Weak Entrainment Research Articles

Alterations in Per2, Bcl2 gene expression, and oxidative status in aged rats liver after light pulse at night.

The aging process is characterized by circadian rhythm disruption, in physiology and behavior, which could result from weak entrainment. Light is the most potent cue that entrains the central circadian clock, which in turn synchronizes peripheral clocks in animal tissues. Period 2 (Per2) is one of the clock genes that respond to light. Moreover, oxidative stress could entrain the clock. Therefore, the present work aimed to investigate the role of light when applied late at night on the Per2, B cell lymphoma 2 (Bcl2) gene expression, and oxidative status in aged rats. Aged rats were divided into a control group and a group exposed to a 30-min light pulse applied daily during the subjective night at 5 am (ZT 22) for 4weeks. Per2 and Bcl2 gene expression were quantified in liver tissue. To evaluate oxidative status, Glutathione (GSH), nitric oxide (NO), and malondialdehyde (MDA) were estimated. The light pulse reduced the expression levels of Per2 and Bcl2 mRNA. Although it diminished the levels of malondialdehyde (MDA), nitric oxide (NO) levels were elevated and the glutathione (GSH) levels were declined. In conclusion, the light pulse late at night abolished Per2 mRNA circadian rhythm and reduced its expression in the liver of the aged rat. Similarly, it diminished the anti-apoptotic gene expression, Bcl2. Moreover, it might attenuate oxidative stress through the reduction in MDA levels.

On the near-field interaction of vertically offset turbulent plumes

The flow in and around a pair of plumes from sources that are vertically and horizontally offset is investigated. An analytical potential flow model is developed using an adapted version of the Milne–Thomson circle theorem to represent the flow due to adjacent circular and point sinks. This approximates the horizontal section through offset plumes, which have differing radii at the same vertical position. The predictions of this model are compared against Reynolds-averaged Navier–Stokes (RANS) simulations of the same system. These yield time-averaged results and so are particularly suitable for investigating the relatively weak entrainment field. Single and double plume results from RANS are also presented to compare with known results. Good agreement is found between the features in the analytical model and in the numerical solutions including the location of the stagnation point between the two plumes.

Jet-supercavity interaction and instability mechanism analysis

In this research, an experimental system that couples the supercavity and the tail jet was established, aiming at exploring on the cavity instability mechanism. Both high pressure gas tank and solid rocket motor were used to generate the tail jet. The model shape and the jet rate were all varied to investigate different flow patterns. Experiments for the cold gas jet were first carried out, obtaining the variation of the flow pattern with the jet strength and the relative location. With strong jet intensity, the supercavity could lose instability by the re-entrained liquid jet, which was mainly generated by the back attack of the tail jet. Furthermore, the effect of the rearward facing step structure on the cavity instability was investigated, validating that the re-entrained jet could be successfully suppressed by this structure. However, when the cavity contacts with the wall surface, another kind of instability induced by cavity/body interaction could be induced. Subsequently, experiments were carried out for the hot jet generated by the solid rocket motor. A new kind of cavity instability at the moment of ignition was observed. The cavity shrinking and collapse processes were compared between different cases. When the ignition process finished, the hot jet transited into a continuous free expansion mode with weak entrainment of liquid. Finally, the cavity instability mechanisms were summarized and compared. Spectral analysis was carried out for different cases. An obvious larger Strouhal number exists for the pressure pulse induced instability.

LOFAR discovery of rare large FR I jets in the low-luminosity radio galaxy NGC 5322

ABSTRACT The discovery of faint Fanaroff–Riley type I (FR I) radio jets in the elliptical galaxy NGC 5322 is reported here using the 144-MHz image from Data Release 2 of the Low-Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS). The jets have an angular extent of ∼40 arcmin or a projected physical extent of ∼360 kpc. The faint jets remain well collimated and disappear in the intergalactic medium, without any detected hotspots or radio lobes. The relatively brighter jets, previously detected only up to the ∼21 kpc extent at higher frequencies, are within the optical extent of the galaxy. The jets become faint abruptly outside, where detection is made only in the LOFAR image. The total radio luminosity of the galaxy at 144 MHz is estimated to be (3.7 ± 0.4) × 1022 W Hz−1. The 144-MHz radio luminosity of the faint jets outside the optical extent is estimated to be (7.1 ± 2.0) × 1021 W Hz−1. The size of the jets is exceptionally large for the galaxy’s low radio luminosity, when compared with other radio galaxies. It makes NGC 5322 a rare radio galaxy, previously not detected in other radio surveys. A combined effect of stellar core depletion and low-density environment around the jets, which results in a weak entrainment of the material surrounding the jets, could be responsible for its large size despite a low radio luminosity.

