UK European Research Articles

First records of Jamaican walnuts Juglans jamaicensis (Juglandaceae) from Irish and UK waters, together with observations on other walnut species reported from NW Europe

On 30 December 2015, a single specimen of Juglans was found stranded on Tramore Beach (54° 48′ 25″N, 08° 30′ 01″W), Rosbeg, Co Donegal, NW Ireland. A second specimen was found on Black Rock Beach, Widemouth Bay, south of Bude, north Cornwall, UK (SS19760178) c.14 March 2016. Based on morphological features, both specimens were identified as J. jamaicensis C. DC., and represent the first records of this species from Irish, UK and NW European waters. It is hypothesised that these walnuts most likely originated in the Greater Antilles where J. jamaicensis is endemic to Cuba, Hispaniola (Dominican Republic & Haiti) and Puerto Rico. At least four other species of walnut have been recorded from NW European waters: J. regia, J. nigra, J. ailanthifolia, and J. californica.

“HOW GRAND IS OUR DESIGN FOR EUROPE?”: INTEGRATION PLANS OF THE GREAT BRITAIN IN THE LATE OF 1950S

The UK European Union membership referendum 2016 and its results actualized the study of the British initiatives in the sphere of integration before the entry into the European Economic Community in 1973. The article is devoted to the little-known in Russian historiography "Grand Design"of H. Macmillan, nominated in the wake of the failure of the Suez operation against Egypt in 1956. Plan with such bright and eye-catching name suggested the creation of a broad integration group in Europe as alternative with Britain as a leader to the preparing for the establishment of projects of the European Economic Community and the European Atomic energy community. The project was designed to restore the prestige of the Conservative Party and to strengthen the shaky position of Britain in NATO and European affairs after Suez Crisis. At the same time the emergence of the plan reflected the desire of the Prime Minister, Harold Macmillan to weaken the struggle inside political establishment between supporters and opponents of the country's full-fledged participation in the European integration and take the lead in the integration movement from France. Analysis of the content of the project and attempts to implement it within the framework of a Free Trade Area (FTA) reveals the essence of the "special position" of the UK towards supranational integration and the British vision of the future of European integration. Modern United Kingdom appeared in the new European realities after the Referendum on the country’s membership in the European Union and returns to the starting point on the path of supranational integration and to the search for its place in Europe. In these circumstances, the ideas expressed by British politicians more than half a century ago, may again prove to be demanded and relevant.

The contributions to long-term health-relevant particulate matter at the UK EMEP supersites between 2010 and 2013: Quantifying the mitigation challenge

Human health burdens associated with long-term exposure to particulate matter (PM) are substantial. The metrics currently recommended by the World Health Organization for quantification of long-term health-relevant PM are the annual average PM10 and PM2.5 mass concentrations, with no low concentration threshold. However, within an annual average, there is substantial variation in the composition of PM associated with different sources. To inform effective mitigation strategies, therefore, it is necessary to quantify the conditions that contribute to annual average PM10 and PM2.5 (rather than just short-term episodic concentrations). PM10, PM2.5, and speciated water-soluble inorganic, carbonaceous, heavy metal and polycyclic aromatic hydrocarbon components are concurrently measured at the two UK European Monitoring and Evaluation Programme (EMEP) ‘supersites’ at Harwell (SE England) and Auchencorth Moss (SE Scotland). In this work, statistical analyses of these measurements are integrated with air-mass back trajectory data to characterise the ‘chemical climate’ associated with the long-term health-relevant PM metrics at these sites. Specifically, the contributions from different PM concentrations, months, components and geographic regions are detailed. The analyses at these sites provide policy-relevant conclusions on mitigation of (i) long-term health-relevant PM in the spatial domain for which these sites are representative, and (ii) the contribution of regional background PM to long-term health-relevant PM.At Harwell the mean (±1 sd) 2010–2013 annual average concentrations were PM10=16.4±1.4μgm−3 and PM2.5=11.9±1.1μgm−3 and at Auchencorth PM10=7.4±0.4μgm−3 and PM2.5=4.1±0.2μgm−3. The chemical climate state at each site showed that frequent, moderate hourly PM10 and PM2.5 concentrations (defined as approximately 5–15μgm−3 for PM10 and PM2.5 at Harwell and 5–10μgm−3 for PM10 at Auchencorth) determined the magnitude of annual average PM10 and PM2.5 to a greater extent than the relatively infrequent high, episodic PM10 and PM2.5 concentrations. These moderate PM10 and PM2.5 concentrations were derived across the range of chemical components, seasons and air-mass pathways, in contrast to the highest PM concentrations which tended to associate with specific conditions. For example, the largest contribution to moderate PM10 and PM2.5 concentrations – the secondary inorganic aerosol components, specifically NO3− – were accumulated during the arrival of trajectories traversing the spectrum of marine, UK, and continental Europe areas. Mitigation of the long-term health-relevant PM impact in the regions characterised by these two sites requires multilateral action, across species (and hence source sectors), both nationally and internationally; there is no dominant determinant of the long-term PM metrics to target.

