Underweight Subjects Research Articles

Effects of canned pineapple consumption on nutritional status, immunomodulation, and physical health of selected school children.

This randomized, controlled trial examined the effects of canned pineapple consumption on immunomodulation, nutritional status, and physical health of ninety-eight (98) school children with mean age of 8.44 ± 0.20. The study participants were divided into three groups: Group A (33) includes subjects who were not given canned pineapple, Group B (33) includes those who were given 140 g, and Group C (32) includes those given 280 g of canned pineapple for nine weeks. Each major group was further divided into two groups: normal (N) and underweight (U) based on 2007 WHO Growth Reference Standards. Sociodemographic, anthropometric, physical examination, dietary intake, hemoglobin level, and immunological data were analyzed. Results showed a decrease in incidence of viral and bacterial infections for both Group B and Group C (normal and underweight) after canned pineapple consumption. Granulocyte production increased by 0.77–26.61% for normal weight subjects and 14.95–34.55% for underweight. CD16+56 count augmented by 20.44–22.13% for normal weight and 3.57–15.89% for underweight subjects. Thus, intake of both one can (140 g) and two cans (280 g) of canned pineapple may shorten the duration and incidence of infection and may increase the production of granulocytes and CD16+56, but intake of two cans (280 g) demonstrated higher granulocyte and CD16+56 production. This trial is registered with Philippine Health Research Registry: PHRR140826-000225.

Evaluation of serum adiponectin concentrations among drug abusers on methadone maintenance treatment.

Background:Adiponectin, an adipocyte-derived protein, modulates a number of metabolic processes. Methadone maintenance treatment (MMT) changes the level of hormones produced by adipose tissue in addicts. However, current data remains contradictory.Objectives:The aim of this study was to evaluate the effect of MMT on serum adiponectin levels in drug addicts.Materials and Methods:Twenty-five drug abusers with a mean age of 37.4 ± 8.7 years were referred to the Baharan Hospital, Zahedan, and 22 healthy age-matched control subjects with a mean age of 35 ± 9.5 years were enrolled in the study. Addicts were treated with methadone at (40 to 120 mg/d) for six months. Measurement of anthropometric parameters, serum adiponectin, and biochemical parameter levels, were assessed in the addicts, before and after six months of MMT, but only once in the healthy controls.Results:The mean basal serum adiponectin level was not significantly lower in the drug abuser group compared to the healthy subjects (P > 0.05). After six months of MMT, the mean serum adiponectin level of the drug addicts was not significantly different from their mean baseline level or that of the healthy subjects (P > 0.05). However, the mean baseline serum adiponectin level was significantly lower in overweight/obese addicts when compared to underweight patients and healthy individuals (P < 0.001). After six months of MMT, the mean level of serum adiponectin increased significantly in the underweight subjects compared to the normal weight and overweight/obese subjects (P < 0.0001) and the control group (P < 0.001). Adiponectin concentration was correlated inversely with body mass index and positively correlated with waist circumference and serum high-density lipoprotein levels.Conclusions:This study showed that MMT did not markedly alter the concentration of serum adiponectin in drug abusers. However, in regard to the variations in the serum lipid profiles and anthropometric parameters, the findings indicated that low concentrations of serum adiponectin might play a role in the pathogenesis of obesity and other metabolic abnormalities. Thus, more long-term studies with larger sample sizes are recommended.

Hypertension and kidney function in an adult population of West Bengal, India: Role of body weight, waist circumference, proteinuria and rural area living

