Vaccination Of Pregnant Women Research Articles

Safety and Efficacy of Antiviral Drugs and Vaccines in Pregnant Women: Insights from Physiologically Based Pharmacokinetic Modeling and Integration of Viral Infection Dynamics.

Addressing the complexities of managing viral infections during pregnancy is essential for informed medical decision-making. This comprehensive review delves into the management of key viral infections impacting pregnant women, namely Human Immunodeficiency Virus (HIV), Hepatitis B Virus/Hepatitis C Virus (HBV/HCV), Influenza, Cytomegalovirus (CMV), and SARS-CoV-2 (COVID-19). We evaluate the safety and efficacy profiles of antiviral treatments for each infection, while also exploring innovative avenues such as gene vaccines and their potential in mitigating viral threats during pregnancy. Additionally, the review examines strategies to overcome challenges, encompassing prophylactic and therapeutic vaccine research, regulatory considerations, and safety protocols. Utilizing advanced methodologies, including PBPK modeling, machine learning, artificial intelligence, and causal inference, we can amplify our comprehension and decision-making capabilities in this intricate domain. This narrative review aims to shed light on diverse approaches and ongoing advancements, this review aims to foster progress in antiviral therapy for pregnant women, improving maternal and fetal health outcomes.

Myths Pertaining to COVID-19 Vaccination in Pregnant Women Attending a Rural Tertiary Care Hospital.

Background The outbreak of the COVID-19 pandemic led to the rise of various social issues apart from medical ones. Several myths regarding COVID-19 vaccination were found worldwide, and some of the common ones identified were abortions, birth defects, bad pregnancy outcomes such as abortions, ectopic pregnancy, risk of infertility, and irregular menstrual cycles. Although no scientific theories or data backed those myths, pregnancy was still omitted from trials for a long time as any drug/vaccine given during pregnancy may affect the fetus. Objective The objective of this study was to evaluate the vaccination status of pregnant women (PW) regarding COVID-19 and explore the factors influencing those who chose not to get the initial dose, second dose, or booster dose. Methodology A total of 747 PW were enrolled in the current study. Information related to sociodemographic data, clinical data, COVID-19 vaccine status, and rationale for choosing not to receive the COVID-19 vaccination was analyzed using a prestructured and validated Performa. Results The mean age and gestational age of the women enrolled for the study was 27.39 ± 3.75 years and 30.21 ± 7.30 weeks, respectively. The first dose of the COVID-19 vaccine was not receivedby 40 (5.4%) subjects, and the second dose was pending in 142 (19%) women, and none of them received booster dose. The prevalent cause for abstaining from receiving the COVID-19 vaccination was the fear of abortion in 179 (24%) subjects, followed by the fear of vaccine-related side effects in 142 (19%) subjects. There was a significant correlation between acceptance of COVID-19 vaccination and education and employment. Conclusion The present study indicated that most women have taken the COVID-19 vaccine before conception and that none received the first, second, or booster dose during pregnancy, even if it was due. Women need to be educated about the benefits of vaccination to enhance the compliance rate of COVID-19 vaccination and reduce COVID-19-related morbidity and mortality during pregnancy.

Determinants of Acceptance of the COVID-19 Vaccine in Pregnant Women, Indonesia: A Literature Review

Pregnant woman are a vulnerable group for COVID-19. Efforts to control and prevent COVID-19 are being made with the implementation of vaccination, but the fact is that still many pregnant woman refuse to be vaccinated because of many factors, such as fear, feeling insecure about their health and their babies, so there is a doubt about receiving the COVID-19 vaccine. This research aims to find out determinants of acceptance of the COVID-19 vaccine among pregnant women in Indonesia. This study used a literature review (PRISMA) model for guide. Literacy is limited to articles published in January 2021 until September 2023. The extracted data is synthesized with a narrative approach. The article search obtained 17 selected articles. There are 19 determinants that influence the acceptance of the COVID-19 vaccine among pregnant women in Indonesia, including: knowledge, perception, vaccination history, vaccine information, participation, education, anxiety, employment status, behavior, attitude, history of comorbid diseases, family support, role of health workers, social media information, age, community culture, pregnancy status, ANC frequency, and vaccine safety. The underlying factors behind receiving the COVID-19 vaccine in pregnant woman are very complex and context-specific, varying all the time. Socio-demographic variables play a major role in it

