Ukrainian Population Research Articles

PREVALENCE AND STRUCTURE OF DENTO-MAXILLOFACIAL ANOMALIES IN CHILDREN

The high level of dental morbidity in the children's population of Ukraine remains one of the urgent problems of modern dentistry. Dental health is largely characterized by the correctness of the structure of the mandibular system, its proper functioning and balance, and its condition is one of the preventive and quite clearly fixed indicators of health/ ill health of the human body in general. The pathology of the maxillofacial system affects not only the state of health, but also the quality of life of the patient, his emotional and social well-being.
 In this context, information on the prevalence of dentomandibular abnormalities and the overall need for orthodontic treatment is essential to provide objective information to health care stakeholders in order to make an adequate allocation of health care resources based on objective epidemiological data. In addition, dento-mandibular anomalies, which are not detected and not eliminated in childhood, in the process of growth and development of the facial skeleton over time acquire more severe forms, which become more pronounced and are less amenable to treatment. Therefore, the analysis of the prevalence and severity of ASD in children is an important stage in the process of planning preventive and therapeutic measures.
 Data from literary sources indicate a high prevalence of dento-maxillofacial anomalies among children in different age periods and depending on the characteristics of the area of residence. In particular, the results of the examination of children aged eight months to seventeen years, residents of different regions of Ukraine, given in scientific works of recent years, indicate a high prevalence of dento-jaw anomalies (41%77.9%).
 The high prevalence of dento-mandibular anomalies indicates the need for timely diagnosis at the early stages of the development of orthodontic pathology, which will contribute to timely treatment, which will subsequently be able to ensure the normal development of the child's dento-mandibular system and improve the quality of life.

Current issues of research on special physical and psychological training of law enforcement forces in extreme conditions

To ensure the protection of the population of Ukraine and counteract these negative phenomena, it is necessary to continuously improve the system of training law enforcement forces and the readiness of the entire security sector to act in extreme situations. The analysis of special scientific and methodological literature showed that insufficient attention was paid to some aspects of the problem of improving the special physical, functional and psychological preparedness of law enforcement forces, in connection with which we consider the chosen direction of research to be relevant. The goal is to research the current state and study the features and importance of special physical and psychological training of law enforcement forces under the influence of extreme situations. We have developed and planned the implementation of a science-based training program (with additions and expansions of the existing program) to improve the special, functional and psychological training of law enforcement forces, taking into account extreme situations.

"PAHTS OF MEMORY": REALITIES AND PROSPECTS OF THE DOMESTIC TOURISM OF UKRAINE IN THE VIEW OF THE MEDIA

The article is devoted to the memorialization of the places that became some evidence of the Russian military crimes during their full-scale invasion of Ukraine. This publication is about the cities, villages, and streets where the blood of the Ukrainian military and civilians was suffered at the hands of the occupiers. It was proposed that some of these places (locations, complexes and trails) may create «Paths of memory». All of them should be included in the national tourist routes and in the programs of the country’s tourist operators. Thus, Ukrainians would be able to pay tribute to the memory of their fallen compatriots and to demonstrate the steadfastness of one nation and to testify the fact of the criminal actions of another nation to foreign visitors. This is necessary that history doesn’t happen again. There is an analysis of journalistic materials which were talking about the initiative of the paths of memory creation, places of widespread destruction of the buildings, infrastructure and about more important question – the killing of the population of Ukraine. The current situation of the objects, an

DYNAMICS OF THE LEVELS OF ASYMMETRIC DIMETHYLARGININE AND PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1 IN PATIENTS WITH ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION AND TYPE 2 DIABETES MELLITUS DEPENDING ON THE REPERFUSION STRATEGY

