Articles published on Titanium plate
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- New
- Research Article
- 10.1016/j.jormas.2025.102698
- Jun 1, 2026
- Journal of stomatology, oral and maxillofacial surgery
- Ntombizodwa P Zwane + 5 more
This study assessed the effect of cold atmospheric plasma (CAP) using argon and oxygen on Candida albicans biofilm growth on titanium. Titanium disks were treated with CAP at 10 and 20 min exposure using argon or oxygen plasma. Typical growth from an unspecified clinical Isolate Test Group (TG) (n = 8 for colony forming culture method, n = 8 for biofilm forming method) and resistant (ATCC 10,231) strain Positive Control (PC) (n = 8 for colony forming culture method, n = 8 for biofilm forming method) were tested. Negative Control (NC) was used, which involved plasma-untreated titanium plates (n = 2 for colony-forming culture method, n = 2 for biofilm-forming method). Colony-forming units (CFU) were counted, inactivation rates calculated, and biofilm quantified using optical density at 495 nm (OD495). ANOVA and two-sample tests were applied. Oxygen plasma achieved 100% inactivation of TG, while argon plasma showed partial reduction. For resistant PC, oxygen plasma showed no effect, whereas argon achieved up to 99.5% inactivation. ANOVA revealed that group (TG vs PC) was the only significant factor (p = 0.011). Biofilm formation differed significantly between TG and PC (p = 0.014). CAP shows strain-specific antifungal activity against C. albicans. Oxygen plasma effectively inhibited TG but not resistant strains, while argon plasma partially reduced both. CAP may have potential as an adjunctive antifungal strategy.
- New
- Research Article
- 10.1016/j.jormas.2026.102836
- May 12, 2026
- Journal of stomatology, oral and maxillofacial surgery
- Chengtao Wang + 7 more
Strategic Optimization of Osseous Reconstruction for Post-Oncologic Resection Maxillofacial Defects: A Clinical Outcomes Analysis.
- New
- Research Article
- 10.1186/s12903-026-08455-8
- May 9, 2026
- BMC oral health
- Amr Hassaan Elyamany + 2 more
Mandibular body fractures are common maxillofacial injuries, often resulting from road traffic accidents. Optimal management seeks anatomical reduction and stable fixation. Recent advances highlight the adjunctive use of low-level laser therapy (LLLT) and Titanium-Prepared Platelet-Rich Fibrin (T-PRF) to enhance bone healing. LLLT stimulates osteogenesis and angiogenesis, while T-PRF provides sustained growth factor release. This pilot study examines the synergistic potential of LLLT and T-PRF in improving bone regeneration and clinical outcomes in mandibular body fracture repair. Open reduction and internal fixation (ORIF) of posterior mandibular fractures was performed using titanium plates and screws. Patients were divided into two groups: the control group received T-PRF placement at the fracture site, while the study group received T-PRF followed by postoperative LLLT sessions. Using Computerized Tomography, bone mineral density was evaluated at three months postoperatively. Clinical parameters, including pain, wound healing, maximum mouth opening, and edema, were monitored postoperatively to evaluate recovery dynamics. Twelve patients (14 fracture lines) were treated with ORIF and divided equally into two groups. All patients achieved satisfactory anatomical reduction and stable occlusion. The study group demonstrated significantly higher bone density at 12 weeks and experienced significantly greater pain reduction during the first and second weeks postoperatively (p < 0.05) compared to controls. Both groups showed similar results in mouth opening, wound healing, and edema resolution, with no significant intergroup differences in these parameters. The adjunctive application of LLLT with T-PRF significantly enhanced osseous regeneration in the study group, yielding higher bone density at 12 weeks and greater pain reduction compared to T-PRF alone. However, both groups demonstrated equivalent improvements in clinical outcomes - including edema resolution, maximum mouth opening, and wound healing - with no significant intergroup differences.