Hypertension (HTN) and chronic kidney disease (CKD) are important emerging problems in low-income countries, with an increasing number of patients dying from their consequences. A project for investigating these issues was carried out in West Bengal, India, in 2536 adult subjects. Body mass index (BMI) was classified using traditional and new cut-offs identified by the World Health Organization for Asian populations. HTN was classified according to the Joint National Committee 7 and CKD according to presence of estimated glomerular filtration rate (eGFR) of less than 60 mL/min per 1.73 m(2) . Normal BMI (Asian reference) was found in 41.5% of subjects, while 33.4% were underweight, 19.3% overweight and 5.8% obese. Prevalence of stage 1 and 2 HTN was 39.4%. Proteinuria (urine dipstick >1+) was present in 7.7% of the sample. In a subsample of 1526 subjects, eGFR of less than 60 mL/min per 1.73 m(2) was found in 4.2%. At multivariate analysis, factors associated with HTN were weight classes (P<0.001), presence of proteinuria (P<0.001) and family history of HTN (P=0.028), while living in rural areas was associated with lower risk for HTN (P=0.003). eGFR was inversely related to BMI (P=0.03), the presence of proteinuria (P<0.001) and HTN (P<0.003), and directly related to living in rural areas (P=0.003). High prevalence of HTN was found in subjects with very limited access to health care in West Bengal. HTN was more common in overweight individuals, but also affected normal weight and underweight subjects in a significant part of the tested population. Preventive medicine should be a strong priority in this setting.

Correlation between body mass index and waist circumference in nigerian adults: implication as indicators of health status.

BackgroundAnthropometric measures have been widely used for body weight classification in humans. Waist circumference has been advanced as a useful parameter for measuring adiposity. This study evaluated the correlation between body mass index (BMI) and waist circumference and examined their significance as indicators of health status in adults.Design and methodsThe subject included 489 healthy adults from Ota, Nigeria, aged between 20 and 75 years, grouped into early adulthood (20-39 years), middle adulthood (40-59 years) and advanced adulthood (60 years and above). Weight, height and abdominal circumference were measured. BMI was calculated as weight kg/height2 (m2) and World Health Organization cut-offs were used to categorize them into normal, underweight, overweight and obese.ResultsAbnormal weight categories accounted for 60 % of the subjects (underweight 11 %, overweight 31%, and obese 18%). The waist circumference of overweight and obese categories were significantly (P<0.05) higher than the normal weight category. There was no significant difference between waist circumference of underweight and normal subjects. The correlation coefficient values of BMI with waist circumference (r=0.63), body weight (r=0.76) and height (r=-0.31) were significant (P<0.01) for the total subjects.ConclusionsThe study indicates that waist circumference can serve as a positive indicator of overweight and obesity in the selected communities; however, it may not be used to determine underweight in adults. Regular BMI and waist circumference screening is recommended as an easy and effective means of assessing body weight and in the prevention of weight related diseases in adults.Significance for public healthThis manuscript describes the correlation between body mass index, waist circumference and body weight of two communities in Ota, Ogun State, Nigeria and the use of these anthropometric measures for body weight classification in human populations of the selected communities. This was carried out to evaluate the health status of the indigenes of the two communities for proper health awareness and public health intervention programmes.

2·30대 저체중 여성의 상의 치수체계 제안

This study helps out-size consumers purchase tops and improve the fitness of unde-weight women in their 20s-30s and by the establishment of a size system. The criteria for subjects in this study were those under 18.5(<TEX>$kg/m^2$</TEX>) of the BMI; subsequently, a total of 233 females were enrolled. The results were: First, the nominal size for female adult formal dress suggested by the KS standard is suggested in 20 sections. The sections for underweight women are 7, (34 women who accounted for 14.59% out of 233 in total). The cover efficiency was 2.08% (which was very low). Second, tests showed that the average difference between the reference part body size of 7 sections for underweight women in the normal size section of bust cir.- hip cir.- height, and KS standard, waist cir. among reference sizes was rather small in the case of a nominal size for long height. Therefore, there is a significant difference with size in the KS standard and a sizing system proven improper for underweight woman. Third, the basic body sizes and reference body sizes were different due to the size system establishment according to measurements of underweight subjects. The research findings suggest that it is necessary to understand underweight types according to bust girth and hip girth sizes that represent basic sizes as well as to design patterns that consider the underweight body shape characteristics when women's tops are designed.

THU0532 Distribution of Body Mass Index and Metabolic Syndrome in Patients with Inflammatory Autoimmune Diseases from a Single Italian Centre

BackgroundObesity is at now considered as a mild, long-lasting inflammatory disease associated with an increased cardiovascular (CV) risk. On the other hand, rheumatic diseases have been associated with increased CV...

