Uric Acid Test Research Articles

Gout diagnoses uncertain when made by general practitioners without serum uric acid testing: an observational study.

General practitioners (GPs) diagnose the majority of all gout patients. They make their diagnosis clinically. Serum uric acid (SUA) level >0.35mmol/l is largely determinative for the clinical diagnosis of gout. We aimed to assess to what extent GPs test SUA when making a first gout diagnosis, and to consider consequences regarding diagnostic certainty of not testing it. We calculated proportions of patients from 87 Dutch general practices (1-1-2013 to 1-1-2022) with a first gout diagnosis and a recorded SUA test, evaluated if SUA testing was punctually timed with respect to the diagnosis date, whether SUA levels were >0.35mmol/L, and whether diagnoses corresponded with diagnoses according to the 'Acute Gout Diagnosis Rule' (AGD-rule). In 43.0% of 7782 patients (mean age 64.4 years; 68.8% male) no SUA test result was recorded, with substantial variation among practices: median 41.9% (IQR 20.2%). 'Gout very likely' according to the AGD-rule was seen in all males and in 83.1% of females when a punctually timed SUA >0.35mmol/L was present. When such SUA level was lacking, 'Questionable or indeterminate gout diagnosis' was seen in all males and in 67.1% of females, and 'Arthritis diagnosis other than gout' in 32.9% of females. GPs diagnosed gout without testing SUA in ~40% of cases. This implies avoidable diagnostic uncertainty with impact for the clinical care of many patients as well as for studies that include primary care patients with gout. Key Points • Serum uric acid (SUA) level > 0.35mmol is determinative when diagnosing gout: however, it is unknown how often SUA testing is applied as such. • More than 40% of patients with a first gout diagnosis according to general practitioners (GPs) had no SUA test result registered in their medical record. • Gout diagnosing by GPs without SUA testing appeared to lead to avoidable diagnostic uncertainty, as diagnoses are often questionable or sometimes even wrong. • Researchers investigating gout need to take into account diagnostic uncertainty if they include gout patients who are diagnosed in primary care in their studies without SUA information.

Serum Uric Acid in Women with Preeclampsia and its Relation to Perinatal and Maternal Outcomes

Background and objective: Preeclampsia is a dangerous, progressive condition that is linked to maternal and neonatal death and morbidity. The purpose of this study was to determine the association between serum uric acid levels in preeclampsia with maternal and fetal outcomes. Method: A case-control study was conducted on 300 women delivered at the labour room of Duhok Obstetrics and Gynecology Hospital, from 1st of April 2021 to 1st of April 2022. The study participants were divided into two groups, pregnant women with preeclampsia and normotensive women. The serum uric acid levels of these women were estimated with the impact on fetal and mother outcomes. Results: There was a highly significant association between preeclamptic and normotensive women in relation to mean serum uric acid (5.862 ±1.416) mg/dL and (3.570 ±0.982) mg/dL respectively. A highly significant association was seen between uric acid test levels and maternal eclamptic fit, HELLP syndrome and admission to intensive care unit. A highly significant association also seen with newborn birth weight, APGAR scores and admission to neonatal intensive care unit. Conclusion: The current study demonstrates a significant raise in serum uric acid level in preeclamptic women and associated with adverse perinatal and maternal outcomes.

HEALTH EXAMINATION AND EDUCATION ON THE USE OF CHOLESTEROL, URIC ACID, AND BLOOD SUGAR MEDICINE FOR THE COMMUNITY OF SUNGAI BAWANG VILLAGE, MUARA BADAK DISTRICT, KUTAI KARTANEGARA

Degenerative diseases that many people suffer from, including heart disease, stroke, hypertension, diabetes mellitus, cancer, and chronic kidney failure, have increased. In demographic data referring to the 2018 Riskesdas, for example, strokes increased to 10,9% from the previous 7%, and diabetes mellitus increased from 6.9% to 8.5% in 2018. Hypertension experienced the highest increase among diseases, from 25.8% to 34.1%. Management of degenerative diseases is through implementing community service activities carried out by lectures from the Study Program of Pharmacy undergraduate at STIKES Dirgahayu Samarinda to implement the tridharma obligations of higher education. The activity was held on Saturday, November 18, 2023, at Lamin Adat Sungai Bawang Village, Muara Badak District, Kutai Kartanegara. This activity aimed to conduct health checks for the community, from children to adults, and health education, especially controlling non-communicable diseases. The method used was education, free examination, and treatment for the community which consists of laboratory examinations, health consultations, pharmaceutical services, and health education, as well as evaluation when the activites have been completed. Based on the activities that have been carried out, it was known that one hundred and five residents came for an examination, then from screening for blood sugar, cholesterol, and uric acid tests, forty-seven people exceeded normal parameters, while ninety-eight received drug therapy.