Mesoscale Convective Systems Simulated by a High‐Resolution Global Nonhydrostatic Model Over the United States and China

AbstractMesoscale convective systems (MCSs) contribute a large fraction of warm‐season precipitation and generate hazardous weather with substantial socioeconomic impacts. Uncertainties in convection parameterizations in climate models limit our understanding of MCS characteristics and reliability of future projection. We examine MCSs simulated by the global 14 km Nonhydrostatic ICosahedral Atmospheric Model (NICAM) without cumulus parameterization against satellite observation from Global Precipitation Measurement during 2001–2008. We focus on MCSs over the central United States and eastern China where MCSs are prevalent from March to August. A process‐oriented tracking method incorporating both cloud and precipitation criteria is used to identify and track MCSs. About 140/100 MCSs initiate in the central United States/eastern China per warm season and most of them initiate in the east of high mountains and in coastal regions. The frequency distribution of MCS lifetime is well captured by NICAM. However, the simulated MCSs have stronger precipitation, smaller precipitation area, and larger cold cloud system than that observed in both regions, which may be caused by weak entrainment as it is not well resolved at 14 km resolution. The simulated MCS number is also underestimated in summer. By examining the climatological and MCS large‐scale environments, the significant underestimation of MCS number in summer over the central United States may be attributed to the large climatological dry bias in the atmosphere. For China, mean moisture in summer is well simulated but deficiency in capturing the dynamic condition related to the coastal topography for triggering convection may have contributed to underestimation of MCS even in a sufficiently moist environment.

Detection of tACS Entrainment Critically Depends on Epoch Length.

Neural entrainment is the phase synchronization of a population of neurons to an external rhythmic stimulus such as applied in the context of transcranial alternating current stimulation (tACS). tACS can cause profound effects on human behavior. However, there remain a significant number of studies that find no behavioral effect when tACS is applied to human subjects. To investigate this discrepancy, we applied time sensitive phase lock value (PLV) based analysis to single unit data from the rat motor cortex. The analysis revealed that detection of neural entrainment depends critically on the epoch length within which spiking information is accumulated. Increasing the epoch length allowed for detection of progressively weaker levels of neural entrainment. Based on this single unit analysis, we hypothesized that tACS effects on human behavior would be more easily detected in a behavior paradigm which utilizes longer epoch lengths. We tested this by using tACS to entrain tremor in patients and healthy volunteers. When the behavioral data were analyzed using short duration epochs tremor entrainment effects were not detectable. However, as the epoch length was progressively increased, weak tremor entrainment became detectable. These results suggest that tACS behavioral paradigms that rely on the accumulation of information over long epoch lengths will tend to be successful at detecting behavior effects. However, tACS paradigms that rely on short epoch lengths are less likely to detect effects.

Nighttime Light Hurts Mammalian Physiology: What Diurnal Rodent Models Are Telling Us.

Natural sunlight permits organisms to synchronize their physiology to the external world. However, in current times, natural sunlight has been replaced by artificial light in both day and nighttime. While in the daytime, indoor artificial light is of lower intensity than natural sunlight, leading to a weak entrainment signal for our internal biological clock, at night the exposure to artificial light perturbs the body clock and sleep. Although electric light at night allows us “to live in darkness”, our current lifestyle facilitates nighttime exposure to light by the use, or abuse, of electronic devices (e.g., smartphones). The chronic exposure to light at nighttime has been correlated to mood alterations, metabolic dysfunctions, and poor cognition. To decipher the brain mechanisms underlying these alterations, fundamental research has been conducted using animal models, principally of nocturnal nature (e.g., mice). Nevertheless, because of the diurnal nature of human physiology, it is also important to find and propose diurnal animal models for the study of the light effects in circadian biology. The present review provides an overview of the effects of light at nighttime on physiology and behavior in diurnal mammals, including humans. Knowing how the brain reacts to artificial light exposure, using diurnal rodent models, is fundamental for the development of new strategies in human health based in circadian biology.