Body mass index, body mass change, and risk of oral cavity cancer: results of a large population-based case–control study, the ICARE study

The association between body mass index (BMI) and the risk of oral cavity cancer, suggested by the few available studies, is controversial because of weight loss preceding cancer diagnosis and possible confounding by tobacco and alcohol consumption. The aim of this study was to evaluate in France, a high-incidence country, the association between the risk of oral cavity cancer and body mass index at interview, 2 years before the interview and at age 30, as well as BMI change. We used data from a population-based case-control study, the Investigation of occupational and environmental CAuses of REspiratory cancers study, with personal interviews and standardized questionnaires including 689 cases of oral cavity squamous cell carcinoma and 3,481 controls. Odds ratios (ORs) and 95% confidence intervals (95% CI) were estimated by unconditional logistic regression and were adjusted for gender, age, area of residence, education, tobacco smoking, and alcohol drinking. ORs were increased in underweight subjects at interview (OR 6.25, 95% CI 3.74-10.45). No association with underweight 2 years before the interview and at age 30 was found. Overweight and obesity at interview, 2 years before the interview and at age 30 were associated with decreased ORs (ranging from 0.13 to 0.60). BMI gain greater than 5% between age 30 and 2 years before the interview was inversely associated with oral cavity cancer (OR 0.42, 95% CI 0.33-0.54). These associations were stronger in men, and in smokers and drinkers. These results add further support to the existence of a reduced risk of oral cavity cancer among overweight and obese people or among people who increased their BMI in adulthood. The underlying mechanisms remain to be clarified.

Inverse association between body mass index and chronic kidney disease in older diabetic adults

PurposeTo identify associations among body mass index (BMI), diabetes, and chronic kidney disease (CKD) in older adults in Taiwan. MethodsThis study enrolled 3334 participants aged 65 years and above who underwent an annual health screening at a medical center from January 2006 to December 2010. CKD was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m2. A multiple logistic regression analysis was used to determine associations among BMI, diabetes, and CKD. ResultsThe prevalence rate of CKD was 19.7% and 10.5% in diabetic and nondiabetic subjects, respectively. A multivariate model indicated that age, diabetes, hypertriglyceridemia, low levels of high-density lipoprotein cholesterol, and hyperuricemia were associated with an increased risk of CKD. Furthermore, there was an inverse association between BMI and CKD in older diabetic patients, with odds ratios of 3.71, 2.32, 2.12, and 1.31 in underweight, normal, overweight, and obese subjects, respectively, compared with nondiabetic subjects of normal weight. ConclusionsThere was an inverse association between BMI and CKD in older diabetic patients but no such association was found in nondiabetic older adults. More attention should be given to older underweight diabetic patients because they have a higher risk of CKD.

IS THERE AN ASSOCIATION BETWEEN BODY MASS INDEX AND MIGRAINE HEADACHES WITHIN THE CANADIAN POPULATION?

IntroductionObesity (a body mass index ≥30 kg/m2) and migraine headaches are both chronic conditions that have become increasingly common within the Canadian population. Increasing body mass index (BMI) is associated...

Examination of the Relationship of Dairy Product Consumption and Dietary Calcium with Body Mass Index Percentile in Children

Aim: The purpose of this study was to assess the relationships of dairy product and calcium intake with BMI percentile in children. Methods: In this cross-sectional analysis, the relationships of dairy product (cup equivalents/day) and dietary calcium (mg/day) (measured by 24 hour recall) consumption with BMI percentile [derived from Centers for Disease Control and Prevention (CDC) sex-specific BMI-for-age growth charts] were assessed in 101 healthy U.S. children (ages 8-13). Results: Subject characteristics included (mean + SD): dairy product consumption (2.8 + 1.4 cup equivalents/day), dietary calcium (1039.4 + 431.4 mg/day), and BMI percentile (70.1 + 29.7). Dairy product intake and dietary calcium were inversely related to BMI percentile (p= 0.005). In subjects &lt;85th BMI percentile (n= 50 normal weight and n= 3 underweight), there was an inverse association of dairy product intake with BMI percentile (p= 0.001) and calcium intake with BMI percentile (p&lt; 0.001). However, no association of dairy product consumption or calcium intake with BMI percentile was observed in overweight (85th percentile ≤ BMI &lt; 95th percentile, n= 19) or obese subjects (BMI &gt; 95th percentile, n= 29). Removal of underweight subjects from the analysis only minimally impacted the results. Differences in dietary intake (MyPyramid food groups, calories, macronutrients, micronutrients) among normal, overweight, and obese subgroups were examined. No significant differences were detected between groups, and removing underweight subjects did not change the findings. Conclusions: These results provide the basis for further investigation into a potential role of dairy and calcium in achieving a healthy body weight in children.