Introduction. Despite the major successes achieved in the treatment of acute coronary syndromes (ACS), acute myocardial infarction (AMI) remains the main cause of death among the working-age population of Ukraine. The means of treatment of interventional cardiology can actually reduce the mortality of patients with ACS, improve the course of the acute period of the disease and ensure less reduction in the functional capabilities of the heart in the future. Among the many pathogenetic mechanisms of vascular inflammation in coronary heart disease and type 2 diabetes, endothelial dysfunction is the determining factor.
 The aim of the study. To evaluate the levels of plasminogen activator inhibitor type 1, asymmetric dimethylarginine and endothelial nitric oxide synthase on the 10-14th day in patients depending on the presence or absence of concomitant diabetes type 2 and the type of reperfusion therapy.
 Materials and methods. 130 patients with acute myocardial infarction were examined, who were divided into 2 groups: 1 group consisted of patients with acute myocardial infarction with accompanying type 2 diabetes (n=73), 2 group – patients with acute myocardial infarction without type 2 diabetes (n =57). The quantitative content of the plasminogen activator inhibitor type 1 (PAI-1) was determined by the immunoenzymatic method using a commercial test system manufactured by Technoclone PAI-1 ELISA Kit (Austria), endothelial nitric oxide synthase (NOS) – Enzyme-Linked Immunosorbent Assay (ELISA) Kit For Nitric Oxide Synthase Endothelial, asymmetric dimethylarginine (ADMA) – Immunodiagnostik ADMA ELISA Kit (Austria).
 Results. Percutaneous coronary intervention (PCI) contributes to a more significant decrease in the content of the marker of endothelial dysfunction – ADMA and an increase in NOS on the 10-14th day of acute myocardial infarction in comparison with standard therapy. During PCI, the level of PAI-1 did not reliably change during treatment due to post-inflammatory and post-traumatic activation of platelets in the vascular wall.
 Conclusions. In patients with acute myocardial infarction with type 2 diabetes mellitus, percutaneous coronary intervention contributes to a significant decrease in the content of asymmetric dimethylarginine and an increase in NOS on the 10-14th day of acute myocardial infarction, but was not accompanied by a significant decrease in the level of PAI-1, which in general indicates positive effect of performed myocardial revascularization.

Legal And Economic Principles of Activity of Public Authorities Under the Legal Regime of Martial Law

In modern society, the legal and economic principles of public authorities are given top priority. In the context of the martial law regime, public authorities face a number of new challenges, the solution of which requires balanced and comprehensive solutions of both legal and economic nature. Today, the specific conditions of martial law, along with social and economic issues, actualize security challenges that are of paramount importance both among the population of Ukraine in general and in the activities of public authorities. Interaction with the public on security issues is a powerful tool for improving the image of public authorities. An equally important issue in the field of public authorities is the issue of countering separatism in the public service under martial law. The solution to this problem is not only to improve the processes of bringing perpetrators to justice, but also to improve the national strategy of national-patriotic education, legislation regulating public service, education, civic activity, etc.

PECULIARITIES OF LEGAL SUPPORT FOR THE FUNCTIONING OF THE CIVIL PROTECTION SYSTEM IN THE EU COUNTRIES

The article analyses the peculiarities of legal support of the European system of civil protection of population and territories. The author emphasizes that over the years, the EU has developed the main instruments through which all of its civilian security policy objectives are achieved.
 It is proved that building a modern and powerful civil defence system of the population and territories of Ukraine requires even more close cooperation with the relevant European structures, including within the framework of the European Union Civil Protection Mechanism (EU Civil Protection).
 The priorities of the EU's civil protection programs are to enhance cybersecurity and a safer online environment through the development and effective use of the digital capabilities of the European Union and its Member States. Significant attention is paid to supporting data and network protection, which strives for technological sovereignty while respecting privacy and other fundamental human rights. Joint European projects contribute to ensuring the security of services, processes and products, and ensure the formation of reliable digital infrastructures that can withstand and counter cyberattacks and hybrid threats.
 The study of the peculiarities of Ukraine's cooperation with the EU in the field of civil protection allows us to state that Ukraine's accession to the EU Civil Protection Mechanism will allow it to fully use all EU instruments and programs to develop the national civil protection system and attract assistance, and to continue future cooperation within the framework of the new strategic program of the EU Civil Protection Mechanism for 2024-2027.
 The peculiarities of using the experience of the EU countries to develop a system for ensuring public safety and protection of critical facilities during emergencies in Ukraine will be determined by the transformation of the public administration system in the post-war period.