Evaluation of Some Blood and Biochemical Parameters for Patients with Diabetes

This study was conducted on patients with diabetes, in Samarra General Hospital. In this study, 50 blood samples were collected, 30 of which were taken from patients with diabetes, 20 of which were from non-diabetic people of both sexes, for ages (18_65) and for the period December 5, 2022 to the period is 1 February 2023. Blood was separated to obtain serum for biochemical analyses, and whole blood was sampled for CBC testing. The sugar test was conducted to ensure the presence of diabetes first, and the study confirmed that there was a significant increase in the patients compared to the control group, where the FBG test was conducted, and we note that there is a significant increase in the FBG test for patients with diabetes. A uric acid test was conducted, and the results showed a significant increase in patients compared to the control group, as the results of the analysis indicated that patients with diabetes appeared to have a significant increase in uric acid levels. The urea and creatinine test did not find a significant difference compared to the control group. As for the cbc test, the results for rbc, wbc, plt, hb, pcv showed no significant difference.

Prevalence and risk factors of hyperuricemia among freshmen at Beijing Sport University from 2021 to 2022

To investigate the prevalence of hyperuricemia among freshmen enrolled in Beijing Sport University and to explore the influencing factors of hyperuricemia in the college population. The study period was from September 2021 to February 2022.3372 freshmen of the class of 2021 from Beijing Sport University in Beijing were selected as the study subjects, and two blood uric acid tests were performed on non-same days to calculate the prevalence of the population and to explore the risk factors of hyperuricemia in the college student population using a case-control method.246 people were selected from the hyperuricemia patients of the population to be included in the case group by convenience sampling, and 211 people were selected from the non-hyperuricemia persons of the population to be included in the control group. They were included in the control group, underwent physical and laboratory examinations, and were retrospectively surveyed with questionnaires that included general information such as age, gender, specialty, place of birth, and diet related to hyperuricemia, awareness of hyperuricemia disease, physical activity level, and sleep. Statistical analysis was performed using chi-square analysis, one-way Logistic regression analysis, and multi-factor logistic regression analysis. The number of patients actually diagnosed with hyperuricemia by two blood uric acid tests on non-same days was 479, with a population prevalence rate of 14.21%. Among them, the number of males in the diseased population was 391(22.39%), and the number of females in the diseased population was 88(5.41%). A total of 457 subjects were enrolled in the case-control study, among them, 246 in the case group(218 males and 28 females, average age 19.74 years), 211 in the control group(177 males and 34 females, average age 19.93 years), and 247 in the case group, 211 in the control group, and 2 groups of subjects were included. A total of 211 subjects, and there was no significant difference between the 2 groups in terms of gender composition and age distribution. One-way logistic regression analysis showed that central obesity(OR=31.52, 95%CI 7.59-130.86), obesity(OR=2.59, 95%CI 1.20-5.58), overweight(OR=1.67, 95%CI 1.08-2.59), frequent consumption of fresh vegetables(OR=0.66, 95%CI 0.43-0.99), and drinking 1500-2000 mL of water per day(OR=0.63, 95%CI 0.41-0.95) were associated with hyperuricemia, and multifactorial Logistic regression analyses were performed to analyze the above factors, and finally central obesity(OR=32.05, 95%CI 7.65-134.20), BMI obesity(OR=3.22, 95%CI 1.44-7.20), and daily water intake of 1500-2000 mL(OR=0.60, 95%CI 0.37-0.95) were included in the model at the level of P=0.05. The current high prevalence of hyperuricemia in the college student population, which is more prevalent in male college students. Obesity and central obesity are risk factors for hyperuricemia in young college students, and daily water intake of 1500-2000 mL is a protective factor.

