Spherical Volume Research Articles

Comparative study on application of 177Lu-labeled rituximab, tetulomab, cetuximab and huA33 monoclonal antibodies to targeted radionuclide therapy

Purpose Dose coefficients from rituximab, tetulomab, cetuximab, and huA33 monoclonal antibodies labelled with the radionuclide 177Lu were estimated for human organs and tumours via a theoretical simulation based on experimental results. Methods The real experimental results were obtained from radiopharmaceutical distribution in hairless mice. Using the Sparks and Aydogan method, the cumulated activity for humans was recalculated. The simulation was used to assess the behaviour of MAbs labelled with 177Lu after injection into the human body. The average absorbed doses were calculated for the most exposed organs and tissues. Results The huA33 monoclonal antibodies (MAbs) labelled with 177Lu (Lu-rituximab, Lu-tetulomab, Lu-cetuximab, and Lu-huA33), presented the maximum nuclear transformation per Bq intake for the main organs (blood, kidneys, liver, lung, and spleen, as well as for a tumour) The absorbed dose in the liver is three times lower for Lu-huA33 compared to the other drugs. In the case of cetuximab, the spleen received the lowest dose compared to the other drugs. The dependencies on absorbed dose for the alveolar, bronchioles, bone surface, heart wall, kidneys, liver, lung, lymphatic nodes, and spleen, are presented. For tumours, the absorbed dose for each drug is calculated separately for a sphere of unit volume by using the information on the injected dose. Conclusion, The ratios of the dose coefficient for the tumour to each organ, indicate that lutetium-177 can be recommended for targeted radionuclide therapy since the dose per tumour is much greater than the dose per organ.

Multitudes of Voigt - Reuss forks and Voigt - Christensen - Reuss tridents

In the literature, there are many studies of the representative volume of a composite material, in particular, those calculated using the formulas of Christensen, Voigt and Reiss. The aim of this work is to study the features of evaluating the set of forks of effective modules. Methods. On the basis of solving the Lame problem (for a thick-walled sphere), a spherical model of a representative volume (cell) of a composite material with a granular (spherical) filler is compiled and the value of the effective modulus of elasticity of a two-phase composite is determined. The study of the obtained formula for the effective modulus, expressed in dimensionless quantities, for the cell material revealed its identity with the R.M. Christensens formula, expressed in dimensional values, for the bulk modulus of composites with a spherical filler. In this case, Christensens solution was previously obtained by a different method when he considered the polydisperse model of the composite. The dimensionless form of the function (effective module) of three dimensionless parameters made it possible in flat spaces (two coordinate planes) to construct graphical images of the function of the named modules according to Christensen, which are compared and combined in one figure with similar images of the functions of estimating the values of the modules (real composites) according to Voigt and Reiss. Graphical studies in relation to the spherical representative volume model show that in the flat space of the set of Voigt - Reuss forks, these forks are not narrowed, but they are partially filled by the flat space of the set of Christensen - Reiss forks. The graphs of the functions of the modules, at the same time, form, simultaneously with the sets of two-toothed forks, a set of Voigt - Christensen - Reiss trident forks (tridents), which, depending on the size of the intervals of the numbers of the studied parameters, have forks of different sizes. Results. Graphic illustrations of numerical examples have been obtained showing that for given values of the module of the matrix and filler and the volume fraction of the latter, it is possible to determine the effective volumetric module and shear module of two-phase composites, and to perform a comparison with the conclusions of the applied plan. The dimensionless form of the obtained expressions makes it possible to solve the inverse problems of the mechanics of polydisperse composites, for example, to determine the volume module of the composite components by the effective modulus obtained by mechanical testing of standard samples.

Characterization of a preclinical PET insert in a 7 tesla MRI scanner: beyond NEMA testing

