Unrestrained Cats Research Articles

The effect of chlorpromazine and methopromazine on the electrical activity of the brain in the cat

1. 1. The effects of chlorpromazine and methopromazine on the electrical activity of the brain and on behaviour have been studies in the conscious unrestrained cat. Both produced ataxia and indifference together with slow and irregular 5–8 c/sec. waves in the electrocorticogram. These effects were less marked with methopromazine. With chlorpromazine the effects seen were independent of the route used, but different doses were required. 2. 2. Both drugs blocked the effects on behaviour and electrical activity which are normally observed with amphetamine and LSD 25. Atropine and physostigmine still produced their characteristic effects on electrical activity but did not modify the behavioural state induced by chlorpromazine or methopromazine. 3. 3. Chloropromazine in doses of 1.5–4.0 mg/kg. produced an increase in the slow waves and spindle activity in the encéphale isolé preparation and at the same time made the preparation more difficult to arouse. Smaller doses produced a transient blocking of this activity with the first injection, but larger doses caused a blood pressure fall and flattening of the record. Chlorpromazine had no effect on the cerveau isolé preparation other than the effects associated with a fall in blood pressure. 4. 4. The results are discussed in relation to the planes of section of the two acute preparations and the possible sites of action of the other drugs used. It is suggested that chlorpromazine has a depressant action on the brain stem reticular system and that this action may be related to its anti-adrenaline properties. It is further suggested that small doses have an excitatory action which can only be observed before the depressant action has appeared.

Studies on amygdaloid nucleus of cat.

ArticlesSTUDIES ON AMYGDALOID NUCLEUS OF CATC. Norman Shealy, and Talmage L. PeeleC. Norman Shealy, and Talmage L. PeelePublished Online:01 Mar 1957https://doi.org/10.1152/jn.1957.20.2.125MoreSectionsPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByThe neurobiology of stress ulcersBrain Research Reviews, Vol. 16, No. 3Electrical stimulation of the medial amygdala facilitates gastric acid secretion in conscious ratsBrain Research, Vol. 524, No. 2Peptide-containing pathways from the parabrachial complex to the central nucleus of the amygdalaPeptides, Vol. 10, No. 2Central nervous system actions of β-endorphin on gastric acid secretionBrain Research, Vol. 413, No. 1Amygdaloid lesions attenuate neurogenic gastric mucosal erosions but do not alter gastric secretory changes induced by intracisternal bombesinBrain Research Bulletin, Vol. 16, No. 1The amygdala and forced immobilization of ratsBehavioural Brain Research, Vol. 16, No. 1The organization of the hypothalamic pathways mediating affective defense behavior in the catBrain Research, Vol. 330, No. 1Calcitonin gene-related peptide acts within the central nervous system to inhibit gastric acid secretionRegulatory Peptides, Vol. 9, No. 4Neural pathways mediating hypothalamically elicited flight behavior in the catBrain Research, Vol. 306, No. 1-2Neural systems and the inhibitory modulation of agonistic behavior: A comparison of mammalian speciesNeuroscience & Biobehavioral Reviews, Vol. 8, No. 1A [14C]2-deoxyglucose analysis of the functional neural pathways of the limbic forebrain in the rat. I. The amygdalaBrain Research Reviews, Vol. 5, No. 1The telencephalic limbic system and experimental gastric pathology: A reviewNeuroscience & Biobehavioral Reviews, Vol. 6, No. 3Central regulation of gastric acid secretion: The role of neuropeptidesLife Sciences, Vol. 31, No. 5GnRH localization in the equine brain and infundibulum: An immunohistochemical studyBrain Research, Vol. 208, No. 1Facilitation and inhibition of gastric pathology after lesions in the amygdala of ratsPhysiology & Behavior, Vol. 25, No. 4The centromedial amygdala and gastric pathology in ratsPhysiology & Behavior, Vol. 25, No. 1Morphine withdrawal syndrome: Differential participation of structures located within the amygdaloid complex and striatum of the ratBrain Research, Vol. 177, No. 1The hypothalamus-amygdala axis and experimental gastric ulcersNeuroscience & Biobehavioral Reviews, Vol. 3, No. 2Amygdaloid hypersexuality in male cats re-examinedPhysiology & Behavior, Vol. 22, No. 2Facilitatory and inhibitory effects of electrochemical stimulation of the amygdala on the release of luteinizing hormoneBrain Research, Vol. 144, No. 1Effects of bilateral amygdaloid lesions on gonadal and pituitary hormones in serum and on sexual behavior in female rhesus monkeysPhysiology & Behavior, Vol. 17, No. 6Influence of hippocampectomy on gastric ulcer in ratsBrain Research, Vol. 109, No. 2A failure of amygdaloid lesions to alter agonistic behavior in the laboratory ratPhysiology & Behavior, Vol. 12, No. 5Gastric secretory response to pressure on vagal nucleiThe American Journal of Surgery, Vol. 123, No. 1Reponses associees incrementales corticales et oculaires d'origine amygdalienneElectroencephalography and Clinical Neurophysiology, Vol. 29, No. 5Changes in bile secretion produced by hippocampal and hypothalamic stimulationExperimental Neurology, Vol. 24, No. 2Responses of hypothalamic neurons to repetitive amygdaloid stimulationBrain Research, Vol. 8, No. 1Comparison of the behavioral effects of electrical or chemical stimulation applied at the same brain lociExperimental Neurology, Vol. 19, No. 4Gastric secretory response of the unrestrained cat following electrical stimulation of the hypothalamus, amygdala, and basal gangliaExperimental Neurology, Vol. 17, No. 2Alterations of behavior following stimulation of the claustrum of the catElectroencephalography and Clinical Neurophysiology, Vol. 17, No. 5Conditioning of subcortical telencephalic stimulation effectsElectroencephalography and Clinical Neurophysiology, Vol. 17, No. 3POSTENCEPHALITIC ENDOCRINE DISORDERS WITH MENTAL SUBNORMALITY5 February 2018 | Journal of Intellectual Disability Research, Vol. 5, No. 2The spread of after-discharge from stimulation of the rhinencephalon in the catElectroencephalography and Clinical Neurophysiology, Vol. 13, No. 5Subcortical structures mediating the attention response induced by amygdala stimulationExperimental Neurology, Vol. 2, No. 2Functional localization within the amygdaloid complex in the catElectroencephalography and Clinical Neurophysiology, Vol. 12, No. 1Viscero-sensory and somato-sensory representation in the rhinencephalonElectroencephalography and Clinical Neurophysiology, Vol. 10, No. 2 More from this issue > Volume 20Issue 2March 1957Pages 125-139 https://doi.org/10.1152/jn.1957.20.2.125PubMed13406596History Published online 1 March 1957 Published in print 1 March 1957 Metrics