Correlation Glucose, Uric Acid, and Cholesterol Levels Towards Health Conditions in the Highlands: POCT Approach

Degenerative diseases arise when age increases due to the weakening of the body's physiological condition. The purpose of this study was to measure glucose, uric acid, and cholesterol levels in residents of Segunung Village to improve lifestyles and quality of life. As many as 110 residents of Segunung Village were used as subjects in this cross-sectional study. Glucose, uric acid, and cholesterol levels were measured using Point of Care Testing (POCT). A cut-off value of <200 was used to define high cholesterol levels. Only cholesterol levels showed an increase when compared with reference values, while glucose and uric acid levels were normal. Interestingly glucose was significantly correlated with age (r=0.309, p=0.001). The approach using POCT describes the overall condition of Segunung villagers and can be used as a basis for glucose, uric acid, and cholesterol screening tests.

#273 Identification of epipin expression in progression of chronic kidney disease—a multi-omic approach

Abstract Background and Aims Chronic kidney disease (CKD) is characterized by irreversible reduction in kidney function eventually leading to end-stage renal disease (ESRD). ESRD is a stage when kidney function is no longer adequate for long-term survival without dialysis or kidney transplant. Over the past the prevalence is increased more than 3 fold. Impaired activity of endogenous renal matrix-degrading proteases enhance interstitial matrix accumulation but specific pathways are involved remain unclear. Hence, an urgent need for sensitive biomarkers can detect disease earlier than traditional one and predict disease progression. Present study intended to identify epipin during chronic kidney disease and also we highlight promising kidney biomarkers that have robust underpinnings in the pathophysiology of kidney damage. Method A cross sectional study was conducted on patients with CKD compared with patients with diabetes mellitus (DM) and healthy controls. The collected samples were analyzed for the biochemical investigations included renal profile tests such as urea, serum creatinine, uric acid and urine spot test was analyzed for the screen of kidney problems. Firstly we identified the novel epipin protein through LC-MS then we estimated its gene expression levels using RT-PCR and levels of protein expression measured by ELISA. Results Epipin was shown higher expression in CKD compared to controls and moderately expressed in patients with diabetes mellitus compared to controls. The expression level of epipin gene was 4 fold in DM compared with controls, 19 fold in CKD compared with controls and 5 fold change between CKD and DM. Epipin showed AUC of 0.99 and 1.00 in DM and CKD respectively. The present study found that epipin was highly expressed in CKD patients and moderately expressed in patients with diabetes mellitus when compared to controls. In a present study, we identified one of the epipin with increased expression in renal disease progression. Conclusion The expression of epipin in virtually all samples suggests that this intracellular protein may have diverse and an extensive biological roles and may be an important therapeutic target for development of renal disease and its progression.

Association of hyperuricemia with coronary heart disease: Protocol for an updated systematic review and dose-response meta-analysis.

Hyperuricemia, characterized by elevated serum uric acid levels, has garnered significant attention in cardiovascular research due to its potential association with coronary heart disease (CHD). While some studies suggest hyperuricemia as a risk factor of CHD, others present conflicting findings. A systematic review and dose-response meta-analysis is warranted to comprehensively summarize the previous studies and determine the association between hyperuricemia and CHD, thereby supporting clinical practice and future studies in this field. In this study, we will comprehensively search Medline, EMBase, Cochrane Central, ICTRP, and ClinicalTrials.gov, from inception to December 31, 2024. Prospective or retrospective cohort studies and case-control studies investigating the association between hyperuricemia and CHD will be included. Two independent reviewers will conduct study selection, data extraction, and risk of bias assessment. The primary outcome will be the pooled relative risk of CHD associated with hyperuricemia by using random-effect model. Dose-response meta-analysis will be performed with linear and non-linear model to explore the the magnitude and direction of the association between serum uric acid levels and CHD risk. Subgroup analyses will be conducted based on uric acid test approaches and corresponding cut-off values and human races. Sensitivity analyses will assess the robustness of the results with leave-one-out method, while publication bias will be evaluated using funnel plots, Egger's test, and Begg's test. We will further use GRADE to evaluate the quality of the evidences provided by our systematic review. From this systematic review and dose-response meta-analysis, we hope out findings will provide reliable conclusion and data support on the association between hyperuricemia and CHD. The transparent and replicable methodologies outlined in this protocol contribute to advancing understanding of hyperuricemia as a potentially modifiable risk factor for CHD, thus supporting evidence-based strategies for cardiovascular disease management. This protocol describes a rigorous plan to systematically review and analyze the quantitative association between hyperuricemia and CHD risk. In a word, we will help further clinical practice and scientific studies in this field. This protocol was registered in PROSPERO CRD42024538553.

