Treatment Of Neurodermatitis Research Articles

Efficacy and feasibility analysis of compound fluocinolone acetonide cream combined with guaiazulene in the treatment of neurodermatitis.

To evaluate the effectiveness and feasibility of combined treatment with compound fluocinolone acetonide cream and guaiazulene in patients with neurodermatitis. A prospective study was conducted on 92 outpatient patients diagnosed with neurodermatitis at our dermatology department from January 2022 to December 2023. Using a random number table, these patients were evenly divided into a control group and an experimental group, with 46 individuals in each group. The control group received treatment with compound fluocinolone acetonide alone, while the experimental group additionally received oral guaiazulene tablets. Clinical symptom and sign scores, Visual Analog Scale (VAS) scores, skin lesion itching scores, comprehensive efficacy, treatment onset time, adverse reactions, and quality of life were monitored, recorded, and compared. In the 2-week treatment period, patients in the experimental group showed significant improvement in skin symptoms and signs, with scores significantly lower than those in the control group (P < 0.05). After treatment, VAS and skin lesion itching scores in the experimental group were significantly reduced (P < 0.05), demonstrating a more pronounced therapeutic advantage compared to the control group (P < 0.05). Although the effective rate in the experimental group was as high as 86.96%, there was no significant advantage compared to the control group, and the difference in treatment efficacy was not significant (P > 0.05). The treatment onset time in the experimental group was significantly shorter than that in the control group (P < 0.05), and the incidence of adverse reactions was lower (P < 0.05). The quality of life in the experimental group improved significantly after treatment, with DLQI scores lower than those in the control group (P < 0.05). Combined treatment with compound fluocinolone acetonide cream and guaiazulene demonstrates excellent efficacy and feasibility in the management of neurodermatitis. Compared to standard treatment alone, it yields superior clinical outcomes.

The Efficacy and Safety of Acupuncture in the Treatment of Neurodermatitis: A Systematic Review and Meta-Analysis.

Background Neurodermatitis is a common chronic inflammatory skin disease associated with neurological dysfunction. This study aimed to explore the efficacy and safety of acupuncture and moxibustion in the treatment of neurodermatitis through meta-analysis. Methods We comprehensively searched 9 databases, including PubMed, Cochrane Library, EMBASE, Web of Science, Scopus, China National Knowledge Infrastructure (CNKI), Wanfang Database, China Science and Technology Journal Database (VIP), and China Biomedicine (CBM), from their inception to November 15, 2021, for published neurological and clinical randomized controlled trials (RCTs) using acupuncture to treat dermatitis. We also searched gray literature in four databases: Chinese Clinical Trials Registry, Chinese Cochrane Center, Open Grey, and GreyNet International. Two authors independently screened the data, extracted the literature, and evaluated the quality of the literature using Cochrane 5.3.3 and Review Manager 5.4.1 software. Results The meta-analysis included 8 studies with a total of 728 participants, including 369 patients in the treatment group and 359 patients in the control group. Compared with conventional treatment, acupuncture significantly increased the effective rate (OR: 2.90, 95% CI: 1.78∼4.75; p < 0.001) and decreased the recurrence rate after treatment (OR: 0.26, 95% CI: 0.12∼0.59; p=0.001). Meanwhile, analysis of disease symptom scores showed that acupuncture group had a greater impact (OR: 3.51, 95% CI: 2.12∼4.91; p < 0.00001). Furthermore, no significant difference in the adverse reaction rate was observed. Conclusion Acupuncture is safe and effective in treating neurodermatitis. However, the current level of research evidence is limited, and therefore, larger sample and high-quality RCTs are needed to confirm its safety and effectiveness. Protocol registration number is INPLASY2021110041.

Therapeutic prospects of mycophenolate mofetil for the treatment of neurodermatitis

Mycophenolate mofetil (MMF), an inhibitor of inosine 5′-monophosphate dehydrogenase, serves to suppress the immune response against alloantigens by hindering purine nucleotide synthesis in immune cells. At present, MMF is US FDA approved for the prevention of allogeneic renal transplant rejection. In this report, the authors demonstrate, to their knowledge, the first case of successful treatment of neurodermatitis complicated by lichen simplex chronicus and prurigo nodularis with MMF.

