Women's Health Research Articles

Religious and Spiritual Experiences, Discrimination, and Stress Among Midlife Women in the USA: The Study of Women's Health Across the Nation.

The harmful effects of perceived discrimination for physical and mental health are well documented. Evidence identifies how dimensions of religious/spiritual (R/S) involvement may reduce these harmful effects. This study examined how R/S experiences are associated with the effects of discrimination on perceived stress. With data from the Study of Women's Health Across the Nation (SWAN), we examined the offsetting and buffering effects of daily spiritual experiences on the relationship between everyday discrimination and perceived stress among 2,221 US midlife women from 5 racial/ethnic groups. Regression analysis identified a positive association between perceived discrimination and perceived stress (p < .001). Daily spiritual experiences were inversely associated with perceived stress (p < .001) for the whole sample and in the subsample of Black women. For this subsample, there was an inverse association between daily spiritual experiences and discrimination. R/S experiences may be one of the ways that R/S reduce the harmful effects of discrimination on health.

How big data can improve women's health.

How big data can improve women's health.

Impacts of disasters on women: the case of Kahramanmaras Earthquake sequence : Post-traumatic stress disorder and other problems among women after the Kahramanmaras Earthquake sequence.

This study aimed to uncover difficulties, living conditions, and post-traumatic stress disorder (PTSD) symptoms among women victims of the Kahramanmaras earthquake sequence on February 6, 2023. The data was collected from 388 participants using an online survey between November 1-30, 2023. We collected the data using a survey form with a 48-question sociodemographic information form and the 9-item Post-Traumatic Stress Disorder (PTSD)-Short Scale.We analyzed the data using independent samples t-test, Chi-square test, and binary logistic regression analysis. While 59.5% of participants reported post-earthquake headaches, 77.8% had difficulty sleeping. Apart from the primary impacts of the disaster, 53.6% of participants reported post-earthquake financial difficulties, and 53.4% had to be employed to generate income. Besides, 22.2% of participants experienced violence, and 38.1% had PTSD symptoms. Furthermore, having to work in a paid job increased their probability of developing PTSD symptoms by 3.4 times. Our analysis showed that singles, smokers, those with a disaster-damaged home and financial difficulties, those who had to work, those receiving psychological support, and those with anxiety had significantly higher PTSD scores (p < 0.05). Despite all such difficulties, 43.3% of them participated in aid activities. It seems imperative to devise and implement efficient strategies to address women's physical and mental health challenges in the wake of the disaster. Moreover, it is of the utmost importance to integrate gender-sensitive approaches into disaster preparedness plans by fostering collaborations among all relevant bodies.

Social determinants of the mental health of pregnant women in Nepal: Stakeholder perspectives.

Women during pregnancy are at a greater risk of experiencing poor mental health, which is one of the major global public health issues, and more so in many developing countries like Nepal, but limited evidence of research on this topic is evident. In this paper, we are focused on exploring the social determinants of the mental health of pregnant women in Nepal from the stakeholder perspectives. This paper utilises eight stakeholder perspectives collected through open-ended in-depth interviews. All the interviews were analysed thematically using an inductive approach. This paper presents three major findings: Inadequate social support, Limited availability and accessibility of maternal health services, and Restricted socioeconomic and cultural context. The inadequate social support from family/relatives, neighbours, community and national policies such as maternity leave, alongside the absence of NGOs/INGOs support, put women at risk of poor mental health. In addition to the inadequate support, limited availability and accessibility of maternal health services potentially cause immense distress among pregnant women. Furthermore, in the context of a patriarchal society, the impact of socioeconomic and cultural context on pregnant women's mental health is also presented as a major determinant of poor mental health among pregnant women. Based on the findings, we conclude that pregnant women are at risk of poor mental health experiences in Nepal and recommend that promoting mental health among pregnant women needs a multifaceted approach that should be considered in all the policies and practices involved in promoting the mental health of pregnant women.

Decolonisation of global conferences: unfinished business for women's health advocates

Decolonisation of global conferences: unfinished business for women's health advocates

Validated questionnaires for the assessment of Italian patients with pelvic floor dysfunctions: a systematic review.

