We address the problem of the vapor-liquid phase transition in the restricted primitive model (RPM) using Wertheim's statistical associating fluid theory to capture the effects of ion pairing, which dominate the low-temperature vapor phase. For this, we employ a reference system in which ion-pairing is suppressed by a judicious modification of the interaction between unlike charges, from 1/r to erf(κr)/r, where the state-point-dependent parameter κ is chosen so that the Helmholtz free energy A is at a null point (∂A/∂κ = 0). Unlike the original RPM, this reference fluid admits real solutions to the hypernetted-chain closure of the Ornstein-Zernike equations over a wide range of densities and temperatures. In the present study, we go beyond previous work [M. Li, Ph.D. thesis, University of Manchester, 2011] to allow ion pairs to assemble into neutral clusters. We find that this has the potential to improve significantly the agreement with the Monte Carlo results for the RPM vapor phase boundary. We can also match recent results on anomalous underscreening in the RPM [A. Härtel etal., Phys. Rev. Lett. 130, 108202 (2023)], assuming that only the free ions contribute to the screening length.

First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping researchers promote themselves alongside their papers. Anne Cathrine Hyde is first author on ‘ Assessing frailty in aged zebrafish using a quick pseudo-frailty index’, published in BiO. Anne Cathrine conducted the research described in this article while a PhD candidate in Fredericus van Eeden's lab at The University of Sheffield, Sheffield, UK. She is now a postdoctoral research associate in the lab of Hilary Ashe at The University of Manchester, Manchester, UK, investigating how RNA molecules affect development and cellular processes.

Matt Houlbrook, Songs of Seven Dials: An Intimate History of 1920s and 1930s London. Manchester: Manchester University Press, 2025. 312pp. 19 figures. £20 hbk.

Aidan Beatty, Private Property and the Fear of Social Chaos. Manchester: Manchester University Press, 2023, 344pp. Bibliography. £85.00 hbk. £25.00 pbk.

The Interpreters: British Internationalism and Empire in Southeastern Europe, 1870–1930. By GeorgiosGiannakopoulos. Manchester University Press, 2025. 304 pp. £85.

PaulSmith: Catholics and the Law in Restoration Ireland. Manchester: Manchester University Press, 2025; pp. viii + 236.

Book Review: Sally Wainwright GortonKristynJohnsonBeth (2025). Sally Wainwright. Manchester University Press. 220pp. ISBN 9781526142870.

ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Astrid Boström is first author on ‘ Auxin-inducible degradation of UNC-116 in C. elegans inhibits bidirectional dense core vesicle transport and worm locomotion on different timescales’, published in JCS. Astrid is a postdoc in the lab of Viki Allan at The University of Manchester, UK, investigating the fundamentals of intracellular transport in neurons.

Sedation during Extracorporeal Membrane Oxygenation (ECMO) is challenging due to altered pharmacokinetics. At Manchester University NHS Foundation Trust, Wythenshawe Hospital, the Richmond Agitation-Sedation Scale is the standard tool for sedation monitoring; however, it lacks precision in assessing deep sedation. Bispectral Index (BIS) monitoring offers an objective assessment but remains underused, partly because of limited nursing training. This article presents the implementation of small-group teaching sessions (SGTS) on ECMO sedation and BIS monitoring, integrated into existing ECMO refresher training. The sessions included interactive presentations, followed by anonymous feedback collection to evaluate perceptions of the clarity, relevance, appropriateness and usefulness of the SGTS. Sixty-one staff members attended, and 44 provided feedback. All respondents indicated that their learning needs were met, and 93% reported confidence in using BIS independently. The training was highly rated for clarity, relevance and practical value. Overall, our SGTS approach improved nurses' understanding and confidence in BIS monitoring and ECMO sedation, supporting broader clinical adoption and highlighting the value of continued professional education.

Teenage Rampage? CharnockHannah, Teenage Intimacies: Young Women, Sex and Social Life in England, 1950–80, Manchester, Manchester University Press, 2025; 304 pp.; £85.00 hbk; ISBN 9781526173157KennySarah, Growing Up and Going Out: Youth Culture, Commerce, and Leisure Space in Post-War Britain, Manchester, Manchester University Press, 2025; 258 pp., £85.00 hbk; ISBN 9781526152640The Subcultures Network, Let's Spend the Night Together: Sex, Pop Music

Paul Smith, Catholics and the law in Restoration Ireland, Manchester: Manchester University Press, 2025, viii + 236 pp, £85 hardback, ISBN: 9781526176356.

