Processing Of Visual Stimuli Research Articles

TOWARDS WEB-BASED VISUAL TRAINING

To an extent, vision is a function that can be learned. Broadly speaking, this learning -named visual perceptive development, takes place spontaneously. Nevertheless, it is not the case of a significant number of children who, due to their visual or perceptual impairment, have difficulties either receiving or processing visual stimuli from their environment. In this case, Visual Stimulation programs should be applied to these people so that their visual functions can be developed.The advances developed in last two decades on information and communication technologies, ICT, are not reflected in the existing software tools for the field. As a contribution to solve this problem, we have designed and developed an Interactive Educational System supported on a web platform with the main aim to provide professionals the required mechanisms to perform the basic Visual Stimulation tasks. At the same time, it takes advantage of the several opportunities offered by the Internet. In this paper, we analyze the limitations of previous existing tools and present EVIN (Visual Stimulation on the Internet). The main objective of the EVIN project is the development of a web platform which exploits the potential of ICT along with the experience gained by low vision professionals.

Associations between neural correlates of visual stimulus processing and set-shifting in ill and recovered women with anorexia nervosa

Women ill with anorexia nervosa (AN) have been shown to exhibit altered cognitive functioning, particularly poor set-shifting (SS). In this study, we investigated whether brain activation in frontal and parietal regions during visual stimulus processing correlates with SS ability. Women currently ill with AN (AN; N=14), recovered women (REC; N=14) and healthy controls (HC; N=15), viewed alternating blocks of food and non-food pictures during functional magnetic resonance imaging (fMRI). The Berg's Card Sorting Task was completed outside the scanner to measure SS. A priori regions of interest (ROIs) were defined in frontal and parietal regions. The activation during visual stimulus processing in several ROIs correlated positively with poor SS ability in REC, particularly in the left dorsal anterior cingulate cortex (dACC). The correlations with poor SS ability were opposite in AN patients, particularly in the right dACC. These findings underscore that addressing heightened levels of cognitive control associated with higher frontal activation could reduce cognitive inflexibility in recovered women. In AN, greater activation in frontal and parietal regions might be necessary to perform at normal levels during various tasks. Thus, weight restoration could be necessary for AN patients prior to addressing cognitive inflexibility.

Eye for Detail: Local versus Global Visual Processing Style Predicts the Development of Re-experiencing after Analogue Trauma

Cognitive theories of posttraumatic stress disorder (PTSD) posit that peritraumatic data-driven processing plays a role in the development of intrusive trauma-related memories (i.e., re-experiencing). Peritraumatic processing may be determined by a pre-existing attentional processing style. This study tested whether a general attentional processing style (relative preference for local or global processing of visual stimuli) was associated with re-experiencing symptoms after analogue trauma. Participants completed measures for neuroticism and reappraisal and an emotional Local-Global Processing task. The next day, they watched an aversive film and indicated horror and perceived control during the film. PTSD symptoms were assessed one week later. A relative preference for local processing was associated with less reappraisal and with less perceived control and more horror during the film. Moreover, it predicted re-experiencing of the film, even after controlling for neuroticism, horror, control, and reappraisal. The results are a first step in exploring the role of pre-trauma cognitive processing styles on traumamemory development and may benefit the identification of risk factors for PTSD.

Differential processing of hierarchical visual stimuli in young and older healthy adults: An event-related potentials (ERP) study.

In tasks involving hierarchical stimuli, young subjects typically show faster RTs and higher accuracy rates in discriminating target stimuli at the global level than at the local level. This pattern of performance is called the global precedence effect (GPE). As individuals age, this patterns shifts to a local precedence effect (LPE). The purpose of this study was to determine whether the decline in GPE in older adults may be due to impairment of grouping processes. The authors recorded event-related potentials (ERP) while young and elderly subjects performed a global/local task in response to hierarchical stimuli, and they focused on the P300 component as an index of grouping processes. Compared to young subjects, elderly individuals showed a lower rate of correct discrimination in global processing conditions, but a higher rate of correct responses in local processing conditions, confirming a shift from a GPE to a LPE during aging. Interestingly, the P300 amplitude increased selectively during global processing in young adults but was not modulated by processing level in older participants. By contrast, the modulation of the early component N2 as a function of precedence level remained preserved in older subjects. The results suggest that the precedence level may depend on early processes that are unaffected during aging. This may explain the preservation of local precedence effect in elderly individuals. However, global processing may depend on extra attentional processing occurring at later stages. The alteration of later processing may explain the decline in global precedence during aging. (PsycINFO Database Record