Credit Rating Agency Regulation after the UK's European Union Membership Referendum

In response to the decision by British voters to leave the European Union in the recent referendum, this article discusses what may lie ahead for the regulation of the credit rating industry in the U.K. With the withdrawal from the Union meaning that the U.K. must now establish its own distinct Laws that will govern the Rating Industry, having relied upon the EU beforehand, understanding what may affect the approach taken is of concern for this short article.

After the Ice Age: The Impact of Post-Glacial Dispersal on the Phylogeography of a Small Mammal, Muscardinus avellanarius

We used genetic tools to assess phylogeographic structure of the common dormouse (Muscardinus avellenarius) since the end of the last glacial maximum, to identify post-glacial dispersal routes and to describe population units for conservation. Comparative analysis of mitochondrial genes (Cytochrome b 704 bp, D-loop, 506 bp) and one nuclear gene (Beta-Fibrinogen, 550 bp) was conducted to reconstruct the recent demographic history within and between UK and Continental European populations. Our analysis indicated phylogeographic variation similar in magnitude to that found in other regions of Continental Europe and suggests a recent population expansion. We present evidence which supports a single post-glacial colonization into the UK. Dispersal time calculations, calibrated with geophysical events, are coincident with the start of the Holocene period, 7.5-11 kya, a time when geological evidence suggests temperatures were stable, woodland habitat was prevalent and a land bridge was present to allow the dispersal of small mammals into the UK. We discuss our findings in the context of the extant geographical genetic structure described here and in relation to conservation management of this threatened species.

A novel HLA-B*14 allele - B*14:53 - genetics and serology.

HLA-B*14:53 was found in a UK European normal blood donor prior to registration on the Welsh Bone Marrow Donor Registry. It differs from B*14:13 by one base (103G>T) in exon 2 resulting in a substitution of alanine (A) in B*14:13 to serine (S) in B*14:53. Unique among current HLA-B*14 alleles, B*14:53 and B*14:13 share a motif of 59 bases between positions 361 and 419 in exon 3. This motif is present in numerous HLA-B alleles the commonest overall being B*08:01, suggesting that both B*14:53 and B*14:13 arose from intralocus gene conversion events with B*08:01. Thus, B*14:53 probably arose from B*14:01:01 (which has TCC at codon 11 (S), while B*14:13 arose from B*14:02:01:01 which has GCC at codon 11 (A). Additionally, the two likely B*14:53-bearing and B*14:13-bearing haplotypes are typical of B*14:01:01-bearing and B*14:02:01:01-bearing haplotypes, respectively. Serological testing, using 49 antisera with HLA-B64, or B64, B65 reactivity, showed that the B*14:53 specificity did not react as a B64 (B*14:01) specificity and may appear as a short/weak HLA-B14. This implies that residues additional to S at position 11 are involved in HLA-B64 serological identity; for example, the motif 11S 97W 116F is possessed by B*14:01 and many other B*14 products (and B*39:79 plus some HLA-C products) but not B65 (B*14:02) or the B*14:53 specificity. B*14:53 was found in a random HLA sequence-based typed population of 32530 normal subjects indicating a low precision allele frequency of 0.000015 in subjects resident in Wales.

Brexit or Bremain: what future for the UK's European diplomatic strategy?

