Toxic Release Inventory Sites Research Articles

Maternal residential exposure to solvents from industrial sources during pregnancy and childhood cancer risk in California

BackgroundMaternal solvent exposure has been suspected to increase offspring cancer risk. The study aimed to evaluate the associations between maternal residential exposure to solvents from industrial pollution during pregnancy and childhood cancer. MethodsThe present study included 15,744 cancer cases (aged 0–19 years at diagnosis) identified from California Cancer Registry and 283,141 controls randomly selected from California Birth Registry (20:1 frequency-matched by birth year: 1998–2016). We examined industrial releases of tetrachloroethylene and 1,1,1-trichloroethane within 3 km of the birth address, while we used a 5 km buffer for carbon disulfide. We calculated the total exposure from all linked Toxic Release Inventory sites during each index pregnancy and assigned “ever/never” and “high/low exposed/unexposed” exposure, using median values. We performed quadratic decay models to estimate cancer risks associated with maternal solvent exposure in pregnancy. Results1,1,1-Trichloroethane was associated with rhabdomyosarcoma (adjusted Odds Ratio (aOR): 1.96; 95% Confidence Interval (CI): 1.16, 3.32) in the “ever exposed” group. Ever exposure to carbon disulfide was associated with increased risks of medulloblastoma (OR = 1.85, 95% CI 1.01, 3.40) and ependymoma (OR = 1.63, 95% CI 0.97, 2.74). ConclusionsOverall, our findings suggested maternal residential exposure to solvents from industrial sources might be associated with elevated childhood cancer risks.

Climate stress and anxiety, environmental context, and civic engagement: A nationally representative study

There is increasing recognition that people are experiencing stress and anxiety around climate change, and that this climate stress/anxiety may be associated with more pro-environmental behavior. However, less is known about whether people's own environmental exposures affect climate stress/anxiety or the relationship between climate stress/anxiety and civic engagement. Using three waves of survey data (2020–2022) from the nationally representative Tufts Equity in Health, Wealth, and Civic Engagement Study of US adults (n = 1071), we assessed relationships among environmental exposures (county-level air pollution, greenness, number of toxic release inventory sites, and heatwaves), self-reported climate stress/anxiety, and civic engagement measures (canvasing behavior, collaborating to solve community problems, personal efficacy to solve community problems, group efficacy to solve community problems, voting behavior). Most participants reported experiencing climate stress/anxiety (61%). In general, the environmental exposures we assessed were not significantly associated with climate stress/anxiety or civic engagement metrics, but climate stress/anxiety was positively associated with most of the civic engagement outcomes (canvassing, personal efficacy, group efficacy, voter preference). Our results support the growing literature that climate stress/anxiety may spur constructive civic action, though do not suggest a consistent relationship between adverse environmental exposures and either climate stress/anxiety or civic engagement. Future research and action addressing the climate crisis should promote climate justice by ensuring mental health support for those who experience climate stress anxiety and by promoting pro-environmental civic engagement efforts.

Abstract C095: Deconstructing the link between neighborhood disadvantage and triple negative breast cancer: Preliminary evidence in support of cumulative exposure to area-level risk factors

