US Intermountain Research Articles

Diverse flies (Diptera) likely pollinate an alpine death camas, Anticlea elegans (Melanthiaceae)

Several populations of a species of death camas (Anticlea elegans) (Melanthiaceae) were found growing and flowering above treeline in the remote Lemhi Mountains of southeastern Idaho USA. The predominant floral visitors were flies representing four families, particularly the Syrphidae. Many individual flies bore visible loads of Anticlea pollen. Various native bees were seen foraging in the locale, but all visited flowers other than Anticlea. The flies, as well as ants, fed from the tepal nectaries. Despite the plant’s common name, no foragers appeared to be impaired by imbibing its nectar. High in a neighbouring mountain range, A. elegans was being used as a trysting site by numerous Tenthredo sawflies. This is the first report of floral visitors to any Anticlea and among the first for any wildflower population above treeline in the vast US Intermountain West.

Assessing Patient Readiness for Hospital Discharge, Discharge Communication, and Transitional Care Management.

Discharge communication between hospitalists and primary care clinicians is essential to improve care coordination, minimize adverse events, and decrease unplanned health services use. Health-related social needs are key drivers of health, and hospitalists and primary care clinicians value communicating social needs at discharge. To 1) characterize the current state of discharge communications between an academic medical center hospital and primary care clinicians at associated clinics; 2) seek feedback about the potential usefulness of discharge readiness information to primary care clinicians. Exploratory, convergent mixed methods. Primary care clinicians from Family Medicine and General Internal Medicine of an academic medical center in the US Intermountain West. Literature-informed REDCap survey. Semistructured interview guide developed with key informants, grounded in current literature. Survey data were descriptively summarized; interview data were deductively and inductively coded, organized by topics. Two key topics emerged: 1) discharge communication, with interrelated topics of transitional care management and follow-up appointment challenges, and recommendations for improving discharge communication; and 2) usefulness of the discharge readiness information, included interrelated topics related to lack of shared understanding about roles and responsibilities across settings and ethical concerns related to identifying problems that may not have solutions. While reiterating perennial discharge communication and transitional care management challenges, this study reveals new evidence about how these issues are interrelated with assessing and responding to patients' lack of readiness for discharge and unmet social needs during care transitions. Primary care clinicians had mixed views on the usefulness of discharge readiness information. We offer recommendations for improving discharge communication and transitional care management (TCM) processes, which may be applicable in other care settings.

Variants at the Interleukin 1 Gene Locus and Pericarditis

Recurrent pericarditis is a treatment challenge and often a debilitating condition. Drugs inhibiting interleukin 1 cytokines are a promising new treatment option, but their use is based on scarce biological evidence and clinical trials of modest sizes, and the contributions of innate and adaptive immune processes to the pathophysiology are incompletely understood. To use human genomics, transcriptomics, and proteomics to shed light on the pathogenesis of pericarditis. This was a meta-analysis of genome-wide association studies of pericarditis from 5 countries. Associations were examined between the pericarditis-associated variants and pericarditis subtypes (including recurrent pericarditis) and secondary phenotypes. To explore mechanisms, associations with messenger RNA expression (cis-eQTL), plasma protein levels (pQTL), and CpG methylation of DNA (ASM-QTL) were assessed. Data from Iceland (deCODE genetics, 1983-2020), Denmark (Copenhagen Hospital Biobank/Danish Blood Donor Study, 1977-2022), the UK (UK Biobank, 1953-2021), the US (Intermountain, 1996-2022), and Finland (FinnGen, 1970-2022) were included. Data were analyzed from September 2022 to August 2023. Genotype. Pericarditis. In this genome-wide association study of 4894 individuals with pericarditis (mean [SD] age at diagnosis, 51.4 [17.9] years, 2734 [67.6%] male, excluding the FinnGen cohort), associations were identified with 2 independent common intergenic variants at the interleukin 1 locus on chromosome 2q14. The lead variant was rs12992780 (T) (effect allele frequency [EAF], 31%-40%; odds ratio [OR], 0.83; 95% CI, 0.79-0.87; P = 6.67 × 10-16), downstream of IL1B and the secondary variant rs7575402 (A or T) (EAF, 45%-55%; adjusted OR, 0.89; 95% CI, 0.85-0.93; adjusted P = 9.6 × 10-8). The lead variant rs12992780 had a smaller odds ratio for recurrent pericarditis (0.76) than the acute form (0.86) (P for heterogeneity = .03) and rs7575402 was associated with CpG methylation overlapping binding sites of 4 transcription factors known to regulate interleukin 1 production: PU.1 (encoded by SPI1), STAT1, STAT3, and CCAAT/enhancer-binding protein β (encoded by CEBPB). This study found an association between pericarditis and 2 independent sequence variants at the interleukin 1 gene locus. This finding has the potential to contribute to development of more targeted and personalized therapy of pericarditis with interleukin 1-blocking drugs.