Poor desynchronisation of resting-state eyes-open cortical alpha rhythms in obese subjects without eating disorders

ObjectiveObese subjects without eating disorders were characterised by poor electroencephalographic (EEG) alpha rhythms during resting-state eye-closed condition (Babiloni et al., 2011b). Is this true also for the desynchronisation of alpha rhythms during resting-state eyes opening? MethodsEEG data were recorded in 15 underweight, 20 normal-weight, and 18 overweight/obese subjects during resting-state eyes-closed and -open conditions. EEG sources were estimated by LORETA for alpha 1 (8–10.5Hz) and alpha 2 (10.5–13Hz). The alpha desynchronisation was calculated as the difference eyes-open minus -closed condition. ResultsThe occipital alpha 1 desynchronisation was lower in overweight/obese and underweight subjects compared with normal-weight subjects (p<0.000005). The same was true for parietal, occipital and temporal alpha 2 (10.5–13Hz) desynchronisation (p<0.000002). The parietal and temporal alpha 1 desynchronisation was lower in overweight/obese than in normal-weight subjects (p<0.00001). These effects spatially matched those observed in the resting-state eyes-closed condition. ConclusionSubjects with abnormal weight and normal eating behaviour are characterised by poor alpha desynchronisation during resting-state eyes opening. SignificanceObese subjects without eating disorders show abnormal mechanisms of cortical neural synchronisation and desynchronisation of alpha rhythms in the resting state condition.

Pretreatment dietary patterns, weight status, and head and neck squamous cell carcinoma prognosis

Few studies have evaluated the association of diet and weight status with head and neck cancer outcomes. The purpose of this study was to determine whether pretreatment dietary patterns and weight status are associated with head and neck cancer prognosis. This was a longitudinal study of 542 patients with newly diagnosed head and neck cancer who completed food-frequency questionnaires and health surveys before treatment. Clinical data were abstracted from medical records and the Social Security Death Index. Dietary patterns were identified by using principal component analysis. Cox proportional hazard models were used to examine the association of derived dietary patterns (fit by quintiles of exposure) and weight status with time to recurrence and survival, with control for covariates. During the study period, there were 229 deaths and 184 recurrences. Two dietary patterns were identified: a whole-foods pattern (characterized by high intakes of vegetables, fruit, fish, poultry, and whole grains) and a Western pattern (characterized by high intakes of red and processed meats, refined grains, potatoes, and French fries). In multivariable analyses, significantly fewer deaths were observed in subjects most adherent to the whole-foods pattern (HR: 0.56; 95% CI: 0.34, 0.92; P-trend = 0.01). Subjects classified as overweight or obese had significantly fewer deaths (HR: 0.65; 95% CI: 0.49, 0.85; P = 0.001) and recurrences (HR: 0.70; 95% CI: 0.52, 0.95; P = 0.02) than did normal-weight or underweight subjects. Consumption of a diet rich in vegetables, fruit, fish, poultry, and whole grains and being overweight before diagnosis with head and neck cancer are associated with a better prognosis.

Do body mass index and fat volume influence vocal quality, phonatory range, and aerodynamics in females?