Abstract Background: Triple negative breast cancer (TNBC) is an aggressive subtype of invasive breast cancer that disproportionately affects Black women and contributes to racial disparities in breast cancer mortality. Prior research has found evidence of a link between TNBC risk and neighborhood/area-level measures of disadvantage, including socioeconomic status and racial segregation. This study evaluated additional area-level exposures as potential mediators of the relationship between neighborhood disadvantage and TNBC risk in New Castle County, DE, a region with elevated rates of TNBC. Methods: The study population included 3,316 Black and White adult female residents of New Castle County who were diagnosed with invasive breast cancer at the Helen F. Graham Cancer Center & Research Institute (HFGCCRI) in Newark, DE from 2012-2020. Patient addresses were geocoded, and demographic and clinical measures were abstracted from the HFGCCRI cancer registry. Neighborhood and environmental exposure measures were generated from electronic health records (EHR), the US Census Bureau American Community Survey, and Environmental Protection Agency (EPA) Risk-Screening Environmental Indicator (RSEI) data; these measures were aggregated to the census tract and linked to patient geocodes. Included neighborhood exposure measures were factors that may influence patient-level exposure to well-known breast cancer risk factors, including alcohol use disorder (AUD) and diabetes prevalence, breastfeeding (assessed with the proxy measure ‘% single female-headed households with children’), and toxic environmental indicators (e.g., toxic release inventory sites). The relationships between these exposures and the odds of TNBC (relative to other subtypes of invasive breast cancer) were first evaluated on a univariate basis. Next, to estimate the relationship between cumulative exposure and TNBC odds, census tract risk scores were calculated by dichotomizing each exposure into low- and high-risk categories and summing the total of high-risk exposures. A multilevel logistic regression model was used to test the association between this risk score and TNBC odds while adjusting for patient-level age and race.Results: TNBC cases accounted for 14% (n = 453) of invasive breast cancer cases. Significantly higher odds of TNBC were observed for patients who reside in census tracts characterized by higher rates of AUD, diabetes, % single female-headed households with children, and RSEI scores. In the multilevel logistic regression model that adjusted for patient demographics, the cumulative exposure risk score was significantly associated with greater odds of TNBC. Conclusion: Results provide preliminary support for a link between TNBC odds and cumulative, area-level exposure to disordered alcohol use, metabolic disorders, lower breastfeeding rates, and toxic environmental indicators. Additional research evaluating the cumulative exposure risk score as a potentially modifiable mediator of the relationship between neighborhood disadvantage and TNBC risk will be presented. Citation Format: Scott D. Siegel, Madeline M. Brooks, Jesse D. Berman, Shannon M. Lynch, Jennifer Sims-Mourtada, Zachary T. Schug, Frank C. Curriero. Deconstructing the link between neighborhood disadvantage and triple negative breast cancer: Preliminary evidence in support of cumulative exposure to area-level risk factors [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr C095.

Environmental Exposures and Seizures Treated by Illinois Emergency Medical Services and Hospitals.

Up to 10% of the population will have at least one seizure in their lifetime, with young children and elderly having the highest risk (WHO 2019). Human epidemiological studies and controlled animal studies have shown that exposure to common environmental pollutants, including carbon monoxide, lead, and nitrogen dioxide may lead to neurotoxicity and alter human susceptibility to seizures. While the biomechanism causing altered human seizure susceptibility is not entirely clear, air pollution has been shown to increase oxidative stress and neuroinflammation in humans and animals. The small number of human studies have included populations exposed to high levels of ambient air pollution, but the results have been inconsistent in regard to an increase in seizure occurrence and sudden deaths among people with epilepsy. There remains no reported data on the presence and strength of an association between chronic low-level environmental exposures to common air pollutants and seizure risk. Using medical billing records from Illinois hospitals and emergency medical services data on ambulance runs from 2011-2019, we evaluated the association between point sources of pollution mixtures (Toxic Release Inventory sites, Superfund sites, highways) and ZIP code level seizure rates.

Schools near Toxics Release Inventory Sites: An Environmental Justice Study for Schoolchildren in Boston, MA

Previous research on environmental justice has demonstrated a disproportionate burden of environmental hazards on low-income and minority residents. This study uses statistical and GIS analysis methods to examine whether, in Boston, there are disparities in the proximity of public schools to Toxics Release Inventory sites based on school-level characteristics, such as schoolchildren’s racial and socio-economic statuses, educational resources and academic achievements. Research results show that schools with high percentages of minority (i.e. Black schoolchildren) and economically disadvantaged schoolchildren are more likely to be located closer to Toxics Release Inventory sites in Boston, indicating the existence of an environmental injustice issue in the city. In addition, schoolchildren in the schools located closer to Toxics Release Inventory sites tend to have lower academic performance. This research suggests that special attention should be given to unequal exposure of public schools to hazardous sites in Boston and calls for decision makers to spend scarce funds on promoting environmental justice. Such changes could have positive effects on schoolchildren’s academic achievements.

Relations Between Residential Proximity to EPA-Designated Toxic Release Sites and Diffuse Large B-Cell Lymphoma Incidence.