Dermatoglyphic Phenotype in Patients with Cardiovascular Disease

Introduction. Since the predisposition to develop cardiovascular disease is genetically determined, it can be assumed that there are phenotypic features (in particular, dermatoglyphic) that allow predicting the predisposition to develop acute myocardial infarction (MI).
 The aim of the study was to determine the dermatoglyphic phenotype in patients with myocardial infarction.
 Materials and methods. The object of the study was dermatoglyphs of distal phalanges of the fingers obtained from 60 male subjects (30 patients with myocardial infarction and 30 healthy men without cardiovascular pathology as a control group). The dermatoglyphic method and the method of statistical analysis were used.
 Results. It was found that patients with MI had a higher frequency of curl patterns, but a lower frequency of ulnar and radial loops and arc patterns compared to the control group. The value of the comb count in patients with MI was lower than in the control group (p>0.05). The total comb count of the palmar fields a-b, c-d was higher, and the fields b-c were lower in patients with MI than in the control group. The mean value of the angle Аtd on both hands was higher in patients with MI than in the control group. Palm patterns and folds showed no significant differences between the groups.
 Conclusions
 The results of this study can be used to standardize the dermatoglyphic pattern of the Ukrainian population and identify individuals prone to MI.

Relationship between hyperleptinemia and cardiometabolic risk in persons with obesity

Background. Obesity remains a global social and medical problem today. The results of recent research demonstrate the pre­sence of overweight in 30–70 % and obesity in 10–30 % of adults, while the prevalence of obesity is increasing at an alarming rate in both economically developed and developing countries of the world. In Ukraine, according to the World Health Organization, 41.2 % of men and 58.5 % of women are overweight or obese. Obesity is a risk factor for the development of a number of diseases — type 2 diabetes, hypertension, coronary heart disease, non-alcoholic fatty liver disease, gastroesophageal reflux disease, obstructive sleep apnea syndrome, etc. The presence of hyperleptinemia and weight loss resistance are common characteristics of obesity. The purpose of the study was to reveal the relationship between leptin levels and cardiometabolic risk in obese patients. Materials and methods. Fifty-three patients (43 women, 10 men) were examined. Body mass index was calculated as the ratio of body weight (kg) to height (m2). The classification criteria of the World Health Organization were used to diagnose overweight, obesity, and its degree. The level of leptin was assessed by an enzyme immunoassay on the ImmunnoChem-2000 device. The relationship between indicators was evaluated using the Spearman’s rank correlation coefficient. Results. Hyperleptinemia in obese patients is an indicator of low-grade inflammation. A significant increase in the serum leptin is noted in obese patients. Correlation analysis of waist circumference with leptin level in women and men demonstrated its importance both before and after treatment. A significant cardiometabolic risk was detected in the examined patients from the Ukrainian population. Against the background of a comprehensive treatment for six months, a decrease in body weight, waist circumference (p < 0.05) and in leptin level (p < 0.05) was noted in both women and men. Conclusions. The relationship was found between leptin level and cardiometabolic risk in obese patients.

Сучасний стан та просторово-часові тенденції аліментарно-залежної захворюваності дитячого населення України

The purpose of the study is a spatio-temporal analysis of the peculiarities of the national and regional dynamics of nutritional morbidity among the children of Ukraine. Research materials and methods: The study design included a retrospective analysis of official statistical data on the prevalence and incidence of food addiction in children and a review of the results of original studies. The research materials included statistical data of the State Statistics Service of Ukraine on certain food-dependent pathologies of the children’s population of Ukraine. The retrospective evaluation of statistical data was 18 years (2000-2017), national and regional data were evaluated. Research methods included statistical evaluation of factual and analytical material. The results: The analysis of trends in the prevalence and incidence of foodborne diseases in children in different age periods during 2000-2017 determines important features of the dynamics of these indicators in different age groups. The total share of alimentary diseases in the total structure of diseases is 9.88-10.00% at the age of 0-14 years old and 17.98% at the age of 15-17 years old. The general analysis shows a trend towards a decrease in the prevalence and incidence of food borne diseases among children of certain age groups over the course of 18 years. This especially applies to diseases of blood organs and the endocrine system. In the group of children aged 0-6 years old, there is an intense decrease in the registration of primary forms of diseases. At the age of 7-14 years old, during 2000-2017, there is an intensive decrease in the incidence and prevalence of diseases of the endocrine system and digestive organs, and at the age of 15-17 years old, there is a significant increase in growth and growth rates according to most indicators. Conclusions: the age-specific features of food-dependent pathology of the children's population, spatial-temporal trends in national and regional sections are determined. The need for further research and monitoring in order to form a policy for the management of food-dependent pathology is shown.

