Vaginal Rhabdomyoma Research Articles

Myogenin expression in vulvovaginal spindle cell lesions: analysis of a series of cases with an emphasis on diagnostic pitfalls

Myogenin (myf4) is a nuclear transcription factor that is considered to be a sensitive and highly specific marker for skeletal muscle differentiation. Following the identification of focal strong nuclear staining with myogenin in two fibroepithelial polyps of the lower female genital tract (the index cases), we stained a series of vulvovaginal spindle cell lesions with this marker in order to investigate how widespread myogenin staining is in these lesions. Fibroepithelial polyps (n = 13), other vulvovaginal mesenchymal lesions (n = 21) and vulval or vaginal spindle cell squamous carcinomas (n = 4) were stained for myogenin. Apart from the index cases, all of the other cases were negative, except for one vaginal spindle cell squamous carcinoma, which showed focal weak nuclear immunoreactivity. Ten of 12 embryonal rhabdomyosarcomas of the lower female genital tract were myogenin-positive, as was a single vaginal rhabdomyoma. Our study illustrates that focal myogenin immunoreactivity occurs uncommonly in fibroepithelial polyps of the lower female genital tract. This may result in diagnostic confusion and misdiagnosis as a skeletal muscle neoplasm, especially the sarcoma botryoides variant of embryonal rhabdomyosarcoma.

Rhabdomyome du vagin. Revue de la littérature à partir d’un cas clinique

The differential diagnosis of vaginal polypoid masses should take rhabdomyoma into consideration even it is an extremely rare tumor. The present report describes a vaginal cystic mass located in the anterior wall of an asymptomatic, 38-year-old, Caucasian, nulliparous woman. Local excision and subsequent pathological examination were performed. The final diagnosis was vaginal rhabdomyoma. The literature is reviewed and differential diagnosis are discussed.

Pathologic quiz case. Vaginal wall mass in a 47-year-old woman. Vaginal rhabdomyoma.

Pathologic quiz case. Vaginal wall mass in a 47-year-old woman. Vaginal rhabdomyoma.

Rhabdomyoma of the vagina

A case of vaginal rhabdomyoma in 35-year-old healthy woman is presented. The lesion, a pedunculated polyp measuring 1.2 cm in diameter, was located in the anterior wall of the vagina. This is an extremely rare entity that pursues a benign course. Light and immunohistochemical features are commented and selected literature briefly reviewed.

Vaginal rhabdomyoma and adenosis

HistopathologyVolume 16, Issue 4 p. 393-394 Vaginal rhabdomyoma and adenosis D. SUAREZ VILELA, Corresponding Author D. SUAREZ VILELA Department of Anatomic Pathology. Hospital Virgen Blanca, León, SpainAddress for correspondence: Dr Dimas Suárez Vilela. Department of Anatomic Pathology. Hospital Virgen Blanca, C/Altos de Nava s/n, León, Spain.Search for more papers by this authorA. GIMENEZ PIZARRO, A. GIMENEZ PIZARRO Department of Anatomic Pathology. Hospital Virgen Blanca, León, SpainSearch for more papers by this authorM. RIO SUAREZ, M. RIO SUAREZ Department of Anatomic Pathology. Hospital Virgen Blanca, León, SpainSearch for more papers by this author D. SUAREZ VILELA, Corresponding Author D. SUAREZ VILELA Department of Anatomic Pathology. Hospital Virgen Blanca, León, SpainAddress for correspondence: Dr Dimas Suárez Vilela. Department of Anatomic Pathology. Hospital Virgen Blanca, C/Altos de Nava s/n, León, Spain.Search for more papers by this authorA. GIMENEZ PIZARRO, A. GIMENEZ PIZARRO Department of Anatomic Pathology. Hospital Virgen Blanca, León, SpainSearch for more papers by this authorM. RIO SUAREZ, M. RIO SUAREZ Department of Anatomic Pathology. Hospital Virgen Blanca, León, SpainSearch for more papers by this author First published: April 1990 https://doi.org/10.1111/j.1365-2559.1990.tb01144.xCitations: 10AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume16, Issue4April 1990Pages 393-394 RelatedInformation