Examining the spatial patterns of diffuse large B-cell lymphoma (DLBCL) incidence and residential proximity to toxic release locations may provide insight regarding environmental and sociodemographic risk factors. We linked and geocoded cancer incidence data for the period 1999-2008 from the Georgia Comprehensive Cancer Registry with population data from the US Census and the Environmental Protection Agency's Toxics Release Inventory. We conducted cluster analyses and constructed Poisson regression models to assess DLBCL incidence as a function of mean distance to the toxic release sites. In total, 3851 incident DLBCL cases occurred among adults residing in Georgia between 1999 and 2008. Significant focal clustering was observed around 57% of ethylene oxide sites, 5% of benzene sites, 9% of tetrachloroethylene sites, 7% of styrene sites, 10% of formaldehyde sites, 5% of trichloroethylene sites, and 10% of all release sites. Mean distance to sites was significantly associated with DLBCL risk for all chemicals. Proximity to Toxics Release Inventory sites can be linked to increased DLBCL risk as assessed through focal clustering and Poisson regression, and confirmatory studies using geospatial mapping can aid in further specifying risk factors for DLBCL.

Total and cardiovascular mortality rates in relation to discharges from toxics release inventory sites in the United States

BackgroundThis study analyzed Toxics Release Inventory (TRI) discharges in association with covariate-adjusted total and cardiovascular mortality rates for males and females in US counties. MethodsAverage annual county-level reported releases from TRI facilities measured in pounds per square mile which were calculated for the years1990–1999, and tested for associations with age-adjusted mortality rates for 2006–2010. Chemicals were grouped into four categories: 1) carcinogens, 2) metals, 3) hazardous air pollutants, and 4) chemicals in the Comprehensive Environmental Response, Compensation and Liability Act. For each of these chemical groups the reported total, water, and air emissions were measured. Age-adjusted mortality rates were found separately for males and females from the Centers for Disease Control and Prevention for total and cardiovascular disease. Covariates included rates of smoking, obesity, high school and college education, race/ethnicity, poverty, unemployment, percent without health insurance, and urban–rural setting. Data were analyzed using multiple linear regression models. ResultsGreater average annual TRI releases in 1990–1999 in all four chemical categories were significantly associated with higher mortality rates in 2006–2010 for both total and cardiovascular mortality, and for both males and females, adjusted for covariates. Associations were stronger for air releases than for water releases. ConclusionsThis study provides the first evidence that greater amounts of TRI releases are related to higher population mortality rates for cardiovascular disease. In addition, the study showed that adverse TRI effects were broadly present for both males and females for multiple chemical groups. Further progress is needed to reduce the use and release of harmful chemicals from TRI facilities in the United States.

Non-random geographic distribution of patients with cutaneous T-cell lymphoma in the Greater Pittsburgh Area

Environmental hazards may play a role in the etiology of cutaneous T-cell lymphoma (CTCL). Some studies have found an increased incidence of CTCL among workers in chemical science, transportation, and manufacturing industries, but other studies have not. This discrepancy may be attributable to population migration, complicating accurate assessment of lifetime exposures. The Pittsburgh population has very low migration rates and most CTCL patients seen at the University of Pittsburgh Medical Center (UPMC) Cutaneous Lymphoma Center are life-long local residents. The Greater Pittsburgh Area used to be an industrial hub. There are residential communities positioned within close proximity to inactive industrial sites that continue to contain pollutants. To determine whether CTCL patients' residences cluster within specific Pittsburgh regions, in particular, those with high levels of environmental pollutants. Our study included patients diagnosed with CTCL at the UPMC Cutaneous Lymphoma Center between 2000 and 2012. We mapped the longitudinal and latitudinal coordinates of patients' residences at diagnosis, superfund sites, toxic release inventory sites, particular matter levels, and dermatologists' offices using ArcMap 10.1. We then performed a SaTScan analysis using zip codes to assess for geographic clustering of patients' residences in the Pittsburgh metropolitan statistical area. We assessed for a correlation between case distribution and both environmental hazards sites and dermatologist density in the area. We identified 274 patients with CTCL in the Greater Pittsburgh area. We identified a statistically significant geographic cluster (p<.001) in zip code 15213, which is the most densely populated neighborhood in Pittsburgh and the site of the region's only CTCL clinic. We observed no relationship between the locations of superfund sites, toxic release inventory sites, or particular matter levels and CTCL case distribution. Our findings do not support an association between exposure to environmental toxins and CTCL. CTCL cases clustered in areas with the highest population density, which also happen to include a regional CTCL center. To evaluate a possibility of urban pollutants playing a role in etiology of CTCL, dermatologist density and access to care need to be addressed as potential confounders in the future studies.