- Research Article
- 10.1093/icvts/ivag131
- May 4, 2026
- Interdisciplinary Cardiovascular and Thoracic Surgery
- Ryu Kanzaki + 5 more
ObjectivesChest wall resection for non-small cell lung cancer (NSCLC) with chest wall invasion is rare and technically demanding, requiring complete resection and durable reconstruction. Although titanium-based devices are increasingly used, NSCLC-specific outcome data remain limited. We evaluated short- and mid-term outcomes of titanium plate-based chest wall reconstruction in NSCLC.MethodsWe retrospectively reviewed 16 consecutive patients who underwent en bloc pulmonary and chest wall resection with titanium plate reconstruction for NSCLC between 2013 and 2019. Indications included resection of ≥3 ribs or anticipated instability. Reconstruction used perforated titanium plates tailored to defect geometry. Postoperative complications, late reconstruction-related events, and oncologic outcomes were analysed.ResultsPreoperative therapy was administered in 8 patients (50%), including chemoradiotherapy in 7. R0 resection was achieved in 94%. Defects were predominantly posterior, with reconstruction adjacent to the scapula in 12 patients (75%). Thirty-day postoperative complications occurred in 9 patients (56%), consisting predominantly of pulmonary events. Postoperative chemotherapy was given to 6 patients (38%). During a median follow-up of 24 months (mean 54 months), 2 late complications occurred: chest wall haematoma and empyema. Only 1 chest wall local recurrence was observed. No structural failure or scapular impingement occurred. Five-year recurrence-free and overall survival rates were 35% and 63%, respectively.ConclusionsTitanium plate-based chest wall reconstruction enables extensive en bloc resection for NSCLC with chest wall invasion while maintaining mid-term structural stability. With appropriate patient selection and follow-up, this technique provides acceptable mid-term outcomes with durable structural stability.
- Research Article
- 10.1016/j.jmbbm.2026.107376
- May 1, 2026
- Journal of the mechanical behavior of biomedical materials
- Devleena Bose + 3 more
PLA-based composite implants for mandibular fracture: towards bioresorbable solutions.
- Research Article
- 10.1002/mrm.70385
- Apr 20, 2026
- Magnetic resonance in medicine
- Diego González-Soto + 5 more
To compare experimentally measured gradient-induced vibrations in MRI with computational results obtained from multiphysics finite element simulations. Gradient-induced vibrations in a 3T scanner were quantified on commercially pure Titanium (CpTi) and polyetheretherketone (PEEK) plates following the ISO/TS 10974:2018 methodology. Sinusoidal and trapezoidal sequences were used. Vibrations were measured using Laser Doppler Vibrometry. The laser beam was redirected with a prism mounted on a custom measuring bench, allowing the measurement of vibrations perpendicular to the static magnetic field. RMS and the magnitude of the static magnetic field were measured and used as inputs for numerical simulations. The experimental results were compared with simulations performed using a weakly coupled multiphysics approach that involved the resolution of both electromagnetic and linear elasticity equations by the finite element method. Both experimental and computational approaches gave access to the distribution of vibration magnitudes on the tested plates. The average relative difference between measured and simulated displacements was across all frequencies and all types of sequences tested. The transmitted vibrations of the scanner accounted for less than of the difference in displacements. The locations of maximal vibration magnitude were consistent between experiments and simulations. Gradient-induced vibrations were evaluated both experimentally and computationally, with good agreement. Observed differences allowed for the evaluation of setup limitations and inherent uncertainties. Based on these results, the proposed computational approach can be used with a good level of confidence to evaluate and predict gradient-induced vibrations of implantable medical devices.
- Research Article
- 10.1007/s11223-026-00870-0
- Apr 14, 2026
- Strength of Materials
- A I Ustinov + 2 more
Effect of Co-Fe Ferromagnetic Coatings on the Dynamic Properties of Titanium Plates
- Research Article
- 10.21037/qims-2025-1-2509
- Apr 8, 2026
- Quantitative Imaging in Medicine and Surgery
- Shaohui Song + 2 more
BackgroundRib fractures are a frequent consequence of thoracic trauma. Although surgical stabilization of rib fracture (SSRF) is the established treatment for severe cases, selecting appropriate rib-encircling plates remains a predominantly subjective, intraoperative process. This empirical assessment carries an inherent risk of implant-anatomy mismatch. This study aimed to evaluate the feasibility and accuracy of a three-dimensional (3D) “virtual overlapping” technique for determining optimal plate dimensions prior to surgery.MethodsThis prospective cohort study enrolled 29 consecutive adult patients with multiple displaced rib fractures (displacement ≥1 shaft width). 3D rib models were generated from preoperative computed tomography (CT) scans. Digital templates of titanium and memory-alloy plates were virtually matched to the fracture sites to preoperatively select the optimal implant size. The primary outcome was intraoperative concordance between the pre-selected size and the actual implanted plate.ResultsThe cohort included 29 patients (21 males, 8 females; mean age, 56.2±14.6 years). Comprehensive preoperative planning, specifically targeting 2–3 critical fracture ends, required approximately 1.5–2 hours per case. Preoperative virtual sizing was successfully performed for all patients. Intraoperative verification confirmed that the pre-selected plates achieved secure fixation and appropriate anatomical fit in all 29 cases (100% concordance), with no need for intraoperative hardware exchange. Postoperative CT confirmed precise plate apposition to the rib surface, with no need for intraoperative hardware exchange.ConclusionsIntegrating 3D virtual overlapping technology into preoperative planning is feasible and enables accurate plate sizing. This approach offers an objective method to reduce intraoperative uncertainty and potential sizing errors in rib fracture surgery.