Phasic alertness enhances processing of face and non-face stimuli in congenital prosopagnosia

Congenital prosopagnosia (CP) is a severe face processing impairment that occurs in the absence of any obvious brain damage and has often been associated with a more general deficit in deriving holistic relations between facial features or even between non-face shape dimensions. Here we further characterized this deficit and examined a potential way to ameliorate it. To this end we manipulated phasic alertness using alerting cues previously shown to modulate attention and enhance global processing of visual stimuli in normal observers. Specifically, we first examined whether individuals with CP, similarly to controls, would show greater global processing when exposed to an alerting cue in the context of a non-facial task (Navon global/local task). We then explored the effect of an alerting cue on face processing (upright/inverted face discrimination). Confirming previous findings, in the absence of alerting cues, controls showed a typical global bias in the Navon task and an inversion effect indexing holistic processing in the upright/inverted task, while CP failed to show these effects. Critically, when alerting cues preceded the experimental trials, both groups showed enhanced global interference and a larger inversion effect.These results suggest that phasic alertness may modulate visual processing and consequently, affect global/holistic perception. Hence, these findings further reinforce the notion that global/holistic processing may serve as a possible mechanism underlying the face processing deficit in CP.Moreover, they imply a possible route for enhancing face processing in individuals with CP and thus shed new light on potential amelioration of this disorder.

Bypassing the Natural Visual-Motor Pathway to Execute Complex Movement Related Tasks Using Interval Type-2 Fuzzy Sets.

In visual-motor coordination, the human brain processes visual stimuli representative of complex motion-related tasks at the occipital lobe to generate the necessary neuronal signals for the parietal and pre-frontal lobes, which in turn generates movement related plans to excite the motor cortex to execute the actual tasks. The paper introduces a novel approach to provide rehabilitative support to patients suffering from neurological damage in their pre-frontal, parietal and/or motor cortex regions. An attempt to bypass the natural visual-motor pathway is undertaken using interval type-2 fuzzy sets to generate the approximate EEG response of the damaged pre-frontal/parietal/motor cortex from the occipital EEG signals. The approximate EEG response is used to trigger a pre-trained joint coordinate generator to obtain the desired joint coordinates of the link end-points of a robot imitating the human subject. The robot arm is here employed as a rehabilitative aid in order to move each link end-points to the desired locations in the reference coordinate system by appropriately activating its links using the well-known inverse kinematics approach. The mean-square positional errors obtained for each link end-points is found within acceptable limits for all experimental subjects including subjects with partial parietal damage, indicating a possible impact of the proposed approach in rehabilitative robotics. Subjective variation in EEG features over different sessions of experimental trials is modeled here using interval type-2 fuzzy sets for its inherent power to handle uncertainty. Experiments undertaken confirm that interval type-2 fuzzy realization outperforms its classical type-1 counterpart and back-propagation neural approaches in all experimental cases, considering link positional error as a metric. The proposed research offers a new opening for the development of possible rehabilitative aids for people with partial impairment in visual-motor coordination.

Neural pathways in processing of sexual arousal: a dynamic causal modeling study.

Three decades of research have investigated brain processing of visual sexual stimuli with neuroimaging methods. These researchers have found that sexual arousal stimuli elicit activity in a broad neural network of cortical and subcortical brain areas that are known to be associated with cognitive, emotional, motivational and physiological components. However, it is not completely understood how these neural systems integrate and modulated incoming information. Therefore, we identify cerebral areas whose activations were correlated with sexual arousal using event-related functional magnetic resonance imaging and used the dynamic causal modeling method for searching the effective connectivity about the sexual arousal processing network. Thirteen heterosexual males were scanned while they passively viewed alternating short trials of erotic and neutral pictures on a monitor. We created a subset of seven models based on our results and previous studies and selected a dominant connectivity model. Consequently, we suggest a dynamic causal model of the brain processes mediating the cognitive, emotional, motivational and physiological factors of human male sexual arousal. These findings are significant implications for the neuropsychology of male sexuality.

