the program "Affordable Medicines" for the selected period, we found a positive trend in the number of patients from different categories of the population who receive quality treatment with medicines from the program.