Droplet Fate in a Cough Puff

The dynamic and thermodynamic evolution of droplets, in a size range characterizing a cough, has been analysed using basic equations of motion and coupled to the evolution of a spherical cloud puff in which they are supposed to be expired. It has been found that the maximum contamination range of the emitted droplets is controlled by two different mechanisms: surface evaporation and inertia-gravitational settling—with a switching threshold between them for a radius around a few tens of microns. For the smallest droplets, the environmental conditions (the temperature and humidity) are found to be very effective in determining the contamination range, even for weak entrainment in the cloud puff. This last fact could be of some relevance in the seasonal behaviour of air-borne epidemics.

Comparative DEM-CFD study of binary interaction and acoustic agglomeration of aerosol microparticles at low frequencies

The paper concerns the problem of acoustic agglomeration due to the acoustic wake in diluted aerosols and addresses the development of the time-accurate discrete element method (DEM) simulation technique. The case of weak entrainment of heavier mono-sized microparticles at low-frequency sound waves is considered. The agglomerative motion of two identical micron-sized spherical particles is simulated numerically, and contribution of the particles boundary layer in transition from the diluted to the dense phase is investigated. A comparative study of the DEM approach against more accurate computational fluid dynamics (CFD) computations is performed. The 3D incompressible viscous flow of aerosol medium described by Navier–Stokes equations is considered regarding the fine scale of particles. The numerical results regarding the agglomeration rate, drag coefficient, and perturbation velocities are discussed. Moreover, the correction to the fluid–particle interaction force is proposed to increase the accuracy of the DEM model.

High Liquid-Gas Ratio Separation in Pre-Cyclone Jet Singlet Oxygen Generator

A novel pre-cyclone jet singlet oxygen generator (PJSOG) has been the focus of research for recent years. In this paper, the high liquid-gas ratio separation performances of PJSOG have been studied by means of theoretical and experimental analysis. The liquid excess of the critical mass concentration portion can be easily captured due to initial BHP particles swirling momentum for a specific designed structure. At high flow speeds, the vacuum mixed Cl2/He with a weak entrainment capability insures high separation efficiency. Large quantities of experiments have verified that the new PJSOG do have the excellent operation performances of high separation efficiency, high O2 (1Δ) output coefficient, high utilization coefficient of Cl2 and excellent operating flexibility and stability. All the results show that the new PJSOG is a feasible and promising technology in singlet oxygen generation cases.

Circadian Synchronization Linked to a Successful Treatment in a Severely Depressed Adolescent

To the Editor: Circadian rhythm abnormalities have recently been considered a key factor to the onset and outcome of affective disorders.1,2 Circadian rhythm irregularities in depressed adults and adolescents have been reported by several authors.3,4 Blunted circadian amplitude or decreases of the 24-hour spectral power expressing weak entrainment to the 24-hour day are the main circadian rhythm dysfunctions observed in major depressive disorder (MDD) patients.4 MDD patients may also show reduced exposure to light and irregularity of daily social activity, also known as social rhythms, which are important cues for the synchronization to a 24-hour environmental cycle. Depressed adolescents spend less time in bright light and show low light exposure compared to healthy controls.5 Disruptions of social rhythms have also been associated with affective episodes.6

Effects of the duper mutation on circadian responses to light.

The circadian mutation duper in Syrian hamsters shortens the free-running circadian period (τ(DD)) by 2 hours when expressed on a tau mutant (τ(ss)) background and by 1 hour on a wild-type background. We have examined the effects of this mutation on phase response curves and entrainment. In contrast to wild types, duper hamsters entrained to 14L:10D with a positive phase angle. Super duper hamsters (expressing duper on a τ(ss) background) showed weak entrainment, while τ(ss) animals either completely failed to entrain or showed sporadic entrainment with episodes of relative coordination. As previously reported, wild-type and τ(ss) hamsters show low amplitude resetting in response to 15-minute light pulses after short-term (10 days) exposure to DD. In contrast, super duper hamsters show high amplitude resetting. This effect is attributable to the duper allele, as hamsters carrying duper on a wild-type background also show large phase shifts. Duper mutants that were born and raised in DD also showed high amplitude resetting in response to 15-minute light pulses, indicating that the effect of the mutation on PRC amplitude is not an aftereffect of entrainment to 14L:10D. Hamsters that are heterozygous for duper do not show amplified resetting curves, indicating that for this property, as for determination of free-running period, the mutant allele is recessive. In a modified Aschoff type II protocol, super duper and duper hamsters show large phase shifts as soon as the second day of DD. Despite the amplification of the PRC in super duper hamsters, the induction of Period1 gene expression in the SCN by light is no greater in these mutants than in wild-type animals. Period2 expression in the SCN did not differ between super duper and wild-type hamsters exposed to light at CT15, but albumin site D-binding protein (Dbp) mRNA showed higher basal levels and greater light induction in the SCN of super duper compared to wild-type animals. These results indicate that the duper mutation alters the amplitude of the circadian oscillator and further distinguish it from the tau mutation.