Pitch and Duration Mismatch Negativity and Premorbid Intellect in the First Hospitalized Schizophrenia Spectrum.

Mismatch negativity (MMN) is a robustly abnormal brainwave in chronically ill schizophrenia that has generated interest as a disease presence biomarker. Reports of MMN reduction in first-episode schizophrenia have been equivocal, raising uncertainty about its reduction at first psychotic break. Here we tested 29 schizophrenia-spectrum participants under 1 year from their first hospitalization for psychosis and 40 age-, gender-, parental socioeconomic status-, and Wechsler Adult Intelligence Scales III Information-matched healthy controls on both pitch and duration MMN. Participants performed a visual checkerboard tracking task while standard (1kHz, 50ms, 80%), pitch-deviant (1.2kHz, 50ms, 10%) and duration-deviant (1kHz, 100ms, 10%) tones were presented over headphones (75 dB) and EEG was recorded. Independent component analysis was used to remove eye movements and visual stimulus processing activity. Groups did not differ in pitch MMN or duration MMN amplitudes. Smaller pitch and duration MMN amplitudes were associated with lower estimates of premorbid intellect in all participants and independently with greater positive symptoms in first hospitalized schizophrenia. Overall MMN reduction was not present in these relatively high functioning individuals at the first episode of schizophrenia, and therefore is not a good disease presence biomarker for this sample. Future research is warranted to determine the degree of MMN reduction at the first episode of psychosis across a greater range of cognitive impairment, the utility of MMN as an indicator of risk or diagnosis, and its role for understanding pathophysiological mechanisms in emerging psychosis.

Acute and short-term effects of caloric restriction on metabolic profile and brain activation in obese, postmenopausal women.

Early anthropometric and metabolic changes during a caloric-restricted diet in obese postmenopausal women and correlations between these factors with activity in brain areas involved in processing of visual food related stimuli were investigated. An 8-week prospective intervention study of 18 healthy postmenopausal women, with a body mass index of 30-35 kg m-2. The first 2 weeks subjects were on an isocaloric diet and 4 weeks on a 1000 kcal restricted diet followed by 2 weeks on an isocaloric diet. Anthropometric and laboratory analyses were performed weekly during the isocaloric diet and three times a week during the caloric-restricted diet. Functional magnetic resonance imaging scans were obtained before and after the caloric restriction in four separate sessions (fasting or sated). Generalized Estimating Equations analysis was used for data analysis. A mean weight loss of 4.2±0.5 kg (4.8%) and a 4.2±0.4 cm decline in waist circumference were achieved. In the first week of caloric restriction, triglyceride, leptin, resistin and adiponectin levels as well as systolic blood pressure decreased and insulin-like growth factor-binding protein 1 levels increased. During and after weight loss, a significant increase in ghrelin levels was observed. Before weight loss, increased activation of the right amygdala was seen in response to food stimuli, and free fatty acids and glucose correlated with activity in various areas involved in food reward processing. After weight loss, fasting ghrelin and sated leptin levels correlated with activity in these areas. Already in the first week of caloric restriction in obese postmenopausal women, various favourable metabolic changes occur before clinically relevant weight loss is achieved. Activity in the amygdala region and correlations of metabolic factors with activity in brain areas involved in food reward processing differ substantially before and after weight loss.

