Category: Epidemiology and Outcomes from AKI Presenter: Dr SHARIFAH NOOR ADRILLA LONG MOHD NOOR AFFENDI Keywords: Human Immunodeficiency Virus, Tenofovir, Protease Inhibitor, Acute Kidney Injury Acute kidney injury (AKI) is an important reason for hospitalization and admission to the nephrology wards . Literature has shown that it often associated with severe consequences. To determine the prevalence, risk factors and outcome in patients admitted to Nephrology ward for AKI. This is a retrospective observational study conducted in Nephrology ward 7B, Hospital Selayang. All patients who were admitted with the diagnosis of AKI from 1st January 2015 till 30th June 2016 were identified and data were collected from patients' electronic medical records in the total hospital information system. Statistical analysis using SPSS version 23. A total of 2500 patients were admitted in Nephrology Ward 7B during study period. 8.44 %(n=211) admissions were diagnosed as AKI but only 3% ( n =84) fulfilled the criteria based on AKIN for diagnosis of AKI. 52% (n=43) of the patients were male and predominantly, 77% below the age of 65. The mean age is 50.2±17.3 years old. 66% were Malay, 25% Chinese and followed by 9% of Indian ethnicity. Comorbidities identified during this study period are hypertension (55%), diabetes mellitus (44%) and glomerulonephritis (14%). 84(64%) of the studied cohort had chronic kidney disease (CKD). Their mean baseline serum creatinine was 145.7±103 umol/L. Precipitating factors for AKI are nephrotoxic agents (40%) mainly non-prescribed medications ie supplements, herbal therapy, infection(38%), dehydration(12%) and relapse of underlying glomerulonephritis (15%). 29% of the patients were subjected for renal biopsy to ascertain cause of AKI. 6 months after AKI event, 21% of the study group were on renal replacement therapy predominantly hemodialysis, 35% remain being CKD stage 2 to 4, 33% had renal recovery to baseline, 6% died during hospitalization and 5% were lost to follow up. Nephrotoxic agents mainly non-prescribed medication was identified as the main cause of AKI in this cohort. AKI is only 3% of total work burden in nephrology generally but the sequelae of AKI are severe which were characterized by increased risk of short-term mortality, incident CKD and accelerated progression to end stage renal disease. Therefore, it is imminent to diagnose AKI and intervene early to minimise complications.