Age Times Research Articles

Media Device Use and Vision Disorders in the Pediatric Age: The State of the Art.

Evidence is consistent with increased screen viewing time among children and adolescents, and anticipation at the age at which children interact with media devices. Incorrect use of technology, as well as overuse, may lead to serious consequences. This study aims to revise scientific international literature and to describe the potential eye risks correlated to screen viewing time in the pediatric age. A review of the literature was performed according to the PRISMA 2020 guidelines, using the search terms "media device" and "eye" with the filter "age 0-18". Analyzing the international literature, we found 26 articles. Pre-myopia, myopia, digital eye strain, and acute acquired comitant esotropia were listed as potential and time-related consequences associated with the incorrect use of media devices among children and adolescents. Family education on media device exposure and potential risk for children and adolescents' sight in case of prolonged digital/screen exposure is required. During pediatric check controls, a dialogue with families on prolonged media device use at a close distance should be undertaken. Pediatricians and ophthalmologists should consider screen viewing time in case of ocular problems.

A systematic review examining outcomes of children following permanency placements

Children in care have experienced adversities, including maltreatment prior to contact with the system, negatively impacting on their mental health outcomes. The type of placement and length of time in care are thought to be important and the child welfare system aim is to achieve a permanent decision for children that best supports their needs by establishing a stable familial network. Permanency decisions can include reunification, foster care, kinship care, adoption, and residential placements. This review aims to establish to what extent permanent placement type, maltreatment experienced, length of time in care and age at which permanency is achieved impacts child mental health outcomes. Following PRISMA guidelines, five databases (ASSIA, CINAHL, PsycINFO, Scopus and SocINDEX) and two registers (CENTRAL and TRoPHI) were systematically searched yielding six articles for inclusion in the study. Data were extracted and articles critically appraised utilising the Crowe Critical Appraisal Tool (CCAT). Papers reported mixed findings for permanent placement type and child mental health outcomes with little or no significant overall differences reported. Type of maltreatment experienced moderated the type of mental health symptomology reported. Difficulties in attachment and social relationships were reported for children placed older than two years, although confounding factors such as type of maltreatment likely reduce the strength of the association. Typically, children in permanent placements had better outcomes compared with peers in short-term or unstable placements. A lack of suitable validated and age-appropriate outcome measures and the existence of confounding factors impair our understanding of the interaction between pre-care adversities, the child welfare system itself and permanent placement outcomes.

Analysis of emergent reoperations after bariatric surgery: an important metric for safe same-day surgery

BackgroundEarly reoperation after sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) is a severe adverse event that may increase the risk of perioperative mortality if there is a delay in care. However, it is unclear what proportion of reoperations occur within 24 hours of surgery and who is at greater risk, which may impact the safety of performing safe same-day surgery. ObjectivesTo evaluate the incidence of reoperation in the first 24 hours after primary SG and RYGB. SettingMichigan Bariatric Surgery Collaborative, Ann Arbor, Michigan. MethodsUsing a statewide bariatric surgery data registry, patients undergoing primary SG (n = 49,848) and RYGB (n = 11,267) cases were analyzed. Patients who had a subsequent reoperation were identified and reasons for reoperation were compared between those occurring <24 hours versus >24 hours. In addition, patients who underwent a reoperation <24 hours were compared with patients who underwent primary SG or RYGB and did not experience any complications. ResultsThe overall rate of reoperation was .72% for SG and 2.1% for RYGB. Reoperation <24 hours of index procedure was 32.0% after SG and 24.2%, after gastric bypass, with the most common reason being hemorrhage (86.15%% and 55.4% respectively). Older age, hypertension, liver disease, and longer operative times were associated with reoperation <24 hours after SG, whereas longer operative times were associated with reoperation <24 hours after RYGB. Concurrent hiatal hernia repair was not associated with increased risk. ConclusionsReoperation after primary bariatric surgery is rare but occurs within 24 hours in approximately one third of the cases after SG and one quarter of cases after RYGB. Older patients with significant comorbidities are at increased risk and should be considered poor candidates for same-day surgery given the possibility of an early life-threatening event.

