There are a number of untapped opportunities for cross-border logistics cooperation, one of which is the operation of virtual logistics centers. The Institute of Logistics of the University of Miskolc researched the possibilities of establishing and operating Virtual Logistics Centers in many fields (e.g. automotive industry, maintenance systems, etc.). The paper describes a proposed concept for the operation of virtual logistics centers for cross-border cooperation, as well as explores the possible benefits of the application. The proposed concept can provide a good basis for the development of a virtual logistics center in the border regions of Miskolc (Hungary) - Košice (Slovakia), and also in the border regions of Bishkek (Kyrgyzstan) -Almaty (Kazakhstan).