Смертність через провідні непухлинні хвороби учасників ліквідації наслідків аварії на ЧАЕС та мешканців радіоактивно забруднених територій у віддаленому періоді після аварії

The purpose of the study: Based on a descriptive analysis, to determine the post-accident changes in the level and structure of mortality of participants in the chornobyl cleanup workers of the accident at the Chornobyl Nuclear Power Plant (ULNA) and residents of RADIATION- contaminated TERRITORIES )residents of the RZT) of Ukraine from the main non-neoplastic diseases depending on age, time since the date of the accident and gender. Materials and methods: Mortality from non-neoplastic pathology in 1986-1987 in ULNA, numbering 64,762, and residents of RZT, numbering 174,860, aged 18-60 on the date of the accident as a result of the accident at the Chornobyl nuclear power plant, was studied based on clinical-epidemiological and dose data of the State Register of Ukraine. Epidemiological, medical-statistical, analytical methods were used during the research. Research results: On the basis of descriptive analysis, a description of the level and structure of mortality from non-neoplastic diseases of the ULNA and the residents of the RZT was provided, both for the entire post-accident period and for five-year periods. In ULNA, mortality increased with each five-year period and in recent years has increased by 15.7 times compared to the initial period. In residents of the radioactively contaminated territory of Ukraine, the mortality rate increased for 25 years after the accident, with the highest rate in the period 2008-2012, regardless of age, with subsequent stabilization of the indicators. The structure of mortality among participants of the ULNA and residents of the RZT throughout the entire observation period remains unchanged and almost does not differ from the general mortality trends of the population of Ukraine. Diseases of the circulatory system, digestive organs, and respiratory organs are stable in terms of the frequency of the causes of death. Age, sex, and temporal differentiation of mortality, differences in nosological causes among defined categories of victims of the consequences of the accident at the Chornobyl nuclear power plant were revealed. Conclusions: During the post-accident observation period (1988-2017), diseases of the circulatory system, digestive organs, and respiratory organs remained the main causes of mortality in ULNA in and among residents of RZT aged 18–60 on the date of the Chornobyl accident. The dynamics of mortality in ULNA was characterized by growth during the entire period of observation, in residents of RZT – growth over 25 years with subsequent stabilization. It is necessary to take into account during dispensation the revealed features of mortality of ULNA and RZT in order to develop comprehensive measures to reduce the mortality of this contingent.

Bridging gaps: improving the access of primary health care in rural Ukraine through mobile health units

Rural healthcare is an integral part of the Ukrainian healthcare system. However, access to healthcare for the rural population is uneven due to poor development of medical infrastructure and staffing. The problem of access to medical care in rural areas has been exacerbated by the full-scale war.The objective: to study and analyze the current state of accessibility of primary health care in rural areas in Ukraine, followed by a discussion of promising areas for the introduction of mobile health units as a tool for implementing the “Medical Guarantees” program in hard-to-reach regions of Ukraine.Materials and methods. The study included data from official statistical reports, regulatory documents and scientific sources. The methodology includes bibliosemantic, medical and statistical methods and the method of structural logical analysis.Results. It has been established that the low level of access to primary health care for the rural population of Ukraine has been significantly exacerbated by the devastating impact of the war on medical and transport infrastructure, especially in the frontline and recently de-occupied rural areas, and by migration processes. The situation is complicated by the fact that most patients in rural areas are elderly people who are physically unable to use public transportation, even if it is available. The analysis of international practice has shown that mobile health units can be introduced into the public healthcare system as a temporary measure to meet the urgent needs of the Ukrainian population, especially in rural areas. Integration of mobile health units into the state program “Medical Guarantees” can effectively address the urgent health care needs to increase access to health care for the rural population of Ukraine. State regulation of the division of these units will eliminate problems such as duplication and uneven service delivery and will create a transparent system of remuneration for the staff included in these units.Conclusions. The results of the study suggest that the practice of mobile medical units should be introduced as a tool for implementing the “Medical Guarantees” program for regions/locations of Ukraine with low access to medical infrastructure, namely remote rural areas and areas that have been devastated by the war. Mobile medical units will ensure the stability of access to primary health care services and contribute to improving the health of the population.

