Use Of Conventional Drugs Research Articles

Preparation, characterization, and in vivo activity of Gossypium hirsutum niosomes against cutaneous leishmaniasis caused by Leishmania major in a murine model: Parasite burden, gene expression, and histopathological profiling

The use of conventional drugs is not a satisfactory treatment for the disease. Therefore, there is a crucial need for alternative therapeutic approaches. This study aimed to investigate the potential anti-leishmanial activity of Gossypium hirsutum niosomes against cutaneous leishmaniasis in a murine model and evaluate their effectiveness by assessing parasite burden, immunomodulatory gene expression, and histopathological profile. We prepared G. hirsutum niosomes and characterized their morphology, size, Fourier transform infrared spectroscopy (FT-IR), and encapsulation efficiency. The in vivo anti-leishmanial activity of the niosomes was evaluated by assessing parasite burden, histopathological profile, and gene expression level. The spleen parasite load in BALB/c mice treated with different groups of G. hirsutum niosomes and G. hirsutum extracts (30%), demonstrated a significant decrease compared to Glucantime®. The least number of leishmanial parasites was observed in H and E-stained histological sections (grade+1), followed by G. hirsutum niosomes or G. hirsutum crude extract (grade+3), Glucantime® (grade+4) and the highest number in the untreated control group (grade+6). There was a substantial difference (P < 0.001) among various treatment groups. Moreover, G. hirsutum niosomes up-regulated the levels of the gene (particularly IFN-γ, P < 0.001) compared to the extract form and Glucantime®. In contrast, IL-4, IL-10, and TNF-β were significantly decreased (P < 0.001) in comparison to untreated control. These results suggest that G. hirsutum niosomes have the potential to be considered a promising alternative therapy for leishmaniasis. Further research is warranted to explore their mechanism of action and optimize their formulation for clinical use.

Wastewater-based epidemiology to monitor 68 NPS/conventional drug use in Taipei metropolitan area in Taiwan during and after COVID-19 pandemic

Amidst far-reaching COVID-19 effects and social constraints, this study leveraged wastewater-based epidemiology to track 38 conventional drugs and 30 new psychoactive substances (NPS) in northern Taiwan. Analyzing daily samples from four Taipei wastewater plants between September 2021 and January 2024—encompassing club reopenings, holidays, Lunar New Year, an outbreak, and regular periods—thirty-one drugs were detected, including 5 NPS. Tramadol, zolpidem tartrate, CMA, and MDPV were newly detected in Taiwanese sewage with frequency of 1.4 %− 89.0 %. Conventional drug use typically increased post-pandemic, aside from benzodiazepines and methadone. Methamphetamine showed 100 % frequency, indicating ongoing daily consumption despite COVID-19 measures. Methamphetamine and morphine's consumption dipped then rose around club reopening, hinting at limited access. The consumption trend of methadone appeared to compensate for the use of morphine. Ketamine and NPS demonstrated similar patterns throughout the entire period. NPS as party drugs seemed influenced by an unstable supply chain and complexities in implementation. Benzodiazepines, commonly abused alongside synthetic cathinones in Taiwan exhibited an opposing trend to NPS while aligned with acetaminophen, suggesting elevated stress and anxiety levels during the pandemic. No significant differences were observed in drug consumption between weekdays and weekends, potentially indicating that COVID-19 measures blurred the traditional distinctions between these timeframes. Environmental ImplicationNew psychoactive substances refer to chemically modified variants of controlled drugs designed to mimic the effects of the original drugs while evading modern detection methods, categorizing them as hazardous materials. The study presents a sewage monitoring project conducted from 2021 to 2024, collecting samples from four WWTPs to analyze NPS and conventional drug trends during and after the COVID-19 pandemic. The findings uncovered connections between drug consumption patterns and pandemic-related policies. In light of the persistent drug abuse and their environmental presence, the results bear critical importance for both environmental and public health. We provide a thorough assessment of these relationships and prioritize areas for future research.

