Prior Information Research Articles

Inference for depending competing risks from Marshall–Olikin bivariate Kies distribution under generalized progressive hybrid censoring

This paper explores inferences for a competing risk model with dependent causes of failure. When the lifetimes of competing risks are modelled by a Marshall–Olikin bivariate Kies distribution, classical and Bayesian estimations are studied under generalized progressive hybrid censoring. The existence and uniqueness results for maximum likelihood estimators of unknown parameters are established, whereas approximate confidence intervals are constructed using the observed Fisher information matrix. In addition, Bayes estimates are explored based on a flexible Gamma-Dirichlet prior information. Furthermore, when there is a priori order information on competing risk parameters being available, traditional classical likelihood and Bayesian estimates are also established under restricted parameter case. The behavior of the proposed estimators is evaluated through extensive simulation studies, and a real data study is presented for illustrative purposes.

A Bayesian complex-valued latent variable model applied to functional magnetic resonance imaging

Abstract In linear regression, the coefficients are simple to estimate using the least squares method with a known design matrix for the observed measurements. However, real-world applications may encounter complications such as an unknown design matrix and complex-valued parameters. The design matrix can be estimated from prior information but can potentially cause an inverse problem when multiplying by the transpose as it is generally ill-conditioned. This can be combat by adding regularizers to the model but does not always mitigate the issues. Here, we propose our Bayesian approach to a complex-valued latent variable linear model with an application to functional magnetic resonance imaging (fMRI) image reconstruction. The complex-valued linear model and our Bayesian model are evaluated through extensive simulations and applied to experimental fMRI data.

Plasma electron density profile tomography for EAST based on integrated data analysis

Abstract Plasma electron density is a crucial parameter in plasma studies. Accurately inverting the plasma electron density profile is vital for plasma control experiments and the investigation of plasma physical mechanisms. This paper proposes an integrated data analysis (IDA) method based on Bayesian inference, which integrates polarimetric interferometry (POINT), hydrogen cyanide (HCN) laser
interferometer, and microwave reflectometer (RFL) diagnostics for inverting the plasma electron density profile. To enhance inversion accuracy, a Gaussian prior probability of the non-stationary hyperparameter is used. This prior probability effectively simulates
situations where there is a large plasma electron density gradient in the pedestal, especially under the condition of high-confinement mode discharge. Compared to the use of Gaussian prior probability for the stationary hyperparameter, the proposed IDA
method based on the non-stationary hyperparameter prior probability achieves higher inversion accuracy.

Efficient object detector via dynamic prior and dynamic feature fusion

Abstract Sparse R-CNN is a new paradigm of object detection, which predicts objects in a sparse way. However, there are some limitations in Sparse R-CNN. One is the presence of weak prior information caused by fixed learnable proposal boxes and features across different images, necessitating excessive iterations for the model to refine its predictions; the other is the inadequate exploitation of multi-scale information, leading to the sub-optimal detection performance. Thus, building upon Sparse R-CNN, we propose an efficient detector that incorporates dynamic prior and dynamic feature fusion, called $D^{2}$-Det. In particular, for the dynamic prior part, a prior information generator module dynamically generates proposal features and boxes as the dynamic prior for different images to alleviate the inference-inefficient iterative refinement process of predictions, and we further propose the class scores decoupling method to reduce the computation overhead. Furthermore, for the dynamic feature fusion part, we develop a novel lightweight multi-scale feature fusion module, which dynamically aggregates features from all layers for each proposal box, enabling adaptive feature fusion and improving detection precision by nearly 2 AP. Experiments show that $D^{2}$-Det can achieve 46.6 AP on COCO 2017 with fewer computations for the backbone ResNet50, surpassing most of the state-of-the-art detectors.

