Characteristics Of Tremor Research Articles

PARKINSON’S DISEASE (PD) / ATYPICAL PARKINSONIAN SYNDROMES. CLINICAL AND THERAPEUTIC CARACTHERISTICS

Parkinson’s disease (PD) and other neurologic conditions are now the leading cause of health loss and disability around the world, affecting nearly half of the world's population. Affecting about 1% of population older than 60 years, the PD is among common neurologic disorders, which causes progressive disability that can only be slowed, but not cured, by treatment. Once patients display symptoms like rigidity, bradykinesia, or tremor it's most probably too late for neuroprotective therapy because 70% of the dopaminergic neurons are already dead. With early preclinical diagnosis, we should be able to identify the preclinical phase of Parkinson's disease and include these patients in future trials for neuroprotection. The goal of medical management of PD is to provide control of signs and symptoms for as long as possible while minimizing adverse effects. Several primary neurodegenerative disorders distinct from PD share parkinsonian features of bradykinesia, rigidity, tremor, and balance disturbances. All these disorders share common features of PD, thus being collectively named Parkinson-plus syndromes. An inadequate response to treatment in a patient with parkinsonian symptoms suggests the possibility of Parkinson-plus syndrome. Clinically, however, 4 separate Parkinson-plus syndromes have been identified, as follows: Multiple system atrophy (MSA), Progressive supranuclear palsy (PSP), Corticobasal ganglionic degeneration (CBD), Dementia with Lewy bodies (DLB).

Ultrasonography for Assessment and Intervention With Botulinum Toxin Injection for Tremors.

Tremors are caused by contractions of reciprocally innervated muscles. The role of ultrasound in diagnosing tremors has not yet been investigated, although it appears to be promising because it can visualize muscle movements. In the present study, we report four cases of tremor (Holmes' tremor, extremity tremor associated with palatal myoclonus, dystonic tremor, and tremor associated with dystonia), which were evaluated using ultrasound and treated with botulinum toxin injections. The muscles of patients with tremors were examined using B- or M-mode ultrasound while they were in the supine position. Tremor was determined by involuntary muscular contraction (B-mode) or fasciculation (M-mode) from recorded sonography clips. Thereafter, tremors were measured as frequency and amplitude of specific muscles. Ultrasound-guided botulinum toxin type A injection was administered, and follow-up ultrasonography was used to assess tremors. Tremors, which manifest as a specific set of muscle contractions, were measured using ultrasonography and treated with botulinum toxin injection. Follow-up ultrasonography revealed improved tremors as seen with decreased frequency and amplitude of specific muscle after the intervention, which included medication and botulinum toxin injections. Ultrasonography is an effective assessment tool for tremors, allowing further information regarding tremor characteristics with high sensitivity, playing a role in detecting specific muscles that are affected by tremors, and guiding an exact intervention with botulinum toxin.

Research on the Correlation Between Overburden Rock Fracture Development and High-Energy Events During Deep Mining in Extremely Thick and Weakly Consolidated Strata for Regional Coal Mining Safety

The environmental damage and mining accidents caused by water inrush accidents and rock burst are two major problems faced in the safe and sustainable deep mining of extremely thick weakly cemented overlying strata. Mastering the fracture development law of the overlying strata, the evolution characteristics of high-energy events, and their correlative relationships in the deep mining of extremely thick weakly cemented overlying strata is the key to solving the above two problems, which is directly related to the sustainable development of regional coal and the protection of underground water resources in mining areas. By integrating the geological characteristics of extremely thick and weakly cemented overburdens in the Shaanxi–Inner Mongolia mining region of China, this study adopts methods such as field measurements, numerical simulations, and theoretical analyses to investigate the energy evolution characteristics of regional mining-induced tremors, as well as the correlation and mutual influence mechanisms between overburden fracture development and high-energy events. The results indicate a positive correlation between high-energy events and the development height of overburden fractures, suggesting that the occurrence of high-energy events can increase the height of overburden fracture development. Furthermore, high-energy events occurring before and after the “parallel joining” of two working faces have a relatively minor impact on the development height of overburden fractures, with an increase in the fracture-to-mining ratio (FMR) ranging from 1.56 to 2.78. In contrast, high-energy events occurring during the “parallel joining” of two working faces significantly affect the development height of overburden fractures, resulting in an FMR increase of 10.33 to 13.44, approximately one-third of the FMR measured through boreholes. The research results can provide a scientific basis for the safe and sustainable coal mining and the protection of underground water resources in similar mining areas with extremely thick weakly cemented overlying strata.

