Vasomotor Research Articles

Stopping Estrogen Therapy Might Trigger Hot Flashes That Weren't There in the First Place

Vasomotor symptoms and vaginal dryness recur when women stop menopausal hormone therapy (HT; JW Womens Health Feb 4 2010). In a follow-up to the

Is Acupuncture as Effective as Venlafaxine for Treating Hot Flashes in Breast Cancer Survivors

Vasomotor symptoms are common and can be debilitating in breast cancer survivors, particularly those who receive antiestrogen therapy. Because estrogen

Clover and Cohosh Don't Alleviate Vasomotor Symptoms — But Standardized Compounds Are Safe

Many women seek natural remedies for relief of menopausal vasomotor symptoms; red clover and black cohosh are two key botanicals that are used for this purpose. Investigations of black cohosh have yielded conflicting efficacy results, and limited data on red clover have shown, at best, modest improvement of symptoms. In a 12-month double-blinded trial, 89 women were randomized to receive one of four treatments: red …

The Search Continues for Effective Nonhormonal Therapies for Hot Flashes

Adverse effects of estrogens have prompted efforts to identify effective nonestrogenic therapies for postmenopausal vasomotor symptoms. Now, two

Hot Flashes That Just Keep Going and Going ...

Common counsel for women in the menopause transition is to suggest “waiting out” vasomotor symptoms because they will abate in a year or two. Now,

Predicting the Onset of Menopause Remains Elusive

Do menstrual patterns and vasomotor symptoms during the menopausal transition forecast the onset of menopause? As part of the Study of Women’s Health

Vasomotor Symptoms and Other Signs of Estrogen Deficiency

In two studies, investigators assessed possible links between vasomotor symptoms and other signs of estrogen deficiency in menopausal women.Using a

Effects of the cardiopulmonary bypass on cerebral vasomotor changes

Objective To study the cerebral vasomotor changes after different cardiopulmonary bypass time and modes. Methods Thirty SD rats were equally divided into 5 groups,which were subjec-ted to CPB for 60 min and 120 min,deep hypothermie low flow bypass 60 min, deep hypothermie circulato-ry arrest 60 min, and sham respectively. The right middle cerebral artery was harvested and prepared for assessment of the myogenic tone with different transmural pressure, the endothelial cell response induced by different concentration of acetylcholine, and the vascular smooth muscle cell response induced by the so-dium nitroprusside and serotonin. The hippocampus tissue was harvested to observe the ultramicrostructure of endothelial cells in capillary by electron microscope. Results The CPB was performed successfully in all the rats. The deep hypothermic bypass altered the results of myogenic tone test with different transmural pressure compared with the sham group [(34.62±2.36) % and (33.83±2.28) % vs (37.75± 1.92) %, P<0.05]. Acetylcholine caused a dose-dependent vasodilation in the sham group that was ab-sent in animals undergoing CPB [(24.26±1.90) % vs (8.59±1.48) %, P<0.05]. Significantly, this was apparent after only 60 min of CPB and the vasodilation response of endothelial cells was worse in DHLF and DHCA groups than in simple CPB. The vascular smooth muscle cell response induced by the so-dium nitroprusside and serotonin was intact in all the rats. Conclusion The specific loss of acetylcholine-induced vasodilation suggests endothelial cell dysfunction,which appeares early after the onset of CPB. The deep hypothermic bypass can cause the dysfunction of cerebrovascular autonomic regulation. And these cer-ebral vasomotor changes may contribute to the neurologic injuries after CPB. Key words: Cardiopulmonary bypass; Cerebrovascular; Brain injury

Desvenlafaxine: Future Nonhormonal Treatment for Menopausal Hot Flashes

Estrogen is the most effective treatment for menopausal vasomotor symptoms, but results from recent randomized trials have raised questions about its

More Body Fat = More Hot Flashes

During late perimenopause and the postmenopausal years, most women experience vasomotor symptoms (hot flashes and night sweats) resulting in overall impairment in quality of life. These symptoms respond to estrogen treatment; moreover, endogenous estrogen levels increase with adiposity. Conventional wisdom has held that vasomotor symptoms are more common in slender women than in overweight or obese women; however, this assumption has …

Acute gastric mucosal lesions induced by vasomotor derangement--participation of xanthine oxidase and neutrophil-mediated oxidative stress

Acute gastric mucosal lesions induced by vasomotor derangement--participation of xanthine oxidase and neutrophil-mediated oxidative stress

Midlife and Menopausal Symptoms

With its hormonal fluctuations, the menopausal transition is characterized by vasomotor symptoms (hot flashes and night sweats), poor sleep, decreased

Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats.