Detection of Rabbit Hemorrhagic Disease Virus 2 in the Pygmy Rabbit (Brachylagus idahoensis) in Nevada, USA.

Rabbit hemorrhagic disease virus 2 (RHDV2 or Lagovirus GI.2) began circulating in wild lagomorph populations in the US in March 2020. To date, RHDV2 has been confirmed in several species of cottontail rabbits (Sylvilagus spp.) and hares (Lepus spp.) throughout the US. In February 2022, RHDV2 was detected in a pygmy rabbit (Brachylagus idahoensis). Pygmy rabbits are sagebrush obligates that only occur in the US Intermountain West and are a species of special concern due to the continual degradation and fragmentation of sagebrush-steppe landscapes. The spread of RHDV2 into occupied pygmy rabbit sites may pose a significant threat to their populations because of already declining numbers associated with habitat loss and high mortality rates.

Once upon a time in Mexico: Holocene biogeography of the spotted bat (Euderma maculatum).

Holocene-era range expansions are relevant to understanding how a species might respond to the warming and drying climates of today. The harsh conditions of North American deserts have phylogenetically structured desert bat communities but differences in flight capabilities are expected to affect their ability to compete, locate, and use habitat in the face of modern climate change. A highly vagile but data-deficient bat species, the spotted bat (Euderma maculatum), is thought to have expanded its range from central Mexico to western Canada during the Holocene. With specimens spanning this latitudinal extent, we examined historical demography, and used ecological niche modeling (ENM) and phylogeography (mitochondrial DNA), to investigate historic biogeography from the rear to leading edges of the species' range. The ENM supported the notion that Mexico was largely the Pleistocene-era range, whereas haplotype pattern and Skyline plots indicated that populations expanded from the southwestern US throughout the Holocene. This era provided substantial gains in suitable climate space and likely facilitated access to roosting habitat throughout the US Intermountain West. Incongruent phylogenies among different methods prevented a precise understanding of colonization history. However, isolation at the southern-most margin of the range suggests a population was left behind in Mexico as climate space contracted and are currently of unknown status. The species appears historically suited to follow shifts in climate space but differences in flight behaviors between leading edge and core-range haplogroups suggest range expansions could be influenced by differences in habitat quality or climate (e.g., drought). Although its vagility could facilitate response to environmental change and thereby avoid extinction, anthropogenic pressures at the core range could still threaten the ability for beneficial alleles to expand into the leading edge.

Human–river relationships depend on human–human relationships: River and watershed organizations in three western US states

AbstractHuman–nature relationship concepts are held collectively within society and guide environmentally oriented actions. This article explores the roles played by environmental organizations, particularly those focused on rivers and watersheds, in catalyzing interaction and action driven by human–river relationship goals. Interviews were conducted with representatives from 64 river and watershed organizations in Montana, Utah, and Wyoming in 2022. Organizational representatives were asked about mission focus areas, human–river relationships, the knowledge they draw upon to guide their efforts, and factors and obstacles that enable and constrain their progress and success. These qualitative data reveal a strong orientation toward steward and partner types of human–nature relationship concepts; however, there are discrepancies in conceptual interpretations. For river and watershed organizations in the US Intermountain West, human–river relationship goals depend strongly on human–human relationships in the form of diverse knowledge integration, collaboration, partnerships, trust, and communication in order to achieve their river‐related goals.