Accelerometry in Diagnosis of Functional Tremor

Introduction. Functional tremor (FT) is the most common phenotype of functional movement disorders. Electrophysiological assessment is included in the diagnostic criteria for tremor; however, there is currently no consensus criteria for the differential diagnosis of FT. The objective of this study was to evaluate the utility of tremor frequency characteristics derived from accelerometry for the differential diagnosis between FT and organic tremor (OT). Materials and methods. Nineteen patients with FT, 20 patients with essential tremor, and 20 patients with Parkinson's disease were enrolled in the study and underwent electrophysiological examination with a two-channel accelerometer and subsequent data processing. Results. The study results revealed the differences in the frequency peak widths in patients with FT and OT, predominantly while performing a cognitive load task. This criterion showed a high sensitivity (100%) and a high specificity (97.5%) for the diagnosis of FT in the study population. Conclusion. Tremor characteristics recorded during accelerometry combined with cognitive load task can serve as an additional testing aid for differential diagnosis between functional and organic tremor.

Relative sparing of dopaminergic terminals in the caudate nucleus is a feature of rest tremor in Parkinson’s disease

Resting tremor (RT) is a Parkinson’s disease (PD) symptom with an unclear relationship to the dopaminergic system. We analysed data from 432 subjects from the Parkinson’s Progression Markers Initiative, 57 additional PD patients and controls and 86 subjects referred for dopamine transporter single-photon emission computed tomography (DaT-SPECT). Caudate binding ratio (CBR), but not putamen binding ratio, was higher in RT patients. Furthermore, higher baseline CBR was linked to RT development. In the smaller cohorts, a 4–6 Hz oscillation-based metric from inertial sensors correlated with RT amplitude, distinguished controls from patients with reduced DaT binding and correlated with CBR in the latter group. In silico modelling uncovered that higher CBR in RT patients explained correlations between RT and DaT-SPECT found in several datasets, supporting a spurious origin for ipsilateral correlations between CBR and RT. These results suggest that caudate dopaminergic terminals integrity is a feature of RT with potential pathophysiological implications.

HAND TREMOR DETECTION AND FEEDBACK SYSTEM BASED ON INERTIAL MEASUREMENT UNIT FOR PARKINSON’S DISEASE: A PILOT STUDY

The hand tremor symptoms of Parkinson’s disease (PD) patients are expressed in a wide variety of forms. These tremors are not limited to specific areas, but the most experienced by PD patients are hand-related. To detect such hand tremor symptoms, a device based on an inertial measurement unit (IMU) was used to measure changes in the vibration speed around the wrist. The sensor data collected from the gyroscope through a dedicated algorithm can be reflected to convert it into a result value of the number of tremors of the user, and hand tremor characteristics can be extracted. The performance of the system was validated using a hand tremor simulator. The experiments confirmed that the algorithm operated normally under the specific conditions set (5–18[Formula: see text]Hz) for hand tremor detection, and the operation results matched those of the theoretically detectable range. The wearable device can measure the user’s bio-kinetic signals in daily life using a gyroscope, adjust the algorithm’s sensitivity based on the severity of tremor symptoms, and continuously monitor symptoms by transmitting the recognition results via Bluetooth communication.

Tremor Following Guillain Barré Syndrome.

Neuropathic tremor occurs with damage to the peripheral nervous system. Guillain-Barré syndrome (GBS) causes acute paralysis following nerve inflammation sometimes resulting in long-term disability. It is unclear how frequent and severe tremor is following GBS. We aimed to assess the frequency and features of tremor following GBS. We enrolled 18 patients with GBS treated in a secondary care center within a 4-year period. Evaluations were done with the Fahn-Tolosa-Marin tremor rating scale (FTM-TRS). We compared these features with a cohort of consecutive patients with untreated essential tremor (ET). There were 13 males and 5 females with a mean age at evaluation (S.D.) of 41.5 ± 14.0 years and at GBS onset of 40.2 ± 13.7. No patient had history of tremor before GBS. Upper limb tremor was identified in 16 (89%) cases, 35.5% of patients had FTM-TRS score ≥10 points. Tremor was mostly kinetic, jerky with low amplitude with a total score of 10.94 ± 11.84 in the FTM-TRS. Compared with patients with ET, those with GBS-tremor were younger and had lower scores in all subscales of the FTM-TRS (P value < 0.05 for all comparisons). In a multivariate linear regression analysis "days of hospitalization" had a positive association with the total FTM-TRS score (P = 0.001). Tremor was common following GBS. This tremor is mild compared with patients with ET, but adds functional impact.