Pelvic floor dysfunctions (PFDs) have a complex, multifactorial pathophysiology that impacts women's health and must be identified to provide the most appropriate care and treatment. Therefore, symptom and quality of life (QoL) questionnaires, briefly identified as patient-reported outcomes (PROs), have been developed. Despite the large number of questionnaires available for the assessment of PFDs and QoL-related issues in English, few of them have been validated for the Italian language. The aim of this article is to systematically review the literature on Italian-language validated PROs for PFDs assessment, along with practical information on literature references and suggestions on how to obtain each individual questionnaire. A systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement was performed up to 1 March 2024. PubMed/MEDLINE databases and websites were used to identify validated questionnaires in Italian language for PFDs. Once identified, the possibility of obtaining a copy of the questionnaire was checked, and the steps to obtain one are given in the text. Thirty-five Italian-validated questionnaires were included: 17 out of 35 (48.6%) questionnaires focused on Lower urinary tract symptoms, 1 (2.8%) on genital prolapse symptoms, 8 (22.8%) on sexuality, 3 (8.6%) on bowel symptoms and 6 (17.2%) on pelvic dysfunctions. The literature search turned up seven more Italian PRO validation papers than the previous review. Specifically, the newly validated PROs include: Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12), Sexual Desire and Erotic Fantasies (SDEF) Questionnaire, Sexual Inhibition/Sexual Excitation Scales (SIS/SES), 12-Item Sexual Distress Scale (SDS) and 5-Item Sexual Distress Scale-Short Form (SDS-SF), Vaizey and Wexner and fecal incontinence severity index (FISI) questionnaires, Pelvic Floor Distress Inventory (PFDI-20) questionnaire, Intermittent Catheterization Acceptance Test (I-CAT). This systematic review is intended to be a tool to promote the adoption of appropriate PROs when studying PFDs in Italian patients.

Anticancer potential of osthole: targeting gynecological tumors and breast cancer.

Gynecological tumors, such as ovarian, endometrial, and cervical cancers, alongside breast cancer, represent significant malignancies that pose serious threats to women's health worldwide. Standard treatments, including surgery, chemotherapy, radiotherapy, and targeted therapies, are commonly utilized in clinical practice. However, challenges such as high recurrence rates, drug resistance, and adverse side effects underscore the urgent need for more effective therapeutic options. Osthole, a natural coumarin compound derived from Chinese herbal medicine, has demonstrated remarkable antitumor activity against various cancers. Emerging evidence indicates that osthole can inhibit the proliferation, invasion, and metastasis of gynecological and breast cancer cells through various mechanisms, including inducing apoptosis and autophagy, regulating the tumor microenvironment, inhibiting tumor angiogenesis, and enhancing the sensitivity of cancer cells to chemotherapy and radiotherapy. This review highlights the recent advancements in osthole research within the context of gynecological and breast cancers, focusing on its molecular mechanisms, and offers a theoretical foundation for its potential development as an anticancer agent.

ECMHA-PP: A Breast Cancer Prognosis Prediction Model Based on Energy-Constrained Multi-Head Self-Attention.

Breast cancer is a significant threat to women's health. Precise prognosis prediction for breast cancer can help doctors implement more rational treatment strategies. Artificial intelligence can assist doctors in decision-making and enhance predictionaccuracy. In this paper, a deep learning model ECMHA-PP (Energy Constrained Multi-Head Self-Attention based Prognosis Prediction) is proposed to predict the prognosis of breast cancer. ECMHA-PP utilizes patients' clinical data and extracts features through a cross-position mix and a channel mix multi-layer perceptron. Then, it incorporates an energy-constrained multi-head self-attention layer to improve feature extraction capability. The source code of ECMHA-PP has been hosted on GitHub and is available at https://github.com/xiaoliu166370/ECMHA-PP. To evaluate our proposed method, prognostic prediction experiments were performed on the METABRIC dataset, yielding outstanding results with an average accuracy of 93.0% and an average area under the curve of 0.974. To further validate the model's performance, we conducted tests on another independent dataset, BRCA, achieving an accuracy of 87.6%. In comparison with other widely used advanced methods, ECMHA-PP demonstrated higher comprehensive performance, making it a reliable prognostic prediction model for breast cancer. Given its robust feature extraction and predictioncapabilities.

Menopause mouth

Anita Stanforth details how best to support patients experiencing the menopause. Aim The aim of this article is to provide a background to women's oral health during the menopause and how dental nurses and oral health practitioners may support their patients during this time. Objective To gain a deeper insight into oral symptoms which may manifest during the menopause and how quality of life may be affected.