Strabismic amblyopia disrupts the hemispheric asymmetry for spatial stimuli in cortical visual processing

Hemispheric asymmetry in processing visual stimuli was assessed in anisometropic and strabismic amblyopia and control subjects. Measurements of contrast sensitivity for low and high spatial frequencies were performed psychophysically and tested under functional magnetic resonance imaging (fMRI) using a stimulus configuration that generates measurements for each temporal and nasal hemifield. The fMRI and the psychophysics results showed a marked hemispheric asymmetry in processing spatial frequencies for normal and anisometropic adults, in which low spatial frequencies were mainly processed in the left visual field – right hemisphere (LVF-RH: 0.3 cycles per degree [cpd]; F = 12.548; p = .002) and the high spatial frequencies were predominating processed in the right visual field – left hemisphere (RVF-LH: 2.0 cpd; F = 4.582; p = .021 and 8.3 cpd; F = 8.561; p = .001). No asymmetry was present in the amblyopic and the fellow eye of the strabismic amblyopia subjects. We conclude that the developmental organization of visual cortex in strabismic amblyopia is impaired differently from what happens in the anisometropic amblyopia and support the impairment of high-level visual-related functions observed in strabismic children.

Visual Illusions: An Interesting Tool to Investigate Developmental Dyslexia and Autism Spectrum Disorder.

A visual illusion refers to a percept that is different in some aspect from the physical stimulus. Illusions are a powerful non-invasive tool for understanding the neurobiology of vision, telling us, indirectly, how the brain processes visual stimuli. There are some neurodevelopmental disorders characterized by visual deficits. Surprisingly, just a few studies investigated illusory perception in clinical populations. Our aim is to review the literature supporting a possible role for visual illusions in helping us understand the visual deficits in developmental dyslexia and autism spectrum disorder. Future studies could develop new tools – based on visual illusions – to identify an early risk for neurodevelopmental disorders.

Visual, Auditory, and Cross Modal Sensory Processing in Adults with Autism: An EEG Power and BOLD fMRI Investigation.

Electroencephalography (EEG) and blood oxygen level dependent functional magnetic resonance imagining (BOLD fMRI) assessed the neurocorrelates of sensory processing of visual and auditory stimuli in 11 adults with autism (ASD) and 10 neurotypical (NT) controls between the ages of 20–28. We hypothesized that ASD performance on combined audiovisual trials would be less accurate with observable decreased EEG power across frontal, temporal, and occipital channels and decreased BOLD fMRI activity in these same regions; reflecting deficits in key sensory processing areas. Analysis focused on EEG power, BOLD fMRI, and accuracy. Lower EEG beta power and lower left auditory cortex fMRI activity were seen in ASD compared to NT when they were presented with auditory stimuli as demonstrated by contrasting the activity from the second presentation of an auditory stimulus in an all auditory block vs. the second presentation of a visual stimulus in an all visual block (AA2-VV2).We conclude that in ASD, combined audiovisual processing is more similar than unimodal processing to NTs.

Commentary: Top-down and bottom-up modulation of pain-induced oscillations.

Commentary: Top-down and bottom-up modulation of pain-induced oscillations.

An exploratory study of visual sequential processing in children with cochlear implants

ObjectiveThe objective of the study was to compare visual sequential processing in school-age children with cochlear implants (CIs) and their normal-hearing (NH) peers. Visual sequential processing was examined using both behavioral and an event-related potential (ERP) measures. MethodsEighteen children with CIs and nineteen children who had hearing within normal limits (NH) participated in the behavioral study. Subtests from the Test of Visual Perceptual Skills and the Sensory Integration and Praxis Test were administered to all children. ERP measures were collected from five children with CI and five age-matched peers. Peak latencies (N200 and P300) and reaction times for visual sequential processing were compared in these two groups. ResultsThe findings of the study revealed significant group differences in visual sequential memory and visuo-motor sequencing tasks suggesting that children with severe-profound hearing loss may have difficulties in visual sequential tasks. The study also revealed longer P300 latencies and longer reaction times for a visual sequential matching task in children with CI when compared to their NH peers suggesting slower or delayed processing of visual sequential stimuli. ConclusionsThis exploratory study involving behavioral and ERP measures showed that as a group, children with prelingual, severe-profound hearing loss who use CIs have difficulties with visual sequential processing. These findings may have implications for rehabilitation for children with hearing loss in the light of recent evidence that accurate and efficient processing of sequentially presented visual stimuli is important for language and reading outcomes.