Simulation of Seasonal Variation of Marine Boundary Layer Clouds over the Eastern Pacific with a Regional Climate Model*

Abstract The seasonal cycle of marine boundary layer (MBL) clouds over the eastern Pacific Ocean is studied with the International Pacific Research Center (IPRC) Regional Atmospheric Model (iRAM). The results show that the model is capable of simulating not only the overall seasonal cycle but also the spatial distribution, cloud regime transition, and vertical structure of MBL clouds over the eastern Pacific. Although the modeled MBL cloud layer is generally too high in altitude over the open ocean when compared with available satellite observations, the model simulated well the westward deepening and decoupling of the MBL, the rise in cloud base and cloud top of the low cloud decks off the Peru and California coasts, and the cloud regime transition from stratocumulus near the coast to trade cumulus farther to the west in both the southeast and northeast Pacific. In particular, the model reproduced major features of the seasonal variations in stratocumulus decks off the Peru and California coasts, including cloud amount, surface latent heat flux, subcloud-layer mixing, and the degree of MBL decoupling. In both observations and the model simulation, in the season with small low-level cloudiness, surface latent heat flux is large and the cloud base is high. This coincides with weak subcloud-layer mixing and strong entrainment at cloud top, characterized by a high degree of MBL decoupling, while the opposite is true for the season with large low-level cloudiness. This seasonal cycle in low-cloud properties resembles the downstream stratocumulus-to-cumulus transition of marine low clouds and can be explained by the “deepening–decoupling” mechanism proposed in previous studies. It is found that the seasonal variations of low-level clouds off the Peru coast are mainly caused by a large seasonal variability in sea surface temperature, whereas those off the California coast are largely attributed to the seasonal cycle in lower-tropospheric temperature.

Phase locking between excess spike synchrony and LFP is independent of rate covariation

A possible strategy of information coding employed by cortical networks involves the propagation of activity through synchronously firing groups of neurons, termed assemblies. A hallmark signature of such an assembly coding scheme is the detection of synchronous spiking in parallel recordings of neuronal activity. Experimental work (e.g., [1]) indirectly substantiates the assembly idea with findings of behavioral correlates of significant excess synchronous spiking activity. Recently, we demonstrated [2] that such excess coincident spikes, or Unitary Events [3], also show an exceptionally strong phase-locking to oscillations of the local field potential (LFP), a signal measured directly at the population level. A theoretical model consistently embeds this experimentally observed relationship within the assembly framework. In this context, the weak entrainment of spikes of a single neuron to the LFP is explained as a reflection of the neuron's participation in different assemblies across the network. Co-varying firing rate modulations induced by LFP oscillations were instead suggested as the cause for preferred locking of excess spike coincidences to the LFP phase. In this study we investigate if this alternative hypothesis can be validated. To this end, we first identify the extremal rate changes within those UE analysis windows that are assumed to be expressions of a rate step. We then relate the magnitude of individual rate steps to the degree of rate co-variation across neurons. In a final step, we relate these two measures to phase and amplitude of the LFP. We find that the locking of significant spike synchrony does not preferentially occur with rate changes. As an additional test we extended our previous work by replacing the parametric distribution of coincidences used for evaluating the significance of observed coincidence counts by numerically derived distributions based on surrogate data. The employed surrogate method (spike train dithering, see [4]) considers the statistical features (non-stationarity of rates, interspike interval distribution,...) of the experimental spike trains, while destroying precise spike coincidences. Simulations show that this method is conservative compared to the UE analysis used in earlier work. Despite the decreased sensitivity of the surrogate based method, this additional analysis confirms our previous findings on the relationship between spike synchrony and the LFP, and demonstrates that they are not explained as a consequence of rate covariation. Taken together, these two analyses corroborate our original interpretation of LFP oscillations as a reflection of assembly dynamics.