Production of basement membrane laminin and type IV collagen by tumors of striated muscle: An immunohistochemical study of rhabdomyosarcomas of different histologic types and a benign vaginal rhabdomyoma

Immunohistochemical methods were used to demonstrate the distribution of basement membrane laminin and type IV collagen in eight tumors derived from striated muscle (three botryoid, two alveolar, and two adult-type rhabdomyosarcomas; one benign vaginal rhabdomyoma). All of the tumors produced significant amounts of both basement membrane components. Stainings clearly revealed the alveolar nature of the rhabdomyosarcomas, with the alveolar spaces surrounded by distinct basement membranes. Different stages of cellular development were identified in the botryoid sarcomas, with the most immature cells of the cambium layer devoid of external basement membrane around the tumor cells, although the stroma contained finely dispersed basement membrane material and some cells contained intracytoplasmic laminin or type IV collagen, indicative of the synthesis of these proteins. The more mature cells, which had abundant granular cytoplasm, were enveloped by distinct basement membranes and seemed to have coalesced, forming structures resembling myotubes. The adult-type rhabdomyosarcomas were composed of large pleomorphic cells that were surrounded by basement membranes, either individually or in small groups. Some giant cells contained intracytoplasmic laminin. The vaginal rhabdomyoma was composed of round rhabdoblastic cells or elongated strap cells with cross-striations. Cells of both of these types were surrounded by thin but distinct basement membranes. The results suggest that demonstration of basement membranes would be helpful in the diagnosis of tumors derived from striated muscle. The findings concerning different stages of maturation of tumor cells are in accordance with previous in vitro observations of myoblastic cells.

Production of basement membrane laminin and type IV collagen by tumors of striated muscleAn immunohistochemical study of rhabdomyosarcomas of different histologic types and a benign vaginal rhabdomyoma

Immunohistochemical methods were used to demonstrate the distribution of basement membrane laminin and type IV collagen in eight tumors derived from striated muscle (three botryoid, two alveolar, and two adult-type rhabdomyosarcomas; one benign vaginal rhabdomyoma). All of the tumors produced significant amounts of both basement membrane components. Stainings clearly revealed the alveolar nature of the rhabdomyosarcomas, with the alveolar spaces surrounded by distinct basement membranes. Different stages of cellular development were identified in the botryoid sarcomas, with the most immature cells of the cambium layer devoid of external basement membrane around the tumor cells, although the stroma contained finely dispersed basement membrane material and some cells contained intracytoplasmic laminin or type IV collagen, indicative of the synthesis of these proteins. The more mature cells, which had abundant granular cytoplasm, were enveloped by distinct basement membranes and seemed to have coalesced, forming structures resembling myotubes. The adult-type rhabdomyosarcomas were composed of large pleomorphic cells that were surrounded by basement membranes, either individually or in small groups. Some giant cells contained intracytoplasmic laminin. The vaginal rhabdomyoma was composed of round rhabdoblastic cells or elongated strap cells with corss-striations. Cells of both of these types were surrounded by thin but distinct basement membranes. The results suggest that demonstration of basement membranes would be helpful in the diagnosis of tumors derived from striated muscle. The findings concerning different stages of maturation of tumor cells are in accordance with previous in vitro observations of myoblastic cells.

Benign vaginal rhabdomyoma

A case of benign polypoid vaginal rhabdomyoma occurring in a 52-year-old female is described. The characteristic histological features were interlacing bands of striated muscle cells with prominent cross and longitudinal striations, with surrounding loose collagenous stroma, within which were many dilated vascular spaces. Electron microscopy confirmed the striated muscle origin of these cells. The pathogenesis is possibly a localized area of abnormal mesenchymal differentiation.

Benign vaginal rhabdomyoma.A light and electron microscopic study

A benign vaginal rhabdomyoma from a 49-year-old woman was examined by light and electron microscopy. While many of the ultrastructural features conformed to those noted in previously described rhabdomyomas, certain features are described for the first time. These include attachment plaques between cells enclosed within a common basement membrane, cytoplasmic bodies, and peripheral couplings. Finally, the literature is reviewed and the reported cases of rhabdomyoma are divided into adult and fetal types based upon light microscopic criteria.