Vitamin B12 Intake Research Articles

Detecting potential outliers in longitudinal data with time-dependent covariates.

Outliers can influence regression model parameters and change the direction of the estimated effect, over-estimating or under-estimating the strength of the association between a response variable and an exposure of interest. Identifying visit-level outliers from longitudinal data with continuous time-dependent covariates is important when the distribution of such variable is highly skewed. The primary objective was to identify potential outliers at follow-up visits using interquartile range (IQR) statistic and assess their influence on estimated Cox regression parameters. Study was motivated by a large TEDDY dietary longitudinal and time-to-event data with a continuous time-varying vitamin B12 intake as the exposure of interest and development of Islet Autoimmunity (IA) as the response variable. An IQR algorithm was applied to the TEDDY dataset to detect potential outliers at each visit. To assess the impact of detected outliers, data were analyzed using the extended time-dependent Cox model with robust sandwich estimator. Partial residual diagnostic plots were examined for highly influential outliers. Extreme vitamin B12 observations that were cases of IA had a stronger influence on the Cox regression model than non-cases. Identified outliers changed the direction of hazard ratios, standard errors, or the strength of association with the risk of developing IA. At the exploratory data analysis stage, the IQR algorithm can be used as a data quality control tool to identify potential outliers at the visit level, which can be further investigated.

Использование витаминов группы В в профилактических и лечебных дозах при сахарном диабете 2-го типа

Polyhypovitaminosis is a risk factor for many diseases. Adequate dietary intake of vitamins may help prevent/reduce the risk of progression of several diseases, including type 2 diabetes (T2D). Objective. To analyze the sufficiency of B vitamins and efficacy of their administration in patients with T2D depending on the dose. Vitamin deficiencies typical for patients with T2D worsen the course of the disease and increase the risk of complications. Higher intake of vitamins B1, B2 and folate is associated with a lower risk of T2D, and higher intake of folate and vitamin B6 is associated with a lower risk of cardiovascular diseases in patients with T2D. Higher intake of vitamin B6 by individuals with T2D is associated with a lower incidence of diabetic retinopathy. In T2D patients, low levels of the coenzyme form of vitamin B6 and high serum levels of 4-pyridoxic acid increase the risk of all-cause mortality. Patients with diabetic retinopathy have significantly reduced levels of vitamin B12. The incidence of vitamin B2 deficiency based on serum levels is found in approximately 30–40% of patients with T2D and diabetic nephropathy. Metformin administration worsens vitamin B12 supply and increases the risk of T2D complications. The need to eliminate vitamin deficiencies and improve the sufficiency of B vitamins is undeniable. There are prophylactic and therapeutic doses of vitamins. Continuous intake of multivitamin supplements with a complete set of all B vitamins in prophylactic doses consistent with the recommended daily intake (RDI) will reduce the risk of T2D progression. Administration of B vitamins during 1 month to 5 years in therapeutic doses well above the RDI results in improvement of carbohydrate metabolism, antioxidant and clinical status in patients with T2D, but may lead to undesirable effects. Conclusion. When prescribing B vitamins to T2D patients, it is recommended to distinguish between prophylactic doses of vitamins that meet the body’s needs and can and should be taken continuously, and therapeutic doses, that are close to the upper safe intake level and may cause adverse reactions. Key words: type 2 diabetes, B vitamins, sufficiency, prophylactic and therapeutic doses of vitamins

Hiperhomocisteinemija kao faktor rizika za razvoj patoloških promena u kardiovaskularnom sistemu - mehanizmi i posledice

Hyperhomocysteinemia represents a pathological condition characterized by an increased concentration of homocysteine in the blood, exceeding the threshold of 15 µmol/L. Hyperhomocysteinemia can be caused by genetic defects in enzymes involved in the metabolism of homocysteine and inadequate intake of vitamin B6, folic acid, and/or vitamin B12, disturbances in kidney and thyroid function, malignant diseases, psoriasis, and diabetes, as well as the use of certain medications, alcohol, tobacco, and caffeine. Hyperhomocysteinemia leads to damage to blood vessels through the induction of the proliferation of vascular smooth muscle cells, disruption of physiological endothelial functions, accumulation of reactive oxygen and nitrogen species, i.e., induction of oxidative and nitrosative stress, increased production of collagen, and degradation of the elastic fibers of the arterial wall, disturbance in the production of nitric oxide, dysfunction in the H2S signaling pathway, cellular hypomethylation, homocysteinylation of proteins, and disturbances in lipid metabolism. These pathophysiological mechanisms lead to accelerated atherosclerosis, which ultimately results in diseases such as acute myocardial infarction, heart failure, stroke, and peripheral vascular disease. In patients with the aforementioned diseases, or with associated risk factors such as hypertension, diabetes, obesity, smoking, or a positive family history of coronary heart disease, it is of great importance to determine and monitor the concentration of homocysteine in the blood and to take measures in the form of lifestyle changes aimed at secondary prevention of the consequences that hyperhomocysteinemia brings with it.

