Levels Of Vaccenic Acid Research Articles

Cis-9, trans-11 CLA Derived Endogenously from trans-11 18:1 Reduces Cancer Risk in Rats

The present study was designed to examine the effects of increasing dietary levels of vaccenic acid (VA) and cis-9, trans-11 conjugated linoleic acid (CLA) on chemically induced mammary carcinogenesis in rats. Both fatty acids were provided as a natural component in butter fat. The conversion of VA to CLA by delta9-desaturase was documented previously in several species, including rats and humans. Specifically, our objective was to determine the relative contribution of dietary VA and CLA to the tissue concentration of CLA and its ability to inhibit the development of mammary carcinomas. A total of 7 diets were formulated with varying levels of CLA and VA. The overall dietary treatment scheme was designed to evaluate the modulation of mammary cancer risk by 1). small increases of CLA in the presence of a low level of VA and 2). more substantial increases of VA against a background of low levels of CLA. As expected, small increases in dietary CLA at the low end of the CLA dose-response range did not reduce tumorigenesis. In contrast, there was a distinct and marked inhibitory response to VA that was dose dependent. The effect of VA was magnified in this experiment because the dose range of VA tested was much broader than that of CLA. Fatty acid analysis showed that the conversion of dietary VA to CLA resulted in a dose-dependent increase in the accumulation of CLA in the mammary fat pad, which was accompanied by a parallel decrease in tumor formation in the mammary gland. The finding confirms that the conversion of VA to CLA is as important for cancer prevention as the dietary supply of CLA. Thus, VA is also anticarcinogenic, and VA and CLA represent functional food components that are present in ruminant fat.

Research on oleic andcis‐vaccenic

Journal of the American Oil Chemists' SocietyVolume 71, Issue 9 p. 1045-1045 Letter to the Editor Research on oleic andcis-vaccenic James K. Daun, James K. Daun Grain Research Laboratory, Grain Commission, WPG, MB, 1014-303 Main St., Winnipeg, Manitoba, R3C 3G8 CanadaSearch for more papers by this authorX. Hu, X. Hu Department of Plant Science, University of Manitoba, Winnipeg, Manitoba, R3T 2N2 CanadaSearch for more papers by this authorR. Scarth, R. Scarth Department of Plant Science, University of Manitoba, Winnipeg, Manitoba, R3T 2N2 CanadaSearch for more papers by this author James K. Daun, James K. Daun Grain Research Laboratory, Grain Commission, WPG, MB, 1014-303 Main St., Winnipeg, Manitoba, R3C 3G8 CanadaSearch for more papers by this authorX. Hu, X. Hu Department of Plant Science, University of Manitoba, Winnipeg, Manitoba, R3T 2N2 CanadaSearch for more papers by this authorR. Scarth, R. Scarth Department of Plant Science, University of Manitoba, Winnipeg, Manitoba, R3T 2N2 CanadaSearch for more papers by this author First published: 01 September 1994 https://doi.org/10.1007/BF02542278Citations: 2 *To whom correspondence should be addressed at Grain Research Laboratory, Canadian Grain Commission, 1014-303 Main St., WPG, MB, R3C 3G8 Canada. AboutRelatedInformationPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessClose modalShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article.Citing Literature Volume71, Issue9September 1994Pages 1045-1045 RelatedInformation RecommendedDibutyrate derivatization of monoacylglycerols for the resolution of regioisomers of oleic, petroselinic, and cis-vaccenic acidsFrédéric Destaillats, Joseph Arul, James E. Simon, Robert L. Wolff, Paul Angers, Lipidscis-Vaccenic acid in mango pulp lipidsAkira Shibahara, Kohei Yamamoto, Takao Nakayama, Goro Kajimoto, LipidsProduction of hydroxy fatty acids from unsaturated fatty acids byFlavobacterium sp. DS5 hydratase, a C-10 positional- andcis unsaturation-specific enzymeChing T. Hou, Journal of the American Oil Chemists' SocietyOleic and vaccenic acid levels in lipid classes of tumorsRandall Wood, LipidsSome chemical processes utilizing oleic safflower oilM. J. Diamond, Glenn Fuller, Journal of the American Oil Chemists' Society