This study evaluates the performance of the Bruker positron emission tomograph (PET) insert combined with a BioSpec 70/30 USR magnetic resonance imaging (MRI) scanner using the manufacturer acceptance protocol and the NEMA NU 4–2008 for small animal PET. The PET insert is made of 3 rings of 8 monolithic LYSO crystals (50 × 50 × 10 mm3) coupled to silicon photomultipliers (SiPM) arrays, conferring an axial and transaxial FOV of 15 cm and 8 cm. The MRI performance was evaluated with and without the insert for the following radiofrequency noise, magnetic field homogeneity and image quality. For the PET performance, we extended the NEMA protocol featuring system sensitivity, count rates, spatial resolution and image quality to homogeneity and accuracy for quantification using several MRI sequences (RARE, FLASH, EPI and UTE). The PET insert does not show any adverse effect on the MRI performances. The MR field homogeneity is well preserved (Diameter Spherical Volume, for 20 mm of 1.98 ± 4.78 without and −0.96 ± 5.16 Hz with the PET insert). The PET insert has no major effect on the radiofrequency field. The signal-to-noise ratio measurements also do not show major differences. Image ghosting is well within the manufacturer specifications (<2.5%) and no RF noise is visible. Maximum sensitivity of the PET insert is 11.0% at the center of the FOV even with simultaneous acquisition of EPI and RARE. PET MLEM resolution is 0.87 mm (FWHM) at 5 mm off-center of the FOV and 0.97 mm at 25 mm radial offset. The peaks for true/noise equivalent count rates are 410/240 and 628/486 kcps for the rat and mouse phantoms, and are reached at 30.34/22.85 and 27.94/22.58 MBq. PET image quality is minimally altered by the different MRI sequences. The Bruker PET insert shows no adverse effect on the MRI performance and demonstrated a high sensitivity, sub-millimeter resolution and good image quality even during simultaneous MRI acquisition.

Is FDG-PET texture analysis related to intratumor biological heterogeneity in lung cancer?

We aimed at investigating the origin of the correlations between tumor volume and 18F-FDG-PET texture indices in lung cancer. Eighty-five consecutive patients with newly diagnosed non-small cell lung cancer (NSCLC) underwent a 18F-FDG-PET/CT scan before treatment. Seven phantom spheres uniformly filled with 18F-FDG, and covering a range of activities and volumes similar to that found in lung tumors, were also scanned. Established texture indices were computed for lung tumors and homogeneous spheres. The dependence between textural indices and volume in homogeneous spheres was modeled and then used to predict texture indices in lung tumors. Correlation analyses were carried out between predicted and texture features measured in lung tumors. Cox proportional hazards regression was used to investigate the associations between overall survival and volume-adjusted textural features. All textural features showed strong, non-linear correlations with volume, both in tumors and homogeneous spheres. Correlations between predicted versus measured texture features were very high for contrast (r2 = 0.91), dissimilarity (r2 = 0.90), ZP (r2 = 0.90), GLNN (r2 = 0.86), and homogeneity (r2 = 0.82); high for entropy (r2 = 0.50) and HILAE (r2 = 0.53); and low for energy (r2 = 0.30). Cox regressions showed that among volume-adjusted features, only HILAE was associated with overall survival (b = - 0.35, p = 0.008). We have shown that texture indices previously found to be correlated with a number of clinically relevant outcomes might not provide independent information apart from that driven by their correlation with tumor volume, suggesting that these metrics might not be suitable as intratumor heterogeneity markers. • Associations between texture FDG-PET indices and overall survival have been widely reported in lung cancer, with tumor volume also being associated with overall survival, and therefore, it is still unclear whether the predictive power of textural indices is simply driven by this correlation. • Our results demonstrated strong non-linear correlations between textural indices and volume, showing an analogous behavior for lung tumors from patients and homogeneous spheres inserted in phantoms. • Our findings showed that texture FDG-PET indices might not provide independent information apart from that driven by their correlation with tumor volume.

Design and analysis of the 16T superconducting magnet for CFETR strand test facilities

Abstract A 16 T superconducting magnet is being designed with the aim of testing the Nb3Sn superconducting strands and high temperature superconductors. The superconducting magnet will produce a magnetic field of 16 T at the magnet center with magnetic field homogeneity better than 0.5 % at 180 A for a diameter spherical volume of 50 mm. The combination of the Nb3Sn and NbTi coils were used to manufacture the superconducting magnet. The superconducting magnet consists of four inner Nb3Sn coils and two NbTi coils. All coils are connected in a series with a power supply. This paper presents the magnet design, electromagnetic and mechanical behavior analysis of the superconducting magnet.

Efficient eddy current characterization using a 2D image-based sampling scheme and a model-based fitting approach.