Spontaneously hypertensive rats (SHRs) were administered the red wine polyphenol resveratrol in drinking water at 0, 0.448, or 4.48 mg/l (control, low, or high, respectively) for 28 days. The low dosage was chosen to mimic moderate red wine consumption. After the treatment period, thoracic aorta rings were excised for in vitro assessment of vasomotor function. Chronic resveratrol significantly improved endothelium-dependent relaxation to acetylcholine (Ach), increasing maximal values to 80.8% +/- 5.2% and 80.8% +/- 5.0% in low and high groups, respectively, compared with 60.7% +/- 1.4% in controls (P<0.01). This treatment effect was eliminated in the presence of the endothelial nitric oxide synthase (eNOS) blocker N(omega)-nitro-L-arginine methyl ester. Resveratrol did not affect relaxation to sodium nitroprusside or systolic blood pressure in SHRs. In contrast to the SHR results, chronic resveratrol in Sprague Dawley rats did not affect vasomotor function in aorta rings in response to Ach. Hydrogen peroxide was reduced in the SHR thoracic aorta by a high dosage of resveratrol (P<0.05), but it was not significantly altered in other tissues tested. Thoracic aorta immunoblots revealed no significant treatment effects in SHRs on eNOS, superoxide dismutases 1 and 2, gp91phox, or Hsp90. Thus, these data provide novel evidence of improved endothelium-dependent vasorelaxation in hypertensive, but not normotensive, animals as a result of chronic resveratrol consumption mimicking dosages resulting from moderate red wine consumption. This response was not dependent on increases in eNOS expression but was dependent on improved NO bioavailability.

When Antidepressants Don’t Relieve Hot Flashes, Gabapentin Might Help

To address concerns about risks associated with hormone therapy for treating women with menopausal vasomotor symptoms, the focus has shifted to

Black Cohosh Doesn’t Improve Menopausal Vasomotor Symptoms

Although women’s use of herbal and botanical treatments for menopausal symptoms is well documented, the efficacy and safety of these products are unproven. In a 1-year, randomized, double-blind trial, investigators compared three herbal regimens, hormone therapy, and placebo in 351 women (age range, 45–55; 93% white). Eligible participants were in menopause transition or were postmenopausal and had experienced at least two vasomotor symptoms daily as …

Antidepressant Does Dual Duty in Menopausal Women

Some antidepressants relieve vasomotor symptoms in menopausal women with or without depression; however, estrogen/progesterone therapy (EPT) might

Menopausal Vasomotor Symptoms and Ethnicity

The idea that the presence and intensity of vasomotor symptoms may vary among racial/ethnic groups during the menopause transition has not previously

SUDDEN CARDIOCIRCULATORY COLLAPSE AND PRIMARY BRAIN TUMOR – A CASE REPORT AND A REVIEW OF THE LITERATURE

Background. We are presenting a case of 62-year old woman with acute cardiocirculatory collapse with signs of obstructive shock. Methods. After succesfull cardiopulmonary resuscitation (CPR) massive pulmonary thrombembolism was excluded by helical chest CT, but following brain CT revealed a brain tumor surrounded by abundant brain edema. With regard to all the accomplished diagnostic procedures, clinical picture, further clinical course and response to treatment, neurogenic cause of obstructive shock was most probable. Results. After surgical removal of glioblastoma, the patient was discharged from the hospital with moderate neurological deficit. Conclusions. During the course of brain tumors acute cardiocirculatory failure presented as a obstructive shock can evolve, because of local effects on brain circulatory (vasomotor) centers.

Tibolone

Tibolone is so called tissue specific compound, which works as estrogen in bone and inhibits postmenopousal bone loss and does not stimulate mammary tissue. Tibolone has been used as medication for postmenopausal vasomotor symptoms.

Renal and Mesenteric Arterial Tone in Rats with Human Renin and Angiotensinogen Genes

P6 The vascular endothelium plays a key role in the control of vasomotor tone, local hemostasis, and vascular wall proliferation processes. We characterized vascular functions in double-transgenic rats (dTGR) harboring human renin and human angiotensinogen. In dTGR, the endothelium-mediated relaxations of noradrenaline (NA)-precontracted renal (large conduit vessel) and mesenteric arterial (smaller conduit vessel) rings to acetylcholine (ACh) were markedly impaired, compared to normotensive Sprague Dawley rats (p