Values For Female Subjects Research Articles

Carrying angle among young adults of Saudi Arabia and its correlation with demographic characteristics: A cross sectional study.

The angle between the median axes of the forearm and arm is called the carrying angle (CA). Sex differences in CA and its relation to age, height, weight, and BMI are unclear. The aim of the present study was to measure the CA in male and female subjects in the Saudi population and correlate it with the above variables. A digital goniometer was used to measure CA in 181 males and 165 females. Information on age, height, weight, and BMI was also recorded. CA showed differences based on sex, though was independent of age, height, weight, and BMI. Hormonal factors may influence CA and could explain larger CA values in female subjects. CA measurement in specific population groups contributes to the successful management of several pathological conditions of the elbow and aids in the design of elbow orthotics and prosthetics.

P1408 Age and gender dependency of left ventricular and left atrial volume ratio assessed by three-dimensional echocardiography

Abstract Funding Acknowledgements Dr. Takeuchi was supported by a Grant-in-aid for Scientific Research (19K12853) from the Japanese Society of Promotion of Science. Background Left ventricular (LV) and left atrial (LA) volumes may change according to advanced aging. Since both chambers affect each other, their ratio, LV and LA volume ratio (LVLAVR) may sensitively detect age- and gender-related change in left chamber volume and function. Purpose We aimed to (1) investigate age and gender dependency of LVLAVR and (2) determine reference values. Methods We simultaneously obtained both LV and LA volume curves using 3D echocardiography with novel speckle tracking software (4D LV analysis v.3 LA, TomTec Imaging systems), and generated LVLAVR curve throughout one cardiac cycle, from which we measured LVLAVR at end-diastole (ED) and at end-systole (ES) in 313 healthy subjects (age, 20-85 years; 51% men). Results The mean values of LVLAVR at ED and ES in male subjects were 5.74 ± 1.54 and 1.37 ± 0.35, respectively. Corresponding values in female subjects were significantly lower (5.20 ± 1.47, p = 0.003 and 1.13 ± 0.29, p < 0.001) than those in male subjects. Their age and gender dependency are shown in table. LVLAVR at ED step wisely decreased to advanced aging, and had a highest F ratio compared with other left chamber volumetric parameters in both gender. Conclusions We proposed new index, LVLAVR which is a sensitive parameter to reflect age- and gender-related change in LV and LA volumes. Further studies should be required to validate clinical utility of this index over traditional volumetric parameters. Male subjects (n = 160) 3rd decade (n = 35) 4th decade (n = 34) 5th decade (n = 34) 6th decade (n = 21) 7th decade (n = 24) F ratio p-value LVEDVI (ml/m2) 81 ± 12 72 ± 11 75 ± 14 71 ± 11 68 ± 12 4.22 0.003 LVESVI 38 ± 7 33 ± 6 35 ± 8 34 ± 5 32 ± 6 2.93 0.023 Maximum LAVI 25 ± 5 25 ± 4 27 ± 5 26 ± 6 30 ± 8 4.07 0.004 Minimum LAVI 12 ± 3 12 ± 3 14 ± 3 14 ± 3 18 ± 6 12.23 <0.001 LVLAVR at ED 6.80 ± 1.54 6.36 ± 1.31 5.42 ± 1.00 5.23 ± 1.37 3.97 ± 0.85 19.72 <0.001 LVLAVR at es 1.53 ± 0.42 1.39 ± 0.29 1.36 ± 0.31 1.35 ± 0.32 1.09 ± 0.26 5.85 <0.001 Female subjects (n = 153) 3rd decade (n = 31) 4th decade (n = 23) 5th decade (n = 30) 6th decade (n = 22) 7th decade (n = 47) F ratio p-value LVEDVI 69 ± 11 68 ± 10 62 ± 8 60 ± 9 63 ± 9 4.29 0.003 LVESVI 29 ± 6 29 ± 6 27 ± 5 26 ± 7 28 ± 6 1.45 0.220 Maximum LAVI 24 ± 5 24 ± 5 24 ± 5 25 ± 5 27 ± 5 1.73 0.147 Minimum LAVI 11 ± 2 11 ± 2 12 ± 3 13 ± 4 16 ± 4 16.59 <0.001 LVLAVR at ED 6.51 ± 1.36 6.20 ± 1.26 5.43 ± 1.28 4.67 ± 0.96 4.03 ± 0.81 25.46 <0.001 LVLAVR at ES 1.22 ± 0.22 1.22 ± 0.32 1.14 ± 0.33 1.06 ± 0.29 1.06 ± 0.25 2.08 0.087 LVED(S)VI, left ventricular end-diastolic (end-systolic) volume index; LAVI, left atrial volume index; LVLAVR, left ventricular left atrial volume ratio

Left ventricular and left atrial volume ratio assessed by three-dimensional echocardiography: Novel indices for evaluating age-related change in left heart chamber size.