To propose two innovations to existing eddy current characterization techniques, which include (1) an efficient spatio-temporal sampling scheme and (2) a model-based fitting of spherical harmonic eddy current components. This work introduces a three-plane 2D image-based acquisition scheme to efficiently sample eddy current fields. Additionally, a model-based spherical harmonic decomposition is presented, which reduces fitting noise using a rank minimization to impose an exponential decay on the eddy current amplitude evolution. Both techniques are applied in combination and analyzed in simulations for their applicability in reconstructing suitable pre-emphasis parameters. In a proof-of-concept measurement, the routine is tested for its propriety to correctly quantify user-defined field dynamics. Furthermore, based on acquired precompensation and postcompensation eddy current data, the suitability of pre-emphasis parameters calculated based on the proposed technique is evaluated. Simulation results derived from 500 data sets demonstrate the applicability of the acquisition scheme for the spatio-temporal sampling of eddy current fields. Compared with a conventional data processing strategy, the proposed model-based approach yields pre-emphasis parameters that reduce the average maximum residual field offset within a 10-cm-diameter spherical volume from 3.17 Hz to 0.58 Hz. Experimental data prove the proposed routine to be suitable to measure and effectively compensate for eddy currents within 10 minutes of acquisition time. The proposed framework was found to be well-suited to efficiently characterize and compensate for eddy current fields in a one-time calibration effort. It can be applied to facilitate pre-emphasis implementations, such as for dynamic B0 shimming applications.

Abstract 14546: Left Ventricular Sphericity Index as a Predictor of Appropriate Implantable Cardioverter-defibrillator Therapy

Introduction: We assessed the hypothesis that markers of LV wall stress, such as LV sphericity index (SI), may predict appropriate therapy for ventricular arrhythmias (VA) in patients with primary prevention defibrillators, independent of LV ejection fraction. Methods: We performed a retrospective analysis of consecutive patients with new ICD or CRT-D placement for primary prevention at a single hospital from 01/01/2015 to 06/30/2018. TTE images were used for calculating LV SI, which was defined as the ratio of bi-plane LV end-diastolic volume to the volume of a hypothetical sphere with a diameter of LV end-diastolic length in apical 4-chamber view. Device interrogations were reviewed for appropriate therapy for VA and inappropriate therapy for non-VAs. Kaplan-Meier curves stratified by LV SI tertile were constructed, and Cox proportional hazards models were used to evaluate time to appropriate and inappropriate therapy, and all-cause mortality. Results: A total of 282 patients (ICD 154, CRT-D 128) were included. Baseline characteristics are described in the Table. We found a trend towards increased appropriate therapy as LV SI increased in the ICD but not the CRT-D group, but this was non-significant in both (ICD log-rank 0.63, p-value 0.73; CRT-D log-rank 0.07, p-value 0.96). There was no correlation between LV SI and time to all-cause mortality in the ICD (log-rank 0.53, p-value 0.76) or the CRT-D patients (log-rank 0.51, p-value 0.77). LV SI correlated significantly with time to inappropriate therapy in the ICD (log-rank 8.6, p-value 0.01), but not the CRT-D patients (log-rank 2.4, p-value 0.3). Conclusions: LV SI demonstrated a non-significant trend towards increased appropriate device therapy in the ICD but not the CRT-D group. LV SI predicted inappropriate therapy in the ICD but not the CRT-D group. Study power was limited by lower than expected event rates, possibly due to changes in device programming and improvements in heart failure therapies over time.

Disinformation and Conspiracy Theories in the Age of COVID-19.

OPINION article Front. Sociol., 12 November 2020Sec. Media Governance and the Public Sphere Volume 5 - 2020 | https://doi.org/10.3389/fsoc.2020.560681

BIOM-61. FUNCTIONAL DIAGNOSTIC TESTING OF LIVE-CELL DRUG RESPONSE USING 3D PATIENT DERIVED GLIOBLASTOMA SPHEROIDS ON THE INCUCYTE PLATFORM

