Isolation rooms are crucial in healthcare facilities to prevent the spread of infectious diseases. Infectious diseases can be transmitted to humans from humans or through animals known as zoonoses. With the increase in the number of COVID-19 cases, isolation rooms have become one of the most critical facilities in hospitals. Maintaining the correct temperature and humidity in these isolation rooms is a challenge, considering the heating, ventilation, and air conditioning (HVAC) systems that continuously consume large amounts of energy. With the application of energy conservation methods, the total energy consumption of HVAC systems can be reduced. Many studies have shown that the heat pipe heat exchanger (HPHE) technology can contribute significantly to energy savings using HVAC systems. In this study, the effectiveness of an HPHE on an HVAC system in an isolation room was examined, and the total energy reduction was quantified. The HPHE consisted of two rows with ten heat pipes in each row, arranged in a staggered configuration with fresh air temperature and mass flow variations. The inlet fresh air temperatures varied at 32, 35, 37, and 40 °C and fresh air velocities at 1.2, 1.6, 2.2, and 2.6 m/s. Using a chiller, the inlet fresh air was cooled to a comfortable temperature zone, approximately 24.4–25.2 °C, in the isolation room. Notably, higher velocities decreased the effectiveness of the HPHE. An increase in the flow rate enhanced the system, thereby improving the heat recovery value. The increase in the inlet fresh air temperature from 32 °C, that yielded an energy saving of 1.23 W, to 40 °C, resulted in a further energy saving of 1.85 W. The application of the HPHE in the HVAC system in isolation rooms represents a significant innovation that contributes to a reduction in total energy consumption.
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