- Research Article
- 10.1177/03913988261439939
- Apr 1, 2026
- The International journal of artificial organs
- Ramananda Sengupta + 4 more
Tibial fractures are a common type of long bone injuries, requiring solid fixation for quicker bone healing and functional recovery. Metallic plates, although widely use, have been associated to stress shielding due to their enhanced stiffness, which can prevent callus formation and adversely affect the long-term outcomes. This study develops and assesses composite bone plates reinforced with unidirectional carbon fibres in different stacking sequences, comparing their biomechanical performance with titanium plates through finite element (FE) analysis. A 3D model of the tibia with a 1 mm oblique fracture gap was reconstructed from scanned bone data and simulated under physiological axial loading (700 N). Stress distribution within cortical and cancellous bone, plates and screws, as well as axial and shear displacements at the fracture site, were analyzed. Results demonstrated that composite plates (particularly configurations C4, C10 and C11) exhibited higher stress transfer to bone and greater controlled fracture gap movements compared with titanium, thereby minimizing stress shielding and promoting favorable conditions for callus formation. Axial and shear displacements with carbon/epoxy plates were 88% and 48% higher, respectively, than titanium plates, without compromising fixation stability. These findings suggest that carbon fibre-reinforced composites offer a promising alternative to metallic implants by balancing flexibility and stability, though further validation with nonlinear material models, cyclic loading and clinical trials is required.
- Research Article
- 10.1016/j.ajodo.2026.01.023
- Apr 1, 2026
- American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
- Shukui Xu + 5 more
Personalized 3-dimensional-printed titanium plate bone-anchored maxillary protraction and 3-dimensional mandibular remodeling in adolescents with skeletal Class III malocclusion: A retrospective limited-sample study.
- Research Article
- 10.3390/jcm15072671
- Apr 1, 2026
- Journal of clinical medicine
- Funda Goker + 7 more
Background/Objectives: Unilateral condylar hyperplasia is an idiopathic condition that causes facial asymmetry and occlusal problems. Currently, traditional treatment protocol is the combination of orthognathic and extra-oral condylectomy surgery via pre-auricular incision, which can create aesthetic problems with additional risks of facial nerve damage. The purpose of this study was to report management of condylar hyperplasia patients through minimally invasive condylectomy that was planned via virtual methods. Methods: The custom-made cutting guides were produced, and unilateral condylectomy operations were performed via intra-oral approach. Orthognathic surgery with/without genioplasty operations were either done with condylectomy in one session or in an additional session. Results: Custom-made cutting guides produced by virtual methods provided easy operations without any need for additional extra-oral incisions. Planned osteotomies were transferred successfully from the virtual surgical plan and resections of the excess bone tissues were performed using novel piezo surgery devices. The bones were fixed to their pre-planned position using 3D-printed titanium plates. The patients healed without any complications. Results of this innovative virtually guided protocol tested showed functional and esthetic results without any extra-oral scars with no facial nerve damage. Conclusions: Combination of intra-oral condylectomy with orthognathic surgery using 3D-printed titanium cutting guides seems to be an advantageous approach with successful results in terms of aesthetics and function for management of mandibular condylar hyperplasia patients; however, there is an urgent need in the scientific literature for further clinical research with a larger number of subjects.