Field Production Methods for Season Extension of Peony ‘Coral Charm’

Paeonia lactiflora is a high-value crop with a temperature-dependent growth response that requires worldwide production to satisfy year-round demand. The objective of this study was to evaluate production and timing of ‘Coral Charm’ peony as a cool-season crop in the US Intermountain West. High-tunnel and field production were trialed in North Logan, UT, USA (lat. 41.77°N, long. 111.81°W; elevation, 1382 m) with the addition of low tunnels and soil heating methods to advance growth in 2019–21. Soil and air temperatures, as well as the date and quality of harvested stems, were measured. High tunnels yielded 15.7 ± 3.3 to 19.4 ± 2.1 stems/m2 [± standard error (SE)] and the high tunnel alone advanced initial harvest 21 to 34 days earlier than natural field conditions. The field yielded 16.1 ± 1.9 to 20.8 ± 1.6 stems/m2 and staggered production, resulting in a harvest duration up to 38 days across the high tunnel and field. The use of a low tunnel with soil heating advanced the initial harvest date compared with natural (i.e., unmanipulated) high-tunnel and field conditions by 3 and 7 days in 2019, 6 days in 2020, and 16 and 6 days in 2021 in the high tunnel and field, respectively. However, the quality decreased significantly under low tunnels with soil heating within high tunnels, compared with unheated plants, as a result of superoptimal temperatures and humidity that damaged buds and led to an increase in disease and insect pressure. Overall, increasing soil temperature advanced early stages of production when the meristem was below or near the soil surface, whereas increased air temperatures accelerated stem elongation and advanced time to flowering.

Anemone Cut Flower Timing, Yield, and Quality in a High-Elevation Field and High Tunnel

A narrow window of optimal spring temperatures limits anemone (Anemone coronaria L.) cut flower production in the US Intermountain West, where fall plantings risk winter injury and spring plantings are limited by summer dormancy. Regional management recommendations are needed to improve anemone harvest timing and yield for growers in USDA hardiness zones 6 and below (average annual minimum temperatures below −18 °C). The aim of this research was to optimize flower timing, yield, quality, and profitability in high tunnel and field production systems by evaluating planting dates, winter insulation, tuber preparation, and cultivar selection. High tunnel and field trials were conducted from fall 2020 to spring 2022 in North Logan, UT (41.767° N, −111.811° W, 1405 m elevation, USDA hardiness zone 5). Tubers were pre-sprouted or directly planted into a high tunnel (left bare or covered with low tunnels) or field (left bare or covered with mulch, a low tunnel, or mulch and a low tunnel) from November to April. Harvest began as early as 2 March in the high tunnel and 9 April in the field, with overall average marketable yields (stems per m2 ± SE) of 142 ± 7 in the high tunnel and 85 ± 4 in the field. Planting pre-sprouted tubers under low tunnels in the high tunnel in November delivered the earliest harvest (2 March), greatest marketable yield (280 stems per m2 ± 73 SE), and greatest net returns ($38 per m2). For November field plantings, insulation improved emergence by 75% and marketable yield by 77 stems per m2 ± 15 SE. Combining high tunnel and field production with the season advancement techniques of fall planting dates, low-cost insulation, and pre-sprouting resulted in high total yields in the Intermountain West compared to traditional industry recommendations.