Antimicrobial utilisation patterns between 2013 and 2022 in Canadian neonates born at less than 33 weeks gestation: a retrospective cohort study

Excessive antimicrobial exposure is associated with an increase in neonatal mortality, morbidities and adverse neurodevelopment. Canadian Neonatal Network has been promoting judicious antimicrobial use through the Evidence-based Practice for Improving Quality processes. Our objective was to evaluate the antimicrobial consumption among neonates in tertiary neonatal intensive care units (NICU) in Canada in the recent decade. This is a retrospective cohort study including data from very preterm infants (born at <33 weeks gestational age) admitted to all NICUs in Canada between January 1, 2013, and December 31, 2022. Nationwide antimicrobial utilization rate (AUR) benchmarking started in 2016, and quality improvement initiatives were continued in the subsequent years to promote judicious use of antimicrobials across the network. AUR is defined as the number of days with ≥1 antimicrobial divided by the total patient days (PD). Culture-proven sepsis refers to a neonate with positive culture of pathogens in blood and/or cerebrospinal fluid. The outcomes were evaluated during pre- (2013-2017) and post-intervention periods (2018-2022). Interrupted time-series analysis was used, and comparison of AUR calculated per each 3-month time block and the slope changes were conducted across the pre- and post-intervention periods regarding total patients and subgroups. A total of 41,253 infants were included, with 22,644 (55%) being male. The AUR was significantly lower among infants from the post- vs. those from the pre-intervention periods (152 vs. 184, p<0.0001). Among 35,670 infants without culture-proven sepsis or necrotizing enterocolitis≥Stage 2, AUR was significantly lower in the post-intervention group vs. the pre-intervention group (110 vs. 136, p<0.0001). Interrupted time-series showed significant reduction in AUR during both pre- and post-intervention periods among all infants with and without culture proven sepsis or necrotizing enterocolitis≥Stage 2 (all p<0.0001), as well as those born at <29 weeks gestational age. A comprehensive, network-wide quality improvement initiatives led to a significant and sustained reduction in antimicrobial use among preterm infants born at <33 weeks gestational age with and without culture-proven sepsis or necrotizing enterocolitis≥Stage2. This study was supported by the Canadian Institutes of Health Research Project Grant 2019 (201903PJT-420294-CA2-CAAA-245530), matched funding from the British Columbia Women's Health Foundation and start-up funding from the Women and Children's Health Research Institute, University of Alberta. The coordinating center in Toronto is funded by the Canadian Institutes of Health Research grant for the Canadian Preterm Birth Network (PBN 150642).

Barriers to Health Care Access among Rural Women: A Qualitative Study in a Village of Bangladesh

Rural women's health inequalities have an extensive discussion on both a global and regional scale. Access to health care is a universal challenge, but the task is even harder for rural people, particularly women. This paper attempts to assess critical barriers to rural women’s health. In this regard, a qualitative approach has been followed using a case study method. The respondents were selected from Kosha Raniganj village of Pirganj Upazila under the district of Thakurgaon in the division of Rangpur, Bangladesh, and data were collected in two consecutive months, i.e., May and June 2024. 20 rural women were interviewed through face-to-face communication, with the help of an unstructured interview schedule, to obtain the necessary data. The research findings showed that the health care coverage for rural women remains low because of multifaceted and interwoven barriers. These are: Economic Barriers, Geographic barriers, Socio-cultural barriers, Shortages of workforce and Healthcare Infrastructure, Educational and Awareness Gaps. Of these barriers, economic challenges were considered to have the greatest impounding effect on the health care access of women in rural areas. The findings of this work are useful in understanding how to reduce health disparities and increase the health care services for rural females.

International PCOS guideline clinical research priorities roadmap: a co-designed approach aligned with end-user priorities in a neglected women’s health condition

