Database Website Research Articles

Association between serum zinc levels and lung cancer: a meta-analysis of observational studies

BackgroundInconsistent results according to numerous studies that had investigated the association between serum zinc levels and lung cancer risk were reported. The aim of this study was to explore whether serum zinc levels were lower in lung cancer patients than that in controls.MethodsWe systematically retrieved the databases of PubMed, Wanfang, Cochrane, ScienceDirect website, CNKI, and SinoMed databases for comprehensive relevant studies published before December 2018 and conducted a meta-analysis. Standard mean differences (SMD) were pooled using a random effects model.ResultsThirty-two articles were eligible to investigate the correlation between serum zinc levels and lung cancer risk, involving 2894 cases and 9419 controls. The pooled results showed sufficient evidence approving the association between serum zinc levels and lung cancer risk. And the serum zinc levels in lung cancer were significantly lower than that in controls (summary SMD = − 0.88, 95% confidence interval (CI) = − 0.94, − 0.82). Meanwhile, consistent results were obtained both in European populations and Asian populations. No publication bias was detected in our analysis.ConclusionsThe present meta-analysis suggested that serum zinc levels were significantly lower in lung cancer patients than that in controls.

Chemical Response Emergency Medical Information System in Chemical Disaster

Introduction:There are many database sets and websites which provide chemical information, but they do not perform an adequate role for emergency medical support in a chemical disaster.Aim:To make the basis of a chemical emergency medical information system.Methods:We reviewed the database sets, mobile applications and websites in the world which provide chemical database and emergency medical response information from a chemical accident or disaster site to hospitals. Also, we examined chemical accident cases which developed during disasters. A chemical database set for emergency medical response was proposed and the algorithm for elicitation of chemicals suitable for emergency medical response and information providing. We performed a survey about chemical emergency medical information system to related personnel.Results:By four steps of elicitation of chemicals, the number of chemicals more than 100,000 was decreased to less than 1,000. The standard of steps includes accident preparedness, toxicity and circulating amount and expert consultation. Algorithm for elicitation of chemicals was made and 82% of related personnel supported the chemical emergency response algorithm. The emergency medical real-time consultation system for chemical disaster was placed under control of the call center.Discussion:When mass exposure by toxic chemicals occurs, the chemical emergency medical information system will be helpful for acute identification of chemicals, protection of related personnel and emergency medical response. Also, it can be possible to guide citizens immediately in case of a chemical disaster.

Database of Immune Cell EQTLs, Expression, Epigenomics

Abstract Database of Immune Cell EQTLs, Expression, Epigenomics (DICE, dice-database.org) is a freely accessible web resource for diving deep into RNA-seq data across 13 human immune cell type (subsets of T cells, B cells, monocytes and NK cells), in a cohort of 91 healthy, genotyped donors1. The site is composed of four main modules that allow users to view the integrated data by gene, limit the scope to individual cell types, compare expression across cell types, and explore the effect of SNPs on gene expression. The site is optimized to be accessible on both desktop and mobile devices. DICE is an evolving resource with data for additional cell types being deposited on a continuous basis, with 3 additional B cell subsets being next in line. In addition to the core database website, an associated tools website (tools.dice-database.org) is actively being developed and currently hosts tools that operate on lists of genes to perform interactive GO enrichment analysis (GOnet), identify cell types most likely responsible for expression of a set of genes (CellTypeScorer), and examine GeneNetworks deduced from gene co-expression analysis.