- Research Article
- 10.1097/scs.0000000000012698
- Apr 1, 2026
- The Journal of craniofacial surgery
- Kamil Nelke + 1 more
A mandibular plating procedure during ORIF (open reduction and internal fixation) is a very common procedure during various types of mandibular fractures. The scope of each trauma can be caused by a majority of factors; however, maintaining proper bone shape, immobility, stable anatomic position, and improving healing after trauma is essential. Various titanium plating systems can be used. The so-called prophylactic or preventive mandibular plating (PMP) is a rare approach and can be applied in some special cases when the possibility of iatrogenic or pathologic mandibular fracture might happen at some period of time after mandibular surgery. The authors want to share and present their experience with PMP based on evaluated cases. A total of 19 cases of PMP from the past 7 years were reviewed and evaluated to measure the necessity for this procedure, its outcomes, and to explore important bone-related remarks. When PMP was used in different cases of bone lesions treated, no pathologic fractures occurred after the procedure (P<0.05). A combination of some bone graft and PMP influenced good and improved healing. The scope of used plating systems, screws, their shape, position, and length have no standardization, and all of them worked in terms of bone stability (P>0.05). Inflammation in the operated area was rare (5.3%), whereas in 21.1% of cases, plates were removed because of further dental and implant procedures. Each mandibular lesion type, patient's age, sex, occurrence side, and used plating system does not have any correlation. The use of random plating in PMP is purely individual case-related, and each plating platform works regardless of load-bearing, load-sharing, or the combination of plates used. A PMP procedure is not a standard approach during teeth, cyst, or mandibular tumor removal; however, it can significantly improve patients' bone stability, healing, and greatly lower the ratio of some unwanted bone events. The authors noted that proper bone stability promotes greater healing, decreases bone bending, and reduces the possibility of granulation tissue formation. Used bone grafts with simultaneous PMP, which promoted good and desired bone healing. It seems that the necessity for PMP removal after some months is case-dependent.
- Research Article
- 10.1016/j.matdes.2026.115803
- Apr 1, 2026
- Materials & Design
- Tianyu Zhou + 10 more
• Multi-phase 3D printing successfully fabricated hybrid resin-titanium alloy (Ti6Al4V) biomedical implants. • Hierarchical surface engineering on titanium alloy, utilizing Al 2 O 3 atomic layer deposition, enhanced interfacial bonding strength with resin. • 3D-printed medical scaffolds exhibited improved mechanical properties, including stiffness, strength, and energy absorption. • Innovative, lightweight, and high-strength patient-specific partial mandible implants were developed for effective large-scale load-bearing bone defect reconstruction. Conventional bone implant materials are limited in achieving high mechanical strength and lightweight design at the same time. To achieve this balance, this study introduces a multi-material design strategy for lightweight, load-bearing structures that incorporates engineered titanium-alloy plates within a bioactive 3D-printable resin composite. The resin is composed of urethane dimethacrylate and triethylene glycol dimethacrylate, enriched with bioactive nano-hydroxyapatite, and strontium-doped SiO 2 glass particles. Titanium-alloy plates underwent surface treatments, including sandblasting, chemical etching, and Al 2 O 3 atomic layer deposition, establishing a hierarchical interfacial structure. Multi-material additive manufacturing allowed for the precise embedding of titanium plates within the polymer composite matrix. The interfacial shear strength significantly improved from 4.98 MPa for untreated interfaces to 16.60 MPa after treatment, shifting the failure mode from adhesive to cohesive fracture. Additionally, the compressive modulus of the three-layer structure increased from 2.54 ± 0.10 GPa to 2.79 ± 0.03 GPa. When demonstrated with a segmental mandibular implant prototype, the design exhibited enhanced stiffness and energy absorption, with compressive energy absorption rising from 6.88 ± 0.35 J to 7.72 ± 0.47 J, and a transition from catastrophic to progressive failure behavior. This framework effectively integrates surface treatment, interfacial morphology, and mechanical performance for advanced multiphasic additive manufacturing.