Effectiveness of Covid-19 Vaccine in Pregnant Women: A Systematic Review

The newly developed COVID-19 vaccine faces public's concerns in terms of its effectiveness and safety as an approach in combating COVID-19 pandemic. It is well-established that COVID-19 vaccine is effective alongside being the most promising approach against COVID-19 infection in both general and vulnerable populations. This study aims to evaluate the effectiveness of COVID-19 vaccine in pregnant women as a subgroup of vulnerable population by analysing several important immunological parameters in pregnant women. Specifically, it investigates how effective the COVID-19 vaccine will reduce the infection rate and how it will affect the mothers' antibody levels against SARS-CoV-2. In this study, the immunological parameters investigated are maternal antibody response against SARS-CoV-2 and the transplacental transfer of the antibody. To test the hypothesis that COVID-19 vaccine is effective in pregnant women, a systematic review was conducted on previous studies regarding COVID-19 vaccine and its outcomes in pregnancy. Results were narratively analysed. The results showed reduced COVID-19 infection rate, elevated maternal antibody titre against SARS-CoV-2 and positive transplacental anti-SARS-CoV-2 IgG antibody transfer in vaccinated pregnant women in comparison to unvaccinated pregnant women. These results suggest that COVID-19 vaccine is highly effective against COVID-19 infection in pregnant women. Furthermore, COVID-19 vaccine not only elicits sufficient maternal antibody response as an immunity for mothers against COVID-19 infection but also provides similar protection for infants via passive immunity by means of transplacental antibody transfer. In conclusion, the uptake of COVID-19 vaccine and future booster dose by pregnant women should be strongly encouraged due to its favourable outcomes and protection against COVID-19 disease.

Factors Associated With Aefi Of Covid-19 Vaccination In Pregnant Women

Latar Belakang. Kelompok ibu hamil menjadi kelompok yang rentan terhadap infeksi COVID-19 karena pada ibu hamil tubuh mengalami penurunan kekebalan imunitas tubuh, sehingga rentan terinfeksi virus. Perubahan fisiologis juga terjadi pada kehamilan, seperti peningkatan diafragma, peningkatan kebutuhan oksigen, dan edema mukosa saluran pernafasan yang sangat berisiko terkena hipoksia (Prawihardjo,2018).Tujuan. Diketahuinya Faktor-faktor yang mempengaruhi KIPI Vaksinasi covid-19 pada ibu hamil di Puskesmas Kemayoran Tahun 2022.Metode. Desain penelitian yang digunakan adalah metode deskriptif kuantitatif dengan pendekatan cross sectional dengan desain penelitian retrospektif suatu penelitian dengan melakukan pengamatan ibu hamil dengan KIPI Vaksinasi covid-19 yang melakukan antenatal care di Puskesmas Kemayoran dalam satu kali waktu pada waktu bersamaan dengan jumlah sampel 80 orang ibu hamil.Hasil. Berdasarkan hasil penelitian yang telah dilakukan di poli KIA Puskesmas Kecamatan Kemayoran dari 80 responden diperoleh informasi bahwa responden mengalami KIPI sebanyak 69 responden (69%), dan tidak mengalami KIPI hanya 11 responden (31%). Berdasarkan data hasil penelitian bahwa ada sekitar 93,5% responden yang berlatar belakang pendidikan tinggi tentang vaksinasi covid 19. Salah satu faktor yang dapat mempengaruhi pengetahuan seseorang adalah tingkat pendidikan.Kesimpulan. Hasil analisis didapatkan bahwa variable pengetahuan adalah variable yang paling dominan p value = 0,024. Sehingga dapat disimpulkan bahwa variable yang paling dominan terkait KIPI vaksinasi adalah variable pengetahuan.Saran Tenaga Kesehatan Puskesmas Kemayoran, Jakarta Pusat, sebaiknya berkolaborasi dengan kader Puskesmas dan tokoh masyarakat untuk memberikan vaksinasi COVID-19 pada ibu hamil, terutama pada usia kehamilan >13 minggu. Kata kunci : Vaksin, IbU Hamil , KIPI, covid 19 ABSTRACT Background. Pregnant women are categorized as the vulnerable group to COVID-19 infection due to their decreased immune system, making them susceptible to virus infection. Physiological changes also occur during pregnancy such as an increase in the diaphragm, increased oxygen demand, and edema of the respiratory tract mucosa which is at high risk of hypoxia (Prawihardjo, 2018).Objective. Determine the factors that influence AEFI of COVID-19 vaccination in pregnant women at Kemayoran Public Health Center in 2022.Method. The research design used was a quantitative descriptive method with a cross-sectional approach with a retrospective research design by observing pregnant women with AEFI of COVID-19 vaccination who carried out antenatal care at Kemayoran Public Health Center one time at the same time with a sample of 80 pregnant women.Results. Based on the results of the study conducted at the MCH polyclinic at Kemayoran Public Health Center, of the 80 respondents, 69 respondents (69%) experienced AEFI, and only 11 respondents (31%) did not experience AEFI. Further, 93.5% of respondents who had a higher educational background were well-informed about the covid 19 vaccination. The level of education can affect a person's knowledge.Conclusion. The results of the analysis found that the knowledge variable was the most dominant variable with a p-value of 0.024. Thus, it could be concluded that the most dominant variable related to the AEFI of vaccination was the knowledge variable.Suggestion Health Workers of Kemayoran Public Health Center, Central Jakarta, should collaborate with cadres of integrated healthcare centers and community leaders to provide COVID-19 vaccinations for pregnant women, especially for those whose gestational age is >13 weeks. Keywords: Vaccines, Pregnant Women, AEFI, COVID -19