PENGARUH AKTIVITAS RUMAH TANGGA TERHADAP POTENSI TERJADINYA CARPAL TUNNEL SYNDROME

Carpal Tunnel Syndrome (CTS) is a syndrome that occurs due to the median nerve being compressed in the carpal tunnel in the wrist. Housework that is done every day has the potential to cause carpal tunnel syndrome because household work is done repeatedly or continuously every day. To broaden the knowledge of the Ngempeng Bangil community, the author submits a community service proposal with the title The Influence of Household Activities on the Potential for Carpal Tunnel Syndrome (CTS) in the Elderly in Ngempeng Bangil Village. Physiotherapy service activities for the elderly community in Ngempeng Bangil Village on Friday, 17 March 2023 can be implemented smoothly, orderly and on time. This activity was attended by approximately 40 people. Carpal Tunnel Syndrome (CTS) is a syndrome that occurs due to the median nerve being compressed in the carpal tunnel in the wrist. In the elderly in Ngempeng Bangil Village, Arbain Housing, there are 20% of elderly people who are positive for Carpal Tunnel Syndrome. The services used in this activity are cholesterol tests, uric acid tests, tinel tests, phallen tests and starching exercises at young joins.

Serum and 24-hour urinary tests cost-effectiveness in stone formers

ObjectiveTo assess the routine serum and 24-hour urine tests proficiency in diagnosing the baseline metabolic abnormality of kidney stone formers.MethodsThis study analyzes the routine serum and 24-hour urine tests proficiency in diagnosing the baseline metabolic abnormality of kidney stone formers. The sensitivity and specificity, false positive, and negative results of the tests are extracted from diagnostic kits used in the laboratories of the target community. To accurately infer the results, a simulation based on 1000 people was used through 22 standard laboratory tests (Additional File 2), including calcium, oxalate, phosphate, uric acid, sulfate, potassium, sodium, citrate, and magnesium in 24-hour urine; and calcium, creatinine, Vit D, uric acid, and intact parathyroid hormone (PTH) in serum. The incremental cost-effectiveness ratio (ICER) was calculated and compared for each diagnostic test versus other diagnostic tests according to the incremental cost required for correct diagnoses of stone causes.ResultsUrinary uric acid, citrate, and serum potassium constitute the cost-effectiveness boundary curve in this study. This means that other diagnostic tests are not cost-effective compared to these three tests in terms of indexing at least one item of cost and effectiveness. The ICER index for each correct diagnosis with the urinary uric acid test was $ 1.25 per diagnosis, the most cost-effective test compared to serum potassium and urinary citrate.ConclusionThe simplified blood and 24-hour urine metabolic evaluation, including urinary uric acid, citrate, and serum potassium, constitute the cost-effectiveness boundary curve. The most cost-effective test was urinary uric acid measurement.

Comparison of Serum Stability against Uric Acid and Glucose

The selection of tools, especially the use of vacutainer tubes, affects the results of the examination to determine the stability of serum from plain vacutainer with vacutainer separation gel on the quality of uric acid and glucose test results. This study used an experimental design. The study took blood samples of 3 ml each in SST vacutainer and plain vacutainer serum. The mean uric acid levels using plain vacutainer and SST vacutainer were 4.5875±0.59048 and 4.9250±0.56318, respectively. The mean glucose levels using plain vacutainer and SST vacutainer were 90.64±12.33 and 94.12±13.30, respectively. Uric acid and glucose levels using gel-separated vacutainer were higher than uric acid levels using plain vacutainer. There was a significant difference in uric acid levels between regular vacutainers and SST vacutainers, similar to glucose levels (p = 0.000, p = 0.000). Uric acid and glucose levels using SST vacutainer were higher than uric acid levels using plain vacutainer. The following types of vacutainer separator gel and plain vacutainer affect the quality of uric acid and glucose test results.