Sea–Land Segmentation of Remote-Sensing Images with Prompt Mask-Attention

Remote-sensing technology has gradually become one of the most important ways to extract sea–land boundaries due to its large scale, high efficiency, and low cost. However, sea–land segmentation (SLS) is still a challenging problem because of data diversity and inconsistency, “different objects with the same spectrum” or “the same object with different spectra”, and noise and interference problems, etc. In this paper, a new sea–land segmentation method (PMFormer) for remote-sensing images is proposed. The contributions are mainly two points. First, based on Mask2Former architecture, we introduce the prompt mask by normalized difference water index (NDWI) of the target image and prompt encoder architecture. The prompt mask provides more reasonable constraints for attention so that the segmentation errors are alleviated in small region boundaries and small branches, which are caused by insufficiency of prior information by large data diversity or inconsistency. Second, for the large intra-class difference problem in the foreground–background segmentation in sea–land scenes, we use deep clustering to simplify the query vectors and make them more suitable for binary segmentation. Then, traditional NDWI and eight other deep-learning methods are thoroughly compared with the proposed PMFormer on three open sea–land datasets. The efficiency of the proposed method is confirmed, after the quantitative analysis, qualitative analysis, time consumption, error distribution, etc. are presented by detailed contrast experiments.

Incorporating patient-specific information for the development of rectal tumor auto-segmentation models for online adaptive magnetic resonance Image-guided radiotherapy

Background and purposeIn online adaptive magnetic resonance image (MRI)-guided radiotherapy (MRIgRT), manual contouring of rectal tumors on daily images is labor-intensive and time-consuming. Automation of this task is complex due to substantial variation in tumor shape and location between patients. The aim of this work was to investigate different approaches of propagating patient-specific prior information to the online adaptive treatment fractions to improve deep-learning based auto-segmentation of rectal tumors. Materials and methods243 T2-weighted MRI scans of 49 rectal cancer patients treated on the 1.5T MR-Linear accelerator (MR-Linac) were utilized to train models to segment rectal tumors. As benchmark, an MRI_only auto-segmentation model was trained. Three approaches of including a patient-specific prior were studied: 1. include the segmentations of fraction 1 as extra input channel for the auto-segmentation of subsequent fractions, 2. fine-tuning of the MRI_only model to fraction 1 (PSF_1) and 3. fine-tuning of the MRI_only model on all earlier fractions (PSF_cumulative). Auto-segmentations were compared to the manual segmentation using geometric similarity metrics. Clinical impact was assessed by evaluating post-treatment target coverage. ResultsAll patient-specific methods outperformed the MRI_only segmentation approach. Median 95th percentile Hausdorff (95HD) were 22.0 (range: 6.1–76.6) mm for MRI_only segmentation, 9.9 (range: 2.5–38.2) mm for MRI+prior segmentation, 6.4 (range: 2.4–17.8) mm for PSF_1 and 4.8 (range: 1.7–26.9) mm for PSF_cumulative. PSF_cumulative was found to be superior to PSF_1 from fraction 4 onward (p = 0.014). ConclusionPatient-specific fine-tuning of automatically segmented rectal tumors, using images and segmentations from all previous fractions, yields superior quality compared to other auto-segmentation approaches.

The InterVision Framework: An Enhanced Fine-Tuning Deep Learning Strategy for Auto-Segmentation in Head and Neck

Adaptive radiotherapy (ART) workflows are increasingly adopted to achieve dose escalation and tissue sparing under dynamic anatomical conditions. However, recontouring and time constraints hinder the implementation of real-time ART workflows. Various auto-segmentation methods, including deformable image registration, atlas-based segmentation, and deep learning-based segmentation (DLS), have been developed to address these challenges. Despite the potential of DLS methods, clinical implementation remains difficult due to the need for large, high-quality datasets to ensure model generalizability. This study introduces an InterVision framework for segmentation. The InterVision framework can interpolate or create intermediate visuals between existing images to generate specific patient characteristics. The InterVision model is trained in two steps: (1) generating a general model using the dataset, and (2) tuning the general model using the dataset generated from the InterVision framework. The InterVision framework generates intermediate images between existing patient image slides using deformable vectors, effectively capturing unique patient characteristics. By creating a more comprehensive dataset that reflects these individual characteristics, the InterVision model demonstrates the ability to produce more accurate contours compared to general models. Models are evaluated using the volumetric dice similarity coefficient (VDSC) and the Hausdorff distance 95% (HD95%) for 18 structures in 20 test patients. As a result, the Dice score was 0.81 ± 0.05 for the general model, 0.82 ± 0.04 for the general fine-tuning model, and 0.85 ± 0.03 for the InterVision model. The Hausdorff distance was 3.06 ± 1.13 for the general model, 2.81 ± 0.77 for the general fine-tuning model, and 2.52 ± 0.50 for the InterVision model. The InterVision model showed the best performance compared to the general model. The InterVision framework presents a versatile approach adaptable to various tasks where prior information is accessible, such as in ART settings. This capability is particularly valuable for accurately predicting complex organs and targets that pose challenges for traditional deep learning algorithms.