Finding the research gap of the potential anti-inflammatory activity of cocoa (Theobroma cacao L.) through systematic literature review

The use of conventional drugs in treating inflammation has various side effects, and thus it is necessary to have an alternative anti-inflammatory agent that is effective and safe. Cocoa (Theobroma cacao L.) is one of the agricultural products with a high content of polyphenols, especially flavan-3-ols potentially used as an anti-inflammatory agent. The purpose of this research is to investigate the research gap of the potential antiinflammatory activity of cocoa based on the published literatures. The systematic method of synthesizing the review follows the guidelines of the PRISMA Statement 2020 using the PICOS literature search strategy. The results of this study showed that the positive effect of cocoa on inflammation indicated by 44 out of 72 biomarkers (61.11%). Flavan-3- ols can effectively reduce inflammation by reducing the activation of transcripts that regulate pro-inflammatory cytokines (NF-kB), prostaglandins, and NO. The antiinflammatory effect was effectively found in different groups, i.e., subjects without health issue (healthy subject), subjects with some health problems record and subjects with obesity. Nevertheless, it was found in the previous researches that the manifest of cocoaderived products as well as the biomarkers for determining the anti-inflammatory effect of cocoa still vary. Also, there is no study investigating the anti-inflammatory effect of cocoa on different age group. Therefore, further researches are required in this area to complete the puzzle of information regarding the potential anti-inflammatory activity of cocoa.

Medicinal plants vs. conventional medicine: treatment assessments for indigenous populations

Introduction: Although traditional healing practices are important for indigenous populations, access to modern health care practices is essential to ensure the health of communities as well as the prevention of diseases and their aggravation. Objective: To examine the acceptance of medication by the Pitaguary indigenous group, who live in Maracanaú, state of Ceará (CE), Brazil. Methodology: An observational and descriptive case of the use of natural plants as a medicinal treatment in the Pitaguary indigenous group, in Maracanaú-CE. The interviews used a questionnaire adapted from the SATIS-BR scale. Results: The majority of the Pitaguary population in the interview presented chronic diseases (diabetes or hypertension). Only 13.3% do not follow up with their community medical doctor. Of the interviewees, 20% use a mix of conventional and herbal treatments; 67.2% use a non-secure method to identify medication; and 52% suspend use of conventional drugs in the middle of treatment and replace them with herbal plants recommended by the village shaman. Discussion: The main strategy when working with indigenous populations ends up being health education about the use of medicinal plants in association with commercial drugs. The involvement of community’s leaders in the delivery of health services seems an effective strategy to promote their understanding about dual use of medicinal plants and western drugs for chronic diseases. Conclusion: A culturally sensitive approach that takes into account indigenous traditions and beliefs should be used to improve medication adherence within indigenous groups.

Intimate partner violence among minority groups: A view from northern Bangladesh

This study investigates the prevalence, characteristics, and associated factors of intimate partner violence (IPV) among minority groups of Bangladesh. A mixed methods approach was employed, combining a survey of 128 participants from minority groups with 10 in-depth case studies. The survey collected quantitative data, while case studies provided qualitative insights. The study reveals a pervasive prevalence of IPV within marginalized communities, with 40.6% of females reporting experiences of IPV. Husbands were identified as the primary abusers (91.4%) of IPV. Various determinants were identified as contributing factors to IPV. These include poor mental health, substance abuse, exposure to childhood violence, patriarchal attitudes, financial pressures, conventional drug use, adherence to cultural and societal norms, and limited education regarding healthy relationships, communication, and conflict resolution skills. Surprisingly, the study highlights that IPV is bidirectional, with 33.6% of respondents admitting to physically harming their spouse during violent incidents. Gender inequality or rigidity was not the predominant determinant of IPV among minority communities in northern Bangladesh. The study underscores the necessity of culturally sensitive strategies to address IPV within marginalized communities. The findings underscore the need to address both sides of the IPV dynamic and advocate for holistic interventions that acknowledge and respect cultural norms and values.

Pharmacotherapy and Nutritional Supplements for Neovascular Eye Diseases.

In this review, we aim to provide an overview of the recent findings about the treatment of neovascular retinal diseases. The use of conventional drugs and nutraceuticals endowed with antioxidant and anti-inflammatory properties that may support conventional therapies will be considered, with the final aim of achieving risk reduction (prevention) and outcome improvement (cooperation between treatments) of such sight-threatening proliferative retinopathies. For this purpose, we consider a medicinal product one that contains well-defined compound(s) with proven pharmacological and therapeutic effects, usually given for the treatment of full-blown diseases. Rarely are prescription drugs given for preventive purposes. A dietary supplement refers to a compound (often an extract or a mixture) used in the prevention or co-adjuvant treatment of a given pathology. However, it must be kept in mind that drug-supplement interactions may exist and might affect the efficacy of certain drug treatments. Moreover, the distinction between medicinal products and dietary supplements is not always straightforward. For instance, melatonin is formulated as a medicinal product for the treatment of sleep and behavioral problems; at low doses (usually below 1 mg), it is considered a nutraceutical, while at higher doses, it is sold as a psychotropic drug. Despite their lower status with respect to drugs, increasing evidence supports the notion of the beneficial effects of dietary supplements on proliferative retinopathies, a major cause of vision loss in the elderly. Therefore, we believe that, on a patient-by-patient basis, the administration of nutraceuticals, either alone or in association, could benefit many patients, delaying the progression of their disease and likely improving the efficacy of pharmaceutical drugs.