Overwintering Improves Ranunculus Cut Flower Production in the US Intermountain West

Ranunculus (Ranunculus asiaticus L.) cut flower production in the US Intermountain West is limited by a narrow window of optimal temperature ranges in the spring. With the increasing number of Intermountain West cut flower growers, regional management recommendations are needed to improve ranunculus harvest timing and yield. The objectives of this research were to evaluate planting dates, winter insulation, tuberous root (TR) preparation, and cultivar selection for flower timing, yield, quality, and profitability in high tunnel and field production systems. Trials were conducted in a North Logan, UT (41.7665° N, −111.811° W, 1405 m elevation, USDA hardiness zone 5) high tunnel and field from fall 2019 to spring 2022. TRs were either pre-sprouted or directly planted into a high tunnel (left bare or covered with low tunnels) or field (left bare or covered with mulch, a low tunnel, or mulch and a low tunnel) from November to April. High tunnels advanced production by four weeks, nearly doubled total yield, and increased the proportion of quality (longer than 25 cm) stems by 50% compared to the field. Planting pre-sprouted TRs in the high tunnel in November delivered the earliest harvest (6 Apr.), highest marketable yield (286 stems per m2 ± 36 SE), and highest net returns ($54 per m2), with 39% greater marketable yield for ‘LaBelle’ than ‘Amandine.’ Insulation nearly doubled emergence and improved marketable yield by 49 stems per m2 ± 8 SE for November field plantings. Ranunculus production was optimized as a fall-planted high tunnel crop in the Intermountain West but may be fall-planted in the field with insulation, allowing growers to maximize production during more optimal, early-season temperatures.

Search and Rescue in the Pacific West States.

The training practices and the level of medical oversight of search and rescue (SAR) organizations in the US National Park Service (NPS) Pacific west region is not known. A database of SAR teams in the NPS Pacific west region was assembled using public sources. SAR team leaders received an electronic survey between May and December 2019. A descriptive analysis characterizing team size, technical and medical training protocols, and medical oversight was completed. Results are reported as median (interquartile range, range). Of the 250 SAR teams contacted, 39% (n=97) completed our survey. Annual mission volume was 25 (10-50, 1-200). Team size was 30 members (22-58, 1-405). SAR teams most frequently trained in helicopter operations (77%), low-angle rope rescue (75%), and avalanche rescue (43%). Nearly all teams (99%) had members with some medical training: first aid or cardiopulmonary resuscitation (89%), emergency medical technicians (75%), registered nurses or midlevel providers (52%), and physicians (40%). SAR members administered field medical care (84%), often in coordination with EMS (77%). Medical direction was present on a minority of teams (45%), most frequently by a provider specialized in emergency medicine (68%). Expanded medical procedures were permitted on 21% of SAR teams. SAR teams across the NPS Pacific west region had composition and training standards similar to those surveyed previously in the US intermountain states. Healthcare professionals were present on most teams, typically as team members, not as medical directors. Few SAR teams use medical protocols in remote care environments.

Agreement and Uncertainty Among Climate Change Impact Models: A Synthesis of Sagebrush Steppe Vegetation Projections

Ecologists have built numerous models to project how climate change will impact rangeland vegetation, but these projections of future changes are difficult to validate, making their utility for land management planning unclear. In the absence of direct validation, researchers can ask whether projections from different models are consistent. High consistency across models, especially those based on different assumptions, would increase confidence in using projections for planning. Here, we analyzed 19 models of climate change impacts on sagebrush (Artemisia tridentata Nutt.), cheatgrass (Bromus tectorum L.), pinyon-juniper (Pinus L. spp. and Juniperus L. spp.), and forage production on Bureau of Land Management (BLM) lands in the US Intermountain West. These models consistently projected the potential for pinyon-juniper declines and forage production increases. In contrast, models of cheatgrass mainly projected no climate change impacts, while sagebrush models projected no change in most areas and declines in southern extremes. In most instances, vegetation projections from high- and low-emission scenarios differed only slightly.The projected vegetation impacts have important management implications for agencies such as the BLM. Pinyon-juniper declines would reduce the need to control pinyon-juniper encroachment, and increases in forage production could benefit livestock and wildlife populations in some regions. Sagebrush conservation and restoration projects may be challenged in areas projected to experience sagebrush declines. Similar projections from high- and low-emission scenario models may increase confidence to consider model projections in planning. However, projected vegetation impacts may also interact with increasing future wildfire risk in ways single-response models do not anticipate. In particular, forage production increases could increase management challenges related to fire.

