The domestic wastewater collection and treatment rate of Nairobi, Kenya are not high. The wastewater in the Kibera slum on the outskirts of the city that is directly discharged to the environment and pollution of the surrounding water body is a serious problem. This paper takes the domestic wastewater in the slum area as the research objective and researches on the wastewater characteristics, collection, and treatment, therefore providing the reference for the wastewater collection and treatment technology in the region. In this paper, domestic wastewater in the Kibera slum of Nairobi was sampled and investigated to find out the characteristics of wastewater discharged, the way of discharge of the household wastewater, and the management in this area. The study shows that there are differences in the concentration of main pollutants such as nutrients and organic matter in the wastewater from the household discharged to the residential river in the slum area. The domestic wastewater in this slum area contained a high concentration of nutrients such as nitrogen and phosphorus and other organics, total suspended solids (TSS), total coliforms and color, and with no treatment methods. Therefore, economic and feasible treatment technology needs to be developed. A pilot study was conducted on the treatment of domestic wastewater in the slum area by combining the seed extract of the natural plant Moringa oleifera as a coagulant and vertical flow constructed wetland (VFCW) at Tongji University, Shanghai, China. The VFCW system was efficient in chemical oxygen demand (COD), TSS, turbidity, total phosphorus (TP), and phosphates (PO4-P) removal, but the removal efficiency of nitrogen (total nitrogen (TN), ammonium nitrogen (NH4-N), and nitrate (NO3-N)) was poor, and the effluent pH reached the required discharge country's standard of the water. The average removal efficiencies for COD (79.99%), TSS (86.84%), turbidity (87.35%), TP (61.29%), PO4-P (65.66%), TN (14.11%), NH4-N (18.17%), and NO3-N (93%) were achieved by the treatment system. Furthermore, the removal efficiencies of pollutants such as TP, PO4-P, TN, and NH4-N were carried out by using the fruit extract of Moringa oleifera as raw material and zeolite as an auxiliary agent. The comprehensive effect of zeolite combined with VFCW and natural coagulant in the treatment of domestic wastewater was investigated. The COD removal efficiency was increased by (9%). TN by (46%), NH4-N by (67%), TP by (19%), and turbidity improved by (9%). In short, the domestic wastewater in the Kibera slum was collected and pretreated with natural plant coagulant, and then purified by vertical flow constructed wetland, which can not only significantly reduce the pollutant concentration but also basically meet the discharge standards. It is a low-cost sewage treatment technology suitable for poor areas.