Clinical and physiological characteristics of tremor in a large cohort of focal and segmental dystonia

ObjectiveTremor is a frequent co-occurring feature in patients with dystonia, especially in focal and segmental dystonia. Clinical studies have shown that tremor is more commonly observed when dystonia spreads to contiguous body regions. However, there is insufficient characterization of tremor physiology in focal and segmental forms of dystonia. We aimed to ascertain the characteristics of tremor presenting in these specific subtypes.MethodsWe enrolled dystonia patients with head and arm tremors presenting to our center. We categorized these participants as focal and segmental dystonia following the Movement Disorders Society guidelines. We recorded the frequency, amplitude, rhythmicity, burst duration, and discharge pattern on accelerometer and electromyography recordings. We compared the physiology of tremors in focal vs. segmental dystonia. We determined whether the physiology was affected by clinical features such as demographics, age at onset, dystonia duration, alcohol responsiveness, family history, and botulinum toxin responsiveness.Results72 patients, mainly focal cervical dystonia and focal cervical + arm or cranial dystonia (segmental) were enrolled. In the analysis of the head tremor recordings (n = 66; frequency range 3–6.5 Hz), we found that focal vs. segmental dystonia comparisons revealed a significantly lower frequency (mean ± standard deviation; 4.0 ± 0.9 Hz vs. 4.7 ± 1.0 Hz; p = 0.02), lower amplitude (0.004 ± 0.008 g2/Hz vs. 0.006 ± 0.008 g2/Hz; p = 0.03) and longer muscle burst durations (111.1 ± 40.4 ms vs. 91.5 ± 24 ms; p = 0.04). In the analysis of arm tremor recordings (n = 31; frequency range 3.5–7 Hz), we found focal vs. segmental dystonia comparison revealed a lower amplitude (0.04 ± 0.07 g2/Hz vs. 0.06 ± 0.06 g2/Hz; p = 0.045). In the stepwise regression analysis, the age at evaluation (β - 0.44; p = 0.006) and age at onset (β - 0.61; p = 0.005) significantly predicted the head tremor frequency whereas the alcohol responsiveness tended to predict the amplitude of the head tremor (β - 0.5; p = 0.04) and the arm tremor (β - 0.6; p = 0.02).ConclusionOur study found that the physiological characteristics of tremor in focal and segmental dystonia are somewhat distinct, suggesting that the spread of dystonia symptoms from one body region to another may have a bearing on the physiology of co-occurring tremor. The frequency of head tremors in younger participants was observed to be higher compared to older participants. The head and arm tremor tended be less severe in patients reporting alcohol responsiveness.

Impact of SARS-CoV-2 Infection on Essential Tremor: A Retrospective Clinical and Kinematic Analysis

In the past few years, SARS-CoV-2 infection has substantially impacted public health. Alongside respiratory symptoms, some individuals have reported new neurological manifestations or a worsening of pre-existing neurological conditions. We previously documented two cases of essential tremor (ET) who experienced a deterioration in tremor following SARS-CoV-2 infection. However, the effects of SARS-CoV-2 on ET remain largely unexplored. This study aims to evaluate the impact of SARS-CoV-2 infection on a relatively broad sample of ET patients by retrospectively comparing their clinical and kinematic data collected before and after the exposure to SARS-CoV-2. We surveyed to evaluate the impact of SARS-CoV-2 infection on tremor features in ET. Subsequently, we retrospectively analysed clinical and kinematic data, including accelerometric recordings of postural and kinetic tremor. We included 36 ET patients (14 females with a mean age of 71.1 ± 10.6 years). Among the 25 patients who reported SARS-CoV-2 infection, 11 (44%) noted a subjective worsening of tremor. All patients reporting subjective tremor worsening also exhibited symptoms of long COVID, whereas the prevalence of these symptoms was lower (50%) in those without subjective exacerbation. The retrospective analysis of clinical data revealed a tremor deterioration in infected patients, which was not observed in non-infected patients. Finally, kinematic analysis revealed substantial stability of tremor features in both groups. The study highlighted a potential correlation between the SARS-CoV-2 infection and clinical worsening of ET. Long COVID contributes to a greater impact of tremor on the daily life of ET patients.