Effects of Direct and Indirect Factors on Attitude toward the COVID-19 Vaccine in Pregnant Women

Background: The administration of the COVID-19 vaccine is facing resistance from pregnant women, leading to a lower attitude toward vaccination uptake. Previous studies have explored several factors that contributed to the issue. However, no studies have investigated further the direct and indirect effects of factors that simultaneously influence attitudes toward the COVID-19 vaccine in pregnant women. Purpose: This study aimed to investigate the direct and indirect effects of factors that influence attitudes toward the COVID-19 vaccine (ACV) in pregnant women, particularly hesitancy, motivation, and history of COVID-19 infection (HCI), and to describe a pathway model that represents the effects.Methods: This cross-sectional study recruited 440 pregnant women living in Bekasi and Pandeglang, Indonesia, in May–June 2022 using consecutive sampling methods. This study employed the Motivations of Vaccination Questionnaire, the Reasons for Hesitation Questionnaire, and the Attitudes toward COVID-19 Vaccine Questionnaire. A path analysis was performed to calculate the data.Results: Hesitancy had a more indirect effect (β=-0.270; p=0.00) than the direct effect (β=-0.193; p=0.00) on ACV, whereas motivation had a more direct effect (β=0.092; p=0.04) than the indirect effect (β=0.074; p=0.00). HCI acted as the mediation variable because it could intercede with the effect of hesitancy on ACV (β=-0.449; p=0.00). It indicated that HCI in pregnant women would lead to a different approach to increasing ACV.Conclusions: All studied factors had significant impacts on ACV, both directly and indirectly. It is recommended that interventions be adjusted according to the program’s purpose, with the aim of increasing motivation or reducing hesitancy.

Attitudes of Pregnant Women toward the COVID-19 Vaccine

Objective: It was carried out to determine the attitudes of pregnant women toward the Covid-19 vaccine and related factors. Methods: The correlational and descriptive study was conducted with 356 pregnant women. In the study, data were collected using an introductory questionnaire, "Attitudes towards Covid-19 Vaccine Scale", "Vaccination Hesitancy in Pandemics Scale", and "Covid-19 Vaccine Literacy Scale". Research data were analyzed with SPSS 25 package program. One-way ANOVA and Student-t test were used to determine the difference between the descriptive characteristics of the pregnant women participating in the study and the total and sub-dimension mean scores of the Attitude Scale towards the Covid-19 Vaccine. Pearson correlation analysis was used to determine the relationship between the Vaccine Hesitancy Scale in Pandemics, the Covid-19 Vaccine Literacy Scale, and the Attitudes Towards Covid-19 Vaccine Scale. Linear regression analysis was used to determine the factors affecting the Attitudes of Pregnants towards the Covid-19 Vaccine. Results: It was concluded that 37.4% of the pregnant women did not have any Covid-19 vaccine, 62.6% had the Covid-19 vaccine before pregnancy, and 22.5% had the vaccine during pregnancy. In pregnant women, those who have hesitations about the vaccine in cases such as working, increase in education level, fear of contracting Covid-19 before birth, having pre-pregnancy Covid-19 vaccine, thinking that pregnant women may have Covid-19 vaccine, getting Covid-19 vaccine during pregnancy, etc. increase their attitudes towards vaccination. Conclusion: Consider to change the conclusion: It was found that quite a few pregnant women received the Covid-19 vaccine during their pregnancy. Pregnant women's vaccination hesitancy influences their attitudes toward Covid-19.