Spatio-temporal patterns of bladder cancer incidence in Utah (1973-2004) and their association with the presence of toxic release inventory sites

BackgroundThe authors analyse the spatio-temporal variations of the incidence of bladder cancer between 1973 and 2004 in Utah at the census tract level (496 areas) to highlight areas of high and low relative risks that remained so throughout the 32 year period. Using these identified areas, a novel strategy is used to carry out a geographical case-control study of association between the risk of bladder cancer and presence of Toxic Release Inventory sites, where areas with stable high RRs are 'case areas' and all remaining areas with stable non increased risks are 'control areas'.ResultsThe time trend of bladder cancer risk fluctuated over the study period: A steady decrease was observed, followed by an abrupt increase from 1992 to 2004. Using a Bayesian space-time model, 93 census tracts were classified as having an excess relative risk and 81 a lower relative risk, sustained over the 32 years. We showed that these high relative risk areas for bladder cancer were associated with the presence of Toxic Release Inventory sites, after adjusting for the proportion of Latter-Day Saint Church members as an area level proxy for smoking habits.ConclusionsOur study has demonstrated that the modeling of data in time and space has additional benefits over a purely spatial analysis. In addition to highlighting the areas with high and low relative risks, this model also allows the simultaneous study of persistency of spatial patterns over time and detection of 'unusual' time trends that may warrant further investigation.

Potential environmental contaminant risks to avian species at important bird areas in the Northeastern United States

Environmental contaminants can have profound effects on birds, acting from the molecular through population levels of biological organization. An analysis of potential contaminant threats was undertaken at 52 Important Bird Areas (IBAs) within the northeastern Atlantic coast drainage. Using geographic information system methodology, data layers describing or integrating contamination (impaired waters, fish or wildlife consumption advisories, toxic release inventory sites, and estimates of pesticide use) were overlaid on buffered IBA boundaries, and the relative threat at each site was ranked. Some species of birds residing at Jefferson National Forrest (NF), Stewart B. McKinney National Wildlife Refuge (NWR), Great Dismal Swamp NWR, Blue Ridge Parkway, Shenandoah National Park (NP), Adirondack Park, Edwin B. Forsythe NWR, George Washington NF, Green Mountain NF, Long Island Piping Plover Beaches, and Merrymeeting Bay may be threatened by environmental contaminants. These sites exhibited moderate to high percentages of impaired waters and had fish consumption advisories related to mercury and polychlorinated biphenyls, and were located in counties with substantial pesticide use. Endangered, threatened, and Watch List bird species are present at these sites. The Contaminant Exposure and Effects-Terrestrial Vertebrates database was searched within buffered IBA boundaries, and for a moderate number of sites there was concordance between the perceived risk and contaminant exposure. Several of the IBAs with apparently substantial contaminant threats had no avian ecotoxicological data (e.g., George Washington NF, Shenandoah NP). Based upon this screening level risk assessment, contaminant biomonitoring of birds is warranted at such sites, and data generated from these efforts could foster natural resource management activities.

Environmental equity and the distribution of toxic release inventory and other environmentally undesirable sites in metropolitan New York City

We study the question of environmental equity via generalized linear modeling for the metropolitan New York City region and ask whether, after accounting for socioeconomic status, particular racial/ethnic populations bear a disproportionate burden of hosting environmentally undesirable sites. Our data consist of population demographics for 2216 census tracts linked to 354 environmentally undesirable facilities, including toxic release inventory sites, hazardous waste treatment, storage, and disposal facilities, and other common urban problem sites such as landfills, incinerators, bus garages and sewage treatment plants. Using generalized linear and additive modeling techniques, we find that racial/ethnic demographics, in particular the Hispanic percentage of a tract's population, are significantly associated with the presence of potentially environmentally adverse sites. This leads us to the conclusion that, over the whole metropolitan New York City area, the Hispanic population is proximate to more sites than other populations. At the same time, we find that both Hispanics and African-Americans are more proximate to these sites in the Bronx and Queens. However, we also find indications that Hispanics and African-Americans are less likely to be proximate to the sites in Manhattan. We establish an empirical relationship that warrants additional study in order to establish the causes for the population distribution and whether a basis for a claim of discrimination exists.