Supporting and Engaging Families: An Examination of Publicly-Funded Health Promotion Programs in the Intermountain West, USA.

Public health programming efforts have traditionally focused on either an individualistic or population approach, neglecting the family as a setting for or partner in health promotion efforts. Due to the multi-faceted influence of families on individual health, family-focused, and family-friendly public health interventions are important to making lasting changes for individual and community health. The purpose of this study was to examine the degree to which health promotion programs in a state in the US Intermountain West involve and support families across four family impact principles: family engagement, family stability, family responsibility, and family diversity. A survey was completed by 67 health promotion administrators and practitioners from 12 out of 13 county health departments with additional responses from public health practitioners at the State Health Department. The results of the survey indicated that health promotion efforts were best at supporting family responsibility and a diverse group of families but were weaker in family engagement and family stability. Applying a more family-centered and family-focused approach to health promotion efforts can be achieved by employing interdisciplinary efforts and by taking advantage of tools like the Public Health Family Impact Checklist to intentionally engage and support families in programs and interventions.

Fire-catalyzed vegetation shifts in ponderosa pine and Douglas-fir forests of the western United States

Increased wildfire activity combined with warm and dry post-fire conditions may undermine the mechanisms maintaining forest resilience to wildfires, potentially causing ecosystem transitions, or fire-catalyzed vegetation shifts. Stand-replacing fire is especially likely to catalyze vegetation shifts expected from climate change, by killing mature trees that are less sensitive to climate than juveniles. To understand the vulnerability of forests to fire-catalyzed vegetation shifts it is critical to identify both where fires will burn with stand-replacing severity and where climate conditions limit seedling recruitment. We used an extensive dendrochronological dataset to model the influence of seasonal climate on post-fire recruitment probability for ponderosa pine and Douglas-fir. We applied this model to project annual recruitment probability in the US intermountain west under contemporary and future climate conditions, which we compared to modeled probability of stand-replacing fire. We categorized areas as ‘vulnerable to fire-catalyzed vegetation shifts,’ if they were likely to burn at stand-replacing severity, if a fire were to occur, and had post-fire climate conditions unsuitable for tree recruitment. Climate suitability for recruitment declined over time in all ecoregions: 21% and 15% of the range of ponderosa pine and Douglas-fir, respectively, had climate conditions unsuitable for recruitment in the 1980s, whereas these values increased to 61% (ponderosa pine) and 34% (Douglas-fir) for the future climate scenario. Less area was vulnerable to fire-catalyzed vegetation shifts, but these values also increased over time, from 6% and 4% of the range of ponderosa pine and Douglas-fir in the 1980s, to 16% (ponderosa pine) and 10% (Douglas-fir) under the future climate scenario. Southern ecoregions had considerably higher vulnerability to fire-catalyzed vegetation shifts than northern ecoregions. Overall, our results suggest that the combination of climate warming and an increase in wildfire activity may substantially impact species distributions through fire-catalyzed vegetation shifts.

Exploring seedling-based aspen (Populus tremuloides) restoration near range limits in the Intermountain West, USA