Novel fungicide and neonicotinoid insecticide impair flight behavior in pollen foraging honey bees, Apis mellifera

Bees are often exposed to pesticides affecting physiological functions and molecular mechanisms. Studies showed a potential link between altered expression of energy metabolism related transcripts and increased homing flight time of foragers exposed to pesticides. In this study, we investigated the effects of thiamethoxam and pyraclostrobin on longevity, flight behavior, and expression of transcripts involved in endocrine regulation (hbg-3, buffy, vitellogenin) and energy metabolism (cox5a, cox5b, cox17) using radio frequency identification (RFID) technology and quantitative polymerase chain reaction. Parallel, a laboratory study was conducted investigating whether pesticide exposure alone without the influence of flight activity caused similar expression patterns as in the RFID experiment. No significant effect on survival, homing flight duration, or return rate of exposed bees was detected. The overall time foragers spent outside the hive was significantly reduced post-exposure. Irrespective of the treatment group, a correlation was observed between cox5a, cox5b, cox17 and hbg-3 expression and prolonged homing flight duration. Our results suggest that flight behavior can impact gene expression and exposure to pesticides adversely affects the expression of genes that are important for maintaining optimal flight capacity. Our laboratory-based experiment showed significantly altered expression levels of cox5a, cox6c, and cox17. However, further work is needed to identify transcriptional profiles responsible for prolonged homing flight duration.

The effects of general anaesthesia on body temperature of dogs subjected to ovariohysterectomy or orchiectomy performed by veterinary students in a teaching hospital

Hypothermia during anaesthesia is a significant concern in veterinary practice, as it can lead to various complications, making it essential to understand the factors that contribute to temperature regulation in animals undergoing surgical procedures. This retrospective study aimed to evaluate the change in body temperature over the course of anaesthesia in dogs undergoing elective ovariohysterectomy and orchiectomy, and determine the effect of gender, dose of premedication, weight, age and duration of anaesthesia of the change of body temperature over time. One-hundred and ten dogs (n=110) that underwent elective ovariohysterectomy (n=75) and orchiectomy (n=35) surgery performed by veterinary students at the University of Adelaide were enrolled in this study. Dogs’ anaesthesia records were evaluated for change in body temperature over the course of anaesthesia, and correlated with gender, two premedication doses of acepromazine (mg/kg), body weight (kg), age (months) and anaesthesia times (minutes). The analyses were performed at TPm (temperature at premedication), T0 (induction), T15, T30, T60, T90, T120 and TRec (recovery) minutes. Statistical analysis was performed using the GenStat software and included repeated measures analysis and ANOVA. Significance was considered when p < 0.05. The data showed a significant time-by-gender interaction with female dogs experienced a greater degree of heat loss than male dogs at T60 (p<0.01), T90 (p<0.01) and T120 (p<0.01). At recovery, female average temperature was higher than in males (p<0.01). There was no significant difference in body temperature when other covariates were used in the analysis. The core body temperature of female dogs decreased significantly over time compared to males, with the most pronounced differenced during the intraoperative period. However, the study’s retrospective nature and limited sample size may influence the generalizability of these findings.

Rethinking Lifetime Abuse in Old Age.

Research on abuse is often piecemeal and focused on specific forms, populations, and social situations. As a result, these studies tend to ignore the web of abuse resulting from the interactive effects of various forms of abuse over the life course, together referred to as "lifetime abuse." An examination of abuse from the point of view of older adults is likely to provide a lifetime perspective based on linking child abuse to elder abuse over the life course and an assessment of its consequences. Despite the growing awareness and resulting body of knowledge regarding this phenomenon, proposed theoretical formulations about it remain limited. The present article aimed to conceptualize the multifaceted phenomenon of lifetime abuse and to gain a deeper perspective of the topic by understanding its dimensions, meanings, and experiences in older age, based on a critical review of empirical studies. A model is suggested, which can be useful for future exploration and understanding of lifetime abuse. Based on a critical review of previous studies, we suggest a theoretical framework of lifetime abuse from the perspective of older adults, identifying three key domains: (a) perception of time and life review in old age; (b) cumulative and interactive abusive life events; and (c) resilience versus vulnerability over the life course. We propose a heuristic model to explore and understand lifetime abuse. We believe our proposed model is open to reflection and elaboration and is intended to raise questions that could enhance the need for our understanding of lifetime abuse in old age.