Abstract Three-dimensional patient derived cultures hold great potential for use as personalized functional diagnostics, enabling more accurate preclinical evaluations of drug treatments compared to conventional cell lines. Optical imaging of live cells allows for continuous, time lapsed measurements, and can provide drug response data based on rich phenotypic changes of cell cultures. However, current imaging techniques based on 2D microscopy evaluation aren’t readily adaptable to evaluate the drug response of intact spheroids, which may better represent the in vivo environment and retain critical cellular interactions within the tumor microenvironment. Using the IncuCyte live cell imaging platform, we successfully imaged a large cohort (n = 77) of patient derived glioblastoma spheroid cultures and evaluated whether changes in sphere volume could be used as a direct measure of treatment response. Improving on the default Incucyte analysis software, we developed an R data processing pipeline better suited for spheroid measurements, which quantified the heterogeneity in GBM baseline spheroid growth, and calculated a drug response score based on spheroid changes in response to DNA damaging agents (TMZ as an example). Compared to conventional viability measurements, this novel 3D drug response score was found to accurately identify both drug sensitive and resistant spheroids and showed robust concordance with genomic biomarkers of response (NGS and MGMT promoter methylation) and patient outcomes. Additionally, we coupled the 3D drug score with known genetic data to explore other key pathways and genes involved in TMZ response. We provide here novel analysis methods and public code (Github) to advance the use of IncuCyte spheroid measurements, and deconvolute 3D spheroid drug response into a quantifiable statistic. These methods are adaptable to freshly isolated patient cells for rapid evaluation of treatment response in GBM patients while remaining widely applicable to other cancers such as pancreatic, colon, and non-cancer organoids/spheroids with 3D growth.

Critical time step for discrete element method simulations of convex particles with central symmetry

AbstractA time step must be selected for any explicit discrete element method (DEM) simulation. This time step must be small enough to ensure a stable simulation but should not be overly conservative for computational efficiency. There are established methods to estimate critical time steps for simulations of spherical particles. However, there is a comparable lack of guidance on choosing time steps for DEM simulations involving nonspherical particles: a fact which is increasingly problematic as simulations of nonspherical particles become more commonplace. In this article, the eigenvalues of the amplification matrix are used to develop an explicit formula for the critical time step for a range of shapes including ellipsoids, convex superquadrics and convex, central symmetric polyhedra. This derivation is based on a linear analysis and applies to both underdamped and overdamped systems. The dependence on the particle mass and contact stiffness expected for a system of spheres is recovered. For a fixed particle mass, as particle shape becomes increasingly nonspherical, the critical time step decreases nonlinearly. Thus, estimating a critical time step by assuming a sphere of equivalent volume may not always be conservative.

Effect of setup error in the single-isocenter technique on stereotactic radiosurgery for multiple brain metastases.

In conventional stereotactic radiosurgery (SRS), treatment of multiple brain metastases using multiple isocenters is time‐consuming resulting in long dose delivery times for patients. A single‐isocenter technique has been developed which enables the simultaneous irradiation of multiple targets at one isocenter. This technique requires accurate positioning of the patient to ensure optimal dose coverage. We evaluated the effect of six degrees of freedom (6DoF) setup errors in patient setups on SRS dose distributions for multiple brain metastases using a single‐isocenter technique. We used simulated spherical gross tumor volumes (GTVs) with diameters ranging from 1.0 to 3.0 cm. The distance from the isocenter to the target's center was varied from 0 to 15 cm. We created dose distributions so that each target was entirely covered by 100% of the prescribed dose. The target's position vectors were rotated from 0°–2.0° and translated from 0–1.0 mm with respect to the three axes in space. The reduction in dose coverage for the targets for each setup error was calculated and compared with zero setup error. The calculated margins for the GTV necessary to satisfy the tolerance values for loss of GTV coverage of 3% to 10% were defined as coverage‐based margins. In addition, the maximum isocenter to target distance for different 6DoF setup errors was calculated to satisfy the tolerance values. The dose coverage reduction and coverage‐based margins increased as the target diameter decreased, and the distance and 6DoF setup error increased. An increase in setup error when a single‐isocenter technique is used may increase the risk of missing the tumor; this risk increases with increasing distance from the isocenter and decreasing tumor size.

Youth Networks' Advances Toward the Sustainable Development Goals During the COVID-19 Pandemic

OPINION article Front. Sociol., 29 October 2020Sec. Media Governance and the Public Sphere Volume 5 - 2020 | https://doi.org/10.3389/fsoc.2020.589539

Phenomenological law for the acoustic reflection by an array of cylindrical cavities in a soft elastic medium

We propose a phenomenological model, built from results obtained by finite-element numerical simulations, for the transmission and reflection of acoustic waves by a two-dimensional array of cylindrical cavities in a soft elastic medium. We show that the acoustic properties of a cylindrical cavity can be described by two geometrical parameters: its aspect ratio (AR) and the radius of the sphere of equivalent volume. Cylinders with AR close to one are acoustically similar to spheres, whereas flat cylinders exhibit a lower resonance frequency and an increased damping due to their ability to emit shear waves. We provide an example of how our new phenomenological analytical model can help to design thin coatings that can turn strong acoustic reflectors into good absorbers.