Accuracy of MRI Sequences in Detecting Multiple Sclerosis (MS) Lesions: A Systematic Review

Introduction: Multiple sclerosis (MS) is one of the chronic autoimmune central nervous system disorder that characterized by demyelination of axon in brain cortex and the other grey and white matter regions and it makes several symptoms. Magnetic Resonance Imaging (MRI) with high sensitivity is the most important preclinical tool for the diagnosis of MS. The aim is to conduct systematic review studies carried out on accuracy of MRI sequences in detecting Multiple Sclerosis (MS) lesions. Methods: This study was systematic review. The related studies accomplished about using MRI in detecting MS lesions in worldwide included by searching in database and journal websites, including PubMed, Google Scholar and Medline. These articles searched by main keywords such as MRI, MS, lesions, sequence, and detecting. Conclusion: Our reviewing study showed that Double Inversion Recovery (DIR) Sequence in MRI has a high sensitivity to detect of lesion of MS. Furthermore, we recommend that the physicians add DIR sequence in routine MR protocols for diagnostic MS in patients.

Gene set enrichment analysis and meta-analysis identified 12 key genes regulating and controlling the prognosis of lung adenocarcinoma.

The aim of the present study was to analyze lung adenocarcinoma-associated microarray data and identify potentially crucial genes. The gene expression profiles were downloaded from the Gene Expression Omnibus database and 6 datasets, of which 2 were discarded and 4 were retained, were preprocessed using packages in the R computing language. Subsequently, Gene Set Enrichment Analysis (GSEA) and meta-analysis was used to screen the common pathways and differentially expressed genes at the transcriptional level. The genes detected from GSEA through The Cancer Genome Atlas databases were subsequently examined, and the crucial genes by survival data were identified. Pathways of the crucial genes were obtained using the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of the online website Database for Annotation, Visualization and Integrated Discovery (DAVID) tool, and the pathways of crucial genes that were upregulated or downregulated were matched using the Venn method to identify the common crucial pathways. Furthermore, on the basis of the common crucial pathways, key genes that are closely associated with the development and progression of lung adenocarcinoma were identified with the KEGG pathway of DAVID. Additional information was obtained through Gene Ontology annotation. A total of two key pathways, including cell cycle and DNA replication, as well as 12 key genes [DNA polymerase δ subunit 2, DNA replication licensing factor MCM4, MCM6, mitotic checkpoint serine/threonine-protein kinase BUB1, BUB1β, mitotic spindle assembly checkpoint protein MAD2A, dual specificity protein kinase TTK, M-phase inducer phosphatase 1, cell division control protein 45 homolog, cyclin-dependent kinase inhibitor 1C, pituitary tumor-transforming gene 1 protein and polo-like kinase 1] were identified. These key pathways and genes may be studied in future studies involving gene transfection/knockdown, which may provide insights into the prognosis of lung adenocarcinoma. Additional studies are required to confirm their biological function.

PENERAPAN ALGORITMA APRIORI DALAM MENENTUKAN POLA PEMBELIAN KONSUMEN DI KAFE HIDDEN TOAST AND FLOAT

Progress in Information Technology encourages culinary businesses to innovate, one of them is a computerized system, online-based sales and several interesting features that can increase consumer interest and increase sales to be the most frequently used innovation today. The cafe "Hidden Toast and Float" is a cafe in the City of Kediri. To increase sales from the cafe, a system is needed to facilitate the owner in recording sales and increasing the number of sales by providing automatic menu recommendations to customers. Based on the problem, in this thesis a website-based sales system and sales system will be created that is accompanied by the application of a priori algorithm to determine the purchasing patterns of customers and automatic menu recommendations from the system for customers. The test results of this thesis are two website-based systems with admin systems used to process existing data on the database and customer websites that are used for online purchases, as well as the application of a priori algorithms with the results of testing sample data and real data that produce menu combination recommendations. most often purchased based on all transaction data, namely Dark Choco Jam and Cappucino with a support value of 15% and a confidence value of 45%.

