Objective To investigate the current situation of lower limb varicose veins among clinical nurses at a ClassⅢ Grade A hospital and analyze its influencing factors, so as to provide a basis for further intervention and improving protective level. Methods From July 2018 to August 2018, we selected 810 clinical nurses at a ClassⅢ Grade A hospital as subjects by convenience sampling. We collected patients' general information and carried out questionnaire survey with the self-designed lower limb varicose veins questionnaire for nurses. Receiver operating characteristic (ROC) curve was used to multivariate prediction of the optimal area under curve (AUC) and critical value. Single factor analysis adopted χ2 test, and the influencing factors analysis adopted the multiple Logistic regression. Results In this study, a total of 827 questionnaire were sent out and 810 of them were valid with 97.94% for the valid recovery rate. There were 289 (35.68%) clinical nurses with lower limb varicose veins. ROC curve analysis showed that the high-risk cutoff values of ages, nursing years and walk time during work of lower limb varicose veins were 29 years old (AUC=0.611, P<0.001, 95%CI: 0.572-0.650) , 8 years (AUC=0.623, P<0.001, 95%CI: 0.584-0.661) and four hours (AUC=0.604, P<0.005, 95%CI: 0.565-0.643) respectively in nurses. Single factor analysis showed that there were statistical differences in the sexes, ages, education levels, positional titles, nursing years, whether having the family history of varicose veins, whether having the history of deep vein thrombosis, night shift conditions, childbearing history, whether taking oral contraceptives, wearing elastic stockings and walk time during working (P<0.05) . Multiple Logistic regression analysis found that the main influencing factors of lower limb varicose veins of clinical nurses included ages, nursing years, having family history of varicose veins, wearing elastic stockings and walk time during working (P<0.05) . Conclusions The incidence of lower limb varicose veins is high in nurses because of profession with the phenomenon of universally inadequate protective measures. Reasonable and comprehensive protection measures should be taken positively to improve the current situation. Hospital managers should attach importance to the situation, and develop related knowledge training or provide elastic stockings for nurses by taking a perspective of caring staff to reduce the occupational injuries of nurses and extend their careers. Key words: Nurses; Lower limb varicose veins; Influencing factors; Protective measures; ROC curve