We have simulated the design and performance of the simplified coaxial ion trap – a dual ion trap mass spectrometer consisting of an outer simplified toroidal trap and an inner cylindrical trap. The device can perform tandem mass analysis by initially trapping ions in the toroidal region, and then transferring ions mass-selectively to the cylindrical region where they can be fragmented, isolated, and mass-scanned. The key benefit of the coaxial trap is the ability to store and retain the original ion population in the toroidal region while tandem mass analysis is being done in the cylindrical region for a selected mass. This study models a miniaturized simplified coaxial ion trap using the ion trajectory simulation software, SIMION, and characterizes its performance in terms of mass resolution and selectivity of transfer from toroidal to cylindrical regions, ion ejection direction from the toroidal trap, and trapping efficiency in the cylindrical trap. Mass resolution was maximized with a slightly positive octopole term in the toroidal trapping region, and the desired inward radial ejection of ions was achieved with a positive hexapole term. We demonstrate the possibility to obtain an optimized electric field for a given aspect ratio of the toroidal trap by varying only three geometric parameters. Simulated mass resolution from the optimized geometry was 0.3 Da for aspect ratio 8. The trapping efficiency was found to be affected by RF and AC voltages, RF phase, as well as the pressure. A mismatch between the kinetic energy of transferred ions and the RF phase in the cylindrical trap at the time of transfer was found to account for most of the ion loss during transfer. The intricate dependence of trapping efficiency on a number of operational variables was found to lead to trade-offs between itself and other operational parameters such as mass resolution and transfer efficiency. The results demonstrate successful operation of the simplified coaxial trap and reveal the geometric and operational constraints to be considered in its operation.
Read full abstract