Increased levels of vaccenic acid in bronchogenic carcinoma tissue : Lawson N, Husband D McGuigan J, Waston DCT, Collins FJ, Pandov HI. Department of Clinical Chemistry, East Birmingham Hospital, Birmingham B9 5ST. Ann Clin Biochem 1989;26:125-31

Increased levels of vaccenic acid in bronchogenic carcinoma tissue : Lawson N, Husband D McGuigan J, Waston DCT, Collins FJ, Pandov HI. Department of Clinical Chemistry, East Birmingham Hospital, Birmingham B9 5ST. Ann Clin Biochem 1989;26:125-31

Increased levels of vaccenic acid in bronchogenic carcinoma tissue.

Employing capillary gas liquid chromatography the levels of palmitic, palmitoleic, stearic, oleic, cis-vaccenic, linoleic, arachidonic and docosahexaenoic acids were measured in lung tissue and lung tumours from 28 patients undergoing surgery for bronchogenic carcinoma. There were significant increases in the majority of fatty acids in tumour tissue compared to normal tissue when the results were expressed in absolute units. However, when the relative changes in fatty acid concentration were studied, the most consistent findings were a significant rise in vaccenic acid and a fall in palmitic acid in tumour tissue compared to normal tissue. This change in the vaccenic:palmitic acid ratio may reflect specific changes in fatty acid metabolism in bronchogenic carcinoma tissue involving a delta-9 desaturase.

Oleic and vaccenic acid levels in lipid classes of tumors

The isomeric octadecenoate composition of triglyceride, phosphatidyicholine, and phosphatidylethanolamine classes from a variety of rat and mouse tumors was examined. Phosphatidylethanolamine from the tumors contained a higher percentage of octadecenoate than reported for many normal tissues. The octadecenoate fractions of the three lipid classes from various tumors consisted of ca. 75% or greater oleate, with vaccenate making up the balance. These data indicate that the loss of lipid class specificity for isomeric octadecenoates reported in hepatomas (Lipids 10:746, 1975, and Lipids 9:987, 1974) also occurs in other tumors.

Lipids of cultured hepatoma cells: V. Distribution of isomeric monoene fatty acids in individual lipid classes.

AbstractMonoenoic acid fractions were isolated from phosphatidylcholines, phosphatidylethanolamines, triglycerides, and cholesterol esters derived from minimal deviation hepatoma 7288C cells cultured on 11 media containing varying levels of serums and lipids. Hexadecenoate (16∶1), octadecenoate (18∶1), and eicosenoate (20∶1) fractions were subjected to ozonolysis and the isomeric composition of the monoene fractions determined quantitatively by gas liquid chromatography. The 16∶1 fractions consisted of palmitoleic acid, the Δ9 isomer (85–90%), and the Δ11 isomer (10–15%) in most of the cases; growth media and lipid class origin had little effect upon composition. The predominate acids of the 20∶1 fraction were the Δ13 and Δ11 isomers. Generally, the Δ13 isomer was present in the highest concentration, and this isomer was higher in phosphatidylcholines than the other classes. Vaccenic acid represented 33–66% of the 18∶1 fraction, and the balance was oleic acid. Oleic acid concentrations decreased, and vaccenic acid levels increased as the growth medium serum and lipid levels decreased. Lipid classes did not exhibit any distinct preference for either isomer. These data represent the first quantitative isomeric analysis of monoenoic acids derived from individual lipid classes and are the first to show the occurrence of high levels of vaccenic acid in neoplastic cells. This study suggests that the elevated levels of oleic acid, one of the most frequently observed changes in tumor lipids, may, in fact, represent elevated levels of vaccenic acid.