Presenter: Joseph Attard MD, MSc, MRCSEd | Queen Elizabeth Hospital Background: As a result of the ageing population, pancreaticoduodenectomy is increasingly being offered as curative therapy for periampullary tumours in patients 80 years of age and older. Our aim was to evaluate clinical outcomes and provide evidence on current UK practice in the elderly population after pancreaticoduodenectomy. Methods: A multicentre retrospective case-control analysis of prospectively-maintained databases was performed. This included pancreaticoduodenectomies undertaken between January 2008 and December 2017. Octogenarians who underwent pancreaticoduodenectomy were matched with consecutively-operated younger patients with 1:1 ratio, based on extent of surgery (venous, arterial or additional resection). Pre-operative comorbidities, intra-operative variables, post-operative complications and mortality were compared. Chi-Square, Fisher’s Exact and Mann-Whitney U tests were used as appropriate to compare variables and outcomes between the two groups, with statistical significance set at p<0.05. A survival analysis, using Kaplan-Meier estimators, was also performed to determine overall survival as well as disease-free survival. Results: Six UK specialist HPB centres participated in this study. 181 octogenarians (median age 81 years, range: 80 - 90) who underwent pancreaticoduodenectomy (either classical or pylorus-preserving) were compared to the same number of controls (median age 67 years, range: 31 - 79). Gender and ASA (octogenarians median grade 2 [range: 1 - 4] versus median grade 2 [range: 1 - 3] for controls) were comparable (p=0.75 and p=0.82 respectively). The distribution of performance status scores (octogenarian median score 0 [range: 0 - 3] versus median score 0 [range: 0 - 2] for non-octogenarians) was found to be significantly different (p=0.02). Similarly, Charlson Comorbidity Index scores were significantly higher overall for octogenarians (median 7 [range: 6 - 11] versus 5 [range: 2 -9], p=0.001). Ninety-nine percent of octogenarians and 97% of controls were offered upfront resection. The remainder underwent neoadjuvant treatment prior to surgery. Median length of hospital stay was longer in octogenarians, 17 days (range: 3 – 120 days) compared to 13 days (range: 5 – 81 days) for controls (p=0.001). Negative resection margin (R0) rates were comparable for the two groups, 61% for octogenarians and 58% for controls (p=0.57), as were lymph node ratios, median 0.1 (range: 0 – 0.8) for octogenarians and 0.095 (range: 0 – 1) for controls, p=0.77. Complication rates across the Clavien-Dindo classification categories were not statistically significant (p>0.05 in all categories). Thirty-day mortality was 3 % for octogenarians and 2% for controls (p=0.54). Ninety-day mortality was 7% for octogenarians versus 3% for controls. This difference was not statistically significant (p=0.1). A survival analysis revealed that, while median overall survival was significantly longer for controls, 59 months versus 23 months for octogenarians, (p=0.006); disease-free survival was not statistically different between both groups, with a median of 19 months for octogenarians and 28 months for controls (p=0.22). Median follow-up was 13 months (range: 0 – 100) for octogenarians and 17 months (0 – 111) for controls. Conclusion: Despite the higher ninety-day mortality, pancreaticoduodenectomy outcomes in octogenarians are comparable to their younger counterparts. Pancreaticoduodenectomy should therefore be offered as a curative surgical option in this cohort, in specialised centres after meticulous preoperative assessment.
Read full abstract