We hypothesized that left ventricular and left atrial volume ratio (LVLAVR) assessed by three‐dimensional echocardiography (3DE) reflects age‐ and gender‐related change in left chamber size. We aimed to (1) determine the reference values of LVLAVR, (2) investigate their age and gender dependency, and (3) clarify which anthropometric and echocardiography parameters are closely associated with these indices. Both left ventricular (LV) and left atrial (LA) volume curves were obtained using 3DE speckle tracking analytical software, and the LVLAVR curve throughout one cardiac cycle was created, from which LVLAVR at ventricular end‐diastole and at ventricular end‐systole were determined in 313 healthy subjects (age, 20–85 years; 51% men). The mean values of LVLAVR at ventricular end‐diastole and ventricular end‐systole in male subjects were 5.74 ± 1.54 and 1.37 ± 0.35, respectively. Corresponding values in female subjects were significantly lower (5.20 ± 1.47, p = .003 and 1.13 ± 0.29, p < .001) than the values in male subjects. LVLAVR at ventricular end‐diastole step wisely decreased to advanced aging, and had a highest F ratio compared with other left chamber volumetric parameters in both genders. LV mass and LA ejection fraction were significantly associated with LVLAVR at ventricular end‐diastole. In contrast, LV mass and LV ejection fraction were significantly coupled with LVLAVR at ventricular end‐systole. This study provides the reference values for LVLAVR from a relatively large number of healthy subjects. LVLAVR may be a sensitive parameter to reflect age‐ and gender‐related change in LV and LA volumes. Further studies should be required to determine its clinical usefulness over traditional echocardiography parameters in various cardiovascular diseases.

Biomass fuel use and the risk of asthma in Nigerian children

Biomass fuel smoke exposure contributes to respiratory infections in childhood, but its association with asthma has not been established. We studied the relationship of biomass fuel use with asthma symptoms and lung function in Nigerian children. A cross-sectional study was performed in 299 village children aged 5-11 years in North Central Nigeria. Data were collected regarding the cooking fuels used and duration of daily smoke exposure in the cooking area. Asthma symptoms were assessed with a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire, and lung function was assessed with spirometry. The prevalence of a lifetime history of wheeze was 9.4% (95% CI: 6.3%-13.2%). Fourteen children (4.7%) had airway obstruction (FEV1/FEV6 <85%). Female subjects had lower FEV1 and FEV6 (110 % and 120% percent predicted, respectively) than males (121% and 130%, respectively, P <0.001 for both differences). Advancing age was associated with a relative decline in the predicted value of FEV1 of 7.8 % per year (r = -0.61; P < 0.001). Children in families that used firewood daily did not have a significantly increased likelihood of asthma-related symptoms (OR = 2.36, 95% CI: 0.66-8.44). Similarly, airway obstruction did not differ significantly between children in households that did and did not use firewood daily (mean FEV1/FEV6 of 0.95 and 0.97, respectively; P = 0.41). Reported smoke exposure was not associated with an increased risk of asthma symptoms or airway obstruction. However, lifetime smoke exposure may explain the reduction in spirometric values in female subjects and with advancing age.

Spiking Expression of μ-Crystallin mRNA during Treatment with Methimazole in Patients with Graves’ Hyperthyroidism

mu-Crystallin is an NADPH-dependent cytosolic T3-binding protein. A knockout study in mice showed that mu-crystallin has a physiological function as a reservoir of T3 in the cytoplasm in vivo. Patients with nonsyndromic deafness were reported to have point mutations in the mu-crystallin gene. The expression of mu-crystallin is regulated by multiple factors. The present study was performed to determine whether thyroid function is related to the expression of mu-crystallin mRNA in peripheral mononuclear cells. We examined 23 normal healthy male and female subjects and 15 patients with Graves' disease. mu-Crystallin protein expression was determined immunohistochemically in peripheral mononuclear cells. The expression of mu-crystallin mRNA was assessed by reverse transcription of total RNA from peripheral mononuclear cells followed by quantitative PCR. mu-Crystallin protein was detected in peripheral mononuclear cells. The mRNA expression was negatively correlated with age in normal female subjects. The values in female subjects were significantly higher than those in males. The values were positively correlated with serum TSH concentration. The values of the thyrotoxic patients with Graves' disease were lower than those in healthy subjects. A transient increase in mu-crystallin expression was observed within 14-42 days after the initial treatment with antithyroid medication. Thyroid hormone inversely relates to the expression of mu-crystallin mRNA in euthyroid mononuclear cells. Abrupt suppression of thyroid function leads to overexpression of mu-crystallin mRNA in thyrotoxic mononuclear cells. Thyroid hormone-regulated mu-crystallin expression may control thyroid hormone action via the intracytoplasmic T (3) capacity.