- Research Article
- 10.1186/s12891-026-09689-x
- Mar 10, 2026
- BMC musculoskeletal disorders
- Yang Gao + 1 more
To evaluate the clinical outcomes of a modified technique combining C3 total laminectomy, C4–C6 open-door laminoplasty, and C7 partial laminectomy (undercutting) decompression with extensive open-door laminoplasty and titanium plate fixation in the treatment of cervical spondylotic myelopathy (CSM).Methods:A retrospective analysis was conducted on 101 CSM patients scheduled to undergo posterior cervical open-door laminoplasty. They were divided into a conventional laminoplasty (C-LAMP) group (n = 50), which received conventional C3-7 open-door laminoplasty with titanium plate fixation, and a modified laminoplasty (M-LAMP ) group (n = 51), which underwent C3 laminectomy, C4–C6 open-door laminoplasty,C7 undercutting decompression, and extensive laminoplasty with titanium plate fixation. The following parameters were compared: operation time, intraoperative blood loss, postoperative drainage volume, Japanese Orthopaedic Association (JOA) scores before and after surgery, JOA improvement rate, cervical curvature and range of motion (ROM) before and after surgery, loss of cervical curvature and ROM postoperatively, visual analog scale (VAS) scores for neck pain, incidence of axial symptoms, and other postoperative complications. All surgeries were completed successfully. No significant differences were observed between the two groups in operation time, blood loss, postoperative drainage, length of hospital stay, JOA scores before and after surgery, JOA improvement rate, or overall complication rates (P > 0.05). At the 3-month follow-up, the incidence of axial symptoms was significantly lower in the M-LAMP than in the C-LAMP (5.88% [3/51] vs. 24.00% [12/50], P = 0.010). However, this difference was no longer statistically significant at 1 year (1.9% [1/51] vs. 8.0% [4/50], P = 0.884). Both groups showed some loss of cervical curvature and ROM after surgery. At 1 year, the loss of cervical curvature did not differ significantly between groups (study: -4.1±4.9 vs. control: -3.0±5.9; P = 0.329; 95% CI: [-3.2,1.1]). Although there was no significant difference in ROM at 1 year (34.6±10.1° vs. 32.9±9.0°; P = 0.396), the M-LAMP had significantly less ROM loss compared to the C-LAMP (-2.0±7.2° vs. 2.3±8.8°; P = 0.008; 95% CI:[-7.5,-1.1]). The M-LAMP—C3 total laminectomy, C4–C6 open-door laminoplasty, C7 partial laminectomy (undercutting) and extensive laminoplasty combined with titanium plate fixation—achieved similar improvements in neurological function compared to conventional open-door laminoplasty. However, by preserving the attachments of the semispinalis cervicis at C2, the cervical extensor muscles at C7, and the insertion of the nuchal ligament, this approach significantly reduced the incidence of early postoperative axial symptoms and better maintained postoperative cervical range of motion.
- Research Article
1
- 10.1016/j.ceramint.2026.01.102
- Mar 1, 2026
- Ceramics International
- Katarina Đ Božić + 5 more
Novel well-adhered composite coatings on titanium plates consisted of Sr-doped hydroxyapatite, zein and TiO2 for biomedical applications
- Research Article
- 10.3390/jcm15051694
- Feb 24, 2026
- Journal of clinical medicine
- Marios Fouzas + 3 more
Introduction: Stage three osteonecrosis of the jaw (ONJ), whether medication-related (MRONJ) or osteoradionecrosis (ORN), often necessitates aggressive surgical management due to extensive necrosis, infection, and risk of pathologic fracture. While free flap reconstruction remains the gold standard post-segmental mandibulectomy, it may not be feasible for elderly or systemically compromised patients. Objective: The presentation of our own experience with advanced mandibular ONJ on patients managed exclusively with a contemporary titanium reconstruction plate system and to evaluate the clinical outcomes of this approach in the context of the current literature. Methods: From a group of 21 patients treated for ONJ, just four patients with Stage 3 MRONJ or Grade III ORN, unfit for microvascular surgery, underwent segmental mandibulectomy followed by alloplastic reconstruction using standard titanium plating. Outcomes were assessed clinically and radiographically over a follow-up period ranging from 3 to 20 months. A focused literature review was conducted to contextualize results. Results: All patients demonstrated stable reconstruction without plate exposure, fracture, or intraoral bone exposure during follow-up. Esthetic and functional outcomes are reported. No hardware complications were reported. The review of the literature supports plate-only reconstruction as a valid alternative for patients unsuitable for free flap surgery, especially when using rigid, anatomically adaptive systems with robust soft tissue coverage. Conclusions: Titanium plate-only reconstruction following segmental mandibulectomy can provide reliable short- to mid-term outcomes in selected patients with advanced ONJ. Used titanium plating systems appears to be a promising option.