Multi-View Graph Learning for Path-Level Aging-Aware Timing Prediction

As CMOS technology continues to scale down, the aging effect—known as negative bias temperature instability (NBTI)—has become increasingly prominent, gradually emerging as a key factor affecting device reliability. Accurate aging-aware static timing analysis (STA) at the early design phase is critical for establishing appropriate timing margins to ensure circuit reliability throughout the chip lifecycle. However, traditional aging-aware timing analysis methods, typically based on Simulation Program with Integrated Circuit Emphasis (SPICE) simulations or aging-aware timing libraries, struggle to balance prediction accuracy with computational cost. In this paper, we propose a multi-view graph learning framework for path-level aging-aware timing prediction, which combines the strengths of the spatial–temporal Transformer network (STTN) and graph attention network (GAT) models to extract the aging timing features of paths from both timing-sensitive and workload-sensitive perspectives. Experimental results demonstrate that our proposed framework achieves an average MAPE score of 3.96% and reduces the average MAPE by 5.8 times compared to FFNN and 2.2 times compared to PNA, while maintaining acceptable increases in processing time.

A 187Re-187Os and highly siderophile element study of diamondiferous kimberlite melt-mantle interactions and the inferred age of continental lithosphere

The ∼ 1.15-billion-year-old (Ga) Premier kimberlite pipe (Cullinan diamond mine), South Africa, is composed of several distinct kimberlite facies (Grey, Brown, Pale Piebald, Dark Piebald, Black Coherent [Type 3C], Blue/Brown Transitional, and Fawn). We report bulk rock Re-Os isotope data for Premier kimberlite facies, as well as for a suite of entrained peridotite and mafic xenoliths. These data are complemented by bulk rock highly siderophile element (HSE: Re, Pd, Pt, Ru, Ir, Os), major- and trace-element abundances. Measured 187Os/188Os for the kimberlite facies range from 0.1223 to 0.1672 (ΥOsi of −2.5 to + 17.4), peridotite xenoliths range from 0.1096 to 0.1244 (ΥOsi of −13.3 to −1.1), and pyroxenite xenoliths range from 0.1796 to 0.938 (ΥOsi of + 27 to + 419). A single measured amphibolite xenolith has the most radiogenic measured 187Os/188Os of 2.86 (ΥOsi of + 43). Harzburgite xenoliths yield time of rhenium depletion model ages (TRD) of ∼ 1.5 to 2.8 Ga, consistent with average TRD ages for Premier peridotites (2.4 ± 0.4 Ga). With these and published data, we considered the relationships between kimberlite and mantle xenoliths, compare estimates of relative peridotite incorporation to sampled diamond grade, and explore recratonization versus refertilization arguments with regards to TRD model ages. Kimberlite melt infiltration into Premier peridotite xenoliths is evident from melt veins accounting for ∼ 2 and ∼ 14 modal % of samples, and has led to incompatible element enrichment, including elevated Re. In turn, kimberlites show geochemical evidence for addition of peridotite xenolith fragments, with Type 3C having > 30 % more peridotite contribution than the Brown volcaniclastic facies. Kimberlites and peridotites plot on a 187Re/188Os versus 187Os/188Os mixing line (R2 = 0.92), with kimberlites having older apparent ages than the true age of crystallization. This mixing line provides estimates of lithospheric incorporation into the kimberlites, where the units with higher peridotite incorporation do not correlate with diamond grade. This is likely due to lithological and post-emplacement alteration heterogeneity within the kimberlite units, perhaps also reflecting the eclogitic paragenesis of many Premier diamonds. The peridotites provide evidence for the nature of the lithosphere beneath Premier prior to ∼ 1.15 Ga. Metasomatism of the peridotites is possibly linked to the Bushveld Igneous Event at ∼ 2 Ga, as well as to other magmatic events that affected the Kaapvaal craton from the Archean to the Mesoproterozoic. Premier peridotites do not suggest that the cratonic lithosphere beneath the region was completely replaced. Samples with Proterozoic TRD eruption model ages may represent Archean lithosphere that experienced alteration by metasomatism and modification, such as during the Bushveld Igneous Event.