Relationship between Uric Acid, Creatinine, Urea and Triglyceride Production in Gout

Background: Gout is a disorder that manifests as a spectrum of clinical and pathologic features built on a foundation of an excess body burden of uric acid, Hyperuricemia and gout are two of the most common metabolic diseases, there has been an increase in the prevalence and has attracted attention as an adult lifestyle-associated disease.
 Objective: The present study was carried to determine the prevalence of goat and uric acid, creatinine, urea, and triglyceride production in patients with hyperuricemia.
 Materials and Methods: Cross sectional study was done to examine associative between (November 2017 to February 2018). Totally 66 patient attended from ( Hawler Private Hospital, Rezgari Governmental Hospital, Ankawa Private Laboratory) in Erbil and may have hyperuricemia can be developed to gout disease from both males (32) and females (34) .the age 18 up to 70 who included in this study. Biochemical tests were performed for all patients (uric acid test, urea test, creatinine test, triglyceride test). These samples were analyzed by using blood serum rather than urine.
 Results: In male statistical analysis showed that significant correlation between high uric acid and age, the age group (41-60) years was significantly higher compared to other age groups (P < 0.05), and in female statistical analysis showed that significant correlation between high uric acid and age, the age group (61-80) years was significantly higher compared to other age groups (P < 0.05). In male statistical analysis showed that significant correlation between high creatinine and age , the age group (41-60) years was significantly higher compared to other age groups (P < 0.05), in female statistical analysis showed that significant correlation between high creatinine and age, the two age groups (41-60) & (61-80) years were significantly higher compared to other age group (P < 0.05). In male statistical analysis showed that significant correlation between high urea and age, the age group (41-60) years was significantly higher compared to other age groups (P < 0.05), in female statistical analysis showed that non-significant correlation between high urea and age groups (P > 0.05). In male statistical analysis showed that significant correlation between high TG and age , the age group (41-60) years was significantly higher compared to other age groups (P < 0.05), in female statistical analysis showed that non-significant correlation between high TG and age groups (P > 0.05).
 Conclusion: gout is a very common form of arthritis might be increasing hinderance of activity of daily living, lifestyle and environmental factors. Although not life-threatening, it has a significant impact on quality of life. The results provide support for possible linkage of influencing creatinine and triglyceride and uric acid and triglyceride with gout.

Multiple Xanthoma Tuberosum

A 43-year-old unmarried healthy woman presented at the dermatology clinic with xanthelasma (Panel A) and asymptomatic multiple rounded, grouped, and yellow to orange colored nodules, located on the hands and feet for 16 years (Panels B and C). The lesions were 15 mm in size; and were indurated, coalesced, and gradually grown. The patient had no history of diabetes mellitus, hypertension, heart problems, or any history of thyroid disease. On the other hand, she had a family history of sudden death when her brother died at the age of 28 years after a cardiac attack. The vital signs were normal. Full blood counts were normal. Fasting blood glucose was 98 mg/dl (reference range 70 to 99 mg/dl), triglycerides 174 mg/dl (reference range < 150 mg/dl), serum total cholesterol 216 mg/dl (reference range < 200 mg/dl), low density lipoprotein 259 mg/dl (reference range < 116 mg/dl), and high density lipoprotein 29.5 mg/dl (reference range > 55 mg/dl for females). Serum uric acid, liver enzymes, and thyroid function tests were within normal limits. The patient had no evidence of ischemic heart disease or pancreatitis. Treatment started with Rosuvastatin at 40 mg/day. The diagnosis is multiple xanthoma tuberosum (MXT). It is characterized by deposition of lipid at the subcutaneous tissue, particularly on the elbows, knees, face, knuckles, and toe joints. Equal prevalence is reported in males and females. The biopsy is not performed owing to the missing of the patient. This case shed light on MXT associated with abnormal serum lipoprotein levels and a family history of sudden cardiac death. The affected subjects with MXT need long-life follow-up to catch its serious cardiovascular complications as early as possible and treated them promptly.

Association between metabolic obesity phenotype, transition of metabolic phenotypes and the risk of hyperuricemia in Chinese adults: A cohort study.