Polycystic ovary syndrome (PCOS) is a common endocrinopathy with significant reproductive, metabolic, and psychological complications. Consensus on PCOS clinical research priorities across end-users is fundamental and necessitates a robust co-development of a clinical research roadmap to guide international research efforts. A multistage process included: i) international surveys of women and healthcare providers to identify research priorities and unmet needs; ii) interrogation of systematic reviews conducted for the International PCOS Guideline to identify research gaps; iii) International PCOS Guideline Network consensus generated clinical research roadmap; and iv) international peer review for external validation. A codesigned survey engaging 1278 women with PCOS and 1474 healthcare providers found general concordance on research priorities. International PCOS Guideline development processes identified gaps in the literature and coproduced over 150 research priorities throughout the women's life course, affirmed in international peer review. Key themes included: 1) Optimizing PCOS diagnosis; understanding natural history across diverse populations and life stages; detecting and preventing complications, and integrating and interrogating large data assets; 2) developing evidence-based resources, exploring optimal modes for information provision and models of care; 3) exploring effective lifestyle and weight management strategies; minimising weight stigma; 4) exploring intervention effects (including treatment efficacy, safety, cost-effectiveness, and long-term follow-up) on diverse features of PCOS across subgroups; and 5) optimising preconception care and fertility treatments in PCOS. This rigorously coproduced International PCOS Guideline clinical research roadmap addresses stakeholder priorities to guide future clinical research in this common yet neglected condition. The roadmap complements the established PCOS Core Outcome Set to enhance research quality, and tackles evidence-practice gaps to improve health outcomes for women with PCOS throughout their life course. The survey, International PCOS Guideline Network and 2018 and 2023 International PCOS Guidelines were funded by the Australian National Health and Medical Research Council (NHMRC) Centres of Research excellence in PCOS (APP1078444) and in Women's Health in Reproductive life (APP1171592). Guideline partners, American Society for Reproductive Medicine (ASRM), Endocrine Society, European Society of Human Reproduction and Embryology (ESHRE), and European Society of Endocrinology (ESE), provided additional funding and assisted in guideline development. HT and AM are NHMRC Research Fellows. LM was funded by a Heart Foundation Future Leader and Veski Fellowship and CTT by the NHMRC Centres of Research excellence in Women's Health in Reproductive life. All disclosures of interest were declared before commencing GDG involvement and updated before all major milestones and are available alongside the PCOS Guideline (https://www.monash.edu/__data/assets/pdf_file/0009/3371292/Register-of-disclosures-of-interest.pdf).

Haven Ley: health and the empowerment of women.

Haven Ley talks to Gary Humphreys about Pivotal's plans to address women's health, including sexual and reproductive rights, as part of broader efforts to empower women.

The Relationship between nutritional status and menstrual cycle and anemia

Introduction: Adolescence is a period of growth and puberty; adolescents are very concerned about appearance, so they pay attention to their diet until they are strict. This causes the intake needed to be unmet, then impacts the menstrual cycle and anemia. Objective: This study aims to analyze the relationship between nutritional status, the menstrual cycle, and the incidence of anemia in adolescent girls. Method: This research is an analytic observational study. The approach in this research is cross-sectional. The population is 447 female students aged 13-15; the sample is 83. Sampling using consecutive sampling. The data collection instrument used a questionnaire to determine the menstrual cycle, measure height and weight, and measure Hb levels with digital tools. Results: This study uses the Spearman Rank test formula value 0.05. The results of nutritional status with menstrual cycles were 0.016 &lt; 0.05, and then significant results were obtained; on nutritional status with anemia, the results were 0.00 &lt; 0.05, then substantial results were obtained, and the results of menstrual cycles with anemia were 0.06 &gt; 0.05 then the result is not essential. Conclusion: It can be concluded that there is a relationship between nutritional status and the menstrual cycle and anaemia, but there is no relationship between the menstrual cycle and anaemia. Optimal nutritional status, including adequate iron intake, is essential for maintaining menstrual health and preventing anemia. Nutrition interventions and health education on the importance of balanced nutrition can be a practical step in supporting women's reproductive health

Actigraphy-derived multidimensional sleep health among breast cancer survivors and controls: Pink SWAN.

To compare breast cancer survivors (BCS) to women without breast cancer (controls) on sleep health risk factors and actigraphy-derived dimensions of sleep (duration, maintenance, timing, and regularity) and examine whether the effect of breast cancer on sleep differs by time since diagnosis. Analyses included data from 68 BCS and 1042 controls who participated in actigraphy and Pink SWAN sub-studies within the Study of Women's Health Across the Nation. BCS and control characteristics were compared using chi-square, Fisher's exact, and Wilcoxon rank sum tests. Sleep measures were regressed onto breast cancer status using binomial logistic and linear regression. The interaction between BCS status and years since diagnosis (< 5; ≥ 5) was tested in these models before and after covariate adjustment. There were no overall sleep differences between BCS and controls; both groups experienced poor sleep health on average across multiple dimensions. Physical inactivity, sleep apnea, and vasomotor and depressive symptoms were associated with worse sleep in both groups. Total sleep time was lower among BCS than controls within 5years of diagnosis (6.13 vs. 6.57h; p = .03) but did not differ at > 5years post-diagnosis (6.59 vs. 6.45h; p = .32). BCS reported greater use of exogenous hormones (p < .0001) and were twice as likely to have initiated anxiolytic use post-diagnosis (p = .03). BCS within 5years of diagnosis experienced shorter sleep duration than controls but did not differ on other sleep parameters. Both groups experienced poor sleep health. BCS and similarly-aged women experience poor sleep health requiring assessment and treatment.