Estimating food consumption, micronutrient intake and the contribution of large-scale food fortification to micronutrient adequacy in Tanzania.

To assess the potential contribution of large-scale food fortification (LSFF) towards meeting dietary micronutrient requirements in Tanzania. We used household food consumption data from the National Panel Survey 2014-15 to estimate fortifiable food vehicle coverage and consumption (standardised using the adult female equivalent approach) and the prevalence at risk of inadequate apparent intake of five micronutrients included in Tanzania's fortification legislation. We modelled four LSFF scenarios: no fortification, status quo (i.e. compliance with current fortification contents) and full fortification with and without maize flour fortification. Tanzania. A nationally representative sample of 3290 Tanzanian households. The coverage of edible oils and maize and wheat flours (including products of wheat flour and oil such as bread and cakes) was high, with 91 percent, 88 percent and 53 percent of households consuming these commodities, respectively. We estimated that vitamin A-fortified oil could reduce the prevalence of inadequate apparent intake of vitamin A (retinol activity equivalent) from 92 percent without LSFF to 80 percent with LSFF at current fortification levels. Low industry LSFF compliance of flour fortification limits the contribution of other micronutrients, but a hypothetical full fortification scenario shows that LSFF of cereal flours could substantially reduce the prevalence at risk of inadequate intakes of iron, zinc, folate and vitamin B12. The current Tanzania LSFF programme likely contributes to reducing vitamin A inadequacy. Policies that support increased compliance could improve the supply of multiple nutrients, but the prominence of small-scale maize mills restricts this theoretical benefit.

Vitamin B12, fatty acids EPA and DHA during pregnancy and lactation in women with a plant-based diet

Pregnancy and lactation represent a complex stage from a nutritional point of view, since energy, protein and micronutrient requirements increase during these stages. The literature describes that a well-planned plant-based diet can be sufficient in energy, macronutrients and micronutrients, with the exception of vitamin B12 and n3 polyunsaturated fatty acids, mainly EPA and DHA. During the last few years, adherence to this diet has increased rapidly in the population, so the main objective of this article is to review the current evidence on the intake and concentrations of vitamin B12, EPA and DHA during pregnancy and lactation in women following a plant-based diet. A literature search was performed in PubMed, Scopus, Web of Science and Ovid MedLine using free terms and MESH. Eleven articles were selected in this review. Well-planned vegetarian and vegan diets, with adequate supplementation of vitamin B12, EPA and DHA, are compatible during pregnancy and lactation, being a positive predictor of their content in breast milk. A similar situation was observed in plasma levels in women supplemented with B12. However, it is important to continue with research in this area that considers an adequate dietary anamnesis, integral evaluation of nutritional status, estimation of nutritional requirements and an individualized nutritional plan.

A Study of Strategies and Methods for the Application of Sports Nutrition in Fitness Training

Abstract Dietary habits are particularly important in fitness training, and a scientific fitness diet needs to be formulated according to the fitness user’s situation, fitness goals and exercise volume. In this paper, a multimodal personalized sports nutrition recommendation model incorporating users’ visual preferences is designed to address the important impact of visual features on the task of sports nutrition recommendation. The user’s visual preference is modeled using the Query-Key-Value attention mechanism, which extracts valuable visual information from their historical data and adds it to textual features. In the sports nutrition program generation part, guided by sports nutrition theory and based on the MMFV model, the sports nutrition program generation method was designed. Then, the multi-objective optimization problem of the sports nutrition scheme is planned and modeled, and a calorie-checking mechanism is added to the multi-objective particle swarm algorithm for the problem of calorie intake not meeting the fitness goal. According to the sports nutrition program recommendation algorithm to improve the three meals diets of the gym participants, through the analysis of relevant data to verify the scientificity of the recommended program. The average intake of protein, vitamin A, vitamin B1 and vitamin C of the fitness participants after the modification increased by 7.4%, 17.77%, 22.33% and 8.46%, respectively, compared with that before the modification. Scapular sebaceous thickness and abdominal sebaceous thickness were reduced by 2.2 mm and 1.47 mm, respectively, compared with the pre-modification period.TC, TG and LDL metabolism were in the normal range, which was significantly different from the pre-modification period (P<0.05).

