AbstractIntroductionTherapeutic plasma exchange (TPE) is crucial for saving lives when used appropriately. This study aimed to assess TPE's impact on tumor necrosis factor‐like weak inducer of apoptosis (TWEAK) protein and IL‐6 levels in critically ill pediatric patients.MethodsConducted between May 2022 and December 2022, the study observed pediatric intensive care unit (PICU) patients undergoing TPE, recording demographics, lab results, TWEAK, and IL‐6 levels pre‐ and post‐procedure.ResultsOf 41 patients, 53.7% were male, 51.2% had underlying conditions, and 39% showed sepsis symptoms. IL‐6 levels significantly rose post‐TPE (p: 0.006), while TWEAK protein levels dropped (p: 0.030). Positive correlations were found between interleukin‐6 (IL‐6) pre‐TPE and ventilation duration, ferritin levels (p <0.05), and TWEAK pre‐TPE and organ failure indicators, D‐Dimer levels (p <0.05). Prognosis showed no significant difference in IL‐6/TWEAK levels (p >0.05).ConclusionSerum IL‐6 and TWEAK can indicate disease severity and inflammation level, but may not predict prognosis accurately.Clinical Trial RegistrationOur study has clinical study registration number B.10.1.TKH.4.34.H.GP.0.01/154 of the University of Health Sciences Ümraniye Training and Research Hospital.
Read full abstract