Informative priors can account for location uncertainty in stop-level analyses of the North American Breeding Bird Survey (BBS), allowing fine-scale ecological analyses

Informative priors can account for location uncertainty in stop-level analyses of the North American Breeding Bird Survey (BBS), allowing fine-scale ecological analyses

A novel unsupervised adaptive density-based clustering filter for remaining useful life prediction of bearings

Abstract Constructing the health indicator (HI) and predicting the remaining useful life (RUL) are essential steps in bearing health management. Some prediction methods depend on prior information about HIs, especially when these indicators are generated by deep learning models. However, acquiring such prior information can be challenging in practical applications. This paper introduces a novel unsupervised adaptive density-based clustering filter (UADCF) for RUL prediction of bearings, which operates without the need for prior knowledge. Firstly, a post-hoc interpretation HI model (PIHIM) is proposed to characterize the deep learning constructed HIs from the perspective of what the deep learning has done. Then, leveraging the classical density-based clustering algorithm, we introduce the UADCF for unsupervised estimation of model parameters, which can dynamically adjust density parameters based on the current conditions. Finally, we develop a prediction framework combining PIHIM and UADCF, enabling unsupervised RUL prediction of bearings. The experimental studies validate the effectiveness of the proposed method.

A novel semi-convex function for simultaneous identification of moving vehicle loads and bridge damage

For the simultaneous identification (SI) problem on the moving vehicle loads and bridge damage, the existing methods fail to appropriately consider the sparse characteristics of structural damage and ignore the prior information of vehicle loads, which make them suffering from challenges such as prolonged computation cost, poor noise robustness, and limited identification accuracy. To address this issue, a novel semi-convex function is proposed to construct a theoretical framework for the SI problem using the bridge dynamic responses subjected to moving vehicles in this study. Firstly, the bridge damage-induced virtual forces are conceptualized as a new form of moving residual forces characterized by block sparsity properties, and the damage location is then determined by the frequency characteristics with the largest fundamental frequency amplitude of moving residual forces. Secondly, a semi-convex function model encompassing moving forces and moving residual forces is defined. Combined with sparse regularization strategy, an improved alternating direction method of multipliers algorithm is proposed and applied to simultaneously solve for both moving vehicle loads and damage degrees. To assess the effectiveness and feasibility of the proposed method, extensive numerical validations are conducted in various bridge damage scenarios. Additionally, a series of truss bridge experiments are performed in laboratory under multiple damage and vehicle axle-weight conditions. The results show that compared with the existing outstanding methods, the proposed semi-convex function method can significantly reduce the identification cost, enhance robustness to noise, and demonstrate notable improvements in accuracy for the SI problem, which provides an innovative and more efficient solution to the SI problem in bridge engineering.