To analyze the impact of body weight and body fat volume on selected parameters of vocal quality, phonatory range, and aerodynamics in females. Based on measurements of body mass index in combination with body fat volume, 29 normophonic female subjects were classified as normal weight, underweight, and obese. Voice quality was investigated via auditory-perceptual ratings of breathiness, roughness, and overall dysphonia severity, via various acoustic measures and a multiparametric index. Phonatory range performance was examined using selected measures of the voice range profile and speech range profile. Measures of vocally relevant aerodynamics included vital capacity (i.e., VC), expected VC, phonation quotient, and maximum phonation time (i.e., MPT). Significant differences between the three weight groups were found across several measures of intensity, VC, MPT, and shimmer. As compared to the other groups, significantly higher values of maximum and minimum intensity levels, as well as sound pressure level during habitual running speech were observed for the obese group (all p-values<0.05); whereas, the underweight group had significantly lower values for VC and ratio of expected to measured VC (p-values<0.01). Furthermore, underweight subjects differed significantly as compared to normal weight subjects with lower MPT (p=0.025) and higher lowest-F0 (p=0.035). Finally the obese group showed significantly lower shimmer values than the normal weight subjects (p<0.05). Body weight and body fat volume appear to influence select objective measures of voice quality, vocal aerodynamics, and phonatory range performance.

Underweight and overweight men have greater exercise-induced dyspnoea than normal weight men

Introduction. Persons with high or low body mass index (BMI), involved in clinical or mechanistic trials involving exercise testing, might estimate dyspnoea differently from persons with a normal BMI.Aims. Our objective was to investigate the relationship between BMI and dyspnoea during exercise in normal subjects with varying BMI.Material and methods. A total of 37 subjects undertook progressive exercise testing. Subjects were divided into three groups: underweight (UW), normal weight (NW), and overweight (OW). Dyspnoea was estimated using the visual analogue scale (VAS). Spirometry, maximum voluntary ventilation (MVV), and respiratory muscle strength (RMS) were measured.Results and discussion. The intercept of the VAS/ventilation relationship was significantly higher in NW subjects compared to UW (P = 0.029) and OW subjects (P = 0.040). Relative to the OW group, FVC (P = 0.020), FEV1 (P = 0.024), MVV (P = 0.019), and RMS (P = 0.003) were significantly decreased in the UW group. The greater levels of dyspnoea in UW subjects could possibly be due to decreased RMS. Healthy persons should aim to achieve an optimum BMI range to have the lowest exercise-induced dyspnoea.

Does reference value of “Normal Liver Stiffness” using fibroscan have a regional variation?

We read with interest the recently published article by Das et al.,1 where the investigators have reported a U-shaped distribution of liver stiffness measure (LSM) among healthy subjects categorized as per body mass index (BMI), and proposed 8.5 KPa as the upper limit of normal (ULN) of LSM in healthy Indian subjects. Such observations can have significant implications in clinical practice. This is a well-conducted study; however, the investigators' interpretation about U-shaped distribution of LSM is not supported by strong data. The mean LSM was similar over a broad range of BMI (18-29.9 kg/m2), and higher values of LSM at one extreme were based on data of obese persons, which were only 4 (<1%) in number. Furthermore, as per the Asian standard of BMI categories, the distribution pattern of LSM would not have been U-shaped. Although underweight subjects had significantly higher LSM values than healthy and preobese subjects, the mean difference in absolute value was only 0.5 KPa, suggesting that the body-size effect is not perceptible using the current FibroScan machines. The ULN of LSM has been reported to vary from 5.3 to 7.0 KPa in various studies,2, 3 including one study based on histopathology.2 Thus, 8.5 kPa as the ULN of LSM seems too high for a healthy liver in any given population across the world. Such a high cutoff may erroneously cause the exclusion of healthy subjects or patients who would require further evaluation. Though this value corresponded to the 95th percentile, the dispersion of data (mean, 95% confidence interval) revealed that 414 of 418 healthy subjects actually had LSM values within 6.5 KPa, as shown in Fig. 2 of the Das et al. study.1 Notably, sufficient investigations were not done to exclude potential underlying liver disease in healthy subjects with high LSM. Also, approximately 16% of LSM results are known to be unreliable. In our experience, in a cohort of 445 healthy adult subjects, the mean LSM value was 5.1 ± 1.1 KPa, and the 95th percentile value was 7.07 KPa. LSM values increased with increasing BMI categories (4.1 ± 0.7, 5.08 ± 0.6, and 6.08 ± 1.2 KPa in healthy BMI, overweight, and obese subjects, respectively).3 None of our patients belonged to the underweight category; hence, the distribution of LSM cannot be compared with the present study. To conclude, the present study results seem to have limited external validity. However, the background population and properly validated regional data are important while interpreting LSM using FibroScan. Ramesh Kumar M.D., D.M.*, Manoj Kumar Sharma M.D., D.M.*, Shiv Kumar Sarin M.D., D.M.*, * Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Physical Fitness, Physical Activity and Sedentary Activities of 7 to 11 Year Old Boys with Different Body Mass Indexes