The study of vaginal wall thickness in adults based on histopathological measurements

To accurately measure the vaginal mucosa thickness across different age groups using histopathologic techniques and investigate the factors that may influence the thickness changes. This study aims to provide clinicians with objective evidence of variations in vaginal mucosal thickness, facilitating personalized medical decisions for patients. A retrospective analysis was conducted on clinical data from 348 patients who underwent local vaginal wall resection at the West China Second University Hospital, Sichuan University, from January 2021 and May 2022. The thickness of vaginal mucosa, epithelium and lamina propria was measured precisely under the microscope. And the 10th, 25th, 50th, 75th, and 90th percentile values of vaginal mucosa thickness across different age groups were counted and charted a dot-line plot. The percentile values for vaginal mucosa thickness exhibited a decreasing trend with increasing age; vaginal mucosa thickness showed significant correlations with times of delivery (P = 0.031) and age (P < 0.001), both of which were negatively associated. And vaginal mucosa thickness demonstrated no significant correlation with body mass index (BMI) (P = 0.325), times of abortions (P = 0.511), times of gestation (P = 0.101), menstrual cycle (P = 0.533), or types of delivery (P = 0.056); epithelial thickness showed significant associations with age (P < 0.001) and types of delivery (P = 0.017), both of which were negative correlations. Moreover, BMI (P = 0.429), times of abortions (P = 0.764), delivery (P = 0.079), gestation (P = 0.475), and menstrual cycle (P = 0.950) were nonassociated with epithelial thickness; lamina propria thickness displayed a significant correlation only with age (P = 0.002), and there were no obvious correlations observed between lamina propria thickness and BMI (P = 0.374), times of abortion (P = 0.417), delivery (P = 0.053), gestation (P = 0.101), types of delivery (P = 0.132) and menstrual cycle (P = 0.495). Moreover, when the age segmentation was thresholded at 35 and 50 years, both epithelial thickness and vaginal mucosa thickness were significantly correlated with age (P < 0.05). Lamina propria thickness was associated with age when the age threshold was set at 35 years (P = 0.007), whereas it showed no strong link with age when the age threshold was 50 years (P = 0.072). This study has innovatively established percentile reference values for vaginal mucosa thickness based on histopathology, furnishing clinicians with objective evidence of variations in vaginal mucosal thickness to facilitate personalized medical decisions for patients. The findings demonstrated a strong link between vaginal mucosa thickness and age, with epithelium likely playing a predominant role, while the association with lamina propria appeared to be less significant. Further research involving a larger sample size is warranted to elucidate the potential relationship with the lamina propria.

Orthopedic injuries due to hoverboard use, reported in the NEISS database, 2015–2022

IntroductionHoverboards are a popular means of recreation in the United States and are associated with significant injury risk, leading to recent efforts to improve their safety. Prior studies on hoverboard-related injuries were either conducted prior to implementation of safety regulations, consisted of short study intervals, or did not place a focus on injuries as they pertain to the orthopedic specialist. The purpose of this study is to provide an updated assessment of the epidemiology of orthopedic hoverboard-related injuries presenting to US emergency departments. Materials and MethodsA retrospective analysis from 2015 to 2022 of the National Electronic Injury Surveillance System (NEISS) database was conducted, limited to product codes detailing hoverboard-related injuries leading to emergency department visits. Diagnoses of interest included fractures, dislocations, contusions/abrasions, and strains/sprains. Diagnoses were further broken down to analyze anatomic region affected. National estimates (NE) were calculated using survey methods. One-way ANOVA and chi square tests were used to test for changes over time in injuries, age, and gender. Results4,718 total hoverboard-related injuries were captured, with a national estimate of 154,121. The majority of patients were under 18 years old (79.6 %; P < 0.001) and female (52.5 %; P = 0.038). Orthopedic injuries accounted for 68.6 % of the total, with no significant year-by-year change in this proportion (P = 0.069). Fractures were the most common orthopedic injury (64.2 %), followed by contusions/abrasions (20.2 %), strains/sprains (14.6 %), and dislocations (1.0 %). Most fractures affected the forearm (33.8 %) followed by the wrist (29.2 %). Injuries peaked in 2018 (NE = 25,192) and 2020 (NE = 24,958), followed by a decline in incidence more recently. ConclusionHoverboard-related injuries continue to be a common presentation to US emergency departments, though injury rates appear to be decreasing. Orthopedic injuries consistently account for the majority of hoverboard-related injuries reporting to emergency departments, with fractures of the forearm and wrist being most common. Continued efforts toward improving safety measures regarding hoverboard use are warranted.