Magnetic resonance–guided focused ultrasound thalamotomy for tremor

Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy has emerged as an effective treatment for tremor, particularly in those patients who are excluded from deep brain stimulation. The authors illustrate an example of MRgFUS thalamotomy, targeting the ventralis intermedius nucleus, in a 78-year-old patient with tremor who had features of essential tremor and tremor-predominant Parkinson’s disease. Significant tremor improvement was seen during the procedure. The authors review step-by-step the preoperative considerations, Vim targeting, treatment, and outcomes for this evolving treatment modality. The video can be found here: https://stream.cadmore.media/r10.3171/2024.7.FOCVID249

Not All Antihistamines Are Created Equal: Alimemazine As A Cause Of Drug Induced Parkinsonism

Abstract Background A 67year old female presented to a Movement Disorder Service for assessment of tremor. She had a history of presbycusis, dermatitis herpetiformis, bronchiectasis, osteoporosis and stage A chronic lymphocytic leukaemia. History elucidated hypophonia, somniloquy, REM-sleep behaviour disorder, bruxism, presence hallucinosis, insidious bradykinesia and of titubation of increasing prevalence and amplitude over 20years. Examination demonstrated cognitive impairment (Montreal Cognitive Assessment 12+1/30) in the domains of visuospatial function, executive thinking, naming, attention, language, abstraction and anterograde recall. Luria test was 0/6. Also found was: micrographia, left exotropia, reduced left arm and leg swing, kinetic tremor asymmetry, decrement of amplitude and frequency of rapid repetitive movements asymmetrically, mandibular and lingual tremor, positive Kinnier-Wilson test and orthostatic deterioration in yes-yes titubation. Drg history identified use of Alimemazine 10mg for insomnia for approximately 20years. Methods Modified Simpson Angus Scale score was 6 indicating a clinically significant degree of extrapyramidal side effects. Unified Parkinson’s Disease Rating Scale part III was 17. Results Functional dopamine uptake imaging did not indicate a parkinsonian syndrome. Drg induced parkinsonism was diagnosed. 0.0097% of the Northern Ireland population were prescribed Alimemazine in 2022 for non-dermatological reasons, representing 73.49% of all dispensed preparations. In the first financial quarter of 2024 in Northern Ireland, all dispensed prescriptions cost £218,395. Conclusion Not all antihistamines are created equal. Alimemazine is an older phenothiazine derivative antihistamine with central sedative effects equivalent to Chlorpromazine but without anti-adrenaline action. It is rarely prescribed and easily overlooked as “just another antihistamine”. It is commonly prescribed by dermatologists for urticaria. It has substantial pharmacoeconomic implications given its cost disparity with other antihistamines. Extrapyramidal features of tremor, akinesia and hypertonicity are more common in older people; usually developing within weeks or months of commencement. Stopping the drug is the first-line intervention. Resolution of symptoms is not guaranteed.

Radiomics based on diffusion tensor imaging and 3D T1-weighted MRI for essential tremor diagnosis.

Due to the absence of biomarkers, the misdiagnosis of essential tremor (ET) with other tremor diseases and enhanced physiologic tremor is very common in practice. Combined radiomics based on diffusion tensor imaging (DTI) and three-dimensional T1-weighted imaging (3D-T1) with machine learning (ML) give a most promising way to identify essential tremor (ET) at the individual level and further reveal the potential imaging biomarkers. Radiomics features were extracted from 3D-T1 and DTI in 103 ET patients and 103 age-and sex-matched healthy controls (HCs). After data dimensionality reduction and feature selection, five classifiers, including the support vector machine (SVM), random forest (RF), logistic regression (LR), extreme gradient boosting (XGBoost) and multi-layer perceptron (MLP), were adopted to discriminate ET from HCs. The mean values of the area under the curve (mAUC) and accuracy were used to assess the model's performance. Furthermore, a correlation analysis was conducted between the most discriminative features and clinical tremor characteristics. All classifiers achieved good classification performance (with mAUC at 0.987, 0.984, 0.984, 0.988 and 0.981 in the test set, respectively). The most powerful discriminative features mainly located in the cerebella-thalamo-cortical (CTC) and visual pathway. Furthermore, correlation analysis revealed that some radiomics features were significantly related to the clinical tremor characteristics in ET patients. These results demonstrated that combining radiomics with ML algorithms could not only achieve high classification accuracy for identifying ET but also help us to reveal the potential brain microstructure pathogenesis in ET patients.

