Objective — to learn the content of certain microand macro elements in serum and erythrocytes of blood, as well as in the affected and unchanged parts of the removed lung preparation in the first diagnosed TB patients.Materials and methods. 61 patients with the first diagnosed infiltrative (45 persons) and disseminated (16 persons) pulmonary tuberculosis were examined. The control group consisted of 50 healthy, similar in age and gender.The content of chemical elements in erythrocytes (iron, copper, zinc, magnesium, manganese, calcium, potassium and sodium), blood serum (iron, copper, zinc, magnesium and calcium) and in the preparation of the removed lung tissue (iron, copper, zinc, magnesium, manganese, calcium, potassium and sodium) were determined on a C 115 atomic absorption spectrophotometer.Results and discussion. The content of zinc and calcium in serum, as well as iron, magnesium, calcium and potassium in erythrocytes of tuberculosis patients is significantly lower than in the control group, while the content of copper, manganese and sodium in erythrocytes of patients was higher compared with healthy persons. Changes in the content of chemical elements in preparations of the affected areas of the lungs, mainly, correlate with the content of chemical elements in the blood of TB patients. All this indicates the presence of metabolic disturbances in patients, dysmicroelementosis syndrome and associated hypoxia as a result of tuberculosis intoxication.Conclusions. In patients with first diagnosed infiltrative and disseminated pulmonary TB in serum and erythrocytes with a specific affected process of the lung tissue, pronounced dysmicroelementosis was observed, both in the direction of decreasing and increasing the content of chemical elements in serum and erythrocytes in the preparations of the affected lung region, which affects the course of a specific process. A decrease in the iron content in erythrocytes is, to some extent, the cause of hypoxia, which is characteristic of these forms of TB, and an increase in the content of copper and manganese in erythrocytes (hemoglobin synthesis) is a compensatory reaction. The results of the study provide a basis for a more adequate approach to pathogenetic therapy, both due to a selected diet and microelement preparations. However, despite all this, the issue of chemical elements in the blood of patients with tuberculosis requires further careful study.
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