Memory Retention and Cultural Resonance: Exploring the Impact of Ephemeral Digital Narratives

The accelerating progress of the digital landscape has led to the rise of consumption of content that is short-lived and fast-paced. In this context, social media platforms such as Instagram and Snapchat have become predominant for their effective use of temporary digital content that lasts for a brief period (usually 24 hours) before disappearing. Ephemerality has become the zeitgeist of the 21st century. In a world where immediacy and instant gratification are highly valued, the pattern of consumption of digital media is also aligned to such quick snippets of information rather than watching a long video. This paradigm shift is redefining how people perceive time and memory in the digital age. This preliminary study analyses the effect of such ephemeral digital narratives on the memory retention of consumers and also explores the implications of such content on cultural and collective memory. A sample of 100 participants ranging from the age of 18-35 years, were exposed to curated ephemeral content from Instagram and Snapchat for seven days. Participants were exposed to different media types, presentation styles, and cognitive demands. Daily surveys examined their memory retention using various question formats. The study examined ten hypotheses using Analysis of Variance (ANOVA) to determine how media type (video, image, both), presentation style (visual, verbal/textual, both), cognitive processing demands (shallow, deep processing), and question format affect recall effectiveness.

Incidence and survival of pediatric and adult hepatocellular carcinoma, United States, 2001–2020

BackgroundHepatocellular carcinoma accounts for approximately 80 % of liver neoplasms. Globally, hepatocellular carcinoma ranks as the third most lethal cancer, with the number of deaths expected to further increase by 2040. In adults, disparities in incidence and survival are well described while pediatric epidemiology is not well characterized. We describe incidence and survival for pediatric (ages 0–19 years) hepatocellular carcinoma cases and compare these measures to adults (ages ≥ 20 years) diagnosed with hepatocellular carcinoma. MethodsWe assessed incidence data from the US Cancer Statistics database during 2003–2020 and 5-year survival from the National Program of Cancer Registries during 2001–2019. Incidence trends were determined by annual percent change (APC) and average APC (AAPC) using joinpoint regression. Five-year survival was evaluated by relative survival, and all-cause survival was estimated using multivariate Cox modeling. Corresponding 95 % confidence intervals (CI) were calculated for all analyses. ResultsIncidence rate per 100,000 persons was 0.056 (95 %CI:0.052–0.060) for pediatric cases and 7.793 (7.767–7.819) for adults. Incidence was stable in the pediatric population (0.3 AAPC, − 1.1 to 1.7). In contrast, after periods of increase, incidence declined in adults after 2015 (-1.5 APC). Relative survival increased over time for both pediatric and adult ages and was higher for children and adolescents (46.4 %, 95 %CI:42.4–50.3) than adults (20.7 %, 95 %CI:20.5–20.9). Regression modeling showed that non-Hispanic Black race and ethnicity was associated with higher risk of death in children and adolescents (1.48, 95 %CI:1.07–2.05) and adults (1.11, 95 %CI:1.09–1.12) compared to non-Hispanic white race and ethnicity. ConclusionsBetween 2003 and 2020 in the United States, pediatric incidence was stable while incidence in adults began to decline after 2015. Survival was higher across all stages for children and adolescents compared to adults. Non-Hispanic Black race and ethnicity showed a higher risk of death for both age groups. Further studies could explore the factors that influence these outcome disparities.

Dynamic responses and damage/element composition analysis of thermoplastic polyamide reinforced epoxy composites exposed to HCI environment

AbstractThe present study aimed to examine how the corrosive environment affected the low‐velocity impact (LVI) characteristics and damage mechanisms of thermoplastic polyamide fiber‐reinforced polymer (PFRP) composites. In this regard, composite specimens were subjected to corrosive environment containing 10 wt.% diluted HCl for one week and one month before LVI tests. To investigate the hostile effects of the corrosive environment on the composites, scanning electron microscope (SEM) coupled with energy‐dispersive X‐ray system (EDX) analyses were carried out, and thus variations in the elemental composition and damage mechanisms for the composites were determined. According to the examinations, it was discovered that the degradation in LVI responses, such as contact stiffness, bending stiffness, and peak force, increased with longer aging time, as expected. Furthermore, when the aging effect was assessed based on absorbed energy, the specimens exposed to a corrosive environment for one month exhibited the highest energy absorption compared to the control and 1‐week‐immersed ones. The degrading effect of the HCI environment appeared as higher damage severity on the composites, which was also detected from the SEM images. According to the SEM analyses, matrix cracks, corrosion pits, and local surface imperfections caused by ion exchange are detected in 1‐week‐immersed specimens, while more serious damage mechanisms such as fiber breakage and fiber pull‐out are noted in specimens exposed to corrosive environment for 1 month. Furthermore, approximately 6.33 wt.% CI was identified in the composites after 1 month of aging, which was associated with the hydrolysis triggered by rise in the composite's damage severity.Highlights Aging effects in mechanical properties of PFRP composites were investigated LVI tests were conducted to determine dynamic responses of aged composites Longer aging time led to more severe damages such fiber rupture, delamination etc. PFRP composites absorbed at least 68% of impact energy.