- Research Article
- 10.1371/journal.pone.0343008
- Feb 23, 2026
- PloS one
- Jianyao Huang + 5 more
Vascularized autologous bone transplantation combined with implant restoration is a preferred method for functional mandibular reconstruction. However, there is currently no consensus on whether internal fixation devices, such as titanium plates and screws, must be removed during the reconstruction process. This study aimed to assess the biomechanical and clinical necessity of removing these fixation devices. Eight patients who underwent mandibular reconstruction with fibula flaps and subsequent dental implantation were included. The study utilized finite element analysis to simulate and compare biomechanical stress distributions in models where fixation devices were either retained or removed. The clinical outcomes including peri-implant health, masticatory efficiency, and oral health-related quality of life were evaluated through follow-up examinations and standardized questionnaires. The biomechanical analysis indicated that the maximum stress on the grafted fibula surrounding the implants was significantly lower in the retention group (42.07 ± 12.06 MPa) compared to the removal group (44.892 ± 14.80 MPa, P = 0.017*). Furthermore, a positive correlation was identified between the simulated stress levels on the implants and the severity of gingival bleeding (coefficient: 0.82, P = 0.013*). Clinically, while there were no significant differences in marginal bone loss between the two approaches, patients who retained the internal fixation devices reported better quality of life scores regarding functional limitations and physical pain. In conclusion, retaining internal fixation devices appears to reduce mechanical stress on the peri-implant fibula graft and is associated with improved patient-reported outcomes. These findings suggest that the routine removal of reconstruction plates may not be necessary and that retention can favour peri-implant health and patient comfort.
- Research Article
1
- 10.3390/ma19040816
- Feb 20, 2026
- Materials (Basel, Switzerland)
- Aleksa Milovanović + 4 more
Orthopaedic plates are long-established medical devices conventionally manufactured from metals, most notably titanium alloys. The introduction of Additive Manufacturing (AM) has created new opportunities to design implants with complex internal architectures, enabling precise control over infill patterns and densities that directly influence mechanical properties and fatigue performance. Biodegradable polymers such as polylactic acid (PLA) have attracted growing interest in biomedical engineering, potentially reducing the need for secondary implant-removal surgery if degradation rates are carefully controlled and clinically approved. Additionally, AM offers the ability to customise internal structure for improved mechanical performance and load-bearing, while also providing the possibility of integrating advanced functionalities, such as controlled drug delivery. Building on previous work by our research group at the University of Belgrade, this study investigates the fatigue behaviour of the best-performing AM-optimised orthopaedic plate design. Numerical models incorporating honeycomb infill structures with the full range of achievable densities were developed to assess structural integrity under fatigue loading. Fatigue crack growth was simulated in ANSYS Mechanical (ANSYS Inc., Canonsburg, PA, USA) software, employing a four-point bending configuration in accordance with the ASTM F382 standard. A validated PLA material model was implemented at a reduced load level (10%) relative to previous studies. Direct comparison with titanium plates was avoided due to fundamentally different material properties, focusing instead on infill architecture to identify optimal AM design strategies for orthopaedic plates.