Dietary Intake of Nutrients Involved in Serotonin and Melatonin Synthesis and Prenatal Maternal Sleep Quality and Affective Symptoms.

Poor sleep quality and psychological distress in pregnancy are important health concerns. Serotonin and melatonin levels may underlie variation in these adverse outcomes. In this study, we examined dietary nutrients involved in serotonin and melatonin synthesis in relation to maternal sleep quality and affective symptoms during pregnancy. Pregnant women at no greater than normal medical risk at enrollment completed 24-hour dietary recalls in mid-late pregnancy. Usual intakes of vitamin B6, vitamin D, eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA), and tryptophan were estimated from dietary intake of foods and supplements using the National Cancer Institute (NCI) method. Sleep quality, depression, and anxiety were measured using validated questionnaires. Associations between nutrient intakes, sleep quality, and affective symptoms were estimated using generalized estimating equation models adjusting for potential confounding factors. In minimally adjusted models, EPA + DHA and tryptophan intakes were associated with a lower score indicating better sleep quality (b: -1.07, 95% CI: -2.09, -0.05) and (b: -12.40, 95% CI: -24.60, -0.21), respectively. EPA + DHA and tryptophan intakes were also associated with a lower odds of shorter sleep duration and sleep disturbances. In addition, tryptophan was associated with a lower odds of higher sleep latency. However, associations were attenuated and nonsignificant after adjustment for demographic and lifestyle factors. In conclusion, intakes of EPA + DHA and tryptophan were associated with improved sleep quality, but these associations were confounded by maternal demographic and lifestyle characteristics. This study highlights the need to consider dietary intake and pregnancy health in the context of demographic characteristics and lifestyle behaviors.

Riboflavin: a scoping review for Nordic Nutrition Recommendations 2023.

Only a few studies have explored relationships between riboflavin intake and function and a few studies have examined the effects of supplements on various clinical or biochemical outcomes. None of these studies, however, make a useful contribution to understanding requirements in healthy populations. Thus, there is no strong evidence to change the recommendations. The requirement for riboflavin is estimated based on the relationship between intake and biochemical indices of riboflavin status, including urinary excretion and enzyme activities.

A validation study comparing energy and nutrient intake between a web-based food frequency questionnaire and a 4-d dietary record

ObjectiveReliable assessments of dietary intake is crucial when examining associations between dietary factors and different outcomes. Today, web-based instead of paper-based food frequency questionnaires (FFQs) are common. A web-based FFQ implies a different experience (including design differences, the possibility only to show relevant questions, and automatic checks for completeness) and may capture dietary intake differently. The aim of this study was to validate a well-used paper-based FFQ transferred to a web-based version against a 4-d dietary record. MethodsBaseline data from a dietary intervention study comprising women and men with type 2 diabetes were used. Diet was assessed with the web-based FFQ and a 4-d dietary record. Energy intake and energy-adjusted nutrient intakes were assessed and compared using Spearman's rank correlation and Bland–Altman analysis. The analysis included 101 participants. ResultsThe average energy intake with the FFQ was 2068 kcal, 157 kcal higher than the average from the dietary record. Significant deattenuated correlations were found for intake of energy (r = 0.37; 95% confidence interval [CI],0.19–0.53), carbohydrates (r = 0.85; 95% CI, 0.78–0.89), protein (r = 0.53; 95% CI, 0.38–0.66) and fat (r = 0.59; 95% CI, 0.44–0.70). Significant deattenuated correlations (ranging r = 0.26–0.73) were found for intake of alcohol, whole grain, fiber, saturated fat, monounsaturated fat, polyunsaturated fat, cholesterol, vitamins A, B12, C, D, and E, folate, iron, potassium, magnesium, and calcium. Bland–Altman analyses showed no clear trends but wide limits of agreement. ConclusionOverall, the web-based FFQ performed well and is similar to the paper-based version. It can be a useful tool for dietary assessments.