Modern Features of the Epidemiological Situation of Tuberculosis in Ukraine (Review)

Objective — to study the epidemiological situation of tuberculosis in Ukraine from 2018 to 2022. Materials and methods. This research utilised a comprehensive source base including official statistical data from the State Statistics Service and the Ministry of Health of Ukraine, scholarly articles from both international and domestic researchers, materials from periodicals and international conferences and internet resources. Additionally, the insights and analyses were enriched by involving six experts and organisers from the phthisiatric service. These experts were instrumental in interpreting statistical data and identifying causal relationships within the dynamics of the epidemiological indicators. Results and discussion. From 2018 to 2022, the incidence of tuberculosis (TB), including its recur­rences, in Ukraine decreased by 27.3 %. During this timeframe, TB incidence among children aged 0—14 years fell by 16.9 %, and among adolescents aged 15—17 years, it dropped significantly by 45.8 %. Despite these overall reductions, a notable increase in TB incidence was observed across the Ukrainian population by approximately 3.5 % and specifically among children aged 0—14 years by 25.4 % in 2021, compared to 2020. The Odesa Oblast reported the highest morbidity rate across all Ukrainian regions over this five-year period, although it experienced a 36.0 % reduction from 2018 to 2022. Importantly, the prevalence of all forms of active TB across the Ukrainian population decreased by 40.7 % from 2018 to 2022. This decline was also reflected among children aged 0—14 and 15—17 years, with decreases of 34.1 and 49.7 %, respectively. Statistically, the highest morbidity rate among healthcare institution employees in Ukraine was observed in 2018, reaching 6.0 per 10,000 employees. Conclusions. Since 2020, a concerning trend has emerged in Ukraine with an increase in the incidence of tuberculosis by almost 3.5 %, and a sharp rise of 25.4 % among children aged 0—14 years in 2021, reversing the previously declining trend. This uptick is likely influenced by the COVID-19 pandemic. Despite this, there was a notable decrease in the prevalence of all forms of active TB across Ukraine's entire population by 40.7 % from 2018 to 2022. The highest morbidity rate among healthcare workers was observed in 2018, at 6.0 per 10,000 workers. A significant concern remains TB's impact on the working-age population, leading to permanent disability. However, the rate of primary disability due to TB among the adult and working-age population showed a decrease in 2022 by 11.4 and 3.9 %, respectively. The underdiagnosis of TB, potentially exacerbated by the COVID-19 pandemic and the ongoing conflict, poses a significant challenge to controlling the disease.

Diagnostic value of clinical-instrumental and hematological indicators in predicting complications of the hospital period of STEMI in conditions of chronic stress caused by wartime

The aim – to develop a diagnostic system that takes into account the peculiarities of clinical, instrumental and laboratory indicators in patients with STEMI against the background of wartime and will allow to objectify a tendency to a more difficult hospital course of ACS.Materials and methods. We studied a cohort of patients (n=133 individuals, 77.4 % men, average age 61.8±0.9 years) with STEMI, part of which (group 1) was hospitalized from February to May 2019 (n=87), while another part of which (group 2) was hospitalized in the period from February 24, 2022 to March 2023 (n=46) within the first 24 hours from the development of symptoms of the disease (average time of admission 5.2±0.4 hours). The groups were compared according to the clinical and anamnestic and laboratory parameters of the first day.Results and discussion. It was found that in the Ukrainian population during wartime, patients with STEMI are admitted to the hospital later, have a more burdensome history of cerebrovascular diseases, a greater number of significant coronary stenoses, a higher percentage of smokers, and also have higher heart rate levels upon admission, ESR, triglycerides, leukocytes (at the expense of lymphocytes and monocytes), as well as platelets (with lower indicators of their size inhomogeneity). Also, invasive treatment of these lesions leads to slightly worse results on the TIMI and MBG scales. Informativeness of hematology analysis indicators and other markers of inflammation/stress on the first day of STEMI in wartime was evaluated for predicting the risk of an complicated course of the hospital period (development of cardiac death, signs of LVEF, ventricular tachyarrhythmias, stent thrombosis, acute renal dysfunction, recurrence of ACS/angina). It was found that predictors of the undesirable course of STEMI during wartime are: heart rate > 70/min, ESR > 10 mm/h, glucose level > 8.5 mmol/l, leukocytes > 13 · 109/l, lymphocytes > 2 · 109/l, platelets > 270 · 109/l, large (>12 fl) platelets < 27 %, triglycerides > 1.3 mmol/l, as well as combined criteria made up of these indicators. Thus, the 6-component score (heart rate, ESR, glucose, levels of leukocytes, lymphocytes, and platelets) had an area under the ROC curve of 0.87 (for values ​​> 30 units – BP 6.39 (2.16–18.9), p<0.0001) when determining the risk of an undesirable course of ACS in patients during wartime. These predictors are specific to the stress-induced effects of war and are not informative in peacetime STEMI patients.Conclusions. The coexistence of acute stress caused by STEMI with chronic exposure to stress-associated wartime factors can worsen the course of the hospital period of STEMI, which is associated with an increase in heart rate, ESR, glucose level, leukocytes, lymphocytes, triglycerides, platelets with a decrease in their inhomogeneity in size. Taking into account these features allows predicting the risk of a complicated course of the hospital period of the STEMI in wartime.