Safety and Protective Effects of Influenza Vaccination in Pregnant Women on Pregnancy and Birth Outcomes in Pune, India: A Cross-Sectional Study.

Maternal influenza vaccination provides effective protection against influenza infections in pregnant women and their newborns. In India, the influenza vaccine has not yet been offered through immunization programs, owing to the lack of sufficient safety data for pregnant Indian women. This cross-sectional observational study enrolled 558 women admitted to the obstetrics ward of a civic hospital in Pune. Study-related information was obtained from the participants through hospital records and interviews using structured questionnaires. Univariate and multivariable analysis was used, and the chi-square test with adjusted odds ratio was estimated to account for vaccine exposure and the temporal nature of each outcome, respectively. Women not vaccinated against influenza during pregnancy had a higher risk of delivering very LBW infants, and possible protective effects were suggested (AOR 2.29, 95% CI 1.03 to 5.58, p = 0.03). No association was observed between maternal influenza vaccination for Caesarean section (LSCS) (AOR 0.97, 95% CI, 0.78, 1.85), stillbirth (AOR 1.8, 95% CI 0.18, 24.64) and NICU admission (AOR, 0.87, 0.29 to 2.85), and congenital anomaly (AOR, 0.81, 0.10 to 3.87). These results show that the influenza vaccine administered during pregnancy is safe and might lower the risk of negative birth outcomes.

Effectiveness, Immunogenicity and Safety of COVID-19 Vaccination in Pregnant Women: A Rapid Review Study.

Pregnant women infected with the coronavirus disease 2019 (COVID-19) are at risk for adverse pregnancy outcomes, and the only real preventive strategy against COVID-19 is mass vaccination. This study aimed to examine the effectiveness, immunogenicity, and safety of Covid-19 vaccination in pregnant women. A combination of search terms was performed by 2 researchers independently in the Web of Science, PubMed, and Scopus databases, the World Health Organization website, and the US Centers for Disease Control (CDC) website up to February 2022. After the selection of eligible studies, the review process, description, and summarization of the selected studies were performed by the research team. Finally, 22 articles were included in this study. Evidence supports the safety of COVID-19 vaccination during pregnancy. There is no risk of transmitting COVID-19 to infants during lactation. In addition, antibodies made by vaccination can protect infants through breast milk. The scientific community believes that being vaccinated as soon as possible is the best course of action because there is no evidence to suggest that the COVID-19 vaccine poses a risk to expectant or nursing women.

Evaluation of Side Effects Associated with COVID-19 Vaccines in Pregnant Women.

A variety of vaccinations have been developed to fight the coronavirus disease 2019 (Covid-19) 2 years after the coronavirus epidemic spread globally. During clinical studies, these vaccinations were linked to mild to severe side effects. This study aimed to evaluate the short-term side effects of Covid-19 vaccination in pregnant women in Zabol (Iran). This cross-sectional study was conducted between August and October 2021 to collect data on the adverse side effects of Covid-19 vaccinations among 117 pregnant women in Zabol (Iran). A questionnaire was used to collect demographic data, vaccination information, and vaccine complications. SPSS software Version 22 was used to analyze the data at 2 levels descriptive and inferential statistics. A total of 117 pregnant women aged 27.67 ± 5.14 years were included. After the first and second doses of Covid-19 vaccinations, 91 (86.7%) and 84 (71.8%) pregnant women, respectively, suffered adverse effects. Moreover, after the first dose, 55(51.4%) and 60 (56.1%) of pregnant women reported fatigue and headache, and after the second dose, 39 (33.3%) and 37 (31.6%) reported fatigue and headache, respectively. The side effects reported in our study after receiving Covid-19 vaccinations in pregnant women were similar to those described in clinical studies of vaccines and were mild to moderate, showing that injectable vaccines had safe profiles. More research is needed, however, to assess the long-term side effects of existing vaccines.

COVID-19 Vaccination in Pregnant Women: Exploring Serious Adverse Events.

Null.