Antiviral Therapy for Herpes Simplex Virus Encephalitis: Systematic Review and Meta Analysis of RCTs

Background: Herpes simplex virus (HSV) infection of the brain is treated with antiviral drugs like Acyclovir. A summary of randomized control trials of antiviral drugs against HSV encephalitis has not been put forward yet. Objectives: To determine the effect of antiviral agents in the treatment of HSV encephalitis on mortality and neurological sequelae at approximately two years. The secondary objective was to assess the adverse effect of antiviral agents on the patients. Search methods: Trials were identified by searching the PUBMED, European Medical Agency, USFDA, US Clinical trials, Elsevier database and Cochrane website and the reference lists of published trials. Selection criteria: Randomized controlled trials of antiviral therapy in biologically proven HSV infection was included. Main results: A total of 5 studies met the criteria. The first study was published in 1980 and the latest was in 2015. All the studies used acyclovir/valacyclovir or vidarabine. Three studies compared acyclovir and vidarabine, one study was placebo controlled vidarabine trial and another one was a placebo controlled trial of long term valacyclovir therapy. Acyclovir improved mortality and lowered the incidence of neurological sequelae. There was no significant reduction in the risk of mortality with vidarabine therapy. Authors' conclusions: Trial evidence suggests that acyclovir decreases mortality and morbidity in acute HSV encephalitis. Funding: None. Declaration of Interest: None.

Meta-analytic framework for modeling genetic coexpression dynamics.

Methods for exploring genetic interactions have been developed in an attempt to move beyond single gene analyses. Because biological molecules frequently participate in different processes under various cellular conditions, investigating the changes in gene coexpression patterns under various biological conditions could reveal important regulatory mechanisms. One of the methods for capturing gene coexpression dynamics, named liquid association (LA), quantifies the relationship where the coexpression between two genes is modulated by a third "coordinator" gene. This LA measure offers a natural framework for studying gene coexpression changes and has been applied increasingly to study regulatory networks among genes. With a wealth of publicly available gene expression data, there is a need to develop a meta-analytic framework for LA analysis. In this paper, we incorporated mixed effects when modeling correlation to account for between-studies heterogeneity. For statistical inference about LA, we developed a Markov chain Monte Carlo (MCMC) estimation procedure through a Bayesian hierarchical framework. We evaluated the proposed methods in a set of simulations and illustrated their use in two collections of experimental data sets. The first data set combined 10 pancreatic ductal adenocarcinoma gene expression studies to determine the role of possible coordinator gene USP9X in the Hippo pathway. The second experimental data set consisted of 907 gene expression microarray Escherichia coli experiments from multiple studies publicly available through the Many Microbe Microarray Database website (http://m3d.bu.edu/) and examined genes that coexpress with serA in the presence of coordinator gene Lrp.

Usage of Commercial and Open Source Digital Resources in Libraries: With Special Reference to Islamic Management Arts & Science Colleges of Tamil Nadu

There are many subscribed resources and open source resources utilized by the Students, Research Scholars and Faculty Members in higher educational institutions. Objective –of this study is to determine the Digital resources usage preferences in Arts & Science college libraries of Tamil Nadu, particularly Islamic Management Arts & Science colleges. This article also examines the usage of e-books, e-journals (both subscribed and open source), Library website and abstracting database. It also deals with the status of the colleges which are subscribing to the digital resources. Research methodology. A systematically designed questionnaire was distributed to the selected colleges and received the data for analysis. Quite a few interesting facts have come out. Findings -Accordingly the data reveals that the undergraduate and postgraduate users preferred opens access resources and Google as their search engine for quick access while on the other hand research scholars insisted that commercial resources are of help and have made a recommendation to increase them. In case of faculty they recommend more number of commercial resources for their study, research and teaching purpose. Suggestions were made by the users to improve the infrastructure facility, regular power connection and a speed increase in the high bandwidth internet connections and to conduct seminars/ workshops/ orientation to the users in order to create awareness to increase the both the category of digital resources.

Inflammatory Periimplant Diseases and the Periodontal Connection Question.

