7269 Background: Sleep disturbances have been reported in up to 79% of pts with cancer. The purpose of this pilot study was to characterize the sleep patterns and possible cognitive/behavioral targets for intervention in early stage lung cancer (LC) pts with insomnia. Secondary endpoints included the evaluation of the relationship between sleep patterns and measures of sleep, mood and LC sxs. Methods: 33 patients with Stage I - IIIA lung cancer were enrolled with 20 pts reporting insomnia and 13 without insomnia. Participants completed a baseline series of questionnaires about their insomnia sxs, sleep habits, mood and LC sxs such as pain, cough, fatigue, and SOB. The following week, they completed sleep logs measuring total sleep time (TST), total wake time (TWT), time in bed (TIB) and sleep efficiency (SE) [(total sleep time/time in bed) x 100]. Results: Pts with insomnia reported significantly more insomnia sxs (p= 0.001), less TST (p=.003), more TWT (p=.003), and lower SE (p=0.0001). In addition, pts with insomnia reported significantly more dysfunctional beliefs and attitudes about beliefs (p-0.0262), and higher generalized anxiety (p = 0.0235) . Correlational analyses examining the relationship between the daily sleep log variables and the baseline measures of sleep, mood and LC sxs revealed that patients who reported lower levels of SE and higher levels of TWT also reported more insomnia sxs (p=.00002 and p=.0006), more negative sleep hygiene practices (p=.0199 and p=.0164), higher generalized anxiety (p=.0058 and p=.0045) more dyspnea (p=.0072 and p=.0035) and higher levels of pain in the chest Pts with insomnia reported a lower quality of life more fatigue and more diarrhea than those without insomnia. Conclusions:These preliminary findings suggest that early stage LC pts with insomnia sleep less efficiently, have more wake time during the sleep period, and experience more anxiety and chest pain than those without insomnia. A second study is on going using cognitive behavioral interventions toward identified targets such as dysfunctional beliefs and negative sleep hygiene practices toward the goal of affecting lung cancer symptomatology. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Aventis Aventis NIH (PREP Grant) Aventis Aventis