BACKGROUND AND AIM: Waste is a daily health hazard that must be addressed through appropriate management. The Institut Pasteur of Côte d'Ivoire (IPCI) produces waste that is generally infectious waste and waste assimilated to household waste. The presence of this mostly infectious waste can create a risk for staff. Thus, since March 11, 2020, the date of the first case of COVID-19, a rigorous health management policy has been taken to protect health workers. METHODS: Diagnosis of the COVID-19 pandemic in Côte d'Ivoire is mainly done at the Institut Pasteur of Côte d’Ivoire (IPCI). Thus, the waste produced in the various laboratories is disinfected, then sorted, packaged in 5 to 10 liter bags, transported in dedicated bins to final storage. The waste is weighed under biosafety conditions before being incinerated in an ATI Environment CP100 incinerator. RESULTS:Waste management at IPCI in 2020 during COVID-19 resulted in biosafety training for staff, collection, packaging, transportation, storage and incineration of 26.4 tons of waste. It should be noted that no waste management personnel were infected during the entire period from March to December 2020 CONCLUSIONS:During the year 2020 and mainly from March 11, 2020 to December 31, 2020, waste management increased significantly from 12.2 tons in 2019 during the same period to 26.4 tons in 2020 and was related to COVID-19. This shows that waste has more than doubled and requires rigorous management. It would therefore be imperative to properly manage waste in order to protect health care personnel. Also, this study showed one aspect of the environmental impact of COVID-19 that needs further research. KEYWORDS: COVID-19, Waste management, incineration