Vitamin B6: a scoping review for Nordic Nutrition Recommendations 2023.

Pyridoxal 5´-phosphate (PLP) is the main form of vitamin B6 in animal tissue and functions as a coenzyme for more than 160 different enzymatic reactions in the metabolism of amino acids, carbohydrates, lipids, and neurotransmitters. Estimated dietary intake of vitamin B6 and plasma PLP values differ a lot between studies, something which may be due to variable use of supplements, variations in dietary assessment and analytical methods. These factors make it difficult to achieve precise data for setting a correct recommended intake of vitamin B6. In addition, a plasma PLP concentration of 30 nmol/L is considered to be sufficient and the current recommendations for vitamin B6 intake is based on this concept. However, the metabolic marker for vitamin B6 status, HK ratio (HKr), starts to increase already when plasma PLP falls below 100 nmol/L and increases more steeply below 50 nmol/L, indicating biochemical deficiency. Consequently, a plasma PLP concentration of 30 nmol/L, may be too low as a marker for an adequate vitamin B6 status.

A Landscape of Micronutrient Dietary Intake by 15- to 65-Years-Old Urban Population in 8 Latin American Countries: Results From the Latin American Study of Health and Nutrition.

Latin American countries have shifted from traditional diets rich in micronutrients to a Westernized diet rich in high energy-dense foods and low in micronutrients. This study aimed to determine the prevalence of adequate micronutrient intakes in urban populations of 8 Latin American countries. Micronutrient dietary intake data were collected from September 2014 to August 2015 from 9216 men and women aged 15.0 to 65.0 years living in urban populations of 8 Latin American countries. Dietary intake was collected using two 24-hour recalls on nonconsecutive days. Micronutrient adequacy of intake was calculated using the Estimated Average Requirement cut-off method. In general terms, the prevalence of inadequate intake of thiamine, riboflavin, niacin, folate, cobalamin, iron, phosphorus, copper, and selenium ranged from 0.4% to 9.9%. In contrast, the prevalence of inadequacy of pyridoxine, zinc, vitamin C, and vitamin A ranged from 15.7% to 51.5%. The nutrients with a critical prevalence of inadequacy were magnesium (80.5%), calcium (85.7%), and vitamin D (98.2%). The highest prevalence of inadequate intakes was observed in the low educational level, participants with overweight/obesity, in men, and varies according to socioeconomic status. There is an urgent need to define direct regional actions and strategies in Latin America aimed at improving micronutrient adequacy, either through staple food fortification programs, agronomic biofortification, or food policies that facilitate economic access to micronutrient-rich foods.

Dietary intake, nutritional adequacy and food sources of vitamins involved in the methionine-methylation cycle from Spanish children aged one to

Methionine-methylation cycle and the derived critical functions during infancy are key regulated by folates, vitamins B12, and B6. At present in Spain, there is an absence of studies that assess the intakes and dietary sources of total folates and B12 by children consuming all types of milks and those regularly consuming adapted milk formulas. Thus, our aim was to evaluate folates intakes alongside with vitamins B6 and B12 while describing their major dietary contributors in Spanish children aged one to <10 years. A total of 1,448 children aged between 1 and 10 years (49.7% girls and 50.3% boys) from the EsNuPI, a prospective cross-sectional study, were allocated into two cohorts: one Spanish Reference Cohort (SRS) of the general population (n = 707), and another including children consuming adapted milks called Adapted Milk Consumers Cohort (AMS) (n = 741) completed two 24 h dietary recalls used to estimate their nutrient intakes and to compare them to the European Food Safety Authority (EFSA) Population Reference Intakes. The median intake of vitamin B6 was 1.35 (1.06-1.70) mg/day in the SRS and 1.45 (1.17-1.79) mg/day in the AMS, being significantly higher in the AMS for all age-groups. Prevalence of adequacy for vitamin B6 in the SRS and AMS was 97.7 and 98.7%, respectively. Total folates intakes in the AMS were significantly higher (p ≤ 0.001) in all age groups than in the SRS, independently of age. In addition, the prevalence of adequacy for folates intakes in all groups was more than 60%. Vitamin B12 intake increased with age independently of the type of milk consumed. The prevalence of adequacy for vitamin B12 was highly compliant by all population groups. The major contributors to vitamin B6 were milk and dairy products being significantly higher in AMS than SRS (p ≤ 0.001). The highest contributors to folates intakes were milk and dairy products, cereals, vegetables, and fruits in both groups whereas for vitamin B12 in the SRS sample were milk and dairy products followed by meat and meats products and for adapted milks, were milk and dairy products, followed by eggs, then meat and meats products. A satisfactory prevalence of adequacy for vitamins B6, and B12 amongst the Spanish children population was observed, which was not the case for folates, regardless of the dietary group evaluated. Nevertheless, a possible strategy to increase folate intake among the youngest children is to increase the consumption of milk and dairy products within a healthier dietary pattern, as these may contribute significantly to the vitamin needs of the infant population.