200 Transcriptomics analyses of mink spleen infected by Aleutian Disease

Abstract Aleutian disease (AD) is one of the most challenging mink diseases that causes high mortality and affects several economically important traits. Aleutian mink disease virus (AMDV) targets multiple organs and among them, the spleen is one of the major targeted organs. Transcriptomics has been widely used to reveal genes and biological pathways and identify biomarkers for early detection or prevention of diseases. This study aimed to identify genes and pathways related to the host response to AD infection in the spleen via transcriptomic study. Twelve (3 sets of 4 full-sibs) AMDV-free black male mink were housed in the clean section of the animal housing facility at the AD Research Centre (Truro, NS, Canada) between 4 to 7 d before inoculation. Before inoculation, sampling, and euthanasia, animals were anesthetized. The viral inoculum was a 10% (W/V) passage 2 of AMDV prepared from the spleens of mink infected with a local strain and stored at − 80 °C. Animals were intranasally inoculated under sedation with 60 µL of the viral homogenate, corresponding to approximately 300 to 700 ID50. Infected mink were humanely euthanized and the spleen tissues were collected for RNA isolation at 24h (d 1), 48h (d 2), and d 7. Libraries were prepared from total RNA using the Illumina TruSeqTM RNA kit, and were sequenced using the HiScanSQ platform, producing 101 bp reads from each end. The raw RNA-Seq data were cleaned using Cutadapt V1.4.2 and after the cleaning process was completed, 942,803,540 paired-end reads remained to be used in downstream analysis. Differential gene expression analyses revealed most (168) significant differentially expressed (DE) genes between d 1 and d 0 (Control or ADMV-free mink) while fewer DE genes (23) were between d 7 and d 0 (Table 1; Figure 1). A total of 19 DE genes are identified between three pair comparisons and seven of them are directly involved in immune response (FGL2, TLF8, LRP1, SERPINB9, MSR1, C3, PLA2R1, and XCR1). Gene enrichment analyses revealed pathways related to innate immune and fat metabolism which are important for the host mechanism to fight against infections. One of the important pathways is neutrophil degranulation which functions as aiding in the elimination of pathogens and the initiation of the inflammatory process. In conclusion, the current study provides insight into the transcriptomic profiles of the spleen in mink infected with AD. Identified candidate genes might be used for functional studies or as prior information for markers or genomic selection against AD in mink. Further studies in other tissues or single-cell RNA sequencing might deliver more comprehensive pictures of host responses to AD infections.

BRAVE: A cascaded generative model with sample attention for robust few shot image classification

Few-shot learning (FSL) confronts notable challenges due to the disparity between training and testing categories, leading to channel bias in neural networks and hindering accurate feature discernment. To address this, we introduce Biased-Reduction Attentive Network (BRAVE), an innovative model that incorporates a refined Vector Quantized Variational Autoencoder (VQ-VAE) backbone, enhanced with our Diverse Quantization (DQ) Module, for unbiased, fine-grained feature creation. Alongside, our Sample Attention (SA) Module is utilized for extracting discriminative features from these unbiased, fine-grained features. The DQ Module in BRAVE strategically integrates prior distribution regularization and stochastic masking with Gumbel sampling for balanced and diverse codebook engagement, while the SA Module leverages inter-sample dynamics for identifying critical features. This synergy effectively counters channel bias and boosts classification accuracy in FSL setups, surpassing current leading methods. Our approach represents a practical balance between preserving detailed features through the decoder and ensuring classification effectiveness, marking a significant advance in FSL. BRAVE’s implementation is accessible for community use and further exploration. Code and models available at https://github.com/ApocalypsezZ/BRAVE.

Simultaneous identification of propeller fluctuating forces and unknown parameters based on a Bayesian inversion approach

Accurate quantification of propeller excitation is essential for effective vibro-acoustic analysis and mitigation in marine vessels. This study introduces a Bayesian statistical framework that indirectly reconstruct uncertain forces and system parameters by fusing available prior information, forward modeling and measured vibration responses through Bayesian theorem. The Markov Chain Monte Carlo (MCMC) algorithm, enhanced with Polynomial Chaos Kriging (PC-Kriging) surrogates, is employed to facilitate efficient estimation of likelihood functions and robust uncertainty propagation, providing posterior probabilistic estimates and credible intervals for the identified forces. Additionally, the framework incorporates model class selection based on model evidence to determine the most plausible empirical spectrum model for the propeller broadband thrust spectrum. Specifically, this study proposes and evaluates two candidate empirical spectrum models, the Ornstein–Uhlenbeck (OU)-Gaussian and OU-Weibull models, which effectively capture the frequency–amplitude characteristics of unsteady thrust. Numerical results demonstrate substantial parameter uncertainty reduction, accurate thrust spectrum reconstruction, and effective quantification of statistical properties. Moreover, the OU-Gaussian model is revealed to be more plausible for characterizing the propeller thrust spectrum and response prediction. This framework may offer a practical solution for propeller excitation identification, enabling rapid vibro-acoustic performance assessments of marine vessels.