Optimisation of scoliosis examinations in children.

To present results of optimising scoliosis examination by changing from a conventional film/grid (F/G) to air-gap technique using computed radiography (CR), and to evaluate different methods for estimating effective radiation doses. Forty-nine children and adolescents were examined with an F/G technique, and 21 with air-gap and CR techniques. Entrance surface doses (ESD) were determined with lithium fluoride thermoluminescence dosimeters. For all patients, the effective radiation doses were determined using a hermaphrodite PCXMC computer program. For all F/G radiographs, the effective doses were also determined according to the NRPB-R279 report, and for 22 children (>9 years and/or >40 kg) also with the ODS-60 program, which allows separate gender calculations. Accumulated doses for 37 children examined more than once with F/G examinations were assessed. For F/G techniques, the ESDs for both frontal and lateral views varied with age and were significantly correlated to the patients' thickness. The calculated effective doses using the PCXMC program and the NRPB-R279 did not differ significantly for all frontal and lateral radiographs, respectively, but ODS-60 gave significantly higher values in female subjects. With air-gap and CR techniques, the mean effective doses were reduced by a factor over 10. The mean accumulated effective dose for 37 children with a mean of seven F/G examinations was 6.1 mSv, implying a risk of death of about 1:2,000 for boys and at least 1:1,000 for girls. Paediatric scoliosis radiography should be considered a specialised procedure, which has to be optimised using a non-grid technique.

Plasma retinol and tocopherol levels in greek elderly population from an urban and a rural area: associations with the dietary habits.

Data on plasma concentrations of retinol and alpha-tocopherol in elderly (over 65 years) living in the Mediterranean countries are sparse. In the current study, plasma retinol and alpha-tocopherol concentrations were determined in 200 healthy subjects (82 men and 112 women) residing in an urban and in a rural area in South Western Greece. High prevalence of low plasma retinol concentration was observed for both sexes in each area. The 16.7% of males in urban and 25.4% in rural area had plasma retinol levels below 0.3 mg/l. The corresponding values for female subjects were 26% and 20.3%. Plasma alpha-tocopherol was found to be within normal range in the rural area (only one male had plasma alpha-tocopherol below 5 mg/l) while in the urban area 68.3% of men and 62% of women had plasma alpha-tocopherol values below 5 mg/l. Differences in dietary habits between subjects living in the rural and in the urban area were revealed through a weekly food frequency questionnaire. This could partly explain the difference in alpha-tocopherol concentrations between the two areas. The results of this study revealed high risk of vitamin A and E deficiency and suggests that the health care system in Greece should pay more attention on the social and health status of its elderly population.

A study of anemia and life activity in the elderly

One hundred senior citizens aged 80 years and over in homes for the aged were evaluated for the incidence of anemia (hemoglobin under 11.0 g/dl), Hb concentration, serum iron, and total iron binding capacity (TIBC). The subjects were classified into different groups according to age distribution (80-84, 85-89, over 90), as well as sex and life activity levels. In the 80-84 year age group, the Hb concentration was 0.5 g/dl higher than that in the other age groups. The Hb values of the male subjects were 1 g/dl higher than the corresponding values for female subjects. Subjects classified as bedridden had Hb values 1.2 g/dl lower than those in the groups that had higher activity levels (p < 0.001). The incidence of anemia was independent of sex and age differences; however, differences in activity levels were significant (p < 0.001). There are 53 patients with some diseases, urinary tract infections, bed sores (over 3 cm diameter), chronic bronchitis, progressive cancers and chronic rheumatoid arthritis, which may be origins of anemia. Seventy six percent of bedridden patients have one or two of the above diseases and 30% of non-bedridden patients have these diseases. The difference was statistically significant (p < 0.001). In the bedridden group, the differences of the mean Hb levels and the rates of anemia in patients with and without disease were not statistically significant (p > 0.1 in both factors). These facts indicate that the bedridden elderly have a high risk of anemia which is independent of some infectious and malignant diseases.

Dopamine receptor blockade induced by metoclopramide and thyroid-stimulating hormone secretion in man.

20 mg metoclopramide, intramuscularly administered to 10 healthy males and 10 healthy females, induced a significant increase in serum thyroid-stimulating hormone values in female subjects only. This finding suggests that dopamine does not play a major role in the regulation of thyroid-stimulating hormone secretion and that estrogens can act in the modulation of dopamine effects at the hypothalamic and/or pituitary level.