Effect of aged garlic extract on blood pressure and other cardiovascular markers in hypertensive patients and its relationship with dietary intake

ObjectivesThis study evaluates the intake, tolerability and effect of aged garlic extract (AGE) on cardiovascular markers (blood pressure, body composition, glycemic and lipid parameters), stool consistency and its relationship with dietary factors. Casuistry and MethodsThis is a randomized, double-blind, placebo-controlled clinical trial that included 19 hypertensive volunteers. Participants were randomly treated daily with 1.2 g of AGE (1.2 mg of s-allylcysteine) or placebo for 12 weeks. Mixed model analysis was used to detect possible pressure, dietary and body changes, which were assessed every 4 weeks. At these times the consistency of the stool was also evaluated using the Bristol scale. The biological markers, collected before and after the experimental period (fasting glucose, glycated hemoglobin, total cholesterol, low density lipoprotein, high density lipoprotein, very low-density lipoprotein, triglycerides, and non-HDL cholesterol) were analyzed using parametric tests. ResultsOnly the AGE group showed significant reductions in systolic levels at week 4 and 12. This pressure variation was correlated with the average intake of vitamin B12 and B9. An improvement in stool consistency was identified only in the experimental group. Modest reductions in biochemical markers were identified in the AGE group and a significant decrease in glycated hemoglobin occurred in the placebo group. There was no significant difference in dietary and anthropometric variables in the treated groups. ConclusionThe 12-week intervention of 1.2 mg of AGE resulted in a decrease in systolic blood pressure and clinical improvements in stool consistency, glycemic parameters and low-density lipoprotein in hypertensive patients with treated but uncontrolled blood pressure. In addition, we found a correlation between the variation in blood pressure levels and the dietary intake of vitamins B9 and B12 in the group treated with AGE.

Beef Intake Is Associated with Higher Nutrient Intake and Nutrient Adequacy in U.S. Adolescents, NHANES 2001-2018.

Nutrient adequacy among adolescents is of concern due to higher nutrient requirements for their developing bodies as well as the gap between the current nutrient intake and the recommendations. The objective of this study was to determine beef intake and assess the relationship between beef consumption and nutrient intake and nutrient adequacy in male and female adolescents, 14-18 years of age. Dietary recalls collected during the What We Eat in America (WWEIA) portion of the National Health and Nutrition Examination Survey (NHANES) cycles 2001-2018 were utilized to determine beef intake. Usual nutrient intakes were determined with the National Cancer Institute method in conjunction with day 1 and day 2 total nutrient files. Nutrient adequacy was assessed by calculating the percentage of the population below the estimated average requirement (EAR) or above the adequate intake (AI). The average beef intake of male and female adolescent beef consumers was 57.9 ± 2.4 and 46.8 ± 2.2 g with a 90th percentile of 82.3 ± 4.3 and 67.8 ± 3.5 g, respectively. Compared to non-consumers, beef consumers had a 10% or higher intake of calcium, iron, phosphorus, potassium, total choline, vitamin B12, and zinc. Over 50% of the adolescent population (regardless of beef consumption) had intakes below the EAR for calcium, magnesium, and vitamins A, C, D, and E. The percentage of the beef-consuming population below the EAR was lower for calcium, copper, folate, iron, phosphorus, zinc, and vitamins B12 and B6 as compared to non-consumers. Additionally, the portion of the population above the AI for sodium was higher in female beef consumers as compared to non-consumers. We estimate approximately 900,000 to 1,400,000, 400,000-700,000, 200,000-600,000, and 200,000-400,000 fewer adolescents to be below the EAR for zinc, phosphorus, vitamin B12, and iron, respectively if beef non-consumers were to consume beef. This study suggests beef can help increase the nutrient intake and nutrient adequacy in the diets of adolescents, helping to close important gaps for this nutritionally vulnerable population. While recommendations to reduce beef intake are widely prevalent, this could result in unintended nutritional consequences regarding under-consumed nutrients including those of public health concern important for adolescent health.