Design of novel super wide band antenna close to the fundamental dimension limit theory

This paper investigates the design and practical implementation of a Super Wide Band (SWB) antenna along with the application of fundamental bandwidth limitation theory of small antennas in the proposed design. The antenna is designed on a material with permittivity, εr = 3 where the patch metallization height is maintained as 0.035 mm. The designed antenna is then modified by enhancing the copper patch with an additional layer of 28.5 mm thickness. The proposed antenna achieves a huge frequency range with a ratio bandwidth starting from 96.96:1 to as high as 115.10: 1. The designed antenna operating band with thinner height starts from 1.65 to 160 GHz while with the added patch metallic height, the antenna operates from a minimum of 1.39 to 160 GHz with an average nominal bandwidth of more than 158 GHz. By enhancing the patch height, the antenna spherical volume is utilized more efficiently. Using this principle, the antenna impedance bandwidth is augmented while a reduction in electrical size is achieved. A comparison with the fundamental theories by Chu and Mclean illustrates that the designed SWB antenna electrical size exceeds Mclean and nearly touches the Chu fundamental limit curve. This eventually offers the maximized bandwidth with the most compact size for an SWB antenna. The designed antenna with thinner patch metallization height is practically fabricated and measured up to 67 GHz using Vector Network Analyzer to provide experimental validation.

An analytical expression for R50% dependent on PTV surface area and volume: a lung SBRT comparison.

In stereotactic body radiation therapy (SBRT), R50% is a common metric for intermediate dose spill and is defined in RTOG 0915 as the ratio of 50% isodose cloud volume (IDC50%) to the planning target volume (PTV). By coupling sound physical principles with the basic definition of intermediate dose spill, we derive an exact analytical expression for R50% for the case of a spherical volume. This expression for R50% depends on three quantities: the surface area of PTV (SAPTV), the volume of PTV (VPTV), and the dose gradient Δr. Validity of our analytical expression for R50% was confirmed via direct comparison to peer‐reviewed, multi‐institutional, diverse clinical data. The comparison of our R50% values computed from our analytical expression to the clinical data yielded an average percent difference of 3.8 ± 4.5%.

Effect of rotation and traverse speeds on the microstructure and mechanical properties of friction stir processed 2205 duplex stainless steel

The effects of rotational speed in range of 800–1600 rpm and traverse speed in range of 12–40 mm/min on the mechanical and microstructural properties of 2205 duplex stainless steel were studied. The temperature and strain were crucial to the microstructural evolutions in the stir and thermomechanical affected zones. The major microstructural evolution is the breaking of austenite islands and morphological change into spherical volumes named as “dynamic globularization”. The hardness was maximum in the stir zone and decreased by passing through the thermomechanical and heat affected zones. A linear equation was developed between hardness and the ratio of ω/S. The highest hardness was obtained at 1000 RPM and 12 mm/Min. The results of tensile test showed that the ultimate tensile strength (UTS) and fracture strain are improved by FSP. UTS and fracture strain increased with increase in the rotation speed and decrease in the traverse speed.

Realization of the New Kilogram Using 28Si-Enriched Spheres and Dissemination of Mass Standards at NMIJ

The new definition of the kilogram was implemented on May 20, 2019. The kilogram is presently defined by a fixed value of the Planck constant. On the basis of the new definition, the kilogram will be realized at the National Metrology Institute of Japan by the X-ray crystal density method using 28Si-enriched spheres. For the realization, the volume of 28Si-enriched spheres is measured by optical interferometry. The sphere surface characterization by X-ray photoelectron spectroscopy and ellipsometry is also performed. The relative standard uncertainty of the realization is estimated to be 2.4 × 10−8. Details of the realization and future dissemination of mass standards in Japan based on the 28Si-enriched spheres are described.

Isolation and Characterization of Two Novel Colorectal Cancer Cell Lines, Containing a Subpopulation with Potential Stem-Like Properties: Treatment Options by MYC/NMYC Inhibition.