Reciprocal effects upon spinal motoneurons from stimulation of bulbar reticular formation.

ArticlesRECIPROCAL EFFECTS UPON SPINAL MOTONEURONS FROM STIMULATION OF BULBAR RECTICULAR FORMATIONB. E. Gernandt, and C. -A. ThulinB. E. Gernandt, and C. -A. ThulinPublished Online:01 Mar 1955https://doi.org/10.1152/jn.1955.18.2.113MoreSectionsPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByImportance of cholinergic, GABAergic, serotonergic and other neurons in the medial medullary reticular formation for sleep-wake states studied by cytotoxic lesions in the catNeuroscience, Vol. 62, No. 4Prefrontal cortex and bulbar reticular formation and behavioral inhibition in the RatBrain Research Bulletin, Vol. 12, No. 1Rostral brainstem contributes to medullary inhibition of muscle toneBrain Research, Vol. 268, No. 2Gripping and Moro responses: differences between small-for-gestational age and normal weight term newbornsEarly Human Development, Vol. 4, No. 1Activity of medullary reticular formation neurons in the unrestrained cat during waking and sleepBrain Research, Vol. 179, No. 1Modulation of masseteric and digastric neural activity by stimulation of the dorsolateral cerebral cortex in the squirrel monkeyExperimental Neurology, Vol. 41, No. 2The convulsive action of 1,2-dihydroxybenzene in the anaesthetized ratElectroencephalography and Clinical Neurophysiology, Vol. 34, No. 4Control of the tonic vibration reflex by the brain stem reticular formation in the catJournal of the Neurological Sciences, Vol. 18, No. 2Activity of vestibulospinal neurons during locomotionBrain Research, Vol. 46Reflexes spinaux chez l'homme et niveaux d'attentionElectroencephalography and Clinical Neurophysiology, Vol. 30, No. 1Finger tremor with an amplified visual display of position and following eye closureJournal of the Neurological Sciences, Vol. 3, No. 4Unit analysis of mesencephalic reticular formation control of spinal cord neuronsElectroencephalography and Clinical Neurophysiology, Vol. 19, No. 3Therapeutic Value of Thioproperazine and the Importance of the Associated Neurological Disturbances8 February 2018 | Journal of Mental Science, Vol. 107, No. 447Vestibular influences on spinal mechanismsExperimental Neurology, Vol. 1, No. 3Descending vestibular activity and its modulation by proprioceptive, cerebellar, and reticular influencesExperimental Neurology, Vol. 1, No. 3The effects of brain-stem stimulation on hind-leg movements in the hooded ratExperimental Neurology, Vol. 1, No. 2Neurophysiological Mechanisms for the Acquisition and Extinction of Conditioned Reflexes31 August 2016 | Psychological Reports, Vol. 1, No. 3 More from this issue > Volume 18Issue 2March 1955Pages 113-129 https://doi.org/10.1152/jn.1955.18.2.113PubMed14354449History Published online 1 March 1955 Published in print 1 March 1955 Metrics

Control of posture by reticular formation and cerebellum in the intract, anesthetized and unanesthetized and in the decerebrated cat.

Control of posture by reticular formation and cerebellum in the intract, anesthetized and unanesthetized and in the decerebrated cat.

A technique for recording the electrical activity of the brain in the conscious animal

1. 1. A method of recording the electrical activity of the brain in the conscious unrestrained cat is described. 2. 2. Details of electrodes used for recording cortical and sub-cortical activity are given, and the method of insertion is described. 3. 3. Simultaneous observations on electrical activity and changes in behaviour have been used for the purpose. 4. 4. Chronic preparations have been kept, and satisfactory records obtained for periods up to 15 months.