Micronutrient gaps during the complementary feeding period in seven countries in Southeast Asia: A Comprehensive Nutrient Gap Assessment

AbstractThe complementary feeding period is a critical stage of child development when micronutrient needs are high and challenging to meet. Understanding if specific micronutrient gaps exist during this period is critical for effective programming. A Comprehensive Nutrient Gap Assessment (CONGA) was conducted in seven countries in Southeast Asia to estimate gaps in micronutrients commonly lacking in the diets of children aged 6–23 months and to establish the certainty of available evidence for each identified gap. Sixty‐eight evidence sources were identified during this analysis, and 310 micronutrient‐specific data points were identified across all seven countries. Data points varied in recency, representativeness and evidence type. The CONGA methodology enabled the estimation of a gap burden rating for each micronutrient in each country, as well as a rating of their evidence certainty. Micronutrient gaps were identified in vitamin D, zinc and iron and a potential gap was identified in calcium during the complementary feeding period in the region. Evidence relevant to intake and deficiency of folate, vitamin B12, thiamine, niacin, vitamin C and vitamin B6 was limited across the region. Proven strategies to address these gaps include increasing the availability and consumption of nutrient‐dense foods, micronutrient supplementation, large‐scale fortification of staple foods and condiments and point‐of‐use fortification through multiple micronutrient powders and fortified speciality foods. More recent data on micronutrient availability, intake and deficiency is urgently needed in Southeast Asia.

The impacts of pharmacological drugs on vitamin B6, B9 and B12 intakes and levels among uk adults: National diet and nutrition survey rolling programme (NDNS) (2008–2017).

The impacts of pharmacological drugs on vitamin B6, B9 and B12 intakes and levels among uk adults: National diet and nutrition survey rolling programme (NDNS) (2008–2017).

Association of vitamin B2 intake with cognitive performance in older adults: a cross-sectional study

BackgroundTo scrutinize the relationship between vitamin B2 consumption and cognitive function based on the NHANES database.MethodsThis cross-sectional study included eligible older adults from the NHANES 2011–2014. Vitamin B2 intake was determined from dietary interview data for two 24-h periods. Cognitive function was evaluated through the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST). The regression analyses were used to evaluate the association of vitamin B2 intake with cognitive performance. Stratified analyses based on gender, race, and body mass index (BMI) were conducted.ResultsHigher vitamin B2 intake was correlated with higher scores on each test. As compared to the lowest quartile, the highest quartile of vitamin B2 intake was related to a 45.1-fold increase (P = 0.004) on the DSST test sores. Moreover, those who were males, non-Hispanic whites, or had a BMI of 18.5 to 30 kg/m2 had a stronger relationship between total vitamin B2 consumption and cognitive function.ConclusionIt's possible that older persons who consume more vitamin B2 have enhanced performance in some areas of cognitive function. To determine the causal link between vitamin B2 consumption and cognitive performance, further long-term research is required.

The Nutritional Benefit of UV-Exposed Mushrooms for the Dutch Population: Modeling the Addition of UV-Exposed Mushrooms to the Diet

