Triethylammonium Formate Research Articles

Formic Acid Reduction. VII. Reduction of Carbon-Carbon Double Bonds adjacent to Carbonyls

Triethylammonium formate, TEAF given by 5HCOOH·2N (C2H5)3 has been introduced as a reagent effective for reduction of carbon-carbon double bond adjacent to carbonyl group, preferably double bond of central methylene carbon of 1, 3-diketone. The reduction is selective at the carbon-carbon double bond. Nitro group, carbonyl group and other carbon-carbon double bond such as cinnamyl of substrate are not affected by the reduction. An improvement in the preparation of substrate compounds, α, β-unsaturated ketones, using boron trioxide as a dehydrating agent, is also given.

Formic Acid Reduction. IV. Barbituric Acid Derivatives. Reduction of 5-Arylmethylenebarbituric Acids and Some Analogous Barbituric Acid Derivatives

By means of heating in triethylammonium formate given by 5HCO2H·2N (C2H5)3, hydrogenation of 5-methylidene bond attached to barbituric acids was effected in general. The method was found to be convenient for preparation of 5-arylmethylbarbituric acids and some other 5-alkylbarbituric acids with certain advantages : good yield of the products and selectivity at the double bond of 5-position.