Correlation between Knowledge and Hesitancy towards COVID-19 Vaccine in Pregnant Women in The Working Area of Ranomeeto Health Centre

Background: Acceptance or refusal of vaccinations can be influenced by hesitancy about the COVID-19 vaccine. Hesitancy is determined by knowledge, attitudes, practices, and public concerns about the safety, efficacy, risks, and benefits associated with the COVID-19 vaccination program. Purpose: To determine the association between knowledge and hesitancy about the COVID-19 vaccine in pregnant women in the Ranomeeto Health Center Working Area. Methods: This is an analytic observational study with a cross-sectional approach. This study was conducted at the Ranomeeto Health Center, Konawe Selatan District. The number of samples is 77 people, collected by purposive sampling technique. Knowledge was measured using a knowledge questionnaire about the covid-19 vaccine. Hesitation was measured using a questionnaire about the COVID-19 vaccine. Data were collected and analyzed using the Chi-Square statistical test with a significance value of p<0.05. Results: The results showed that most pregnant women had good knowledge about the COVID-19 vaccine (42.9%) and had no hecitation about the COVID-19 vaccine (61.0%). Statistical tests obtained a significant p-value between knowledge and hesitancy about the COVID-19 vaccine (p=0.010). Conclusion: There is a significant correlation between knowledge and hesitancy about the COVID-19 vaccine in pregnant women in the Working Area of the Ranomeeto Health Center. Keywords: covid-19 vaccine; hesitancy; knowledge; pregnant women

Pilot Study for Immunogenicity of SARS-CoV-2 Vaccine with Seasonal Influenza and Pertussis Vaccines in Pregnant Women.

Background: It is well known that the implementation of routine immunizations to prevent vaccine-preventable diseases has a significant impact on the health and well-being of infants, children, and pregnant women. We aimed to evaluate the influence of influenza, tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccine on the immunogenicity of SARS-CoV-2 vaccine among pregnant women, the priority population recommended for vaccination. Methods: We conducted a prospective study among pregnant women without previous SARS-CoV-2 infection in Taiwan. Maternal and umbilical cord blood samples at delivery were analyzed for the percentage of inhibition of neutralizing antibodies (NAbs) against the original strain, Delta, and Omicron variants of SARS-CoV-2 as well as the total antibody to the SARS-CoV-2 spike protein. We examined the association between different doses of SARS-CoV-2 vaccine in combination with influenza and Tdap vaccination, and two-dose SARS-CoV-2 vaccination with or without influenza and Tdap vaccines via a two-sample t-test. Results of p < 0.05 were considered to be statistically significant. Results: 98 pregnant women were enrolled in our study, with 32 receiving two doses of SARS-CoV-2 mRNA-1273 vaccine, 60 receiving three-dose of mRNA-1273, and 6 receiving one-dose of ChAdOx1 and two-dose of mRNA-1273. Twenty-one participants were immunized with SARS-CoV-2, influenza, and Tdap vaccines. Of these 21 individuals, there were no significant NAbs levels in maternal and cord blood samples against the Omicron variant, regardless of doses or type of SARS-CoV-2 vaccine. However, antibody responses against the wild-type and Delta variant were significantly lower in all maternal sera in the two-dose SARS-CoV-2 vaccine group. Among 32 women receiving two-dose mRNA-1273, significantly lower levels of NAbs in maternal sera were observed against the Delta variant and total antibody both in maternal sera and cord blood were observed in individuals receiving SARS-CoV-2 and influenza vaccine. Conclusion: This is the pilot study to demonstrate the effects of influenza and the Tdap vaccine on the immunogenicity of the SARS-CoV-2 vaccine among pregnant women. These results suggest that combination vaccination during pregnancy may result in immunogenic interactions.

Assessment of Efficacy and Effectiveness of Vaccines in Pregnant Women and their Infants

Assessment of Efficacy and Effectiveness of Vaccines in Pregnant Women and their Infants

Analysis of Covid 19 Vaccination Education on Interest in Implementing Vaccines for Pregnant Women

Covid-19 vaccine education program to increase public knowledge and interest, especially pregnant women, considering that pregnant women have a vulnerable immune system and are at high risk of being infected with COVID-19. This research was conducted in Bahomohoni Village, Morowali Regency. The purpose of this study is to analyze the effect of Covid-19 Vaccination Education on the Interest in Implementing Vaccines in Pregnant Women in Bahomohoni Village, Morowali Regency in 2022. This study used a one group pre test post test design. The population in this study amounted to 34 pregnant women. Total sample of 30 respondents used the Accidental Sampling Technique. Data analysis used the Wilcoxon Rank Sum Test. The research instrument used a questionnaire and an extension program unit. Most of the respondents before education had interest in the less category, which was 18 people (60%). The Effect of Covid 19 Vaccination Education on Interest in Implementing Vaccines for Pregnant Women in Bahomohoni Village, Morowali Regency in 2022 with a P-Value of 0.000 There is an Effect of Covid 19 Vaccination Education on Interest in Implementing Vaccines for Pregnant Women in Bahomohoni Village, Morowali Regency in 2022.