Optimization and Evaluation of Anti-Inflammatory Herbal Emulgel loaded with Vitex Negundo for Enhanced Permeation

The use of conventional drugs for the treatment of pain and inflammation has largely resulted in various side effects. These challenges have triggered the search for alternative therapy such as herbal medication that may serve as a safe, effective, and alternate treatment approach to managing pain and inflammation. Vitex negundo, a potential lipophilic molecule, possesses limited solubility and permeability. Emulgels are either water-in-oil or oil-in-water type emulsions, mixed with a gelling agent to form a gel for the delivery of lipophilic active ingredients. Therefore the current study is undertaken for the effective delivery of vitex negundo locally in the form of oil-in-water emulgel for improving solubility and permeability. The emulgel was formulated from carbopol 934 with vitex negundo in mineral oil emulsion using tween 80 (surfactant), and triethanolamine (co-surfactant). The formulations were optimized using the design of experiment software. The optimized emulgel formulation containing Smix (tween 80 and triethanolamine) ratio of 61.90, mineral oil 50.58%, and carbopol 934 3% showed a pH of 6.5±0.3, a viscosity of 17793 – 939 cps, and spreadability of 7.07 g.cm/s. Data from in-vitro and ex-vivo diffusion studies demonstrated improved permeability properties. The stability of the optimized emulgel formulation was additionally examined at ambient temperature for 28 days. The emulgel remained stable for 28 days. Based on the overall results we can conclude that emulgel can be a promising and suitable formulation for the application of vitex negundo.

Green Solid-Phase (Micro)Extraction of Andrographolides’ from Human Plasma Samples Followed by UHPLC-DAD-QqQ-MS/MS Analysis

Since inflammatory bowel disease is a progressive disease, optimal treatment early in the disease course is paramount. Still, the use of conventional drugs is accompanied by side effects. The herbal therapies for gastrointestinal disorders are traditionally widespread in Asia, while in Western countries have been adopted in recent years. Andrographis paniculata is a herbaceous plant used in anti-inflammatory treatment. To improve its clinical application, an analytical method with the potential to define a relationship between dose and plasma concentration of active ingredients is prerequisite. Considering the increasing demand for eco-friendly bioanalytical methods, our research aimed to implement new sample preparation technique microextraction by packed sorbent for extraction of marker compounds of A. paniculata from plasma. This green procedure using polymeric sorbent based on the poly (styrene-divinylbenzene) allowed miniaturization of sample volume (100 µL), decrease in consumption of solvents, and high recovery (92–98%). A highly selective and sensitive reversed-phase ultrahigh-performance liquid chromatography method has been developed and validated. The newest greenness assessment software AGREE calculator was used for evaluation of the method’s environmental performance. It suggests that our method conforms to the eco-friendly conditions (score 0.8). The sample preparation was identified as weak point of the bioanalytical methods which highlights the importance of microextraction.

Chitosan and HPMCAS double-coating as protective systems for alginate microparticles loaded with Ctx(Ile21)-Ha antimicrobial peptide to prevent intestinal infections

The incorrect use of conventional drugs for both prevention and control of intestinal infections has contributed to a significant spread of bacterial resistance. In this way, studies that promote their replacement are a priority. In the last decade, the use of antimicrobial peptides (AMP), especially Ctx(Ile21)-Ha AMP, has gained strength, demonstrating efficient antimicrobial activity (AA) against pathogens, including multidrug-resistant bacteria. However, gastrointestinal degradation does not allow its direct oral application. In this research, double-coating systems using alginate microparticles loaded with Ctx(Ile21)-Ha peptide were designed, and in vitro release assays simulating the gastrointestinal tract were evaluated. Also, the AA against Salmonella spp. and Escherichia coli was examined. The results showed the physicochemical stability of Ctx(Ile21)-Ha peptide in the system and its potent antimicrobial activity. In addition, the combination of HPMCAS and chitosan as a gastric protection system can be promising for peptide carriers or other low pH-sensitive molecules, adequately released in the intestine. In conclusion, the coated systems employed in this study can improve the formulation of new foods or biopharmaceutical products for specific application against intestinal pathogens in animal production or, possibly, in the near future, in human health.