The Role of Entrainment in the Diurnal Cycle of Continental Convection

Abstract In continental convective environments, general circulation models typically produce a diurnal cycle of rainfall that peaks close to the noon maximum of insolation, hours earlier than the observed peak. One possible reason is insufficient sensitivity of their cumulus parameterizations to the state of the environment due to weak entrainment. The Weather Research and Forecasting (WRF) model, run at cloud-resolving (600 and 125 m) resolution, is used to study the diurnal transition from shallow to deep convection during the monsoon break period of the Tropical Warm Pool–International Cloud Experiment. The WRF model develops a transition from shallow to deep convection in isolated events by 1430–1500 local time. The inferred entrainment rate weakens with increasing time of day as convection deepens. Several current cumulus parameterizations are tested for their ability to reproduce the WRF behavior. The Gregory parameterization, in which entrainment rate varies directly with parcel buoyancy and inversely as the square of the updraft speed, is the best predictor of the inferred WRF entrainment profiles. The Gregory scheme depends on a free parameter that represents the fraction of buoyant turbulent kinetic energy generation on the cloud scale that is consumed by the turbulent entrainment process at smaller scales. A single vertical profile of this free parameter, increasing with height above the boundary layer but constant with varying convection depth, produces entrainment rate profiles consistent with those inferred from the WRF over the buoyant depth of the convection. Parameterizations in which entrainment varies inversely with altitude or updraft speed or increases with decreasing tropospheric relative humidity do not perform as well. Entrainment rate at cloud base decreases as convection depth increases; this behavior appears to be related to an increase in vertical velocity at downdraft cold pool edges.

Mixing and Entrainment in the Red Sea Outflow Plume. Part I: Plume Structure

Abstract When the salty and heavy water of the Red Sea exits from the Strait of Bab el Mandeb, it continues downslope into the Gulf of Aden mainly along two channels. The 130-km-long “Northern Channel” (NC) is topographically confined and is typically only 5 km wide. In it, the Red Sea plume shows unanticipated patterns of vertical structure, turbulent mixing, and entrainment. Above the seafloor a 25–120-m-thick weakly stratified layer shows little dilution along the channel. Hence this bottom layer undergoes only weak entrainment. In contrast, a 35–285-m-thick interfacial layer shows stronger entrainment and is shown in a companion paper to undergo vigorous turbulent mixing. It is thus the interface that exhibits the bulk of entrainment of the Red Sea plume in the NC. The interfacial layer also carries most of the overall plume transport, increasingly so with downstream distance. The “Southern Channel” (SC) is wider than the NC and is accessed from the latter by a sill about 33 m above the floor of the NC. Entrainment into the bottom layer of the SC is diagnosed to be strong near the entry into the SC such that the near-bottom density and salinity are smaller in the SC than in the NC at the same distance from Bab el Mandeb. In comparison with winter conditions, the authors encountered weaker outflow with shallower equilibration depths during the summer cruise. Bulk Froude numbers computed for the whole plume varied within the range 0.2–1. Local maxima occurred in relatively steep channel sections and coincided with locations of significant entrainment.

Mixing and Entrainment in the Red Sea Outflow Plume. Part II: Turbulence Characteristics

Abstract South of the Strait of Bab el Mandeb, saline Red Sea Water flows downslope into the Gulf of Aden mainly along the narrow 130-km-long “Northern Channel” (NC) and the shorter and wider “Southern Channel” (SC). In the NC, the Red Sea plume simultaneously exhibited weak entrainment into a 35–120-m-thick, weakly stratified bottom layer while a 35–285-m-thick interfacial layer above showed signs of vigorous mixing, overturns up to 30 m thick, and extensive zones of gradient Richardson numbers below 1/4. Turbulent overturning scales, or Thorpe scales, are extracted from regular CTD profiles and equated to Ozmidov scales. On this basis, interfacial mixing is quantified in terms of estimated turbulent dissipation rates, vertical turbulent salt flux, and interfacial stress. Even though these estimates are subject to significant uncertainty, they demonstrate the intensity of mixing during strong winter outflow in terms of eddy diffusivities Kρ on the order of 10−2 m2 s−1. The large Kρ occur in strong stratification such that vertical turbulent salt fluxes are also large. Along the NC, relative maxima of Kρ correspond to maxima in the bulk Froude number. Direct short-term measurements of the Reynolds stress just above the seafloor at two locations, one in the NC and one in the SC, allow comparisons of the bottom stress τb with the interfacial turbulent stress τi. The ratio τi/τb shows large scatter in a small sample, with maximum values on the order of 1. An appendix outlines procedures of making and reducing lowered acoustic Doppler current profiler measurements optimized for observing descending plumes.

