Transfer Of Contact Sensitivity Research Articles

Anatomical location of cells which mediate contact sensitivity in the lympho nodes and bone marrow.

AFTER immunization for contact sensitivity with picryl chloride, increased DNA synthesis occurs in the draining lymph nodes and spleen but not in the bone marrow1. The best cell populations for transferring contact sensitivity (when the challenge is made immediately afterwards), however, are peritoneal exudate cells. Bone marrow and spleen cells are less active and lymph node cells, at least 7 d after immunization, are relatively inactive2. It is unexpected that there should be no direct relation between increased DNA synthesis in a tissue after immunization and its ability to transfer contact sensitivity.

The passive transfer of chemical hypersensitivities in rabbits.

SummaryPassive transfer of contact sensitivity in rabbits was demonstrated with peritoneal exudative cells, lymph node cells, alveolar cells, and spleen cells from sensitive animals. Cell-free incubation fluids from these four leukocytic populations were as effective in transferring delayed reactivity as were whole cells. The active material was found to be dialyzable. The results suggest a common mechanism for the delayed-type hypersensitive response in several species.

Attempts to transfer contact sensitivity passively with subcellular fractions in the guinea pig. A study of the specificity of such reactions.

Attempts to transfer contact sensitivity passively with subcellular fractions in the guinea pig. A study of the specificity of such reactions.

Passive transfer of contact sensitivity to picryl chloride in guinea pigs, with subcellular material.

Passive Transfer of Contact Sensitivity to Picryl Chloride in Guinea Pigs, with Subcellular Material