Simple SummaryThe aim of this study was to gain a better understanding of cancer stem cells, which are a small subpopulation of tumor cells with high plasticity driving tumor growth and metastasis. Here we isolated two novel colorectal cancer cell lines originating from a rectal neuroendocrine carcinoma and a colorectal adenocarcinoma, depicting stem-like properties. These in vitro models offer the possibility to evaluate pathophysiological mechanisms in order to develop tailored therapeutic strategies for distinct colorectal malignancies. Investigations revealed gene copy number gain of the N-myc proto-oncogene for both. Accordingly, inhibition of the protein–protein interaction of myc and N-myc proto-oncogenes with the myc-associated factor X utilizing small molecule KJ-Pyr-9, exhibited a significant reduction in survival of both cell lines by the induction of apoptosis. Consequently, the blockage of these interactions may serve as a possible treatment strategy for colorectal cancer cell lines with gene copy number gain of the N-myc proto-oncogene.Cancer stem cells (CSC) are crucial mediators of cancer relapse. Here, we isolated two primary human colorectal cancer cell lines derived from a rectal neuroendocrine carcinoma (BKZ-2) and a colorectal adenocarcinoma (BKZ-3), both containing subpopulations with potential stem-like properties. Protein expression of CSC-markers prominin-1 and CD44 antigen was significantly higher for BKZ-2 and BKZ-3 in comparison to well-established colon carcinoma cell lines. High sphere-formation capacity further confirmed the existence of a subpopulation with potential stem-like phenotype. Epithelial–mesenchymal transition markers as well as immune checkpoint ligands were expressed more pronounced in BKZ-2. Both cell populations demonstrated N-myc proto-oncogene (NMYC) copy number gain. Myc proto-oncogene (MYC)/NMYC activity inhibitor all-trans retinoic acid (ATRA) significantly reduced the number of tumor spheres for both and the volume of BKZ-2 spheres. In contrast, the sphere volume of ATRA-treated BKZ-3 was increased, and only BKZ-2 cell proliferation was reduced in monolayer culture. Treatment with KJ-Pyr-9, a specific inhibitor of MYC/NMYC-myc-associated factor X interaction, decreased survival by the induction of apoptosis of both. In summary, here, we present the novel colorectal cancer cell lines BKZ-2 and BKZ-3 as promising cellular in vitro models for colorectal carcinomas and identify the MYC/NMYC molecular pathway involved in CSC-induced carcinogenesis with relevant therapeutic potential.

Can Na18F PET/CT bone scans help when deciding if early intervention is needed in patients being treated with a TSF attached to the tibia: insights from 41 patients

PurposeTo demonstrate the usefulness of positron emission tomography (PET)/computed tomography (CT) bone scans for gaining insight into healing bone status earlier than CT or X-ray alone.MethodsForty-one prospective patients being treated with a Taylor Spatial Frame were recruited. We registered data obtained from successive static CT scans for each patient, to align the broken bone. Radionuclide uptake was calculated over a spherical volume of interest (VOI). For all voxels in the VOI, histograms and cumulative distribution functions of the CT and PET data were used to assess the type and progress of new bone growth and radionuclide uptake. The radionuclide uptake difference per day between the PET/CT scans was displayed in a scatter plot. Superimposing CT and PET slice data and observing the spatiotemporal uptake of 18F− in the region of healing bone by a time-sequenced movie allowed qualitative evaluation.ResultsNumerical evaluation, particularly the shape and distribution of Hounsfield Units and radionuclide uptake in the graphs, combined with visual evaluation and the movies enabled the identification of six patients needing intervention as well as those not requiring intervention. Every revised patient proceeded to a successful treatment conclusion.ConclusionNumerical and visual evaluation based on all the voxels in the VOI may aid the orthopedic surgeon to assess a patient’s progression to recovery. By identifying slow or insufficient progress at an early stage and observing the uptake of 18F− in specific regions of bone, it might be possible to shorten the recovery time and avoid unnecessary late complications.

Nonlinear waves of a surface charge at a curved plasma boundary

The nonlinear behavior of the surface charge has been analyzed for the curved plasma boundary. Detail descriptions of the solitary surface wave motion are obtained for the cold uniform plasma occupying a spherical volume with immobile ions. Some features of nonlinear azimuthally symmetric circle oscillations are revealed for half-space plasma. The dependence of the nonlinear structure of the surface charge on a shape of the time-varying curvature of the plasma boundary is found in the case when some deviations occur on the plasma surface. Substantiations of optimal conditions of carrying out are presented for specially aimed interactions of the electromagnetic radiation with some features of plasma surface distortions and processes caused by the occurrence of these perturbations.