Adverse Events Related to COVID-19 Vaccines in Pregnant Women: Correspondence

Adverse Events Related to COVID-19 Vaccines in Pregnant Women: Correspondence

Antibody Responses Following Covid-19 Vaccine in Pregnant Women- A Prospective Study

Objective: To assess the antibody responses and adverse effects of sinopharm vaccine in pregnant women.Study Design: A prospective cohort study.Place and Duration of Study: The study was conducted in the Gynaecology Department of Ibn-e-Siena HospitalMultan, Independent Hospital Faisalabad and Mayo Hospital Lahore from January 2021 to January 2022.Materials and Methods: A total of 90 women were included in the study who were administered Sinopharm.Three out of ninety (3.3%) women received shots in 1st trimester, 56/90 (62%) in 2nd trimester and 31/90 (34%) in third trimester. Enzyme-linked immunosorbent assay (ELISA) was used to measure SARS-CoV-2 receptorbinding domain (RBD) specific total antibodies and angiotensin-converting enzyme 2 (ACE2) blockingantibodies. The adverse effects on the mother and fetus were evaluated after the delivery.Results: The administration of the sinopharm vaccine showed no adverse effects or pregnancy complicationssuch as congenital anomalies, miscarriage, preterm delivery, thrombotic events, fetal death or hypertensivedisorders. SARS-CoV-2 specific total antibodies were found in 57/90 (63%) women at the time recruitment(when receiving 1st dose); thus they were considered to be previously infected. After the second dose, allwomen were seroconverted. Significantly high levels of RBD binding antibodies and ACE2 blocking antibodieswere observed in previously infected women after administration of the second dose compared to uninfectedindividuals.Conclusion: The Sinopharm vaccine showed positive results in pregnant women and induced highseroconversion rates and ACE2 blocking antibodies in second and third trimesters.&#x0D; How to cite this: Hamayun Z, Javaid U, Ahmed R, Shehzad K, Gul PI. Antibody Responses Following Covid-19 Vaccine in Pregnant Women- A Prospective Study. Life and Science. 2022; 3(4): 196-199. doi: http://doi.org/10.37185/LnS.1.1.273

Coronavirus Disease 2019 (COVID-19) and messenger RNA Vaccination in Pregnant Women

Coronavirus Disease 2019 (COVID-19) and messenger RNA Vaccination in Pregnant Women

MRNA Covid-19 Vaccines in Pregnant Women

(N Engl J Med. 2021;384:2342–2343) Pregnant women were not included in initial trials for the Moderna and Pfizer-BioNTech messenger RNA (mRNA) vaccines for coronavirus disease 2019 (Covid-19), but were among the first persons eligible to receive the vaccines under an Emergency Use Authorization.

Covid-19 Vaccination Maternal Services for Pregnant Women in the Work Area of Telaga Community Health Centers

This study aims to provide an overview of how the covid-19 vaccination service for pregnant women in the work area of the Telaga Health Center. This study uses a qualitative method that focuses on ANC services with in-depth interview techniques, data analysis is carried out descriptively and presented in narrative form. This research was carried out in the working area of the Telaga Health Center from September 2021 to November 2022. The informants in this study were pregnant women in the Telaga Health Center working area as many as 7 participants and 2 key informants were the program coordinator midwives. With a snowball sampling technique. The results of the study found that there were 5 themes that described Covid-19 vaccination services for pregnant women, namely Socialization of Covid-19 Vaccination for pregnant women, Issue of KIPI for Covid-19 Vaccination, Supporting Factors for Successful Vaccination in Pregnant Women, Body Response of Pregnant Women after Covid-19 Vaccination. 19, and Covid-19 Vaccination Requirements for Pregnant Women. The mandatory output in this research is the publication of research results in one of the international journals.