Implant therapy has become a widespread reality in modern dentistry. Nevertheless, dental implants can fail due to different causes, among which inflammatory peri-implant diseases (IPDs) are a major challenge, with prevalences that are much higher than previously believed.Specific searches were undertaken for each question raised between October and November 2017, in the PubMed website database (US National Library of Medicine, National Institutes of Health; Bethesda, Maryland, United States). Only articles written in English and published from 2007 onward were considered initially. The following keywords were used in the searches “periimplantitis (PI),” “periimplant mucositis (PM),” “dental implant failure,” “periimplant microbiota,” “periodontal microbiota,” “implant failure” (no temporal limit), and “foreign body reaction” (no temporal limit). The selection process resulted in the selection of 239 articles that were analyzed in detail in elaborating this review. The reference list was limited to the 47 most relevant articles due to editorial limits of this Journal.Intrinsic differences between natural teeth and dental implants are able to give rise to inflammatory diseases that share only minor and scarcely relevant characters, and would consequently deserve different and specifically designed instruments and strategies, for both diagnosis and therapy.

Impacts of Terrorism in the United Kingdom and Europe on Tourism in the United Kingdom

Terrorist attacks occur more and more frequently. Therefore, people from all over the world pay more and more attention to them. This paper will focus on the relationship between terrorism and tourism in the United Kingdom, especially focusing on the relationship between terrorism in the United Kingdom or in Europe and tourism in the United Kingdom. This paper applies the Auto Regressive Distributed Lag (ARDL) model to figure out their relationship. The data used in this article are from the website of the United Kingdom’s office for national statistics and the website of the global terrorism database respectively. Firstly, using the ADF test to figure out whether all these three variables, tourists arrivals, terrorist attacks happened in the U.K. and terrorist attacks happened in Europe continent, are stationary. Secondly, use the ARDL model to test whether terrorism in the United Kingdom and Europe respectively has an impact on British tourism. The results show that terrorism in the United Kingdom has a negative impact on British tourism while terrorism in Europe has a positive impact on it. The results are unexpected. Then analyzing the reasons why terrorism in Europe has a positive impact on tourism in the United Kingdom. But whether these reasons are true needs to explore furtherly.

Chronic Wound Healing Assessment System Based on Different Features Modalities and Non-Negative Matrix Factorization (NMF) Feature Reduction

Identification and treatment of chronic wounds (CWs) are considered economic and social challenges, especially with respect to bedridden and elderly persons. CWs do not follow a predictive course of healing within a particular period. Their treatment and management costs are very high. Also, CWs decrease quality of life for patients, which cause severe pain and discomfort. In this paper, we proposed a comprehensive wound healing assessment framework based on current appearance, texture, and prior visual appearance analysis to handle different types of CWs depending on extracting various tissue types. The framework provided an accurate evaluation tool for the CW healing process depending on extracting and fusing significant features from the CWs RGB images. Non-negative matrix factorization (NMF) was used to retrieve the most significant features to reduce computation time. The gradient boosted trees (GBT) classifier was used to classify different tissue types. Finally, the healing assessment of the CWs depended on calculating the improvement in the area of the necrotic eschar, slough, granulation, and healing epithelial tissues. The framework was trained and tested using 377 RGB images from Medetec wound database and national pressure ulcer advisory panel website. The proposed system achieved an average accuracy of 96% for tissue classification, which helps in obtaining an accurate CW healing assessment. This result can be considered as a promising result when compared to the other state-of-the-art techniques.

PP113 A Framework To Enhance Eurasian Economic Union Cooperation On Health Technology Assessment: Lessons From The European Network for Health Technology Assessment