Analysis of the list of medicines for arterial hypertension therapy during pregnancy

Preserving the pregnant women health is one of the most important task in the health care system. In 2020, more than 21,000 cases of hypertensive disorders were diagnosed during pregnancy in Ukraine. Arterial hypertension during pregnancy is the main risk factor for negative consequences for the child and mother. During pregnancy, antihypertensive therapy reduces the risk of morbidity or premature birth, as well as adverse effects to the fetus/newborn.
 The purpose of the study was to analyze the list of registered antihypertensive medicines under the INN, which are presented on the domestic pharmaceutical market, and to analyze their socio-economic availability.
 Research materials and methods. Analysis of antihypertensive medicines in accordance with national recommendations for the arterial hypertension treatment during pregnancy in Ukraine; analysis of the State Register of Medicinal Products of Ukraine, the National List of Essential Medicines, the State Formulary of Medicines (15 issue). Data from the information resource «Tabletki.ua» were used to determine the pharmaceuticals prices. Methods – information search, analysis, generalization, marketing research, «minimization of cost» method, calculation of socio-economic affordability ratios – the liquidity ratio Cliq, the ratio of adequacy solvency Ca.s.
 The results of the analysis of antihypertensive medicines that are registered and have indications during pregnancy showed that the following medicines with INNs are available on the pharmaceutical market: methyldopa, nifedipine, metoprolol tartrate, esmolol, nicardipine, uradipyl, but the following INNs labetalol, hydralazine, acebutolol, mepindolol, oxprenolol are missing. It was established that the list of antihypertensive medicines used during pregnancy is represented by 33 trade names of various medicinal forms from 10 countries of the world, the specific weight of which is 69% of medicines of foreign production. There is an insufficient amount of methyldopa medicines on the domestic pharmaceutical market, as there is only one name of a foreign manufacturer.
 It was determined by the «cost minimization» method that the costs for one month of treatment when using nifedipine of a domestic manufacturer compared to a drug of a foreign manufacturer are lower by 90%. For metoprolol of the domestic manufacturer, the costs are 73% lower than for the imported drug.
 The socio-economic availability of medicines was determined using the price liquidity ratio and the solvency adequacy ratio, which indicated relatively adequate price competition and the high availability of most antihypertensive medicines for the population of Ukraine.

Study of the effect of bifonazole concentration on the antifungal activity of vaginal suppositories

The analysis of the current state of pharmacotherapy for vulvovaginal candidiasis reveals that there is a contemporary need for the development of soft dosage forms for the local treatment of infectious diseases affecting the vulva and vagina. This should be based on azole derivatives that, despite possessing a well-established wide spectrum of antifungal and antibacterial effects, have not been utilized for vaginal administration in domestic formulations. The successful realization of this project would enable the field of domestic dermatology to provide effective, compliant, and affordable drugs for gynecological practice to the general population of Ukraine. Additionally, it would establish a viable alternative to imported pharmacotherapeutic agents. Aim. The purpose of this work is the scientific substantiation of the concentration of bifonazole in suppository compositions for vaginal use. Materials and methods. Research was conducted to investigate the influence of bifonazole concentration ranging from 1 % to 15 % in soft dosage forms for vaginal use. Model compositions were formulated on a polyethylene oxide carrier, considering its solubility. The antifungal activity of the experimental suppository compositions was chosen as the optimization parameter and assessed using the diffusion method in agar against Candida albicans ATCC 885-653. Variance analysis of the results revealed a significant impact of bifonazole concentration on the antimycotic activity of the suppository compositions based on the model polyethylene oxide. Results. The research results show that increasing the concentration of the active pharmaceutical ingredient in suppository masses above 10 % does not lead to a statistically significant increase in their antimycotic activity. Conclusions. As a result of the conducted study on the antifungal effect of suppository masses with bifonazole on a model polyethylene oxide basis, it was found that the concentration of the active pharmaceutical ingredient has a statistically significant effect on the effectiveness of the soft dosage form. It was established that a ten percent concentration of bifonazole, equivalent to 0.3 g of the biologically active substance in vaginal suppositories, provides the optimal level of their antifungal effect.