The purpose of this study was to examine the differences in physical fitness, physical activity, and sedentary activities among 7 to 11 year old boys with varying body mass index in Ardabil, Iran. The sample consisted of 766 boys who participated in eight weight bearing (1 mile walk/run, sit ups, standing long jump, vertical jump, shuttle run 4 × 10 m, 30-meter sprint, pull ups, pushups) and four non-weight-bearing physical fitness tests (flamingo balance, handgrip; sit and reach and finger reaction time). Physical activity and sedentary activities were assessed by questionnaires. Body mass index (BMI) was computed to classify participants into normal weight, underweight, overweight and obese groups. The prevalence of underweight, overweight and obesity was 10.7%, 14.1% and 4.2% respectively. Cardiorespiratory fitness (VO(2max)) decreased progressively as the BMI increased and differences among the all body mass index categories were significant (P<0.01). Obese subjects performed worse in all weight bearing fitness tests than normal weight subjects (P<0.01). Moreover, overweight subjects performed worse in one mile, pushups and pull ups than normal weight subjects (P<0.01). Underweight subjects had significantly lower Pushups than normal weight subjects (P<0.01). Obese subjects had significantly higher sedentary activities and lower physical activity than other counterparts (P<0.01). This study showed that weight bearing physical fitness, cardiorespiratory fitness and physical activity progressively decreased as the BMI increased and conversely, sedentary activities increased as the BMI increased.

Functional tooth units and nutritional status of older people in care homes in Indonesia

To investigate the relationship between functional tooth units (FTUs) and nutritional status. One hundred females (mean age: 72.4 ± 8.2 years) at four private care homes in Jakarta, Indonesia were interviewed and clinically examined. The oral examination included the assessment of teeth, prosthetic status, and number of FTUs. The total number of FTUs was further divided by tooth composition: natural tooth against natural tooth (NN-FTUs), natural tooth against denture (ND-FTUs), and denture against denture (DD-FTUs). Nutritional status was evaluated using the body mass index (BMI) and the Mini Nutritional Assessment (MNA). The mean numbers of teeth present, NN-FTUs, ND-FTUs, DD-FTUs, and total FTUs were 13.1 ± 10.4, 1.7 ± 3.0, 1.2 ± 3.3, 0.4 ± 1.2 and 3.3 ± 4.4, respectively. The mean BMI and MNA scores were 24.8 ± 5.0 and 22.6 ± 2.8, respectively. Subjects with a normal BMI had a significantly higher total number of FTUs (3.6 ± 4.6) compared with underweight subjects (0.1 ± 0.3). Subjects with a normal MNA had a significantly higher number of NN-FTU (2.6 ± 3.7) compared to those who were at risk or in a state of under-nutrition (1.2 ± 2.4). This study revealed significant relationships between the number of FTUs and nutritional status. Keeping the posterior occlusion should be emphasized in order to maintain good nutritional status in older subjects.