IntroductionThe Eurasian Economic Union (EAEU), which currently includes Armenia, Belarus, Kazakhstan, Kyrgyzstan, and Russia, was established in 2015. Pursuing economic integration, and modeled in part after the structure of European Union, the EAEU launched a common medicines market in 2017. There have been various developments regarding cooperation in health technology assessment (HTA) across the EAEU countries, exemplified by a conference held in Kazakhstan in 2017. Here we discuss some considerations for developing cooperation in HTA throughout EAEU based on the experiences of implementing the European Network for Health Technology Assessment (EUnetHTA).MethodsLegal and review documents regarding the implementation of EUnetHTA were obtained from the European Commission website and research databases to inform this narrative review.ResultsAchieving recognition of the role of HTA at an inter-governmental level, akin to the actions of the European Commission prior to establishing EUnetHTA, appears pivotal at the current stage of HTA development among EAEU members. Similar to the EUnetHTA project stage of 2006-2008, the existing HTA structures and national standards will need to be accurately and systematically assessed by a working-group appointed specifically for that purpose. Besides the importance of accepting a unifying framework similar to the EUnetHTA core model, implementation features that are specific to the context of EAEU countries could include the development of common adaptation toolkits and glossaries. Capacity building efforts may also prove crucial to ensure the sustainability of HTA-related cooperation.ConclusionsOptimization of resources by streamlining HTA processes, whether in research, policy, or results dissemination, and avoiding duplication of effort by HTA agencies, is relevant in the context of limited healthcare resources in developing countries. This overview is an attempt at facilitating discussion to inform policy and research efforts to streamline HTA processes.

A Closer Look at the Relationship Between Industry and Orthopaedic Sports Medicine Surgeons

Background:A recent study demonstrated that discrepancies exist between disclosures reported by authors publishing in The American Journal of Sports Medicine and disclosures listed in the Physician Payments Sunshine Act–initiated Open Payments database, managed by the Centers for Medicare & Medicaid Services (CMS). However, no study to date has explored the relationship between the biopharmaceutical and device industry (industry) and the membership base of the American Orthopaedic Society for Sports Medicine (AOSSM).Purpose:To critically examine the relationship between orthopaedic sports medicine surgeons and industry.Study Design:Cross-sectional study.Methods:The publicly available CMS Open Payments database website was accessed to search for sports medicine orthopaedic surgeons in the United States who were members of the AOSSM. Financial data, specifically general, research, and ownership payments for 2015, were recorded for each surgeon. The American Academy of Orthopaedic Surgeons (AAOS) disclosures of each surgeon were then obtained. Descriptive statistics and simple proportions were calculated to summarize the collected data, including years in practice and amount of payment. Median values for general payments were compared to provide a more accurate reflection of payments transferred to a “typical” sports medicine surgeon.Results:A total of $58,113,561 in general payments, $3,996,051 in research payments, $72,481,814 in money invested, and $144,552,383 in interest earned from money invested were identified as being paid to 2274 surgeons (all amounts in US$). The distribution of total general payments received was skewed: 10% of surgeons received 95.4% ($55,463,183) of the total general payments. A total of 1433 surgeons had completed, up-to-date AAOS disclosures. Although 44% (635 surgeons) self-reported no financial conflict to the AAOS, the Open Payments database indicated some level of industry support to these surgeons. Unreported general payments totaled $1,393,212, or a median of $561 per surgeon (interquartile range, $10-$200,048).Conclusion:Although orthopaedic sports medicine surgeons received substantial payments from industry, most of the total general payments were given to a small proportion of people. The regional distribution of these payments did not differ significantly. Summary reports of data are largely skewed by outliers and should be interpreted with caution. However, a large percentage of these surgeons failed to reveal industry support of any kind in their AAOS disclosures, including meals and educational funding, demonstrating the importance of transparency and accuracy when completing financial disclosures.

The raspberry: An analysis of production in the Republic of Serbia from 2006 to 2016

Raspberry production has a long tradition in the Republic of Serbia, and the raspberry is the most economically important berry crop. According to data for the period from 2006 to 2016, the Republic of Serbia was ranked fourth in the world in the production of this fruit crop. The paper presents an analysis of raspberry production in the Republic of Serbia using statistical data from the previous years, which were compared with 2016 data. For comparison and analysis, we used the data presented on the FAOSTAT statistical database website and the Statistical Office of the Republic of Serbia (RZS) website. The analysis of the available data for the period 2006-2016 shows that the total yield of raspberries in this period varied, as did yield in tonnes per hectare, which ranged from 5.3 to 6 tonnes, depending on year. A sudden decrease in total yield in 2012 and in all subsequent years until 2016 was also observed. This was caused by a sudden reduction in the area under raspberries.