BackgroundMushrooms are rich in fiber and vitamins B and vitamin D when exposed to UV light and are sometimes used as a meat substitute. A modeling study showed that adding a mushroom portion (84 g/d) to the diet of an American population caused a significant improvement in the intake of several nutrients. ObjectiveTo study the association between habitual intake of mushrooms and nutrient intake and to assess the change in micronutrient intake with the modeled addition of 60 or 84 grams of UV-exposed mushrooms to the diet of the Dutch population, with a subanalysis on subjects with a low animal: plant protein ratio. MethodsA modeling study was conducted in 3121 Dutch persons aged 9-80 y, using cross-sectional data from the Dutch National Food Consumption Survey 2012-2016. Linear regression was used to explore the association between habitual intake of mushrooms and nutrients. Habitual intake and nutritional adequacy were calculated before and after the modeled addition of mushrooms. ResultsA small association was observed between the habitual intake of mushrooms and the intake of copper, niacin, and vitamin B2 (beta ranging from 0.002 to 0.039). The modeled addition of UV-exposed mushrooms increased the intakes of plant protein (by 5–7%), fiber (4–6%), niacin (10–20%), vitamin D (176–388%), folate (11–17%), potassium (6–10%), and copper (29–48%). Nutritional adequacy also improved significantly. For subjects with a low animal:plant protein ratio, the added mushrooms increased the intakes of niacin (11–22%), potassium (6–11%), and vitamin D (190–445%). ConclusionsConsumption of mushrooms contributes to higher intakes of copper, niacin, and vitamin B2. Addition of UV-exposed mushrooms to the diet of the Dutch further improves nutrient intakes and, most notably, vitamin D, especially for people with low animal food consumption.

Management of Vitamin B12 Deficiency: A Comparative Analysis of Intramuscular Injections versus Oral Medications

Abstract Introduction: Regular monitoring of Vitamin B12 (VB12) levels and intake of supplements is crucial since their deficiency may cause serious health conditions including neurological and cardiovascular complications. Medical professionals recommend supplements in the form of oral tablets and parenteral replacement for patients who cannot obtain these nutrients through diet or who are deficient due to other health conditions. This study aimed to compare the efficacy of oral medications and parenteral administrations, especially intramuscular (IM) injections for managing VB12 deficiency. Methods: The patients diagnosed with confirmed VB12 deficiency (&lt;211 pg/mL) were divided into two groups. One group received oral tablet (Mecobal 1000 μg); the other received VB12 injection (1000 μg) IM. The blood levels of both the groups were assessed after 6 months. The data were statistically analyzed to compare the efficacy of both routes. Results: The mean age of oral and IM groups was 57 ± 10 years and 53 ± 11 years, respectively. The baseline serum VB12 values for the oral and IM groups were 158 pg/mL and 139 pg/mL, respectively (P = 0.01), and the mean VB12 values after treatment for the oral and IM groups were 301 pg/ml and 1416 pg/ml, respectively (P &lt; 0.0001). The oral group observed a mean change of 143, while the IM group experienced a change of 1277 pg/ml (P &lt; 0.0001). Conclusion: Our findings support the use of parenteral replacement over oral medications for the management of VB12.

Is There any Correlation Between Nutrient Intake and Mental Health in Patients with Chronic Kidney Disease? A Cross-Sectional Study

Background: The prevalence of stress, anxiety, and depression seems to be high in patients with chronic kidney disease (CKD), which may influence their quality of life. Due to limiting some food groups, these patients suffer from a deficiency of some nutrients, which may be related to mood disorders. Objectives: This study aimed to investigate the correlation between nutrient intake, stress, anxiety, and depression in patients with CKD. Methods: The present cross-sectional study was conducted on 90 patients with CKD. To assess the diet of the patients, the researchers completed three days of the 24-hour food recall. The short self-report Iranian version of the Depression, Anxiety, and Stress Scale 21 (DASS-21) was also used to investigate the participants' mental health. Results: Of the 90 patients examined, 64 were men and 26 were women. There was a significant inverse correlation between depression and the dietary intake of polyunsaturated fatty acids (PUFAs) (β = -0.214, P = 0.039) and α-tocopherol (β = -0.225, P = 0.025). A significant inverse correlation was also found between anxiety and the dietary intake of iron (β = -0.319, P = 0.003), copper (β = -0.25, P = 0.031), vitamin B1 (β = -0.314, P = 0.004), vitamin B5 (β = -0.262, P = 0.016), vitamin B6 (β = -0.292, P = 0.007), vitamin B9 (β = -0.241, P = 0.026), fiber (β = -0.224, P = 0.04), and vitamin K (β = -0.26, P = 0.015). Conclusions: The dietary intake of nutrients such as PUFAs, α-tocopherol, B vitamins, vitamin K, iron, copper, and fiber might be associated with depression and anxiety. However, further studies with longitudinal designs are needed to reveal cause-effect relationships in this regard.