STEP TOWORDS THE FORMULATION OF INJECTABLE HYDROGEL: PREFORMULATION STUDIES OF TERIFLUNOMIDE

Purpose: The aim of formulation of this hydrogel is to treat the osteoarthritis which is one of the common inflammatory autoimmune disorders of joints. The use of conventional drugs like NSAIDs having various side effects.&#x0D; The aim of our research was to develop a formulation of injectable hydrogel containing teriflunomide. This study will be helps us for the development of stable, robust and therapeutically effective dosage form.&#x0D; Method: Solubility of Teriflunomaide was determined by using various solvents. By using infrared spectrum and absorption maxima the purity of sample was checked. With the help of UV spectrophotometer standard UV curve was developed. Drug excipients compatibility studies were performed using Fourier transform infrared spectroscopy, differential scanning colorimetry, partition coefficient and also short term drug solution stability studies were performed.&#x0D; Result: Teriflunomide is soluble in methanol &amp; 0.1 N NaOH on the other hand poorly soluble in distilled water, phosphate buffer (pH 7.4) and 0.1 N HCl. Absorption maxima was observed at 292nm and infrared spectrum was showing the characteristic peaks. The standard curve obtained was linear with correlation coefficient below 1. Log P value obtained at 2.78 it confirms that teriflunomide is having both hydrophilic &amp; hydrophobic nature. After the entire short term stability studies drug was found to be stable in short term stability studies.&#x0D; Conclusion: The studies like melting point, FTIR etc suggested that drug selected for the formulation was found to be pure. Partition coefficient values suggested that it is having both hydrophilic and hydrophobic nature. Results obtained from short term stability studies were suggested that drug is stable showing no degradation on phosphate buffer which confirmed by no shift of λ max.

Evolving spectrum of diabetic wound: Mechanistic insights and therapeutic targets.

Diabetes mellitus is a chronic metabolic disorder resulting in an increased blood glucose level and prolonged hyperglycemia, causes long term health conse-quences. Chronic wound is frequently occurring in diabetes patients due to compromised wound healing capability. Management of wounds in diabetic patients remains a clinical challenge despite many advancements in the field of science and technology. Increasing evidence indicates that alteration of the biochemical milieu resulting from alteration in inflammatory cytokines and matrix metalloproteinase, decrease in fibroblast and keratinocyte functioning, neuropathy, altered leukocyte functioning, infection, etc., plays a significant role in impaired wound healing in diabetic people. Apart from the current pharmacotherapy, different other approaches like the use of conventional drugs, antidiabetic medication, antibiotics, debridement, offloading, platelet-rich plasma, growth factor, oxygen therapy, negative pressure wound therapy, low-level laser, extracorporeal shock wave bioengineered substitute can be considered in the management of diabetic wounds. Drugs/therapeutic strategy that induce angiogenesis and collagen synthesis, inhibition of MMPs, reduction of oxidative stress, controlling hyperglycemia, increase growth factors, regulate inflammatory cytokines, cause NO induction, induce fibroblast and keratinocyte proliferation, control microbial infections are considered important in controlling diabetic wound. Further, medicinal plants and/or phytoconstituents also offer a viable alternative in the treatment of diabetic wound. The focus of the present review is to highlight the molecular and cellular mechanisms, and discuss the drug targets and treatment strategies involved in the diabetic wound.

Effectiveness of low-level Diode laser therapy in recurrent aphthous stomatitis treatment at Can Tho University of Medicine And Pharmacy Hospital in 2020-2022

Background: Recurrent aphthous stomatitis (RAS) are the most common oral ulceration in lesions of the oral mucosa. Treatment aims to reduce pain and healing time. Low-level Diode laser therapy can relieve pain, anti-inflammatory, reduce edema, stimulate cell biology, and stimulate healing. Low-level Diode laser therapy is an alternative therapy to conventional drug use, promising to help improve the quality of life, improve the patient's quality of life and avoid complications caused by long-term drug use. Objectives: To evaluate the therapeutic effect of a low-level Diode laser on RAS treatment to reduce pain, size of ulcers, and healing time. Materials and methods: A clinical study was conducted on 30 patients who presented RAS lesions were treated with low-level laser therapy. The patients were evaluated for the size, position, pain score, form of ulcers, healing time before and immediately, fourth and sixth day after treatment. The data was analyzed using SPSS 20. Results: The VAS score pre-treatment was 4.33±1.65, immediately post-treatment was 1.20±1.06. The size of ulcers pre-treatment was 4.58±2.35mm, and post-treatment fourth day was 2.47±2.30mm. The healing time was 5.04±0.32 days. Conclusion: Low-level Diode laser therapy is effective in RAS treatment to reduce pain, size of ulcers, and healing time.