With the effects of climate change expected to intensify over the coming century, land managers will require more proactive and novel approaches to conserve and restore threatened ecosystems. In the US Intermountain West, quaking aspen (Populus tremuloides Michx.) is a foundation species of considerable conservation interest. However, traditional silvicultural practices in the region focus exclusively on its vegetative regeneration potential, limiting restoration efforts to locations where aspen is already established, and precluding approaches such as afforestation and assisted migration. Planting nursery-grown aspen seedlings could overcome these limitations. This approach has become common for forest land reclamation and afforestation projects in the boreal forests of western North America, but has received little attention in the US Intermountain West to date. In this study we explored the potential for seedling-based aspen restoration in an Intermountain West landscape. We planted 7,200 nursery-grown aspen seedlings across 15 unirrigated plots at three high elevation (~2,800 m) sites in southwestern Utah, USA and monitored their growth and survival rates for two growing seasons. Overall seedling survival was only 10% by the end of the study, with 49% of mortality due to apparent drought stress, 38% due to small mammal herbivory, and 3% due to unknown causes. 79% of the surviving seedlings were located in just two plots, where higher levels of soil moisture were present during the driest summer months. A subsequent test of wood mulch to retain moisture in one of the plots increased seedling survival to 62%, compared to 0% in a non-mulched treatment. Together, these findings indicate that seedling-based aspen restoration in these habitats was limited primarily by site conditions. For this approach to become operational, additional study on seedling quality, site selection and site preparation will be necessary.

Climate Change Views, Energy Policy Support, and Personal Action in the Intermountain West: The Anti-Reflexivity Effect

Reducing the environmental impacts of energy production and consumption is part of addressing climate change. Prior research finds political-economic factors shape climate change views, perceptions of and policy support for renewable and nonrenewable energy, and pro-environmental behaviors (PEBs). This study contributes to research in these three areas by empirically testing the anti-reflexivity thesis, which posits that forces defending the industrial capitalist system are sources of anti-reflexivity, obstructing critical self-evaluation and societal action to address climate change. Using OLS and logistic regression analysis of survey data from respondents in five states in the US Intermountain West region, we find empirical support for the effect of anti-reflexivity on climate views, energy policy support, and PEBs. We also find that PEBs in the Intermountain West still largely occur in the realm of personal conservation actions rather than being politically focused, collectively organized, or leading toward systemic change.

Ethnic Entrepreneurship Without Ethnicity: Latino Entrepreneurs in Northern Utah

Over the past two decades, Latinos have been making their way to new destinations in the US South, Midwest, and Intermountain West. Although most are flocking to jobs in agriculture and manufacturing, a number are starting businesses. To better understand Latino entrepreneurs in these new destinations, we present a case study of northern Utah, where the Latino population has skyrocketed in recent decades. Findings from surveys and interviews with Latino entrepreneurs suggest that they rely less on ethnic networks than their counterparts in established destinations due to differences in national origin. In the process of running their businesses, however, Latino entrepreneurs in this and other new destinations may be laying the groundwork for an ethnic community to emerge. Their recruitment of Latino workers, their visible presence in the community, and the space for intra-ethnic interaction they provide may help Latinos in this community overcome internal differences to forge an ethnic identity. In this case, the relationship between ethnic entrepreneurship and the ethnic community moves in the opposite direction, with entrepreneurs helping to establish rather than exploit intra-ethnic ties.

Multi-morbidity and Highly Effective Contraception in Reproductive-Age Women in the US Intermountain West: a Retrospective Cohort Study.

Women with chronic health conditions benefit from reproductive planning and access to highly effective contraception. To determine the prevalence of and relationship between chronic health conditions and use of highly effective contraception among reproductive-age women. Retrospective cohort study using electronic health records. We identified all women 16-49 years who accessed care in the two largest health systems in the US Intermountain West between January 2010 and December 2014. We employed administrative codes to identify highly effective contraception and flag chronic health conditions listed in the US Medical Eligibility Criteria for Contraceptive Use (US MEC) and known to increase risk of adverse pregnancy outcomes. We described use of highly effective contraception by demographics and chronic conditions. We used multinomial logistic regression to relate demographic and disease status to contraceptive use. Of 741,612 women assessed, 32.4% had at least one chronic health condition and 7.3% had two or more chronic conditions. Overall, 7.6% of women with a chronic health condition used highly effective contraception vs. 5.1% of women without a chronic condition. Women with chronic conditions were more likely to rely on public health insurance. The proportion of women using long-acting reversible contraception did not increase with chronic condition number (5.8% with 1 condition vs. 3.2% with 5 or more). In regression models adjusted for age, race, ethnicity, and payer, women with chronic conditions were more likely than those without chronic conditions to use highly effective contraception (aRR 1.4; 95% CI 1.4-1.5). Public insurance coverage was associated with both use of long-acting reversible contraception (aRR 2.2; 95% CI 2.1-2.3) and permanent contraception (aRR 2.9; 95% CI 2.7-3.1). Nearly a third of reproductive-age women in a regional health system have one or more chronic health condition. Public insurance increases the likelihood that women with a chronic health condition use highly effective contraception.