Clinical efficacy of 0.1％ tacrolimus ointment combined with paroxetine for the treatment of neurodermatitis

Objective To evaluate the clinical efficiency of 0.1％ tacrolimus ointment combined with paroxetine in patients with neurodermatitis associated with insomnia.Methods Totally,74 patients suffering from neurodermatitis and insomnia were consecutively enrolled in this study,and randomly assigned into the combination group and control group according to their number (odd or even).Both groups were given topical 0.1％ tacrolimus ointment twice a day,and the combination group was additionally given oral paroxetine 10 mg once a day,for 8 weeks.The outcome parameters included main symptoms of neurodermatitis and Pittsburgh sleep quality index (PSQI) score.Results No significant difference was observed in the cure rate (54.3％(19/35) vs.53.1％ (17/32),P＞ 0.05) or response rate (82.9％ (29/35) vs.81.3％ (26/32),P＞ 0.05),between the combination group and control group.PSQI score was significantly lower in the combination group than in the control group after 8 weeks of treatment (P ＜ 0.05).Conclusions The 0.1％ tacrolimus ointment can be used to treat neurodermatitis safely.Antianxiety treatment can reduce the recurrence of neurodermatitis associated with insomnia,and improve the quality of sleep in patients. Key words: Neurodermatitis; Sleep initiation and maintenance disorders; Tacrolimus ointment; Antianxiety agents

Neurodermitis im Kindesalter: Zwei Kasuistiken

The treatment of neurodermatitis especially in children is a domain of homeopathy. The proceeding will be demonstrated with two cases.

Efficacy of fluticasone propionate in 0.05% cream for the treatment of neurodermatitis and eczema

目的 评价0.05%丙酸氟替卡松乳膏治疗皮炎湿疹的疗效及安全性.方法对73例神经性皮炎和湿疹患者分别外用0.05%丙酸氟替卡松乳膏和0.1%糠酸莫米松乳膏进行治疗,观察记录患者的临床表现和治疗效果.结果治疗2周后0.05%丙酸氟替卡松乳膏的有效率为89.5%,0.1%糠酸莫米松乳膏的有效率为68.6%,两组相比差异有显著意义(P＜0.05);两组不良反应均少.结论 0.05%丙酸氟替卡松乳膏治疗神经性皮炎和湿疹疗效显著,安全性好。

Treatment of neurodermatitis with seven-star needle plus moxibustion: A report of 63 cases

Sixty-three cases of neurodermatitis were treated with seven-star needle, tapping the affected area until slight bleeding and then ignite moxa-stick to make lsft-right repeated rotation moxibustion about 2 cm away from the skin. The total effective rate was 100% after three treatment course.

Bronchial asthma: information on phytotherapy with essential fatty acids: Interactions between essential fatty acids and steroid hormones

The pharmacological treatment of bronchial asthma is based on the inhalation of bronchodilative β2agonists and steroid hormones. In view of the therapeutic successes obtained with evening primrose oil in the treatment of neurodermatitis in children, the question arises whether this phytotherapeutic substitution therapy could at least partly replace symptomatic pharmacotherapy in bronchial asthma. It is shown that this will only be successful if one dispenses with the anti-inflammatory effect of the treatment with steroid hormones.

Immunotherapy of neurodermatitis in children with bacterial allergies

For the diagnosis and treatment of neurodermatitis with bacterial sensitization in children, purified bacterial allergens of Staphylococcus aureus, Streptococcus pyogenic and Escherichia coli were used. Specific immunotherapy was administered to 99 patients. Good and excellent results were obtained in 76.8% of patients, satisfactory - in 12%, unsatisfactory - in 11.1% of children. The clinical effect was accompanied by a decrease in body sensitization indices and activation of the humoral-cellular link of immunity.

Treatment of neurodermatitis by behavior therapy : a case study

Treatment of neurodermatitis by behavior therapy : a case study

Psychotherapy in Neurodermatitis

To the Editor:— In QUESTIONS and ANSWERS (198:1230, 1966) there was an extensive discussion on the treatment of neurodermatitis by Dr. Sigfrid A. Muller in his reply to an inquiry. I should like to add to Dr. Muller's answer that psychiatric investigation and treatment are of great value to many patients with this condition even though many do have a personal and family history of allergic diseases. Almost all invariably have emotional problems which precipitate or aggravate their neurodermatitis. Unfortunately, their personality problems are so deeply entrenched that they require skilled psychiatric care, in addition to sedation, tranquilization, and topical treatment. A casual, superficial discussion of their emotional problems usually is fruitless since most patients are reluctant to discuss their personal lives early in the course of treatment. It frequently takes a few lengthy visits before trust and rapport are sufficiently established, and the patient is able to expose

Dietetic treatment of neurodermatitis in childhood

Dietetic treatment of neurodermatitis in childhood