You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology and Natural History/Evaluation and Markers1 Apr 20111732 URINARY NERVE GROWTH FACTOR LEVEL IN PATIENTS WITH BENIGN PROSTATIC OBSTRUCTION (BPO) IS CORRELATED WITH SEVERITY OF SYMPTOMS AND RESPONSE TO MEDICAL TREATMENT Toyohiko Watanabe, Miyabi Inoue, Ayano Ishii, Katsumi Sasaki, Katsutoshi Uematsu, Shinya Uehara, Hiromi Kumon, Teruhiko Yokoyama, and Hitoshi Takamoto Toyohiko WatanabeToyohiko Watanabe Okayama, Japan More articles by this author , Miyabi InoueMiyabi Inoue Okayama, Japan More articles by this author , Ayano IshiiAyano Ishii Okayama, Japan More articles by this author , Katsumi SasakiKatsumi Sasaki Okayama, Japan More articles by this author , Katsutoshi UematsuKatsutoshi Uematsu Okayama, Japan More articles by this author , Shinya UeharaShinya Uehara Okayama, Japan More articles by this author , Hiromi KumonHiromi Kumon Okayama, Japan More articles by this author , Teruhiko YokoyamaTeruhiko Yokoyama Kurashiki, Japan More articles by this author , and Hitoshi TakamotoHitoshi Takamoto Kurashiki, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2003AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Our previous study has shown that urinary NGF levels increase in patients with overactive bladder (OAB) (Yokoyama T et al, Neurourol. Urodynam. 27:417–420, 2008). However, the urinary NGF levels in patients with benign prostatic obstruction (BPO) with OAB and after relief of BPO have not been fully investigated. Our aim is to measure the urinary NGF levels in patients with OAB due to BPO and to determine whether urinary NGF can serve as a biomarker for OAB with BPO. METHODS Urinary NGF levels were measured in 20 patients (66±17 yrs old) with OA due to BPO. Patients were treated with tamsulosin 0.2 mg once daily. Urinary NGF levels were measured by enzyme-linked immunosorbent assay technique (ELISA) and the results were normalized based on creatinine (Cr) concentration. The urinary NGF/ Cr levels , International Prostate Symptom Score (IPSS), QOL index, OAB symptom score (OABSS) were compared at baseline, 4, and 12 weeks after treatment with tamsulosin. In addition we measured the current perception threshold of C and A delta fibers by Neurometer (Neurotron, Inc, Baltimore, Maryland) before and after treatment to evaluate clinical significance. RESULTS Average IPSS total score, OABSS, and Qmax were improved significantly from 17.4, 8.4, and 10.9 ml/sec. at baseline to 11.3, 4.5, and 15.1 ml/sec, respectively, at 12 weeks after treatment with tamsulosin. The urinary NGF levels were decreased from 10.7 pg/ml Cr at baseline to 7.7 pg/ml Cr at 4 weeks, and 4.8 pg/ml Cr at 12 weeks after treatment with tamsulosin. Mean current perception threshold values of C fibers improved from 23.3 to 28.7, but this change was not statistically significant. CONCLUSIONS Changes in the urinary NGF levels were associated with the changes of the IPSS and OABSS after alpha 1-adrenergic antagonist treatment with tamsulosin. The urinary NGF level could be a potential biomarker for evaluating therapeutic results of alpha-1 blackade therapy. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e695-e696 Peer Review Report Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Toyohiko Watanabe Okayama, Japan More articles by this author Miyabi Inoue Okayama, Japan More articles by this author Ayano Ishii Okayama, Japan More articles by this author Katsumi Sasaki Okayama, Japan More articles by this author Katsutoshi Uematsu Okayama, Japan More articles by this author Shinya Uehara Okayama, Japan More articles by this author Hiromi Kumon Okayama, Japan More articles by this author Teruhiko Yokoyama Kurashiki, Japan More articles by this author Hitoshi Takamoto Kurashiki, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...