A major public debate on the costs and benefits of the United Kingdom's membership of the European Union is presently under way. The outcome of the referendum on 23 June 2016 will be a pivotal moment in determining whether the EU has a future as a component of the UK's European diplomatic strategy or whether there is a major recalibration of how the UK relates to Europe and more widely of its role within international relations. Since accession to the European Economic Community the UK has evolved an uncodified, multipronged European diplomatic strategy. This has involved the UK seeking to reinforce its approach of shaping the security of the continent, preserving a leading diplomatic role for the UK in managing the international relations of Europe, and to maximize British trade and investment opportunities through a broadening and deepening of Europe as an economically liberal part of the global political economy. Since accession the UK's European diplomatic strategy has also been to use membership of the EU to facilitate the enhancement of its international influence, primarily as a vehicle for leveraging and amplifying broader national foreign and security policy objectives. The strategy has been consistent irrespective of which party has formed the government in the UK. Increasing domestic political difficulties with the process of European integration have now directly impacted on this European strategy with a referendum commitment. Whether a vote for a Brexit or a Bremain, the UK will be confronted with challenges for its future European strategy.

The European Struggle to Educate and Include Roma People: A Critique of Differences in Policy and Practice in Western and Eastern EU Countries

Multiculturalism is an established feature of the UK and other European States since the establishment of the Treaty of Rome in 1959. Enlargement has brought EU membership from six (1952) to twenty eight members since its foundation, and allowed free migration across its borders. However, many countries, in spite of agreements to adhere to ‘democratic’ practices, deny minority citizens their full rights, particularly in education contexts. Some recent accession EU States have education systems that are less adaptive to expected policy responsibilities. It is a more unstable aspect of Eastern Europe because of the failure of many of these countries to reduce social and educational inequalities and to establish rights for minority groups, particularly the Roma. An educational focus is used as a platform to highlight issues re the segregation, and discrimination against, Roma children in Europe, typically through the use of special education, which is not suitable for them. Europe generally, both East and West has failed to fully integrate the Roma. Often, institutional blame is placed on Roma communities, rather than situate them socially and economically due to ingrained structural inequalities. Stereotyped categories are often used to ‘label’ them. Countries with high Roma populations, four in Western and five in Eastern Europe are evaluated and compared in relation to the education of Roma children.

Immunogenetics of three novel HLA-Class II alleles: DRB1*03:112, DQB1*03:02:16 and DQB1*03:139.

Three novel HLA-Class II alleles, DRB1*03:112, DQB1*03:02:16 and DQB1*03:139, are described with predicted bearing haplotypes of A*02:01, B*40:01, C*03:04, DRB1*03:112, DQB1*02:01; A*23:01, B*15:01, C*03:03, DRB1*04:01, DQB1*03:02:16 andA*01:01, B*44:02, C*05:01/03, DRB1*04:01, DQB1*03:139. Serological tests showed that the DRB1*03:112 and DQB1*03:139 specificities failed to react as expected with some well-documented monoclonal antibodies. Subsequent examination of published HLA-Class II epitopes and inspection of amino acid motifs suggested that epitopes exist that include the positions of their single substitutions (F31C between DRB1*03:01:01:01 and DRB1*03:112, and R48P between DQB1*03:01:01:01 and DQB1*03:139 specificities). This suggests that the reactivity of the monoclonal antibodies used was dependent on these epitopes and that their loss from these rare allele products resulted in their aberrant serology. The new alleles were found after the sequence-based typing of 32530 random UK European routine blood donors suggesting that each has a maximum carriage frequency of 0.0031% in the blood donor population resident in Wales.

Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study

SummaryBackgroundThe global prevalence of X-linked glucose-6-phosphate dehydrogenase (G6PD) deficiency is thought to be a result of selection by malaria, but epidemiological studies have yielded confusing results. We investigated the relationships between G6PD deficiency and both malaria and non-malarial illnesses among children in Kenya.MethodsWe did this study in Kilifi County, Kenya, where the G6PD c.202T allele is the only significant cause of G6PD deficiency. We tested the associations between G6PD deficiency and severe and complicated Plasmodium falciparum malaria through a case-control study of 2220 case and 3940 control children. Cases were children aged younger than 14 years, who visited the high dependency ward of Kilifi County Hospital with severe malaria between March 1, 1998, and Feb 28, 2010. Controls were children aged between 3–12 months who were born within the same study area between August 2006, and September 2010. We assessed the association between G6PD deficiency and both uncomplicated malaria and other common diseases of childhood in a cohort study of 752 children aged younger than 10 years. Participants of this study were recruited from a representative sample of households within the Ngerenya and Chonyi areas of Kilifi County between Aug 1, 1998, and July 31, 2001. The primary outcome measure for the case-control study was the odds ratio for hospital admission with severe malaria (computed by logistic regression) while for the cohort study it was the incidence rate ratio for uncomplicated malaria and non-malaria illnesses (computed by Poisson regression), by G6PD deficiency category.Findings2863 (73%) children in the control group versus 1643 (74%) in the case group had the G6PD normal genotype, 639 (16%) versus 306 (14%) were girls heterozygous for G6PD c.202T, and 438 (11%) versus 271 (12%) children were either homozygous girls or hemizygous boys. Compared with boys and girls without G6PD deficiency, we found significant protection from severe malaria (odds ratio [OR] 0·82, 95% CI 0·70–0·97; p=0·020) among G6PD c.202T heterozygous girls but no evidence for protection among G6PD c.202T hemizygous boys and homozygous girls (OR 1·18, 0·99–1·40; p=0·056). Median follow-up for the mild disease cohort study was 2·24 years (IQR 2·22–2·85). G6PD c.202T had no effect on other common diseases of childhood in heterozygous girls (incidence rate ratio 0·98, 95% CI 0·86–1·11; p=0·82) or homozygous girls or hemizygous boys (0·93, 0·82–1·04; p=0·25), with the sole exception of a marginally significant increase in the incidence of helminth infections among heterozygous girls.InterpretationHeterozygous girls might be the driving force for the positive selection of G6PD deficiency alleles. Further studies are needed to definitively establish the mechanisms by which G6PD deficiency confers an advantage against malaria in heterozygous individuals. Such studies could lead to the development of new treatments.FundingWellcome Trust, UK Medical Research Council, European Union, and Foundation for the National Institutes of Health (as part of the Bill & Melinda Gates Grand Challenges in Global Health Initiative).

Three new HLA-DQB1 alleles – DQB1*03:113, DQB1*06:02:15 and DQB1*06:129.

Three novel HLA-DQB1 alleles were found after sequence-based typing of 3558 random UK European routine blood donors.

Trends and drivers of ozone human health and vegetation impact metrics from UK EMEP supersite measurements (1990–2013)

Abstract. Analyses have been undertaken of the spatial and temporal trends and drivers of the distributions of ground-level O3 concentrations associated with potential impacts on human health and vegetation using measurements at the two UK European Monitoring and Evaluation Program (EMEP) supersites of Harwell and Auchencorth. These two sites provide representation of rural O3 over the wider geographic areas of south-east England and northern UK respectively. The O3 exposures associated with health and vegetation impacts were quantified respectively by the SOMO10 and SOMO35 metrics and by the flux-based PODY metrics for wheat, potato, beech and Scots pine. Statistical analyses of measured O3 and NOx concentrations were supplemented by analyses of meteorological data and NOx emissions along air-mass back trajectories. The findings highlight the differing responses of impact metrics to the decreasing contribution of regional O3 episodes in determining O3 concentrations at Harwell between 1990 and 2013, associated with European NOx emission reductions. An improvement in human health-relevant O3 exposure observed when calculated by SOMO35, which decreased significantly, was not observed when quantified by SOMO10. The decrease in SOMO35 is driven by decreases in regionally produced O3 which makes a larger contribution to SOMO35 than to SOMO10. For the O3 vegetation impacts at Harwell, no significant trend was observed for the PODY metrics of the four species, in contrast to the decreasing trend in vegetation-relevant O3 exposure perceived when calculated using the crop AOT40 metric. The decreases in regional O3 production have not decreased PODY as climatic and plant conditions reduced stomatal conductance and uptake of O3 during regional O3 production. Ozone concentrations at Auchencorth (2007–2013) were more influenced by hemispheric background concentrations than at Harwell. For health-related O3 exposures this resulted in lower SOMO35 but similar SOMO10 compared with Harwell; for vegetation PODY values, this resulted in greater impacts at Auchencorth for vegetation types with lower exceedance ("Y") thresholds and longer growing seasons (i.e. beech and Scots pine). Additionally, during periods influenced by regional O3 production, a greater prevalence of plant conditions which enhance O3 uptake (such as higher soil water potential) at Auchencorth compared to Harwell resulted in exacerbation of vegetation impacts at Auchencorth, despite being further from O3 precursor emission sources. These analyses indicate that quantifications of future improvement in health-relevant O3 exposure achievable from pan-European O3 mitigation strategies are highly dependent on the choice of O3 concentration cut-off threshold, and reduction in potential health impact associated with more modest O3 concentrations requires reductions in O3 precursors on a larger (hemispheric) spatial scale. Additionally, while further reduction in regional O3 is more likely to decrease O3 vegetation impacts within the spatial domain of Auchencorth compared to Harwell, larger reductions in vegetation impact could be achieved across the UK from reduction of hemispheric background O3 concentrations.