Ureteral Calculi Detection Using Low Dose Computerized Tomography Protocols is Compromised in Overweight and Underweight Patients

Low dose computerized tomography protocols have demonstrated a reduction in radiation exposure while maintaining excellent sensitivity and specificity in the detection of stones in patients of average size. Low dose computerized tomography protocols have not yet been evaluated in subjects in the extremes of weight. We evaluated the effect of body weight when using low dose protocols to detect ureteral calculi. Three cadavers of increasing weight (55, 85 and 115 kg) were prepared by inserting 721 calcium oxalate stones (range 3 to 7 mm) in 33 random configurations into urinary tracts. Cadavers were then scanned using a GE LightSpeed® at 7 radiation settings. An independent, blinded review by a radiologist was conducted to generate ROC curves, with areas under the curve compared using a 1-way ANOVA (α = 0.05). Sensitivity and specificity were significantly lower in the low and high weight cadavers compared to the medium weight cadaver at 5 mAs (p <0.001) and 7.5 mAs (p = 0.048). Differences in sensitivity and specificity at radiation settings of 15 mAs or greater were not significant. The sensitivity and specificity for the detection of ureteral calculi on computerized tomography were decreased for underweight and overweight subjects when using extremely low dose radiation settings (less than 1 mSv). Low dose protocols of 15 mAs (2 mSv) can still be used for these subjects without jeopardizing the ability to identify ureteral stones.

Symptoms and quality of life in underweight gastroesophageal reflux disease patients and therapeutic responses to proton pump inhibitors

A correlation to obesity has been reported in patients with gastroesophageal reflux disease (GERD). However, insufficient data have been obtained regarding underweight GERD patients. Post hoc analysis of a multicenter prospective cohort study was conducted to evaluate subjective symptoms and health-related quality of life (HRQOL) in underweight GERD patients (body mass index [BMI] < 18.5) and to evaluate therapeutic response to proton pump inhibitors. A total of 2646 patients who underwent endoscopy were classified by BMI and analyzed. Rabeprazole was administered for 8 weeks. Subjective symptoms and HRQOL were assessed using questionnaires (F-Scale and SF-8™). Baseline endoscopy revealed 29.2% of patients had non-erosive reflux disease (NERD). Underweight status was identified in 5.8% of GERD patients, and mean baseline symptoms score and SF-8 physical component summary (PCS) score were 18.6 and 42.4, respectively, reflecting greater impairment compared with the values of 15.4 and 45.6 in normal-weight patients (BMI ≥ 22 but < 25). Treatment with rabeprazole resulted in a decrease from 18.6 at baseline to 6.7 at week 8 in underweight reflux esophagitis subjects, and from 15.0 to 6.3 in underweight NERD patients. PCS score improved in underweight patients. These changes were about the same as in normal-weight or obese patients. Japanese GERD patients are often obese, as reported previously, but some GERD patients are underweight. Baseline symptoms and QOL in underweight GERD patients tended to be more severe than in normal-weight patients, but therapeutic response with proton pump inhibitors was about the same as in normal-weight or obese patients.

Body mass index was positively correlated with blood triglyceride and total cholesterol levels

To investigate the associations among anthropometric and selected biochemical indices, fasting blood samples were obtained from 208 healthy adults (62 males, 146 females), 20–64 y old, living in South Korea. Weight and height were measured, and body mass index (BMI) was calculated. According to WHO BMI cut‐offs for Asians, 5.8% were underweight; 40.9%, normal weight; 28.9%, overweight; and 24.5%, obesity. Plasma triglyceride levels (TG) of 43.6% were &gt;=150 mg/dl and 22.1% had plasma total cholesterol levels (TC) &gt;=200 mg/dl. TG of overweight and obese subjects were significantly higher than those of underweight and normal subjects (p&lt;0.05). TC of obese subjects was significantly higher than those of underweight and normal subjects. Total protein and albumin levels were positively correlated with height (r=0.32237, p&lt;0.0001; r=0.16231, p=0.0192, respectively). TG and TC had positive correlations with BMI (r=0.24891, p=0.0003; r=0.20752, p=0.0026, respectively), but HDL‐cholesterol levels had a negative correlation with BMI (r=−0.24689, p=0.0003). The findings of this study indicate that BMI is positively correlated with blood lipid concentrations, TG and TC. To reduce a risk of cardiovascular diseases related to hyperlipidemia, weight control programs with nutritional education may be of benefit to Koreans. Supported by 2011 research fund of National Research Foundation of Korea (2011‐0021273).