- Research Article
- 10.1021/acsabm.5c02407
- Feb 19, 2026
- ACS applied bio materials
- Xue Dong + 7 more
Metallic plating systems composed of titanium and its alloys remain the standard treatment for craniofacial bony fixation but may require secondary removal due to infection, implant migration, or discomfort. Absorbable polymeric alternatives reduce those risks but lack sufficient strength for load-bearing applications. Thus, biodegradable metallic implants may eliminate complications and secondary procedures while maintaining the structural integrity. Our previous work demonstrated the fabrication of immiscible Fe-AZ31 composites via additive manufacturing with improved degradation kinetics over pure iron. This study aimed to evaluate the in vitro and in vivo biocompatibility of Fe-AZ31 composites for potential craniofacial fixation applications. Pure iron (Fe), magnesium (Al-Mg-Zn) alloy (AZ31), and Fe-AZ31 samples were fabricated for extract-based cytotoxicity testing using HFF-1 fibroblasts, L929 fibroblasts, and hFOB osteoblasts. Metal extracts were prepared at a 3 cm2/mL surface-to-volume ratio in complete media at 37 °C and cell viability was measured by live/dead assay after 24 and 72 h exposure. For in vivo evaluation, Fe-AZ31, Fe, and titanium (Ti) plates were implanted subcutaneously in wild type mice for 6 weeks and 3 and 6 months. Implant degradation, histologic response, hematology, and serum biochemistry were assessed. Fe-AZ31 extracts demonstrated ≥70% cell viability across all cell types at both time points with normal cell morphology and adhesion, whereas AZ31 extracts caused marked cytotoxicity associated with pronounced alkalization (pH 10.53). In vivo, Fe-AZ31 implants exhibited gradual surface corrosion accompanied by mild, transient inflammation and minimal capsule formation over time. No systemic toxicity was observed. Hematology and serum biochemistry remained within the physiological limits. Additively manufactured Fe-AZ31 composites demonstrate acceptable cytobiocompatibility and favorable tissue responses, supporting their development as bioresorbable metallic fixation devices for craniofacial reconstruction.
- Research Article
- 10.7507/1002-1892.202508063
- Feb 15, 2026
- Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
- Lei Chen + 3 more
To compare the effectiveness of arthroscopy-assisted and orthopaedic robot-assisted techniques in the treatment of Rockwood type Ⅲ and Ⅳ acute acromioclavicular dislocation. The clinical data of 33 patients with acromioclavicular dislocation who were treated with titanium plate with loop fixation between October 2022 and December 2024 and met the selection criteria were retrospectively analyzed. The patients were divided into robot group (17 cases) and arthroscopy group (16 cases) according to the different ways of assisted surgery. There was no significant difference in baseline data between the two groups ( P>0.05), such as gender, age, cause of injury, side, Rockwood classification, time from injury to operation, and preoperative visual analogue scale (VAS) score, Constant-Murley score, coracoclavicular distance (CCD). The operation time, intraoperative blood loss, total length of incision, intraoperative fluoroscopy frequency, changes of VAS score at 1 day after operation (compared with those before operation), and complications were recorded and compared between the two groups, and the degree of acromioclavicular joint separation was evaluated by CCD measurement on three-dimensional CT coronal plane at 2 days and 6 months after operation. The accuracy of the clavicular and coracoid drilling position was evaluated at 2 days after operation. Constant-Murley score was used to evaluate the function of the shoulder joint before operation and at 1 and 6 months after operation. The incisions of the two groups healed by first intention. The operation time, intraoperative blood loss, total length of incision, and the change of VAS score at 1 day after operation in the robot group were significantly less than those in the arthroscopy group ( P<0.05), and the intraoperative fluoroscopy frequency in the robot group was significantly more than that in the arthroscopy group ( P<0.05). Patients in both groups were followed up 6-12 months, with an average of 10.15 months. At 2 days after operation, digital radiography showed that the acromioclavicular joint had been reduced. The CCD at 2 days and 6 months after operation were significantly lower than those before operation, and the CCD at 6 months after operation was significantly higher than that at 2 days after operation ( P<0.05). There was no significant difference in CCD between the two groups at two time points after operation ( P>0.05). There was no significant difference in the accuracy of clavicular drilling position between the two groups at 2 days after operation ( P>0.05); the accuracy of coracoid drilling position in the robot group was significantly lower than that in the arthroscopy group ( P<0.05). There was no complication such as vascular and nerve injury, coracoid process fracture, or redislocation in both groups. Constant-Murley scores at 1 and 6 months after operation were significantly higher than those before operation, and that at 6 months after operation was higher than those at 1 month after operation, and the differences were all significant ( P<0.05). The Constant-Murley score of the robot group was significantly higher than that of the arthroscopy group at 1 month after operation ( P<0.05), and there was no significant difference between the two groups at 6 months after operation ( P>0.05). Both assisted techniques of internal fixation with titanium plate with loop can achieve good effectiveness in the treatment of acromioclavicular dislocation. Robot assisted surgery has advantages in incision length, intraoperative blood loss, postoperative VAS score, and early postoperative shoulder joint function, but arthroscopic assisted surgery has advantages in intraoperative fluoroscopy frequency and accuracy of coracoid drilling.