Psychological well-being in Europe after the outbreak of war in Ukraine

The Russian invasion of Ukraine on February 24, 2022, has had devastating effects on the Ukrainian population and the global economy, environment, and political order. However, little is known about the psychological states surrounding the outbreak of war, particularly the mental well-being of individuals outside Ukraine. Here, we present a longitudinal experience-sampling study of a convenience sample from 17 European countries (total participants = 1,341, total assessments = 44,894, countries with >100 participants = 5) that allows us to track well-being levels across countries during the weeks surrounding the outbreak of war. Our data show a significant decline in well-being on the day of the Russian invasion. Recovery over the following weeks was associated with an individual’s personality but was not statistically significantly associated with their age, gender, subjective social status, and political orientation. In general, well-being was lower on days when the war was more salient on social media. Our results demonstrate the need to consider the psychological implications of the Russo-Ukrainian war next to its humanitarian, economic, and ecological consequences.

Засоби розміщення мігрантів: досвід Польщі

The social properties of the hotel business are objectively determined by the course of phenomena and processes that reflect, on the one hand, the relevance of the increase in the economic activity of the social component, which is focused on the social needs of the consumer, and on the other hand, the strengthening of the importance of the social factor in the conditions of humanitarian crises. The trigger that led to the growth of the social function of the hotel business was the full-scale invasion of Russian troops into Ukraine, which caused a wave of migration of the Ukrainian population. In these conditions, the Polish hotel business imple­mented the function of social responsibility towards Ukrainian refugees, offering temporary shelter and organizing needs. The research aim of this paper is to analyze the role of hotels in the direction of Ukrainian refugees support during 2022. General scientific and special methods of cognition were applied: abstract-logical and comparison; analysis and synthesis, analogies, questionnaires; theoretical generalization and formulation of conclusions. The obtained results of the research on the peculiarities of providing temporary accommodation and food services to refugees indicate that the satisfaction of their primary needs intensified the determination of the importance of the social functions of the hotel business in the conditions of humanitarian crises. It has been proven that it is expedient to include informational and social services (assistance in employment) in the structure of hotel services. It has been established that the needs and expectations of refugees will require the hotel business to develop a certain algorithm of actions to attract external funding, which is a factor in ensuring (growth) of revenue and the ability of hotels to increase the amount of support to refugees without reducing key indicators of economic activity. The relevance of the topic of gender is confirmed by the coverage of the issue of providing guarantees to the hotel business by the United Nations Refugee Agency in order to create proper conditions for refugees in the conditions of military conflicts. Support for migrants is, on the one hand, "search for sources of funding" and, on the other, "assis­tance in the integration process." The article describes the areas of support offered by hotels to refugees seeking temporary shelter in Poland. Taking into account the experience of the social activities of Polish hotels will allow to increase the level of social responsibility of national hotel chains, gives them the opportunity to be involved in the decision-making process that will restore the hotel business in Ukraine.

