PurposeTo determine the effect of patient’s vertical off-centering and scout direction on the function of automatic tube voltage selection (ATVS) and tube current modulation (TCM) in chest computed tomography (CT). MethodsChest phantom was scanned with Siemens and GE CT systems using three clinical chest CT protocols exploiting ATVS and a fixed 120 kVp chest protocol. The scans were performed at five vertical positions of the phantom (−6 to +6 cm from the scanner isocenter). The effects of scout direction (posterior-to-anterior, anterior-to-posterior, and lateral) and vertical off-centering on the function of ATVS and TCM were studied by examining changes in selected voltage, radiation dose (volume CT dose index, CTDIvol), and image noise and contrast. ResultsBoth scout direction and vertical off-centering affected ATVS. The effect differed between the vendors for the studied geometry, demonstrating differences in technical approaches. The greatest observed increase in CTDIvol due to off-centering was 91%. Anterior-to-posterior scout produced highest doses at the uppermost table position, whereas posterior-to-anterior scout produced highest doses at the lowermost table position. Dose varied least using lateral scouts. Vertical off-centering impacted image noise and contrast due to the combined effect of ATVS, TCM, structural noise, and bowtie filters. ConclusionsPatient vertical off-centering and scout direction affected substantially the CTDIvol and image quality in chest CT examinations. Vertical off-centering caused variation also in the selected tube voltage. The function of ATVS and TCM methods differ significantly between the CT vendors, resulting in differences in CTDIvol and image noise characteristics.