Gravity-driven membrane (GDM) filtration is a promising technology for decentralized water and wastewater treatment due to its negligible energy consumption and low maintenance. This study investigated the flux development and permeate quality of the GDM process in treating the secondary effluent, as well as the influences of two practical pre-treatments, including GAC filter and microfiltration (MF), on its filtration performance. The results indicated that the GAC filter could significantly enhance the removal of organic contaminants (i.e., DOC, UV254, and fluorescent substances), with an average removal of 70 % for DOC and 80 % for UV254, respectively. Meanwhile, GAC/GDM systems exhibited a superior removal performance of manganese and sulfamethoxazole (SMX) for more than 95 % and 80 %, respectively. Furthermore, the optimized mixing ratio between GAC permeates and secondary effluent was 7:3 (GAC7:3) to reach a flux level close to the GDM control and achieve a superior permeate water quality than the other processes. The flux of GDM control could stabilize at the level of 5.47 ± 0.71 L m−2h−1 during long-term filtration. Unexpectedly, limited flux improvements were observed with the pre-treatments, and the stable flux of GAC/GDM and MF/GDM was close to or slightly lower than the GDM control. In GDM control, a rough, heterogeneous, and porous biocake layer was observed on the membrane surface. By contrast, the cake layer structures in the GDM system coupled with pre-treatments appeared denser, compact, and homogeneous, resulting in relatively lower stable flux relative to the GDM control. The economic assessment indicated that the optimized process of GAC7:3 showed a significant cost advantage in the small and medium-scale water reuse scenarios. These findings were beneficial to develop new energy-saving membrane-based technology for the reclamation of wastewater.