A comprehensive review on phytopharmacological investigations of Acacia auriculiformis A.Cunn. ex Benth

Acacia auriculiformis A.Cunn. ex Benth. is a perennial shrub having a wide range of medicinal potentials and is widely distributed throughout the world. It is being used traditionally to overcome various medical complications like sore eyes, aches, rheumatism, allergy, itching, and rashes. Besides, Acacia auriculiformis has been proven for many pharmacological activities like central nervous system depressant activity, antioxidant, antimicrobial, antimalarial, anti-filarial, cestocidal, antimutagenic, chemopreventive, spermicidal, wound healing, hepatoprotective and antidiabetic activity due to its low toxicity (LD50 = 3 741.7 mg/kg) and high efficacy. In addition, various phytochemical investigations reveal the presence of chief constituents as flavonoids (Auriculoside) and triterpenoid saponin glycosides (acaciasides- acaciaside A & B) in different parts of this plant. Since many years researchers have been carrying out various studies on this medicinal important shrub to elicit the various biological activities. This review attempts to highlight the pharmacognostical, phytochemical and pharmacological observations from 1965 to 2018 retrieved from SciFinder, Scientific journals, books, Google Scholar, and botanical electronic database websites. The various plant extracts evaluated for different pharmacological activities showed significant efficacy. Bioactive phytoconstituents isolated from various parts of the plant are highlighted. Pharmacognostical standardization of the plant done with various standard parameters is also reported. The low toxicity of this plant and the presence of major bioactive phytoconstituents like flavonoids and triterpenoid saponin glycosides are responsible for a therapeutic remedy for various diseases and pharmacological activities respectively. This review provides exhaustive information about the pharmacognostical, phytochemical, and pharmacological investigations of Acacia auriculiformis till date.

A review on the prevention of inflammatory periimplant diseases

Background: An impressive number of dental implants are inserted worldwide. Evolution in dental implants and simplification of surgical techniques allowed a significant increase in the number of dentists involved in implant surgery. Most of them are general dentists, are not always sufficiently formed and experienced, frequently use low-quality implants, do not adopt the proper patient selective criteria, do not adequately monitor and maintain the inserted implants, and do not report their own statistics to the dental community. Consequently, the incidence of inflammatory periimplant diseases (IPDs) has progressively increased to values significantly higher than those previously indicated by the scientific literature. Materials and Methods: Two main literature searches were undertaken in October 2018 in the PubMed Website database. Only articles written in English and published from 2008 onward were considered; “Clinical Trial,” “Meta analysis,” “Observational study,” “Review,” and “Validation study” were selected as article type filters. The following keywords were used in the searches: “Peri implantitis prevention” and “Dental implant failure prevention.”Results: Preventive measures are analyzed according to the different factors that can favor the occurrence of an infection. The factors are divided into (i) implant dependent, (ii) patient dependent, and (iii) surgeon dependent. Conclusions: Scientific and clinical data confirm that when materials are selected with care, patients are carefully evaluated for factors of risk and attitude to adhere to the necessary maintenance program, and operative protocols and maintenance programs are respected dental implants can be attractive and effective tools for oral rehabilitation. Nevertheless, dentists and patients should have greater awareness that in many cases the decision to utilize dental implants cannot be taken lightly.

Comparison of Maize and Wheat Production in Serbia During the 2007-2016 Period

The objective of this paper is to show and compare the production of maize and wheat in Serbia from 2007 to 2016. This paper presents an analysis of the production of maize and wheat in the Republic of Serbia, by applying the method of comparison and using the data on previous years and comparing them with the 2016 data. The data are available on the website of the FAOSTAT statistical database and on the website of the Statistical Office of the Republic of Serbia (RZS), which were used for comparison and analysis. The record year when it comes to the harvest of maize was 2014, in the period from 2007 to 2016, with its production over 7.951.583 tonnes. The highest production of wheat was in 2016, and it amounted to 2.884.537 t. The year 2016 recorded the highest production of wheat in the last decade while corn advanced in comparison to the previous year, the best production having been achieved in 2014. We can say that, as far as production is concerned, the situation is improving with minor fluctuations.