Quaternion-Aware Low-Rank Prior for Blind Color Image Deblurring

Blind image deblurring is a critical and challenging task in the field of imaging science due to its severe ill-posedness. Appropriate prior information and regularizations are normally introduced to alleviate this problem. Inspired by the fact that the matrix representing a natural image is intrinsically low-rank or approximately low-rank, we employ the low-rank matrix approximation (LRMA) approach for tackling blind image deblurring problems with unknown kernels. When applied to color image restoration tasks, making use of the quaternion representation in the hypercomplex domain enables us to better illustrate the inner relationships among color channels and thus more accurately characterize color image structure. Following this idea, we develop a novel model for color image blind deblurring by implementing the quaternion representation to the LRMA method. This proposed model facilitates better results for blur kernel estimation through preserving the sharper color intermediate latent image, which is first implemented for addressing the blind color image deblurring problem. Extensive numerical experiments demonstrate that our proposed quaternion-aware low-rank prior model greatly improves the performance when compared with the conventional low-rank based scheme and outperforms some of the state-of-the-art methods in terms of some criteria and visual quality.

A Bayesian network-based probabilistic framework for seismic vulnerability assessment of road networks

After an earthquake, roadside debris from collapsed buildings, structural damage to bridges, and large-scale emergency evacuations are major obstructions to the connectivity of road networks (RNs). However, few studies have comprehensively examined the impact of all these obstructions on the seismic vulnerability of RNs while considering uncertainties. In this paper, a novel probabilistic framework is proposed for seismic vulnerability assessment of RNs based on Bayesian networks (BNs). Herein, the vulnerability of RNs is defined as a combination of the failure probability of a road link and its conditional consequences in terms of network dis-connectivity. The framework can be used to assess the effects of debris distributions, the functionality losses of bridges, and evacuation flows on the failure probabilities of road links and the seismic vulnerability of RNs. Uncertainties in the post-earthquake damage states of buildings and bridges, building collapse types, building-to-road distances, and travel costs are explicitly considered and propagated in the framework using Monte Carlo (MC) simulations. The MC results are used to establish prior probabilities, and based on bidirectional inference with BNs, it is possible to assess the seismic vulnerability of RNs and identify critical roads. The proposed methodology is verified through a real-world RN in China.

Multisensory perceptual and causal inference is largely preserved in medicated post-acute individuals with schizophrenia.

Hallucinations and perceptual abnormalities in psychosis are thought to arise from imbalanced integration of prior information and sensory inputs. We combined psychophysics, Bayesian modeling, and electroencephalography (EEG) to investigate potential changes in perceptual and causal inference in response to audiovisual flash-beep sequences in medicated individuals with schizophrenia who exhibited limited psychotic symptoms. Seventeen participants with schizophrenia and 23 healthy controls reported either the number of flashes or the number of beeps of audiovisual sequences that varied in their audiovisual numeric disparity across trials. Both groups balanced sensory integration and segregation in line with Bayesian causal inference rather than resorting to simpler heuristics. Both also showed comparable weighting of prior information regarding the signals' causal structure, although the schizophrenia group slightly overweighted prior information about the number of flashes or beeps. At the neural level, both groups computed Bayesian causal inference through dynamic encoding of independent estimates of the flash and beep counts, followed by estimates that flexibly combine audiovisual inputs. Our results demonstrate that the core neurocomputational mechanisms for audiovisual perceptual and causal inference in number estimation tasks are largely preserved in our limited sample of medicated post-acute individuals with schizophrenia. Future research should explore whether these findings generalize to unmedicated patients with acute psychotic symptoms.