First record of an Antidote Vine Seed Fevillea cordifolia (Cucurbitaceae) from UK and north-western European waters

On 8 October 2000, a single intact seed of Fevillea cordifolia L. was found stranded at Perranporth (SW760570), north Cornwall. The specimen represents the first known record of F. cordifolia from UK and NW European waters.

Prevalence of HLA-DQA1 alleles and haplotypes in blood donors resident in Wales.

Two hundred and fifty-four normal blood donors, from a largely UK European population, were sequence-based typed for HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQA1 and HLA-DQB1. The fit to Hardy-Weinberg expectations was good for all loci (all P values >0.5). Fifteen DQA1 alleles were identified to the second field. DQA1 carriage, allele and DQA1-DQB1 and DRB1-DQA1-DQB1 haplotype frequencies, linkage disequilibria and related values are presented.

Increasing synergies between institutions and technology developers: Lessons from marine energy

This paper describes innovation activities in the marine energy sector across ten European countries in 2011. Intense knowledge creation occurred in the UK and northern European countries, while European research networks encouraged public–private partnerships facilitating knowledge diffusion. An analysis based on a technological innovation system (TIS) has identified challenges for the system to evolve from one phase of development to another, i.e. from pre-development to take-off phase. In order for marine energy to pass successfully through the commercialisation ‘valley of death’, entrepreneurial experimentation and production is crucial. Entrepreneurial initiatives were developed mainly in the United Kingdom, Denmark, Norway and Ireland, whereas France, Germany and Sweden were active through venture capital initiatives. Additional system-builders, such as the authorities in charge of energy policies, could offer guidance for research, ensure legitimacy and effectively mobilise resources for system development. Although public support was efficient in stimulating private investment, national targets seemed less efficient in creating a long time horizon for private investors, due to consecutive, unexpected changes. In contrast, positive interactions between technology developers and policy-makers could empower market formation. Ultimately, the creation of a policy community, also involving local communities, could foster a positive environment for the development of innovation activities.

East versus West? Over-qualification and Earnings among the UK's European Migrants

West and East Europeans have been important components of the migration flows into the UK in the last decade, but they remain largely under-studied. This paper utilises 12 quarters of the Labour Force Survey for the years 2002–2013 to examine patterns of over-qualification and their impact on those migrants' earnings. The findings show a clear and greater penalty for East Europeans. They were more likely than the majority White-British and West European migrants to be substantially over-qualified and have earned the lowest pay premium on their excess education. The East European migrants' double penalty is explained by their over-concentration in the secondary labour market where discrimination by employers, exploitation and lower rewards are common practices. Contrary to this, West European migrants enjoy a much better labour market position as they are able to successfully negotiate access to its primary sector.

Emerging infectious disease selects for darker plumage coloration in greenfinches

Outbreaks of emerging infectious disease offer a unique chance to study viability selection in action in short time windows. Finch trichomonosis, caused by a protozoan Trichomonas gallinae emerged in Great Britain in 2005 and led to epidemic mortality and a significant population decline of greenfinches, Carduelis chloris in UK and Northern European countries in subsequent years. We recorded covariation between plumage characteristics and trichomonosis-induced mortality among wild-caught greenfinches brought into captivity in Tartu, Estonia. Occurrence of fault bars (markers of stressful conditions experienced during feather growth) on tail feathers was five times higher among the dead birds than among survivors. Black (eumelanotic) compartments of tail feathers of survivors were on average 22 % darker than feathers of dead birds. Such pattern is best explained by proposed pleiotropic effects of genes involved in eumelanin production on immune function. These findings suggest that melanin-based coloration can evolve via mechanisms that are independent of visual information provided by the pigment.