Prospective evidence on the association of obesity and metabolic health status and its transition over time with the risk of hyperuricemia in the Chinese population is limited. This study aims to investigate the phenotypic transition characteristics of metabolic obesity in Chinese adults and its association with hyperuricemia. Using the China Health and Retirement Longitudinal Survey (CHARLS) survey data in 2011 and 2015, 6059 adults aged ≥ 18 years were selected as the research people. The participants' general information, living habits, blood sample testing, and blood uric acid testing data during follow-up were extracted. According to body weight and metabolic health status, obesity phenotypes were divided into: metabolically normal weight group (MHNW), metabolically normal overweight/obesity group (MHOWO); metabolically abnormal normal weight group (MUNW); metabolically abnormal overweight/obese group (MUHOWO). Multiple linear regression was used to evaluate the correlation between metabolic obesity phenotype and serum uric acid level, and logistic regression model was used to analyze the association of metabolic obesity phenotype and transition with the risk of hyperuricemia. The average age of all subjects was (58.62 ± 8.93) years old, and 42.1% were male. The MHOWO phenotype was present in 19.2% of the general population and 48.6% of the baseline who were overweight or obese population. During the 4-year follow-up period, only 10.7% of participants with MHNW at baseline converted to MHOWO. Among MHOWO participants, 21.2% converted to MUHOWO. MHOWO also increased the risk of hyperuricemia (OR, 1.57; 95% CI 1.15-2.13; P = .004), both in obese and normal-weight individuals, even when metabolic status changed from unhealthy to healthy. Risk of hyperuricemia was high among those who remained metabolically unhealthy but of normal weight (OR, 3.09; 95% CI 1.51-6.30; P = .001). MHOWO also increases the risk of hyperuricemia, and MHOWO remains stable or changes to MUHOWO, which increases the risk of hyperuricemia. Therefore, close attention should be paid to the transition of metabolic health status over time, and individualized prevention strategies should be focused on metabolically unhealthy and obese individuals.

The Occurrence of Thrombosis during Intensive Chemotherapy Treatment for Acute Myeloid Leukemia Patients Does Not Impact on Long-Term Survival

Introduction A thrombotic event is seen in 10% of newly diagnosed acute myeloid leukemia (AML) patients and has been shown to be associated with disseminated intravascular coagulation (Libourel et al. Blood. 2016). As of yet, the association of developing thrombosis during intensive chemotherapy with AML risk models such as the Medical Research Council (MRC) cytogenetics-based assessment and the European LeukemiaNet (ELN) 2017 molecular based risk model has not been rigorously evaluated. In addition, there is a paucity of data pertaining to the long-term prognostic impact of thrombosis in AML patients. Aiming to investigate these prognostic facets of thrombosis in AML, we performed an analysis of patients with AML diagnosed with thrombosis during treatment with intensive chemotherapy. Methods For this analysis, we collected data on baseline clinical, laboratory, cytogenetic and molecular characteristics of patients with newly diagnosed AML who were treated with intensive chemotherapy and were diagnosed with venous thrombosis. These data were compared with intensively treated patients who did not experience thrombosis to assess for clinical parameters associated with a higher likelihood of developing thrombosis, and to determine whether overall survival was affected by thrombosis. Results The analyzed cohort consisted of 335 newly diagnosed AML patients diagnosed and treated between 2007 through 2021 at the Sheba Medical Center. Median patient age at diagnosis was 55 years. At the time of data analysis 162 patients were alive (48%). Two hundred and eighty-three patients were classified as de novo AML (85%) and the remainder were categorized as secondary disease (15%). Ninety patients harbored the FLT3-ITD mutation (28%) and 117 patients harbored NPM1 mutations (39%). Of evaluable patients, 7 were found to have biallelic CEBPA mutations (8%). In terms of MRC cytogenetic risk, 35 patients (11%) were classified as favorable risk, 219 (66%) patients as intermediate risk, 58 patients (17%) as adverse risk and 21 patients had technically insufficient cytogenetic studies. Using the ELN 2017 risk stratification model, 132 patients (40%) had favorable risk disease, 122 patients (36%) intermediate risk, and 80 patients (24%) adverse risk disease. Venous thrombosis was seen in 33 patients (9.9%) with 28 patients diagnosed with central catheter related thrombosis and 5 patients with lower extremity deep vein thrombosis. In 23 patients (70%) thrombosis occurred during the initial induction chemotherapy phase, in 5 patients (15%) during the first consolidation treatment phase, in 3 patients (9%) during the second consolidation treatment phase, and in 2 patients (6%) during admission for salvage chemotherapy. Following diagnosis of thrombosis, the central catheter was taken out in 9 patients (28%), and 3 patients (8.8%) experienced a recurrence of thrombosis. At the time of thrombosis diagnosis, 14 patients (42%) were found to have a concurrent blood stream bacterial infection. Nineteen patients (58%) were started on anticoagulation following the diagnosis of thrombosis. In univariate analysis, patient age, initial levels of white blood cells, hemoglobin, platelets, creatinine, uric acid, lactate dehydrogenase, INR, albumin, and liver function tests were not significantly different between patients who developed thrombosis and those who did not. Disease type (de novo versus secondary), FLT3-ITD and NPM1 mutational status, achievement of remission, and ELN 2017 risk category also not did not differ to a significant degree between groups. However, MRC intermediate risk group patients were significantly more likely to experience thrombosis compared to favorable risk and adverse risk patients (12.8% versus 5.7% and 1.7%, respectively; p=0.049). Overall survival was not significantly impacted by the diagnosis of thrombosis with an estimated median overall survival of 3.7 years seen in patients without thrombosis compared with 2.2 years in patients with thrombosis (p=0.47). Leukemia-free survival was also comparable between groups (2.4 years versus 1 year; p=0.15). Conclusion Venous thrombosis is seen mostly during the initial induction phase of AML patients receiving intensive therapy with a tight association with the MRC intermediate risk category, however long-term survival and leukemia related outcomes are not significantly impacted by the diagnosis of thrombosis.