Structural damage prediction based on Bayesian updating with Monte Carlo sampling

A series of engineering accidents in recent years have caused people to worry about the safety of engineering structures. As buildings continue to age, engineering accidents are increasing, and it is necessary to monitor their health. Bayesian updating can determine the probability of damage to a structure by collecting a posteriori information, and can more accurately estimate the location and extent of damage, thereby predicting the risk of structural damage and repairing the damage in time, significantly improving engineering efficiency. This paper attempts to update the information of the simulated structure based on the Bayesian updating method to obtain a more accurate posterior distribution of the potentially damaged components to demonstrate the feasibility and superiority of the technique. This paper finds that Bayesian updating can be used in conjunction with modeling software such as SMsolver. By constructing a structural model with SMsolver and processing the data with Bayesian updating, it is possible to calculate the damage problems of the structure accurately. At the same time, this paper also uses Monte Carlo sampling technology in combination with the Bayesian updating method to explore the prediction effect of structural damage. Using Monte Carlo sampling methods, the failure probability and damage location of the structure can be effectively estimated under the condition of known prior information, thereby improving production efficiency and the accuracy of structural inspection.

Variational inference based on a subclass of closed skew normals

Gaussian distributions are widely used in Bayesian variational inference to approximate intractable posterior densities, but the ability to accommodate skewness can improve approximation accuracy significantly, when data or prior information is scarce. We study the properties of a subclass of closed skew normals constructed using affine transformation of independent standardized univariate skew normals as the variational density, and illustrate how it provides increased flexibility and accuracy in approximating the joint posterior in various applications, by overcoming limitations in existing skew normal variational approximations. The evidence lower bound is optimized using stochastic gradient ascent, where analytic natural gradient updates are derived. We also demonstrate how problems in maximum likelihood estimation of skew normal parameters occur similarly in stochastic variational inference, and can be resolved using the centered parametrization. Supplemental materials are available online.

Anisotropic regularization for inversion of fast-ion loss detector measurements

Abstract We introduce an anisotropic regularization framework for the reconstruction of distribution functions from measurements, utilizing an approach that applies distinct regularization techniques such as non-negative constrained Tikhonov, total variation, and Besov-space priors, either penalizing the one-norm or the two-norm, in each dimension to reflect the anisotropic characteristics of the multidimensional data. This method, applied to fast-ion loss detector (FILD) measurements, demonstrates a significant improvement over conventional nonnegative-constrained zeroth-order Tikhonov regularization because the prior information of the form of the distribution allows better reconstructions. The validity of the approach is corroborated through FILD measurements of prompt fast-ion losses in an ASDEX Upgrade discharge, where the reconstructed distribution function agrees well with the prompt-loss distribution predicted by ASCOT simulations. Moreover, we develop a composite quality metric, Q, that combines the mean squared error and the Jaccard index for a comprehensive evaluation of reconstruction accuracy and spatial fidelity. Finally, anisotropic regularization is applied to FILD measurements at ASDEX Upgrade to study fast-ion acceleration by edge-localized modes. The refined analysis resolves fine structure in the pitch of the accelerated ions and clearly shows that some ions are accelerated to over twice the injection energy.

Kinetic profile inference with outlier detection using support vector machine regression and Gaussian process regression

Abstract We propose an outlier-resilient Gaussian process regression (GPR) model supported by support vector machine regression (SVMR) for kinetic profile inference. GPR, being a non-parametric regression using Bayesian statistics, has advantages in that it imposes no constraints on profile shapes and can be readily used to integrate different kinds of diagnostics, while it is vulnerable to the presence of even a single outlier among a measured dataset. As an outlier classifier, an optimized SVMR is developed based only on the measurements. Hyper-parameters of the developed GPR model with informative prior distributions are treated in two different ways, i.e. maximum a posteriori (MAP) estimator and marginalization using a Markov Chain Monte Carlo sampler. Our SVMR-supported GPR model is applied to infer ion temperature Ti profiles using measured data from the KSTAR charge exchange spectroscopy system. The GPR-inferred Ti profiles with and without an outlier are compared and show prominent improvement when the outlier is removed by the SVMR. Ti profiles inferred with the MAP estimator and the marginalization scheme are compared. They are noticeably different when observation uncertainties are not small enough, and the marginalization scheme generally provides a smoother profile.