Investigations on the mechanism of progesterone in inhibiting endometrial cancer cell cycle and viability via regulation of long noncoding RNA NEAT1/microRNA-146b-5p mediated Wnt/β-catenin signaling.

Progesterone is often used to protect the endometrium and prevent endometrial cancer. An intensive study on its molecular mechanism in endometrial cancer would contribute to the development of more promising therapies. Relevant lncRNAs and mRNAs expression data in endometrial cancer cell line Ishikawa pretreated and post-treated with progesterone were derived from Gene Expression Omnibus (accession no. GSE29435), and then we analyzed long noncoding RNAs and mRNAs with differential expressions in two different conditions. The Cytoscape software, TargetScan, miRanda, and Human microRNA Disease Database (HMDD) websites were employed. Gene set enrichment analysis (GSEA) was used to determine related Kyoto Encyclopedia of Genes and Genomes pathways alteration in Ishikawa cells treated with progesterone. In addition to bioinformatics analysis, Reverse Transcription-Polymerase Chain Reaction (RT-PCR), Western blot, and dual-luciferase reporter assays were performed. The impact of progesterone on cell propagation and cell cycle was testified by colony formation and flow cytometry analysis. LncRNA nuclear enriched abundant transcript 1 (NEAT1) was the most significantly downregulated lncRNA in endometrial cancer cells treated with progesterone. Lymphoid enhancing factor 1 (LEF1) was positively associated with NEAT1, and eventually hsa_miR-146b-5p was validated to target both LEF1 and NEAT1. Wnt/β-catenin signaling pathway was identified to involve in endometrial cancer. NEAT1 or LEF1 was overexpressed in endometrial cancer cells while downregulated following post-treatment with progesterone. Conversely, miR-146b-5p was notably decreased in Ishikawa cells while upregulated after treatment with progesterone. Downstream gene c-myc or MMP9 regulated by upstream gene LEF1 in Wnt/β-catenin signaling pathway was remarkably increased in Ishikawa cells and positively related with NEAT1. Progesterone inhibited cell cycle and viability through regulating NEAT1/miR-146b-5p axis via Wnt/β-catenin signaling pathway. Progesterone exerted suppressive influence on endometrial cancer progression via regulation of lncRNA NEAT1/miR-146b-5p-mediated Wnt/β-catenin signaling pathway, which might reveal new strategies for developing more effective therapeutics. © 2018 IUBMB Life, 71(1):223-234, 2019.

Association of maternal iron deficiency anemia with the risk of gestational diabetes mellitus: a meta-analysis.

The aim of the study was to conduct a meta-analysis investigating the association of maternal iron deficiency anemia (IDA) and risk of gestational diabetes mellitus (GDM). Literature search was conducted in various database websites such as PubMed, Cochrane Library, and Web of Science up to 17 June 2018 for related publications written in English. Selected data were extracted from the included studies and were subjected to statistical analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed, pooled, and interpreted. Subgroup analysis by ethnicity (Asians vs. Caucasians) was also performed. Six studies with a total sample size of 15,157 from various countries were included in this meta-analysis. Pooled ORs of all publications included show that pregnant women with IDA have a reduced risk of developing GDM (OR 0.61; 95% CI 0.47-0.80; PA = 0.0003). Subgroup analysis, on the other hand, showed significant associations among Asians (OR 0.60; 95% CI 0.45-0.79; PA = 0.0003) than Caucasians (OR 0.76; 95% CI 0.32-1.76; PA = 0.52). Results of this meta-analysis suggests that pregnant women with IDA are 39% less likely to develop GDM. However, more studies are needed to confirm the claims of our results.