Effect Analysis and Evaluation of Serum Bilirubin and Uric Acid Test in Clinical Diagnosis of Coronary Heart Disease

Effect Analysis and Evaluation of Serum Bilirubin and Uric Acid Test in Clinical Diagnosis of Coronary Heart Disease

Correlation between Uric Acid and Lipid Profile in Untreated Dyslipidemic Patients

Background: The effects of cholesterol and statin therapy on serum uric acid (SUA) concentration are poorly known, and the latter's effects are even less clear. A mean atorvastatin dosage of 24 mg/dl satisfies the American Cardiovascular Assessment Campaign management objectives and dramatically lowers prevalence of chronic in individuals with cardiovascular events, according to the Greek Drug and Cardiovascular Evaluation research. We compare the temporal evolution of SUA levels in patients receiving standard treatment who received insufficient statin therapy (12 percent received statins) to patients receiving formalised care who received atorvastatin therapy almost exclusively (98 percent). Methods: In this study 160 individuals with abnormal lipid profiles in their blood were enrolled to investigate the connection between lipid profile and uric acid in dyslipidemic patients (dyslipidemia). It was a 5-month cross-sectional study conducted at Dr Abdul Sattar Lab Sialkot using a convenient sampling method. The uric acid, total cholesterol, triglycerides, LDL, and HDL cholesterol levels of enrolled participants were measured. In short, we performed uric acid and lipid profile tests on under-observation samples to investigate the association between uric acid and lipid profile parameters in the enrolled (dyslipidemic) individuals. Result: This research looks at people between the ages of 20 and 60. The Graph shows that (15) patients are between the ages of 20 and 30, (46) patients are between the ages of 31 and 40, (74) patients are between the ages of 41 and 50, and (25) patients are between the ages of 51 and 60.Patients of both sexes are covered. It was found that there exist significant positive relationship between uric acid and lipid profile in dyslipidemic patients. This study shows a positive correlation between LDL, triglycerides, total cholesterol and uric acid whereas a negative correlation was observed between HDL and uric acid. According to the current results, when uric acid rises, Total Cholesterol, Triglycerides, and Low Density Lipoproteins (LDL) rise as well. But High Density Lipoproteins (HDL) falls with the increase in uric acid levels. As a result, this study may be useful in reducing the incidence of related cardiovascular morbidities, and we will be able to predict dyslipidemia more accurately, which may further leads to CVDs. As the rate of CVDs rises in Pakistan, it is becoming increasingly necessary to investigate the factors that are directly linked to the disease. Conclusion: This article's objective was to investigate any connections between Uric Acid and Lipid Profile. Because dyslipidemia predicts the risk of coronary artery disease, so uric acid levels should be considered in these individuals for more complete risk factor prediction and treatment. Increased levels of lipid profile parameters can lead to serious heart diseases, and the only way to avoid this is to get a quick diagnosis of the disease.