Disruption of Layer 4 Development Alters Laminar Processing in Ferret Somatosensory Cortex

Treatment with the anti-mitotic agent methylazoxymethanol (MAM) on embryonic day 33 (E33) in ferrets changes features of somatosensory cortex. These include dramatic reduction of cells in layer 4, and altered distributions of thalamocortical afferent terminations and GABA(A) receptors. To determine the effect of the relative absence of layer 4 on processing of sensory stimuli we used current source-density profiles to assess laminar activity patterns. Nearly synchronous activation occurs across all layers in treated animals, which contrasts with the normal cortical activation pattern of initial sinks in layer 4. This change after MAM treatment is consistent with the absence of layer 4 cells and widespread termination of thalamocortical afferents. Using periodic stimulation at 'flutter' frequency, layer 4 neurons in normal somatosensory cortex fire reproducibly to the stimulus rate; the capacity for entrainment is best for layer 4 and weaker in the extragranular layers. The capacity to encode periodic sensory stimuli is disrupted in MAM-treated somatosensory cortex; after an initial response to the onset of periodic stimuli, neurons in all cortical layers show weak entrainment. Neural responses to sensory drive in E33 MAM-treated cortex are also embedded in levels of neural activity substantially above those in normal somatosensory cortex. Sustained stimulation additionally reveals different capacities in each layer for improved signal-to-noise ratios, with layer 4 neurons in normal animals exhibiting the most improved signaling over time. We conclude that normal thalamic terminations, an intact layer 4 and subsequent intracortical processing are integral to proper encoding of stimulus features.

Observations of the Storfjorden overflow

The mixing and spreading of the Storfjorden overflow were investigated with density and horizontal velocity profiles collected at closely spaced stations. The dense bottom water generated by strong winter cooling, enhanced ice formation and the consequent brine rejection drains into and fills the depression of the fjord and upon reaching a 120-m deep sill, descends like a gravity current following the bathymetry towards the shelf edge. The observations covered an approximate 37-km path of the plume starting from about 68 km downstream of the sill. The plume is identified as two layers: a dense layer 1 with relatively uniform vertical structure underlying a thicker layer 2 with larger vertical density gradients. Layer 1, probably remnants from earlier overflows, almost maintains its temperature–salinity characteristics and spreads to a width of about 6 km over its path, comparable to spread resulting from Ekman veering. Layer 2, on the other hand, is a mixing layer and widens to about 16 km. The overflow, in its core, is observed to have salinities greater than 34.9, temperatures close to the freezing point, and light transmissivity typically 5% less than that of the ambient waters. The overall properties of the observed part of the plume suggest dynamical stability with weak entrainment. However local mixing is observed through profiles of the gradient Richardson number, the non-dimensional ratio of density gradient over velocity gradient, which show portions with supercritical values in the vicinity of the plume–ambient water interface. The net volume transport associated with the overflow is estimated to be 0.06 Sv (Sv≡10 6 m 3 s −1) out of a section closest to the sill and almost double that as it leaves the section furthest downstream. The weak entrainment is estimated to account for the doubling of the volume transport between the two sections. A simple model proposed by Killworth (J. Geophys. Res. 106 (2001) 22267), giving the path of the overflow from a constant rate of vertical descent along the slope, compares well with our observations.

Three-dimensional modelling of the characteristics of long laminar plasma jets with lateral injection of carrier gas and particulate matter

A long laminar plasma jet has adjustable high-temperature region length, small temperature and velocity gradients in the axial direction, low noise emission and weak entrainment of ambient air into the jet, and thus it has potential applications in materials processing. A three-dimensional modelling approach is used in this paper to study the spatial distributions of plasma parameters in the long laminar plasma jet for the case with and without lateral injection of particulate matter and its carrier gas. The combined diffusion coefficient method is employed in the modelling to treat the diffusion of ambient air into the plasma jet. Typical computed distributions of temperature, velocity and species concentration in the jet are presented using the long laminar argon plasma jet issuing into ambient air as a calculation example. It is shown that similarly to the turbulent plasma jet case, the long laminar plasma jet has good enough stiffness to endure the impact of the laterally injected carrier gas, although the laminar jet assumes slight deflection from its original geometrical axis in the injection plane due to the action of laterally injected carrier gas. The three-dimensional effects caused by the lateral carrier-gas injection on the jet characteristics and thus on the particle moving trajectories and heating histories are shown to be appreciable. Particulate matter can be fed into the high-temperature region of the laminar plasma jet with the aid of the carrier gas.