Objective: This study aims to use appropriate neuromonitoring modalities in operations with high neural injury risks, in the Neurosurgery Department of Istanbul Faculty of Medicine, and also purposes to enhance our clinical experience and technical skills on different neuromonitoring techniques. Patients and Methods: We performed multimodal neuromonitoring in 15 patients. There were 3 cerebellopontine angle tumor, 4 spinal cord tumor, 2 cervical spondylosis, 1 arteriovenous malformation, 1 middle cerebral artery aneurysm, 2 tethered cord, 1 Chiari malformation, and 1 syringomyelia operations. Somatosensory-evoked potentials (SEP), transcranial electrical stimulation–motor-evoked potentials (TES-MEP), brainstem auditory–evoked potentials (BAEP), and electromyographic (EMG) monitoring of cranial nerves were used. Results: In a cerebellopontine angle tumor patient, critical EMG alterations were observed. In that patient transient hemiparesis and lateral gaze defect were found postoperatively for 3 days. In one patient with a spinal cord tumor, MEP responses disappeared during surgery. That patient did not develop any postoperative neurological deficit. We did not see any critical changes in monitoring and any new neurological deficit in other 13 patients. Conclusions: We acquired the experience of multimodal neuromonitoring techniques, especially in high-risk neurosurgeries in coordination with surgery and anesthesia crews. Our preoperatory data and postoperative outcomes suggest that intraoperative monitoring provides benefits to the surgeon for minimal neural injury.