Virtual car accidents of epilepsy patients, interictal epileptic activity, and medication.

To investigate effects of interictal epileptic activity (IEA) and antiepileptic drugs (AEDs) on reactivity and aspects of the fitness to drive for epilepsy patients. Forty-six adult patients with demonstration of focal or generalized bursts of IEA in electroencephalography (EEG) readings within 1 year prior to inclusion irrespective of medication performed a car driving computer test or a single light flash test (39 patients performed both). Reaction times (RTs), virtual crashes, or lapses (RT ≥ 1 s in the car or flash test) were measured in an IEA burst-triggered fashion during IEA and compared with RT-measurements during unremarkable EEG findings in the same session. IEA prolonged RTs both in the flash and car test (p < 0.001) in individual patients up to 200 ms. Generalized IEA with spike/waves (s/w) had the largest effect on RT prolongation (p < 0.001, both tests), whereas mean RT during normal EEG, age, gender, and number of AEDs had no effect. The car test was better than the flash test in detecting RT prolongations (p = 0.030). IEA increased crashes/lapses >26% in sessions with generalized IEA with s/w. The frequency of IEA-associated RT >1 s exceeded predictions (p < 0.001) based on simple RT shift, suggesting functional impairment beyond progressive RT prolongation by IEA. The number of AEDs correlated with prolonged RTs during normal EEG (p < 0.021) but not with IEA-associated RT prolongation or crashes/lapses. IEA prolonged RTs to varying extents, dependent on IEA type. IEA-associated RTs >1 s were more frequent than predicted, suggesting beginning cerebral decompensation of visual stimulus processing. AEDs somewhat reduced psychomotor speed, but it was mainly the IEA that contributed to an excess of virtual accidents.

Audio-visual multisensory training enhances visual processing of motion stimuli in healthy participants: an electrophysiological study.

Evidence from electrophysiological and imaging studies suggests that audio-visual (AV) stimuli presented in spatial coincidence enhance activity in the subcortical colliculo-dorsal extrastriate pathway. To test whether repetitive AV stimulation might specifically activate this neural circuit underlying multisensory integrative processes, electroencephalographic data were recorded before and after 2h of AV training, during the execution of two lateralized visual tasks: a motion discrimination task, relying on activity in the colliculo-dorsal MT pathway, and an orientation discrimination task, relying on activity in the striate and early ventral extrastriate cortices. During training, participants were asked to detect and perform a saccade towards AV stimuli that were disproportionally allocated to one hemifield (the trained hemifield). Half of the participants underwent a training in which AV stimuli were presented in spatial coincidence, while the remaining half underwent a training in which AV stimuli were presented in spatial disparity (32°). Participants who received AV training with stimuli in spatial coincidence had a post-training enhancement of the anterior N1 component in the motion discrimination task, but only in response to stimuli presented in the trained hemifield. However, no effect was found in the orientation discrimination task. In contrast, participants who received AV training with stimuli in spatial disparity showed no effects on either task. The observed N1 enhancement might reflect enhanced discrimination for motion stimuli, probably due to increased activity in the colliculo-dorsal MT pathway induced by multisensory training.

Data of ERPs and spectral alpha power when attention is engaged on visual or verbal/auditory imagery.

This article provides data from statistical analysis of event-related brain potentials (ERPs) and spectral power from 20 participants during three attentional conditions. Specifically, P1, N1 and P300 amplitude of ERP were compared when participant׳s attention was oriented to an external task, to a visual imagery and to an inner speech. The spectral power from alpha band was also compared in these three attentional conditions. These data are related to the research article where sensory processing of external information was compared during these three conditions entitled “Orienting attention to visual or verbal/auditory imagery differentially impairs the processing of visual stimuli” (Villena-Gonzalez et al., 2016) [1].