The Effect of Using Anchored Wake Time to Derive 24-h Device Measured Circadian Physical Behavior Patterns.

Tailoring physical activity interventions to individual chronotypes and preferences by time of day could promote more effective and sustainable behavior change; however, our understanding of circadian physical behavior patterns is very limited. To characterize and compare 24-h physical behavior patterns expressed relative to clock time (the standard measurement of time-based on a 24-h day) versus wake-up time in a large British cohort age 46. Data were analyzed from 4979 participants in the age 46 sweep of the 1970 British Cohort Study who had valid activPAL accelerometer data across ≥4 days. Average steps and upright time (time standing plus time stepping) per 30-min interval were determined for weekdays and weekends, both in clock time and synchronized to individual wake-up times. The mean weekday steps were 9588, and the mean weekend steps were 9354. The mean weekday upright time was 6.6 h, and the mean weekend upright time was 6.4 h. When synchronized to wake-up time, steps peaked 1 h after waking on weekdays and 2.5 h after waking on weekends. Upright time peaked immediately, in the first 30-min window, after waking on both weekdays and weekends. Aligning accelerometer data to wake-up times revealed distinct peaks in stepping and upright times shortly after waking. Activity built up more gradually across clock time in the mornings, especially on weekends. Synchronizing against wake-up times highlighted the importance of circadian rhythms and personal schedules in understanding population 24-h physical behavior patterns, and this may have important implications for promoting more effective and sustainable behavior change.

The Synthesis of Ag/TiO2 via the DC Magnetron Sputtering Method and Its Application in the Photocatalytic Degradation of Methyl Orange in Na2SO4 Solution

TiO2 and TiO2 films modified with Ag (Ag/TiO2) were prepared via the DC magnetron sputtering method and the degree of modification was controlled via the sputtering power and time of Ag. The microstructures and properties of these films were characterized using field emission scanning electron microscopy, X-ray diffractometry, ultraviolet–visible diffuse reflectance spectrometry, atomic force microscopy, and X-ray photoelectron spectroscopy (XPS). The results show that the prepared films have an anatase structure. Compared with pure TiO2, Ag deposition can improve the utilization of light. The three-dimensional images of Ag/TiO2 clearly show that with the increase in Ag sputtering power and sputtering time, Ag particles on the surface of the film gradually increase, and the structure of the film is relatively dense. The photocatalytic effect of Ag/TiO2 films is the best when the Ag sputtering power is 5 W and the sputtering time is 50 s. Under high-pressure mercury lamp irradiation, the photocatalytic degradation rate of methyl orange (MO) in pure MO solution with Ag/TiO2-5 W-50 s can reach 100% within 55 min, whereas that in MO-Na2SO4 mixed solution can reach 99.55% within 65 min. The results suggest that the presence of Na2SO4 in MO solution can inhibit the degradation of MO using Ag/TiO2, the result of XPS suggests that Na2SO4 accelerates the oxidation of Ag, which may lead to an increase in the recombination rate of photogenerated electron–hole pairs and a decrease in the degradation rate. During the process of recycling photocatalysts, the degradation rate of MO was apparently reduced. A possible reason is that the Ag particles have been oxidized and products of photocatalytic degradation are on the surface of the photocatalyst. The photocatalytic degradation mechanism was studied.