Evaluation of serum uric acid and liver function tests among pregnant women with and without preeclampsia at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.

Pre-eclampsia can be described as new-onset hypertension (blood pressure ≥140/90 mmHg) together with proteinuria (24-hr urinary protein ≥ 0.3 g) or any indication of end-organ damage after 20 weeks of gestation. Liver and kidney dysfunction, thrombocytopenia, pulmonary edema, and neurologic dysfunction are common manifestations of end-organ damage due to pre-eclampsia. Pre-eclampsia is the most common cause of liver and kidney dysfunction due to hypoxia and endothelial dysfunction. Hyperuricemia indicates kidney dysfunction and is considered a predictor of the severity of preeclampsia. Therefore, the objective of this study is to evaluate the utility of the levels of serum uric acid and liver function tests [alanine aminotransferase (ALT) and aspartate aminotransferase (AST)] as biomarkers of preeclampsia-related organ damage. An institutional-based comparative cross-sectional study design was conducted, and a total of 102 subjects (51 patients with preeclampsia and 51 normotensive pregnant women) were recruited. The parameters measured were levels of serum uric acid and liver function tests. There were statistically significant differences in the mean serum uric acid, ALT, and AST levels between preeclamptic pregnant women and normotensive pregnant women (p<0.05). There were no statistically significant differences in the mean total and direct bilirubin levels. There was also a significant difference in mean serum uric acid, alanine transaminase, and aspartate transaminase levels across different gestational age categories. Our study revealed that serum uric acid, ALT, and AST levels were higher in pre-eclamptic pregnant women compared to those of normotensive pregnant women, and the differences were statistically significant. As such, serum uric acid and liver function tests may be considered biomarkers of pre-eclampsia-related end-organ damage.

Effect of high-intensity aerobic exercise on serum uric acid in hypertension: compare with moderate-intensity aerobic exercise

Hypertension is one of the major risk factors for cardiovascular morbidity and morbidity since high blood pressure can cause damage to microvascular and macrovascular organs. The Sixty non-smoker participants were divided into two main groups. Thirty participants group with high-intensity aerobic exercise and a second thirty group with moderate-intensity aerobic exercise. The electrical treadmill exercise is used three times per week for eight for each 25-30 minutes. Peripheral arterial blood pressure measurements and blood investigation in the form of serum uric acid and renal function tests were tested for each participant. The resulting data showed a significantly decreased effect on both serum uric acid and renal function tests in high-intensity intervals and continuous moderate exercise with more improvement with continuous moderate exercise 16% in serum uric acid and 27.5 % in creatinine. In conclusion, moderate continuous exercise reduces serum uric acid and creatinine better than high-intensity interval exercise. Both have the same effect on blood pressure and urea, but moderate continuous exercise has a crystal-clear effect that cannot be denied.

Optimization of Ultrasound-Assisted Extraction of Andrographis paniculata Nees Leaves, Phytochemical Screening, Total Phenolic Content and Anti-Gout Potential Activity

Gout is a type of arthritis that causes painful inflammation in one or more joints. In gout, an increase in uric acid in the blood triggers the formation of crystals, causing joint pain. Indonesia is a country rich in the biodiversity of medicinal plant species. Therefore, its flora offers promising therapy for gout, one of which is Andrographis paniculata Nees. This study aims to obtain the leaf extract of A. paniculata through the application of ultrasound-assisted extraction (UAE) with variations in time and amplitude to produce optimal extraction conditions. Then the extract obtained was subjected to phytochemical screening, a total phenolic content test and uric acid test. The results of phytochemical screening of A. paniculata leaf extract using UAE contained saponins, phenols, tannins and alkaloids. The high total phenolic content has an effect on the high potential for reducing uric acid levels. Sample B with a time variation of 35 minutes and an amplitude of 65% showed the highest total phenolic content and potential for reducing uric acid levels compared to the other samples, which were 1104.53 ± 0.5 mg GAE/g extract and 72.81±0.2 %, respectively. From the results of the study, it can be concluded that the UAE extract from the leaves of A. paniculata has good potential as an anti-gout agent.