Action tremor features discovery for essential tremor and Parkinson's disease with explainable multilayer BiLSTM

Action tremor features discovery for essential tremor and Parkinson's disease with explainable multilayer BiLSTM

Resting-State Network Analysis Reveals Altered Functional Brain Connectivity in Essential Tremor.

Introduction: Essential tremor (ET) comprises motor and non-motor-related features, whereas the current neuro-pathogenetic basis is still insufficient to explain the etiologies of ET. Although cerebellum-associated circuits have been discovered, the large-scale cerebral network connectivity in ET remains unclear. This study aimed to characterize the ET in terms of functional connectivity as well as network. We hypothesized that the resting-state network (RSN) within cerebrum could be altered in patients with ET. Methods: Resting-state functional magnetic resonance imaging (fMRI) was used to evaluate the inter- and intra-network connectivity as well as the functional activity in ET and normal control. Correlation analysis was performed to explore the relationship between RSN metrics and tremor features. Results: Comparison of inter-network connectivity indicated a decreased connectivity between default mode network and ventral attention network in the ET group (p < 0.05). Differences in functional activity (assessed by amplitude of low-frequency fluctuation, ALFF) were found in several brain regions participating in various RSNs (p < 0.05). The ET group generally has higher degree centrality over normal control. Correlation analysis has revealed that tremor features are associated with inter-network connectivity (|r| = 0.135-0.506), ALFF (|r| = 0.313-0.766), and degree centrality (|r| = 0.523-0.710). Conclusion: Alterations in the cerebral network of ET were detected by using resting-state fMRI, demonstrating a potentially useful approach to explore the cerebral alterations in ET.

REM sleep behavior disorder and Prodromal Parkinson’s Disease in patients with Essential Tremor

REM sleep behavior disorder and Prodromal Parkinson’s Disease in patients with Essential Tremor

Measurement of Tremors for the Seismic Station of Gllogovc-Kosovo

To select a potential location for a future seismological station properly, it is of crucial importance to explore the existing local seismic tremor recorded by seismographs. This tremor/noise is referred to as seismic tremor, whereas it is necessary to define as precisely as possible its spectral characteristics. It is very important that the station location be as quiet as possible because the seismic noise can obscure the records at the selected location for seismic station. Therefore, in addition to other geophysical methods, it is of particular importance to define the spectral characteristics of the local tremor at the investigated sites.Seismic noise measurements were made at seismic station of Gllogovc - Kosovo. It is very important that the station location be as quiet as possible because the seismic noise can obscure the records at the selected 8 locations for seismic stations.Seismologists are necessary for such investigations.Considering the requirement regarding their sensitivity and resolution,geophones are not recommended to be used. Still, geophones were also used in these measurements for the purpose of comparing the obtained results. The most important requirement that should be fulfilled is that the instrumental noise of the seismometres be much lower than the level of the natural seismic noise at the location.

Matsuoka Nonlinear Oscillator Integration for Investigating Parkinsonian Tremor Dynamics through Multibody Simulation

Parkinson's disease (PD) stands as a relentless neurodegenerative condition marked by a cascade of motor symptoms, such as tremors, rigidity, and bradykinesia. Among these manifestations, tremor emerges as a central feature, exerting a profound impact on the daily lives of those afflicted. Unraveling the complexities of Parkinsonian tremor dynamics holds importance in shaping innovative treatment modalities and interventions aimed at enhancing the well-being of individuals grappling with PD. In recent years, computational modeling techniques have emerged as powerful tools for investigating the complex dynamics of Parkinsonian tremor. Among these techniques, multibody simulation offers a versatile framework for analyzing the biomechanical interactions within the musculoskeletal system. By incorporating realistic anatomical structures and physiological parameters, multibody simulations enable researchers to mimic the dynamics of tremor generation and propagation in the upper limb with high fidelity. The integration of the Matsuoka nonlinear oscillator into the multibody simulation framework presents a novel approach for investigating Parkinsonian tremor dynamics. Inspired by neural circuitry underlying rhythmic movements in biological systems, the Matsuoka oscillator captures the nonlinear dynamics of neuromuscular interactions, producing oscillatory patterns closely resembling tremor characteristics observed in individuals with PD. By leveraging this integration, researchers can replicate pathological tremor phenomena and investigate the underlying mechanisms driving tremor generation. This paper provides a comprehensive overview of the methodology employed for modeling the upper limb and implementing the Matsuoka nonlinear oscillator within a multibody simulation framework. Through the synergistic combination of multibody simulation and the Matsuoka nonlinear oscillator, this study contributes to advancing our understanding of Parkinsonian tremor dynamics and lays the foundation for developing personalized therapeutic interventions for individuals with PD.

