In the modern agricultural landscape, numerous challenges, such as climate change, diminishing arable lands, and the reduction of water resources, represent significant threats. The Mediterranean greenhouse farming model relies on low-input strategies to maximize both yield and quality. Its protected horticulture is essential for the year-round cultivation of high-value crops, ensuring efficient and sustainable production. In the realm of future agricultural strategies, leveraging internet-based approaches emerges as a pivotal factor for real-time and remote control of various agricultural parameters crucial for crop growth and development. This approach has the potential to significantly optimize agronomic inputs, thereby enhancing the efficiency of targeted vegetable production. The aim of the present review is to underscore the challenges related to the intensive greenhouse production systems emphasizing various strategies leading to low-input greenhouse vegetable production. The goal is to promote more sustainable and resource-efficient approaches in the cultivation of greenhouse vegetables. This review highlights several key strategies for optimizing the greenhouse environment, including efficient water management through conservation tillage, drainage water reuse, and selecting the most appropriate irrigation systems and timing. Additionally, light modulation and temperature control—using solar energy for heating and pad-and-fan systems for cooling—are crucial for enhancing both crop performance and resource efficiency. The review also explores low-input agronomical strategies, such as pest and disease control—including solarization and optimized integrated pest management (IPM)—as well as fertilization and advanced growing techniques. These approaches are essential for sustainable greenhouse farming.