Biogeographical patterns of variation in Western European populations of the great green bush-cricket (Tettigonia viridissima; Orthoptera Tettigoniidae)

The great green bush-cricket, Tettigonia viridissima, is at the northern limits of its geographic distribution in the UK and has suffered a significant reduction in population abundance and range over the last 50 years, now being largely confined to the southern UK. This study uses five characters to investigate differences between UK and mainland Western European populations, questioning the possibility that UK populations might represent a distinct species or sub-species and thus deserve special conservation status. Males of T. viridissima from UK, France and Spain were compared using morphometry, flight, male calling song and analysis of mitochondrial DNA sequences. Results suggest morphological differences between UK population samples and continental Europe with the UK samples showing shorter wing length relative to body length than populations in continental Europe. Morphological differences between French and Spanish populations followed a size cline related to latitude with more southerly populations showing larger features. Analysis of male flight distances and calling song showed significant differences with increased flight distance and minimum stridulation following a southerly latitude which correlates with wing length results. No differences consistent with geographical distributions were found in mitochondrial DNA COI sequence alignments. Morphological differences could be due to developmental differences linked to differing temperature clines or a non-adaptive difference caused by the colonisation history of the species. The consequences of morphometric variation on flight function and stridulation in bush-crickets are discussed.

Pricing of collectibles: Baedeker guidebooks

We analyze the prices of Baedeker guidebooks issued between 1828 and 1945 in the English, French and German languages. We compile a repeat sales regression index of eBay hammer prices, which reveals a common factor in Baedeker guidebook prices. We find mixed evidence on the underperformance of masterpieces (defined as the most expensive guidebooks). No significant difference is found between the average returns of masters and those of non-masters; however, under a five-factor asset-pricing model consisting of Carhart's four factors and the Pástor–Stambaugh liquidity factor, only masterpieces exhibit significant underperformance. The average price levels of the US, UK and Continental European Baedeker markets do not differ significantly, indicating that the law of one price cannot be rejected. The Baedeker market posts significant negative abnormal returns between 2005 and 2009; however, this result is not found for returns of German-language and non-master guidebooks.

Cardiometabolic Risk Markers in Indian Children: Comparison with UK Indian and White European Children

ObjectiveUK Indian adults have higher risks of coronary heart disease and type 2 diabetes than Indian and UK European adults. With growing evidence that these diseases originate in early life, we compared cardiometabolic risk markers in Indian, UK Indian and white European children.MethodsComparisons were based on the Mysore Parthenon Birth Cohort Study (MPBCS), India and the Child Heart Health Study in England (CHASE), which studied 9–10 year-old children (538 Indian, 483 UK Indian, 1375 white European) using similar methods. Analyses adjusted for study differences in age and sex.ResultsCompared with Mysore Indians, UK Indians had markedly higher BMI (% difference 21%, 95%CI 18 to 24%), skinfold thickness (% difference 34%, 95%CI 26 to 42%), LDL-cholesterol (mean difference 0.48, 95%CI 0.38 to 0.57 mmol/L), systolic BP (mean difference 10.3, 95% CI 8.9 to 11.8 mmHg) and fasting insulin (% difference 145%, 95%CI 124 to 168%). These differences (similar in both sexes and little affected by adiposity adjustment) were larger than those between UK Indians and white Europeans. Compared with white Europeans, UK Indians had higher skinfold thickness (% difference 6.0%, 95%CI 1.5 to 10.7%), fasting insulin (% difference 31%, 95%CI 22 to 40%), triglyceride (% difference 13%, 95%CI 8 to 18%) and LDL-cholesterol (mean difference 0.12 mmol/L, 95%CI 0.04 to 0.19 mmol/L).ConclusionsUK Indian children have an adverse cardiometabolic risk profile, especially compared to Indian children. These differences, not simply reflecting greater adiposity, emphasize the need for prevention strategies starting in childhood or earlier.