In 2024, Cochrane Oral Health (COH) celebrated its 30th anniversary, marking 3 decades of advancing global oral health through rigorous evidence synthesis. Based at The University of Manchester, COH has become a cornerstone of trusted health information, contributing to clinical practice, policy, and patient care. COH's mission centers on producing accessible, high-quality systematic reviews to inform decision-making and promote equitable oral health. Its prioritization strategy, involving diverse stakeholders, ensures relevance and impact. COH exemplifies methodological excellence and innovation, adhering to Cochrane methodological standards and promoting transparency through protocol publication and freely available plain language summaries. Our reviews are widely cited in international guidelines and policy documents, with notable contributions to evidence synthesis and knowledge translation in the areas of fluoride interventions, antimicrobial use, oral cancer management, and infection control during COVID-19. COH has embraced innovation through the conduct of a diverse range of review methodologies including living reviews, diagnostic test accuracy reviews and overviews of systematic reviews, AI-assisted synthesis, and commissioned evidence synthesis. Cochrane Oral Health's legacy is defined by its commitment to methodological rigor, stakeholder engagement, and global impact. As it enters its fourth decade, COH continues to evolve, addressing emerging challenges and advancing oral health through trusted evidence. Its strategic goals of expanding reach, innovating methods, promoting equity, and effective knowledge translation position COH as a leader in evidence-based oral healthcare.

Review of Culture is not an industry: reclaiming art and culture for the common good by Justin O’Connor, 2024, Manchester: Manchester University Press

Abstract Introduction Manchester Vascular Centre (MVC) is one of the largest Arterial Centres in the UK. It serves approximately 2 million people. Older people who are living with frailty are at increased risk of perioperative complications. Perioperative care for Older People undergoing Surgery (POPS) can reduce incidence of these complications by providing Comprehensive Geriatric Assessments (CGA) (Partridge et al 2017). In Manchester Royal Infirmary, the Older Person Assessment and Liaison (OPAL) team have been providing CGAs for older people living with frailty undergoing surgery. Manchester University NHS Foundation Trust uses EPIC electronic patient records”. The team aimed to use EPIC to identify eligible patients and record outcomes. Method In 2024 the MRI began work with NHS Elect on a Quality Improvement Project aiming to improve reach of the service to improve outcomes. A report was created through EPIC which identified patients eligible for CGA. Using this report the team could identify the demand and reach for the service. Outcomes such as delirium assessment and length of stay (LOS) was measured. Results Data suggests an average of 30 patients aged 65+ are admitted weekly to MVC. Previously, 60% of these patients had a CGA. Data from the EPIC report enabled identification of the resources necessary to reach all eligible patients. A 6-week ‘Test of Change’ was implemented with daily Geriatrician input leading MDT board rounds. As part of the test of change, educational sessions were provided to the nursing staff and medical team. Following the test of change, 100% of eligible patients had a CGA, closed LOS reduced by 6 days on average and delirium assessment compliance reached 100%. Conclusion Utilising EPIC, the team have identified the resources necessary to provide CGA for all older people living with frailty in MVC. Providing CGA has improved patient outcomes including delirium assessment and LOS.

Since its establishment in the late 1980s, the UK Clinical Practice Research Datalink (CPRD) has become one of the most widely utilised data resources in both national and international research. Its value lies in the richness, scale and quality of its routinely collected primary care data, as well as the availability of numerous linkable datasets. This study provides comprehensive scientometric analyses of CPRD-related research output, impact, and data usage from 1988 to 2024. A total of 3779 peer-reviewed publications were identified, and for 98.78% of them, enriched bibliometric metadata were retrieved through Scopus and Web of Science. The UK emerged as the leading contributing country, with the United States and Canada ranking second and third. 'McGill University' was the most frequently affiliated institution, followed by the 'University of Manchester' and the 'University of Oxford', with seven UK universities among the top ten. The three journals most frequently publishing CPRD-based research overall, and since 2020, were 'BMJ Open', 'Pharmacoepidemiology and Drug Safety' and 'British Journal of General Practice'. Analyses of primary care data sources utilisation revealed that overall, 86.35% of manuscripts used CPRD GOLD exclusively, 8.39% used both CPRD GOLD and CPRD Aurum, and 4.76% used CPRD Aurum alone, although recent years showed an increased use of CPRD Aurum. Between 2016 and 2024, most articles (80.26%) were associated with CPRD research applications that referenced linked or CPRD algorithm-derived datasets. The three most frequently used were 'Hospital Episode Statistics' (69.77%), 'Small Area Linkages' (62.27%) and 'Office for National Statistics' mortality data (53.28%).