Impact of migraine on changes in cardiovascular health profile among Hong Kong Chinese women: insights from the MECH-HK cohort study

BackgroundPrevious research has shown an association between migraine and cardiovascular diseases (CVDs). However, limited studies have explored the progression of cardiovascular health (CVH) among individuals with migraine. This cohort study aimed to explore the relationship between changes in CVH and migraine among women of Chinese descent in Hong Kong.MethodData from a cohort study titled “Migraine Exposures and Cardiovascular Health in Hong Kong Chinese Women (MECH-HK)” were analysed. A total of 2,603 women, averaging 56.5 ± 8.5 years of age, were selected, all with complete data at baseline and at a follow-up occurring on average 1.27 years later. CVH profile was assessed by an adapted Life’s Essential 8, comprising dietary habits, physical activity, nicotine exposure, sleep duration, body mass index (BMI), lipid levels, blood pressure, and stress. Each component was scored from 0 to 100, with overall CVH as the average. CVH levels were categorized as low (0–49), moderate (50–79), and high (80–100), representing poor to excellent health. Changes in CVH were defined as shifts between these categories from baseline to subsequent follow-up. Migraine cases were identified utilizing the International Classification of Headache Disorders 3.ResultA total of 275 (10.6%) women were identified as having migraine. By follow-up, both women with and without migraine experienced significant declines in CVH profiles (all p-value < 0.05). In the fully adjusted model, women with migraine had a 1.36 times higher risk (OR 95% CI: 1.33, 1.39) of decline in overall CVH compared to non-migraineurs. They also had a higher likelihood of shifting to worse CVH levels in several individual CVH components, including physical activity (OR: 1.09), nicotine exposure (OR: 4.27), sleep quality (OR: 1.80), blood lipid levels (OR: 1.03), and stress (OR: 1.23) (all p-value < 0.05). Among women with migraine, those experiencing aura had a higher risk of poorer physical activity, greater nicotine exposure, higher BMI, and increased stress than those without aura (all p-value < 0.05).ConclusionWomen with migraine exhibited worse progression in CVH compared to those without migraine. Targeted monitoring and management of CVH-related factors in this population are crucial to reducing their elevated risk of CVDs.

Obstetrics and gynecology devices designed for low- andmiddle-income countries: A narrative review.

There are many barriers contributing to poor health outcomes for women in low- and middle-income countries (LMICs), one of which is the lack of necessary medical devices. Presently, the development of various kinds of devices intended to improve women's health outcomes specifically in LMICs remains underrepresented in the literature; therefore, we performed a narrative review to understand this current state of literature. A literature search was conducted in Scopus and Overton between December 2023 to February 2024, and PubMed in October 2024 to broadly explore peer-reviewed publications focusing on understanding the development of devices used specifically in obstetrics and gynecology (OBGYN) care in LMICs. The initial search identified 132 published manuscripts: 114 non-duplicates from 1993 to 2024. After a two-research team member independent review, 22 manuscripts from 2011 to 2023 were included, and 18 devices identified. Nine devices focus on postpartum hemorrhage, four on general obstetrics, one on fetal monitoring, one on vaginal deliveries, one on gynecology hemorrhage, one on gynecology screening, and one on OBGYN anesthesia. This review provides recommendations for areas of improvement of key gaps affecting the development and implementation of OBGYN devices for use in LMICs. Recommendations are provided for various stages of the development to early commercialization phases. We believe future incorporation of these recommendations can aid in equitable and implementable medical device design for OBGYN care in LMICs.