Fabrication of activated carbon fiber functionalized core–shell silver nanoparticles based in situ and low-cost technology for wound dressings with an enhanced antimicrobial activity and cell viability

• A uniformed dispersible & stable coating layer of poly(tannic acid) (PTA) on AgNPs was prepared. • Core–shell AgNPs@PTA with a high yield of 95.8% and minimal toxicity was prepared. • Chitosan improved the half maximal inhibitory concentration of AgNPs@PTA up to 1000 ppm . • A competitive wound dressing was engineered by integrating AgNPs@PTA into activated carbon fiber. Wound dressings are considered to be effective barriers against bacterial attack. They also facilitate wound healing in nursing-management functions. Silver nanoparticles (AgNPs) in wound dressings could overcome the problems associated with bacterial immunity, which is often observed in the use of conventional drugs. In the present work, a high concentration of cost effective and environmentally friendly AgNPs (16.3 ± 3.7 nm) with a uniform core–shell of poly(tannic acid) (PTA) was prepared. The preparation in high yield (95.8%) was based on an autoxidation-reduction reaction that was induced based on pH-responsive reduction affinity of tannic acid (TA). Despite the high antimicrobial activity of the prepared AgNPs@PTA, their cytotoxicity hindered their practical applications. The addition of different concentrations of natural cell viability enhancers, including TA and chitosan, to the prepared AgNPs@PTA solution improved significantly the cell viability. We have succeeded in improving the half maximal inhibitory concentration ( IC 50 ) from 1 to 1000 ppm with minimal cytotoxicity toward L929 cells and 99.99% antimicrobial performance against both E. coli and S. aureus . Finally, the prepared AgNPs@PTA was integrated in an activated carbon fibers for wound-dressing application and exhibited excellent performance when compared with some commercial wound-dressing products.

Tingkat Pengetahuan Mahasiswi Fakultas Kedokteran Universitas Tanjungpura Tentang Manfaat Jahe Merah Terhadap Penurunan Dismenore

The use of conventional drugs in overcoming dysmenorrhea (painful menstruation) is known to cause side effects. Alternative medicine that can be done to overcome dysmenorrhea by using red ginger. The purpose of this study was to describe the level of knowledge of age in students of the Faculty of Medicine, Tanjungpura University, Department of Medicine, Pharmacy, and Nursing about the benefits of red ginger in reducing dysmenorrhea. This research is a descriptive observational study using a cross sectional research design. The technique used in sampling is purposive sampling technique. The research instrument was an online questionnaire in the form of a google form. Univariate analysis was used to describe the distribution of respondents from each variable. The results showed that respondents with a good level of knowledge aged 17-18 years were 57 (82.61%) respondents, respondents aged 19-20 years were 131 (81.88%), and respondents aged 21-22 years were found. as many as 68 (88.31%). The conclusion of this study is that the level of knowledge of female students about the benefits of using red ginger in overcoming dysmenorrhea is quite good (83.66%).

POSB118 Cost-Effectiveness of Elvitegravir, Cobicistat, Emtricitabine and Tenofovir Alafenamide Fumarate Tablets in Acquired Immunodeficiency Syndrome from the Chinese Payer Perspective

In China, long-term use of conventional drugs treating acquired immunodeficiency syndrome (AIDS) is associated with toxicity, adverse effects (AEs), and poor compliance. On January 1, 2020, elvitegravir, cobicistat/emtricitabine/tenofovir alafenamide fumarate tablets (E/C/F/TAF) were included in the Chinese National Medical Insurance list. E/C/F/TAF is a fixed-dose-combination tablet for once-daily administration. This study assessed the cost-effectiveness of E/C/F/TAF vs other combination regimens for the treatment of AIDS from the Chinese payer perspective.

Treatment of heart failure in adult congenital heart disease

The progressive shifting in adult patients with congenital heart disease (ACHD) epidemiology with aging and superimposed acquired cardiac pathology on top of complex congenital heart defects is leading to an increase of hospitalizations for heart failure (HF), which nowadays represents one of the main causes of death in this patient population. Although there is a theoretical evidence to support the use of conventional drugs indicated for the general population with HF, randomized controlled trials do often exclude ACHD patients. Anatomical and physiological heterogeneity makes it difficult to define the role of cardiac resynchronization, and indications are less established. Timing of assessment for heart transplantation is challenging and referral often occurs too late. The present review wants to offer a summary of current therapeutic strategies and discuss future perspectives for ACHD-related HF treatment.