At home, in public, and in between: gender differences in public, private and transportation pro-environmental behaviors in the US Intermountain West

ABSTRACTResearch in environmental sociology finds differences between men and women in the performance of pro-environmental behaviors, but gender effects change over time, and vary by location and type of pro-environmental behavior. Thus, research needs to explore gender differences in various pro-environmental behaviors across different contexts, in order to contribute to better understanding of the connections between sustainability and gender equity. This paper analyzes the gendered differences in pro-environmental behaviors in the Intermountain West region of the United States using survey data collected in 2016 from five states: Colorado, Idaho, Montana, Utah, and Wyoming. Results of ordinary least squares and ordered logistic regression analyses indicate women are more likely than men to engage in pro-environmental behaviors in the private sphere. Gendered differences are also evident in public pro-environmental behaviors, though results suggest those may be a consequence of higher levels of environmental concern among women. An analysis of transportation behaviors yields mixed results. All three types of behaviors have implications for gender equity.

PSVIII-34 In vitro digestibility and fermentation kinetics of six irrigated forage hays in the US Intermountain West.

PSVIII-34 In vitro digestibility and fermentation kinetics of six irrigated forage hays in the US Intermountain West.

Expected Net Benefit of Vaccinating Rangeland Sheep against Bluetongue Virus Using a Modified-Live versus Killed Virus Vaccine.

Recurring outbreaks of bluetongue virus in domestic sheep of the US Intermountain West have prompted questions about the economic benefits and costs of vaccinating individual flocks against bluetongue (BT) disease. We estimate the cost of a BT outbreak on a representative rangeland sheep operation in the Big Horn Basin of the state of Wyoming using enterprise budgets and stochastic simulation. The latter accounts for variability in disease severity and lamb price, as well as uncertainty about when an outbreak will occur. We then estimate the cost of purchasing and administering a BT vaccine. Finally, we calculate expected annual net benefit of vaccinating under various outbreak intervals. Expected annual net benefit is calculated for both a killed virus (KV) vaccine and modified-live virus vaccine, using an observed price of $0.32 per dose for modified-live and an estimated price of $1.20 per dose for KV. The modified-live vaccine’s expected annual net benefit has a 100% chance of being positive for an outbreak interval of 5, 10, or 20 years, and a 77% chance of being positive for a 50-year interval. The KV vaccine’s expected annual net benefit has a 97% chance of being positive for a 5-year outbreak interval, and a 42% chance of being positive for a 10-year interval. A KV vaccine is, therefore, unlikely to be economically attractive to producers in areas exposed less frequently to BT disease. A modified-live vaccine, however, requires rigorous authorization before legal use can occur in Wyoming. To date, no company has requested to manufacture a modified-live vaccine for commercial use in Wyoming. The KV vaccine poses less risk to sheep reproduction and less risk of unintentional spread, both of which facilitate approval for commercial production. Yet, our results show an economically consequential tradeoff between a KV vaccine’s relative safety and higher cost. Unless the purchase price is reduced below our assumed $1.20 per dose, producer adoption of a KV vaccine for BT is likely to be low in the study area. This tradeoff between cost and safety should be considered when policymakers regulate commercial use of the two vaccine types.