Design, synthesis and characterization of novel thiazolidinone derivatives: Insights from a network pharmacology approach for breast cancer therapy

Among various types, breast cancer remains the most prevalent reason of cancer-related fatalities, underscoring its profound effect on women's health globally. In this study, we reported the synthesis and characterization of a new sequence of thiazolidinone derivatives linked to 2,4-dichlorobenzaldehyde. The compound's structures were confirmed through HRMS, while their detailed structural features were determined via IR, ¹H- and ¹³CNMR spectroscopic analysis. To identify potential biological targets, network pharmacology techniques were applied to the synthesized 2,4-dichlorobenzaldehyde derivatives, which pointed to STAT3 as a primary target of interest. Additionally, the ADMET properties and molecular docking of these compounds were evaluated against the STAT3 protein. Virtual docking analyses acknowledged compound 11 as having the competent binding affinity, with a docking score of -7.87 kcal/mol, suggesting robust interactions with the key amino acid residues, Trp243 and His457. Furthermore, molecular dynamics simulation recognised the stability of compound 11, as it maintained its structural integrity within the protein binding pocket throughout the 100 ns simulation.

A Novel Approach for Monitoring Training Load and Wellness in Women's College Gymnastics.

Monitoring training load has the potential to improve sport performance and reduce injuries in athletes. This study examined training load and its association with wellness in artistic gymnastics. Training load and changes in training load (acute:chronic workload ratio [ACWR]) vary throughout 1 season; wellness is inversely correlated with training load and ACWR. Prospective case series. Level 3. A total of 30 female collegiate gymnasts from 4 Division I National Collegiate Athletic Association teams participated (mean age, 20 ± 2 years). During 4 months, before daily training, wellness surveys assessed sleep, energy, soreness, and mood (1-10; higher = better). After daily training, training load surveys assessed training duration per event (warm-up, vault, bars, beam, floor, strength and conditioning) and session rating of perceived exertion (RPE; 1-10; 10 = hardest) per event. Coaches reported technical complexity of training per event (1-4; 4 = hardest). Training load was calculated as [duration] × [RPE] × [technical complexity]. ACWR represented a ratio between acute [1-week] and chronic [4-week rolling average] training loads. ACWR and weekly training load fluctuated throughout the season (ACWR mean weekly range: 0.68-1.11; training load mean weekly range: 2073-6193 arbitrary units). ACWR and weekly training loads were trichotomized into low, medium, and high groups; positive correlations were observed between each wellness variable and ACWR (P < 0.01) and between each wellness variable and weekly training load (P < 0.01). Our novel training load monitoring framework for women's college gymnastics enabled us to characterize training load and its relationship with wellness throughout 1 season. This method should be explored in gymnasts across various ages and competitive levels. This study proposes a framework and the initial findings of monitoring training load and wellness in collegiate women's gymnastics.

In vitro and in silico studies of a Zn(II) complex as a potential therapeutic agent for breast cancer.

Breast cancer (BC) is one of the most life-threatening diseases of women's health worldwide. This work was conducted to assess the anti-BC potency of a new Zn(II)-based complex. The Zn(II) complex coordinated to dimethoxy-substituted bipyridine was synthesized and its molecular structure was elucidated as [Zn(2Meobpy)3](clo4)2 (2Meobpy-Zn) by single-crystal X-ray diffraction, 2Meobpy represents 4,4'-dimethoxy-2,2'-bipyridine. The cytotoxicity results indicated that 2Meobpy-Zn, unlike cisplatin, acts potently and selectively on the human breast cancer cells (MCF-7) compared to normal murine embryo cells (NIH/3T3) by IC50 value of 4.6 ± 0.5µm and selectivity index (SI) of 2.0 over 48h. 2Meobpy-Zn and cisplatin showed anti-metastatic activity as evidenced by inhibition of the colony formation and cell migration. The flow cytometric assessment of MCF-7 cells supported that 2Meobpy-Zn and cisplatin exert their cytotoxic effect through the apoptotic pathway. Moreover, 2Meobpy-Zn could induce overproduction of intracellular reactive oxygen species (ROS) in MCF-7 cells. The apoptotic mechanism in 2Meobpy-Zn-treated MCF-7 cells is probably related to the regulation of apoptosis-relevant genes expression, including BAX and BCL2. Moreover, 2Meobpy-Zn is able to cleave pUC19 plasmid DNA through the hydrolytic reaction pathway. Finally, 2Meobpy-Zn's affinity towards antiapoptosis-related proteins, as a potential apoptosis inducer, as well as breast cancer-relevant proteins, as a potential anti-BC agent, was evaluated by in silico molecular docking studies. Altogether, the results of this work strongly evidenced that 2Meobpy-Zn can be the subject of experimental validation and clinical trials to introduce this complex as a promising BC therapeutic agent.