Ensuring Gender Equality in the Armed Forces of Ukraine

The article reviews Ukrainian legislation and Ukraine’s international obligations to ensure gender equality in the Armed Forces of Ukraine. The authors note the aspects of gender policy in the institutes of education and media, which are also crucial for military policy. The main results of a series of sociological studies from the “Invisible Battalion” project are characterized, and the successes and problems on the way to the integration of women in the Armed Forces during the last ten years of the war, starting with the ATO, are highlighted. Gradual overcoming of the phenomenon of vertical and horizontal gender segregation in the military sphere, departure from paternalistic gender policy, granting women formal access to all combat specialties and to military education are listed among the successful results of the policy of ensuring equal rights and opportunities in the Armed Forces. For the professional integration of women in the Armed Forces, urgent issues such as the absence of a clear mechanism to address instances of sexual harassment, understanding the needs of women as combatants (implementation of a gender-sensitive approach), and enhancing the visibility of women within the military elite and expert military environment need to be addressed.Based on a survey representative of the Ukrainian population, public opinion on ensuring gender equality in the military sphere was studied for the years 2018 and 2023. The focus was on supporting the idea of equal employment opportunities for women and men in the Armed Forces of Ukraine, promoting the army as a professional field with equal access for both genders. In conclusion, it was discovered that, at the level of public opinion, both men and women are willing to engage in armed resistance to halt the Russian occupation of Ukraine.

The Demographic Factor in Shaping State Policy for Higher Education of Ukraine

The article examines key indicators of the demographic crisis in Ukraine, highlighting manifestations of the nation’s aging and natural population decline.It’s determined that understanding and analyzing the demographic situation allows for predicting changes in the size and structure of the student population, which is crucial for the effective development of higher education in Ukraine. Considering the trends of declining birth rates and an aging population, it is important to adapt admission strategies for students and educational programs accordingly. The examination of the demographic crisis helps identify key challenges, such as a decrease in the number of high school graduates, which can impact competition within the higher education environment.The trends examined in the article, including the decline in the birth rate of the Ukrainian population, the aging of the nation, the level of migration, and the loss of the civilian population due to the war, enable us to characterize the situation in Ukraine as depopulation. Notable changes in the demographic landscape and shifts in the population structure occurred after February 24, 2022, including irreversible human losses, population emigration (over 10 million people), and a decline in the average birth rate. A correlation was identified between the number of births each year and the dynamics of educational services’ capacity. It was observed that higher education in Ukraine will confront significant demographic challenges in the next 17 years. In the context of the strategic goal to restore Ukraine’s human capital, the article suggests viewing higher education as an effective instrument of state policy in a cyclical process: attaining higher education, integrating graduates into the national economy, ensuring financial stability, fostering active citizenship, and promoting loyalty to the state—all contributing to an improvement in the demographic situation.

СANCER INCIDENCE IN UKRAINE: TRENDS IN 2010-2019 AND THE IMPACT OF COVID-19 PANDEMIC.

In 2020, a sharp decrease in the number of new cancer cases was registered in Ukraine in the setting of the quarantine restrictions due to the COVID-19 pandemic, which contrasted with the previous trends. To study trends of cancer incidence rates in Ukraine in the recent decade and to assess the impact of COVID-19 pandemic on cancer detection in 2020. Records on cancer cases diagnosed during 2010-2020 (n = 1,498,911) from the database of the National Cancer Registry of Ukraine were used; the data being submitted early in 2022. Trends of the age-standardized incidence rates in 2010-2019 were estimated by the Joinpoint Regression Program. During 2010-2019, the incidence rates increased (p < 0.05) for colon, prostate, and pharyngeal cancers in males and for colon, thyroid, and pancreas in females with the rates of other prevalent cancers being stable or decreasing (lung and larynx in males, cervix and rectum in females, stomach in both genders); the incidence increased mainly at the expense of the population aged 60-74 years. A significant decrease in cancer incidence was in males aged 40-59 years. In 2020, the serious negative impact of COVID-19 outbreak on the timely detection of cancer occurred in all adult age groups of the Ukrainian population and involved all the most common cancers. The most pronounced diminution of the incidence rate was observed for non-melanoma skin cancers (by 35.9%- 37.9%); the decrements of the rates for other prevalent cancers varied from -23.0% (prostate gland) to -9.7% (pharynx) in males and from -21.2% (kidney) to -9.1% (pancreas) in females, the greatest ones being in the population aged 75+. The sharp drop of the cancer incidence rates registered in Ukraine 2020 is evidently the result of the limited access to healthcare facilities as well as the reduced oncological alertness of the population due to the predominant focus on COVID-19 during the pandemic. However, it is not a manifestation of a decrease in cancer incidence as such. In the following years, this may increase the proportion of advanced-stage diagnoses, the load on the cancer care system, and cancer mortality in the Ukrainian population. An evaluation of the short-termand long-term effects of the COVID-19 pandemic on the cancer burden in Ukraine requires further monitoring.