The study was conducted on the effect of spacing and fertilizers on growth, quality and yield of Artemisia pallens Wall. cv. Theni in northern Karnataka (Zone III) for two consecutive years in rabi 2021 and 2022. The research was set out in a factorial RCBD and replicated thrice in nine treatment combinations, that is three levels of spacing (S1: 15 x 7.5 cm, S2: 20 x 10 cm and S3: 30 x 10 cm) and three fertilizer levels (F1: 60:30:20 N, P2O5, K2O kg ha-1, F2: 90:30:30 N, P2O5, K2O kg ha-1 and F3: 120:40:40 N, P2O5, K2O kg ha-1). The pooled data of two years was statistically analysed using the Fisher's method of "Analysis of variance". Among the spacing levels, 20 x 10 cm spacing was noticed the maximum inflorescences plant-1 (87.40), hundred flower weight (3.83 g), fresh herbage yield (11.29 t ha-1), dry herbage yield (2.83 t ha-1) & essential oil yield (13.23 kg ha-1). Among various fertilizer doses application of F3 (120:40:40 N, P2O5, K2O kg ha-1) was noticed economically feasible, it has obtained maximal growth and yield parameters. The highest fresh herb yield (12.78 t ha-1), dry herbage yield (3.16 t ha-1) and essential oil yield of (15.46 kg ha-1) were noticed with 120:40:40 N, P2O5, K2O kg ha-1 (F3) application. Spacing of 20 x 10 cm (S2) and application of 120:40:40 N N, P2O5, K2O kg ha-1 (F3) found to be economical with highest benefit cost ratio of 4.08.