Comparing Essential Tremor with and without Soft Dystonic Signs and Tremor Combined with Dystonia: The TITAN Study.

Tremor disorders remain as clinical diagnoses and the rate of misdiagnosis between the commonest non-parkinsonian tremors is relatively high. To compare the clinical features of Essential Tremor without other features (pure ET), ET plus soft dystonic signs (ET + DS), and tremor combined with dystonia (TwD). We compared the clinical features of patients with pure ET, ET + DS, and TwD enrolled in The ITAlian tremor Network (TITAN). Linear regression models were performed to determine factors associated with health status and quality of life. Three-hundred-eighty-three patients were included. Sex distribution was significantly different between the groups with males being more represented in pure ET and females in TwD. The initial site of tremor was different between the groups with about 40% of TwD having head tremor and ET + DS unilateral upper limb tremor at onset. This pattern mirrored the distribution of overt dystonia and soft dystonic signs at examination. Sensory trick, task-specificity, and position-dependence were more common, but not exclusive, to TwD. Pure ET patients showed the lowest degree of alcohol responsiveness and ET + DS the highest. Midline tremor was more commonly encountered and more severe in TwD than in the other groups. Regression analyses demonstrated that tremor severity, sex, age, and to a lesser degree the variable "group", independently predicted health status and quality of life, suggesting the existence of other determinants beyond tremor. Pure ET and TwD manifest with a phenotypic overlap, which calls for the identification of diagnostic biomarkers. ET + DS shared features with both syndromes, suggesting intra-group heterogeneity.

Bedside clinical assessment of patients with common upper limb tremor and algorithmic approach.

The diagnostic approach for patients with tremor is challenging due to the complex and overlapping phenotypes among tremor syndromes. The first step in the evaluation of tremor is to identify the tremulous movement and exclude the tremor mimics. The second step is to classify the tremor syndrome based on the characteristics of tremor from historical clues and focused examination (Axis 1). Comprehensive tremor examinations involve the assessment of tremor in different conditions (rest, action or mixed, position or task-specific), distribution of tremor (upper limb, lower limb, head, jaw), positive signs for functional tremor (FT) if suspected (distractibility, entrainment, co-contraction), and associated neurological signs including parkinsonism, dystonic posture, cerebellar/brainstem signs, neuropathy, and cognitive impairment. A pivotal feature in this step is to determine any distinct feature of a specific isolated or combined tremor syndrome. In this review, we propose an algorithm to assess upper limb tremors. Ancillary testing should be performed if clinical evaluation is unclear. The choice of investigation depends on the types of tremors considered to narrow down the spectrum of etiology (Axis 2). Laboratory blood tests are considered for acute onset and acute worsening of tremors, while structural neuroimaging is indicated in unilateral tremors with acute onset, nonclassical presentations, and a combination of neurological symptoms. Neurophysiological study is an important tool that aids in distinguishing between tremor and myoclonus, etiology of tremor and document specific signs of FT. Treatment is mainly symptomatic based depending on the etiology of the tremor and the patient's disabilities.

Propagation and impacts on roadway of mining-induced far-field strong tremors: insights from numerical simulations

Mining-induced far-field mine tremors, which often cause strong ground tremors, are receiving more attention due to their increasing occurrence. Investigating the rock burst risk of roadway caused by those tremors is crucial to ensure production safety. In this study, Variational Mode Decomposition was used to investigate the wave characteristics of strong mine tremors. The propagation and attenuation of these tremors were explored using the dynamic analysis of Flac3d. The amplification factor was introduced to assess the impact of these tremors on roadways. Plastic zone volume increment and Brittle Shear Ratio (BSR) are used to assess the roadway failure and the rock burst potential caused by these tremors, respectively. The main findings are as follows: 1) Compared with the main frequency of near-field mine tremor waveform, the far-field mine tremors waveform are mainly low frequency below 5 Hz; 2) In the simulation, peak vibration velocities of P-wave and S-wave follow a power-law decay as the propagation distance increases, with P-wave attenuating faster than S-wave; 3) Under similar conditions, P-wave induce higher vibration velocities than S-wave, but S-wave generally exhibit a greater amplification factor than P-wave; 4) When the direction of dynamic load is consistent with the direction of maximum principal stress, the rock burst potential of roadway is higher, which explains the phenomenon that the rock burst potential of roadway under S-wave loading is higher than that under P-wave.