Role of Plant-based Natural Products in the Treatment of Type 2 Diabetes

Diabetes mellitus is caused by the elevation of blood sugar levels and has become a serious health concern worldwide with the number of cases steadily increasing annually. Due to the increased side effects and costs associated with the use of conventional drugs, alternative treatment methods that use natural compounds from medicinal plants have been researched. This review summarizes the recent advances and discoveries of plant based natural compounds used for the treatment of Type 2 diabetes as well as their mechanisms of action, which include the inhibition of carbohydrate metabolizing enzymes, reducing oxidative stress, modifying the activity of the PPARγ receptor, and modifying the activity of glucose transporters. We also describe the most prevalent classes of chemical compounds that have been shown to exhibit significant antidiabetic activity, thereby showing promise for development into novel drug molecules. These classes include polysaccharides, polyphenols, alkaloids, terpenes and quinones among others. .

Challenge in the Discovery of New Drugs: Antimicrobial Peptides against WHO-List of Critical and High-Priority Bacteria.

Bacterial resistance has intensified in recent years due to the uncontrolled use of conventional drugs, and new bacterial strains with multiple resistance have been reported. This problem may be solved by using antimicrobial peptides (AMPs), which fulfill their bactericidal activity without developing much bacterial resistance. The rapid interaction between AMPs and the bacterial cell membrane means that the bacteria cannot easily develop resistance mechanisms. In addition, various drugs for clinical use have lost their effect as a conventional treatment; however, the synergistic effect of AMPs with these drugs would help to reactivate and enhance antimicrobial activity. Their efficiency against multi-resistant and extensively resistant bacteria has positioned them as promising molecules to replace or improve conventional drugs. In this review, we examined the importance of antimicrobial peptides and their successful activity against critical and high-priority bacteria published in the WHO list.

Ethnomedicinal Value of Antidiabetic Plants in Bangladesh: A Comprehensive Review.

The use of conventional drugs to treat metabolic disorders and the pathological consequences of diabetes further increases the complications because of the side effects, and is sometimes burdensome due to relatively higher costs and occasionally painful route of administration of these drugs. Therefore, shifting to herbal medicine may be more effective, economical, have fewer side effects and might have minimal toxicity. The present review amasses a list of ethnomedicinal plants of 143 species belonging to 61 families, from distinctive domestic survey literature, reported to have been used to treat diabetes by the ethnic and local people of Bangladesh. Leaves of the medicinal plants were found leading in terms of their use, followed by fruits, whole plants, roots, seeds, bark, stems, flowers, and rhizomes. This review provides starting information leading to the search for and use of indigenous botanical resources to discover bioactive compounds for novel hypoglycemic drug development.

Effect of Drugs and Combination of Diets with Exercise on Biochemical Parameters in Patients with Type 2 Diabetes Mellitus in Barishal, Bangladesh: A Follow up Study

Diabetes Mellitus is a chronic metabolic disorder associated with an increased rate of glucose which can be reduced by diets, drugs, lifestyle changes and physical activity. The present study aimed to investigate the comparison of the effectiveness of drugs and combination of diets with exercise on biochemical parameters of Type 2 Diabetes mellitus patients. A follow up study of 150 diabetes patient’s biochemical test >30 years of age were conducted in two phages before and after three months from Diabetes Hospital, Barishal. The investigator categorized two groups of diabetes patients where intervention of diets with exercise was given to 75 respondents and on the other hand 75 respondents by drugs to find out which intervention was more effective. This study found the incidence of reduced blood glucose from 50% to 13.33% by diets with exercise and 50% to 10.67% by drugs during fasting after three months of intervention. After 2 hours eating, blood glucose reduced to 14% and 18% respectively. Analyst established diets with exercise and drugs both had a great effect on fasting glucose, after two hours glucose and serum creatinine which was statistically significant between two phages of same respondents (P<.05). Drugs over fasting glucose, after 2 hours glucose and serum creatinine were statistically significant. Diets with exercise over fasting glucose, after 2 hours glucose, LDL and serum creatinine were also highly significant. Combination of diets and physical activity targeting this factor has proven to be superior to conventional drug use for reducing blood glucose of diabetic patients.