Chemosensory stimulation during sleep – Arousal responses to gustatory stimulation

The processing of nociceptive, visual, vibrotactile, thermal and acoustic stimuli during sleep has been extensively investigated in the past. Recently, interest has focused on the impact of olfactory stimulation on sleep. In contrast to all other sensory systems, olfactory stimulation does not lead to an increased arousal frequency, regardless of hedonicity and concentration. The impact of the second chemosensory system, gustation, on sleep however has not been investigated to date.Twenty-one normosmic and normogeusic volunteers of both genders, aged 19–33years, participated in the trial. Stimulation was performed with a gustometer using the following aqueous solutions: saccharose 20% (sweet), sodium chloride (NaCl) 7.5% (salty), citrate 5% (sour), and quinine 0.02% (bitter). A tasteless solution was used as negative control. Capsaicin, a strong trigeminal stimulus, served as positive control. Primary outcome was arousal frequency per stimulus in each sleep stage, as assessed with polysomnography.The frequency of arousals decreased in deeper sleep stages (N1: 211 arousals of 333 stimuli=63%, N2: 676/2728=25%, N3: 43/1378=3%, REM: 57/1010=6%). Statistically significant differences in terms of arousal frequency were found in N2 between the negative control and NaCl 100μl (p<0.001), saccharose 100μl, citrate 50μl & 100μl, and quinine 100μl (p<0.05). Capsaicin led to complete awakenings in 94% of stimuli (30/32).These results demonstrate that gustatory stimulation during sleep induces arousals depending on stimulus intensity and sleep stage, which is different to olfactory stimulation and may be related to differences in central processing of the two chemosensory systems.

Using Functional Near Infrared Spectroscopy (fNIRS) to Study Dynamic Stereoscopic Depth Perception.

The parietal cortex has been widely implicated in the processing of depth perception by many neuroimaging studies, yet functional near infrared spectroscopy (fNIRS) has been an under-utilised tool to examine the relationship of oxy- ([HbO]) and de-oxyhaemoglobin ([HbR]) in perception. Here we examine the haemodynamic response (HDR) to the processing of induced depth stimulation using dynamic random-dot-stereograms (RDS). We used fNIRS to measure the HDR associated with depth perception in healthy young adults (n = 13, mean age 24). Using a blocked design, absolute values of [HbO] and [HbR] were recorded across parieto-occipital and occipital cortices, in response to dynamic RDS. Control and test images were identical except for the horizontal shift in pixels in the RDS that resulted in binocular disparity and induced the percept of a 3D sine wave that ‘popped out’ of the test stimulus. The control stimulus had zero disparity and induced a ‘flat’ percept. All participants had stereoacuity within normal clinical limits and successfully perceived the depth in the dynamic RDS. Results showed a significant effect of this complex visual stimulation in the right parieto-occipital cortex (p < 0.01, η2 = 0.54). The test stimulus elicited a significant increase in [HbO] during depth perception compared to the control image (p < 0.001, 99.99 % CI [0.008–0.294]). The similarity between the two stimuli may have resulted in the HDR of the occipital cortex showing no significant increase or decrease of cerebral oxygenation levels during depth stimulation. Cerebral oxygenation measures of [HbO] confirmed the strong association of the right parieto-occipital cortex with processing depth perception. Our study demonstrates the validity of fNIRS to investigate [HbO] and [HbR] during high-level visual processing of complex stimuli.Electronic supplementary materialThe online version of this article (doi:10.1007/s10548-016-0476-4) contains supplementary material, which is available to authorized users.

Phantoms on the hands: Influence of the body on brief synchiric visual percepts

Recent studies have found preferential responses for brief, transient visual stimuli near the hands, suggesting a link between magnocellular visual processing and peripersonal representations. We report an individual with a right hemisphere lesion whose illusory phantom percepts may be attributable to an impairment in the peripersonal system specific to transient visual stimuli. When presented with a single, brief (250ms) visual stimulus to her ipsilesional side, she reported visual percepts on both sides – synchiria. These contralesional phantoms were significantly more frequent when visual stimuli were presented on the hands versus off the hands. We next manipulated stimulus duration to examine the relationship between these phantom percepts and transient visual processing. We found a significant position by duration interaction, with substantially more phantom synchiric percepts on the hands for brief compared to sustained stimuli. This deficit provides novel evidence both for preferential processing of transient visual stimuli near the hands, and for mechanisms that, when damaged, result in phantom percepts.