Ian Cawood / Tom Crook (Eds.), The Many Lives of Corruption. The Reform of Public Life in Modern Britain, c. 1750–1950. Manchester, Manchester University Press 2022

PurposeLimited resources including staff, technology, and space in United Kingdom National Health Service (NHS) environments present challenges for working teaching and learning. Cumulative pressures impact mental health and prompt medical students to question career choices, leave the profession, or emigrate. There is little understanding of the experience of inclusivity in clinical environments for medical students. This pilot study explores students’ perspectives of these environments, the barriers to formulating change, and possible solutions.Materials and MethodsSix diverse clinical medical students from the University of Manchester, based at a single NHS Trust, voluntarily participated in one of four recorded focus groups facilitated by a near-peer with protected characteristics. Low participation emphasised the importance of undertaking this pilot study to consider methods for future study design. Transcriptions were independently analysed by two reviewers to generate themes using NVivo.ResultsKey themes included positive experiences with resident doctors; negative interactions with patients; negative attitudes and poor role modelling from some staff; perceived lack of institutional support; and poor learning opportunities. Students suggested staff training and better support structures to improve learning environments.ConclusionThis study highlights universal issues from the perspectives of minoritised students and emphasises their low participation in research. Authors suggest exploring clinical faculty support and training to improve learning environments, and innovations in study design for wider, more democratic and culturally sensitive participation.

BackgroundMDR Enterobacterales are an increasingly common cause of urinary tract infections (UTIs) and present significant treatment challenges. These pathogens are usually resistant to most, and sometimes all, oral antibiotic options and hospital admission for IV therapy with carbapenems is often necessary. Temocillin is a narrow-spectrum agent with stability against many ESBLs and AmpC enzymes. In April 2020, EUCAST published clinical breakpoints for certain Enterobacterales species and categorized those with MIC ≤16 mg/L as I (susceptible, increased exposure). This further recommended temocillin only be used for infections of urinary origin and in practice would necessitate 2 g three times daily dosing.ObjectivesWe aimed to evaluate the use, appropriateness and clinical outcomes of temocillin at standard doses (up to 2 g twice daily) for OPAT treatment of UTI.MethodsWe conducted a retrospective review of all adult patients treated for UTI with temocillin via the OPAT service at a large NHS Trust (Manchester University NHS Foundation Trust) over a 12 month period between 1 April 2024 and 31 March 2025. The OPAT service maintains a comprehensive patient database of all referrals, which was used to identify patients eligible for inclusion and search electronic health records. Baseline demographics, UTI diagnosis, microbiological data, treatment duration and clinical outcomes were documented and analysed. Significant adverse events and 60 day hospital re-admission or re-referral to OPAT for UTI were also recorded. Outcomes were categorized according to UK good practice recommendations for OPAT (2019).ResultsA total of 27 OPAT episodes were included, representing 24 individual patients (female, 16; 58%). Median age was 70 years (range 26–88). Twenty-one cases (78%) had a diagnosis of complicated UTI (including pyelonephritis, urosepsis and catheter-associated infection). Gram-negative organisms in urine and/or blood cultures were present in 25 cases (93%) prior to starting treatment. Concurrent bacteraemia was present in 11 cases (44%). ESBL/AmpC-producing organisms accounted for 22 (88%) of all positive cultures (Escherichia coli [10]; Klebsiella pneumoniae [6]; Morganella morganii [5]; Proteus mirabilis [1]). The remainder were either non-ESBL/AmpC E. coli or mixed growth/no predominant organism. Standard dosing of temocillin was used for all patients, with doses ranging from 1 g od to 2 g bd and adjusted for renal function where appropriate. Median total duration of therapy was 8 days (range 3–14). Treatment aim (cure) was achieved in all patients, with a single episode of acute kidney injury and hyperkalaemia as the only recorded adverse event. Three OPAT episodes (11%) resulted in re-presentation to Trust services with UTI symptoms within 60 days of discharge from OPAT. There was one patient death of unknown causes.ConclusionsOur experience supports the use of temocillin at standard dosing up to 2g twice daily for OPAT treatment of Gram-negative urinary tract infections and is a particularly valuable agent for those caused by resistant organisms. In our study cohort, temocillin achieved excellent clinical outcomes and was shown to be very well tolerated. Temocillin also has important antimicrobial stewardship advantages as a narrow-spectrum, carbapenem-sparing agent where once-daily ertapenem may otherwise be the only alternative OPAT option.

University of Manchester to Lead <b>Long-Duration Energy Storage Project</b>

Review of Kevin Morgan 2025: Serving the Public. The Good Food Revolution in Schools, Hospitals and Prisons. Manchester: Manchester University Press.