Advances in oral and systemic chemotherapy have enabled administration of chemotherapy in day oncology or outpatient settings although as chemotherapy regimens have become more aggressive in toxicity the risk of side effects has increased. Patients receiving chemotherapy as out-patients are required manage health issues at home without direct supervision of nursing and medical staff. Given the increased administration of chemotherapy as in outpatient settings, Emergency Departments (EDs) play a key role in the management of patients undergoing chemotherapy. The aim of this study was to conduct an analysis of ED presentations among patients undergoing chemotherapy. A retrospective audit of adult day oncology patients across three Victoria health services was conducted. Information was collected from Victorian Emergency Minimum Dataset and medical records of a random sample of 750 patients who received chemotherapy through day oncology and who presented to ED due to chemotherapy complications in 2007. Health care resources to manage the complication were collected, including all medical interventions, laboratory and microbiological tests, diagnostic imaging procedures, number of specialist visits among hospitalised patients, and number of consultations in relation to the episode. To date, data analysis for 120 patients is complete. Age ranged from 24 to 82 years; 59% were male, 35% were admitted to hospital from ED, and the average ED length of stay was eight hours. The major diagnostic groups were fever/infection (20%), GI symptoms (18%); cardiac (10%); respiratory (6%); CVA (4%); and haematology (3%). The implications of these results in terms of service delivery will be discussed.