Differences in clinical features according to survival and gender in patients admitted for cardiac arrest

Abstract Funding Acknowledgements None. Introduction Cardiac arrest (CA) is a condition with poor vital and neurological prognosis. Although there are widely known clinical features modifying prognosis –such as time to return of spontaneous circulation (ROSC) and neuron-specific enolase values-, there is uncertainty around whether gender, ischemic etiology or classic cardiovascular risk factors may influence in the management and prognosis. Purpose The aim of this study was to analyze the differences in baseline characteristics and management between survivors and non survivors, among patients admitted for CA in an Intensive Cardiac Care Unit. Methods A prospective unicentric registry was performed from January 2010 to December 2021, including all consecutive cardiac arrest patients admitted to an intensive cardiac care unit of a university hospital. Patients were classified into survivors –to hospital discharge- and non-survivors –deceased during hospital admission, irrespective of time of death. Univariate analysis were performed using Chi-square and Student t tests, and logistic regression was used for a multivariate analysis to compare both groups. Results A total of 324 patients were included, mean age 59.7 (DE 12.2) years, 17.9% were women. In-hospital mortality was 42% (136 patients) and 188 patients survived to hospital discharge. Survivors were significantly younger (mean of 57,37 vs 62,98 years) and had less prevalence of diabetes (17 vs 33%) and previous myocardial infarction (15 vs 25%) than non-survivors. Among survivors, there was a higher prevalence of in-hospital CA (26,6 vs 12,5%), CA due to acute coronary syndrome (68,62 vs 57,78%) and shockable first rhythm (90,43 vs 72,06%). They also had shorter ROSC (mean 22,13 vs 34,25 minutes) and no flow times (mean 2,54 vs 5,67 minutes). Gender, arterial hypertension, dyslipidemia and smoking habit did not modify prognosis. When comparing genders, women had significantly less prevalence of smoking habit and previous ischemic heart disease, their time to ROSC was lower and they received less coronary angiographies than men. The multivariate analysis showed significant in-hospital mortality risk increase with age (OR 1,04 per year), ROSC (OR 1,04 per minute) and no-flow (OR 1,09 per minute) times, out of hospital CA (OR 2,26) and non shockable rhythm. Conclusions In a consecutive cohort of 324 patients admitted after cardiac arrest, survivors were significantly younger, and had less prevalence of diabetes mellitus and previous myocardial infarction. In-hospital arrest, shockable rhythm, and shorter ROSC and no-flow times were associated with better survival. No differences in survival were found between genders, although women had significantly shorter resuscitation times.Univariate analysisMultivariate analysis

Presentation of enthesitis-related arthritis and juvenile-onset spondyloarthritis: a cross-sectional study in a pediatric and adult clinic

BackgroundJuvenile idiopathic arthritis (JIA) comprises a whole spectrum of chronic arthritis starting before 16 years of age. The study aims to explore the clinical and demographic descriptors, treatment, and disease progression of enthesitis-related arthritis (ERA) in comparison with juvenile-onset spondyloarthritis (SpA).MethodsCross-sectional analysis of consecutive patients in two dedicated clinics, with a single visit and retrospective case-notes review. Arthritis, enthesitis and sacroiliitis were evaluated by scoring disease activity and damage. Continuous variables were reported by median, interquartile range; categorical variables were reported by the frequency comparison of the two groups.ResultsThirty-three cases were included, being 23 (69.7%) with ERA. The median age at diagnosis was 12.5 y (SpA) vs. 9 y (ERA) (p < 0.01); the time from symptom onset to diagnosis was 5.5 y (SpA) vs. 1.5 y (ERA) (p < 0.03). In both groups, the predominant presentation was a single joint or < 5 lower limb joints and asymmetric involvement, with a high frequency of enthesitis. There was a higher frequency of mid-tarsal and ankle synovitis in the ERA group and hip involvement in those with SpA. The comparison of the frequency of spine symptoms at presentation, 30% SpA vs. 21.7% ERA (p = 0.7), was not significant, and radiographic progression to spinal involvement occurred in 43.5% of ERA patients. The median time for spinal progression and age at onset was 2.2 and 12 y for ERA, and 4 and 16.5 y for SpA, respectively. Activity and damage scores were not significantly different between the groups. Treatment comparison resulted in 91.3% of ERA and 100% SpA being treated, predominantly with NSAIDs in both groups, followed by DMARDs and biologics, with a higher frequency of biologics in SpA.ConclusionThe main differences were the late diagnoses of SpA, and the hip and spine involvement, with higher frequency of biologic treatment in juvenile-onset SpA compared to ERA.

A life course perspective on sexual minorities: Implications for the study of homophobic prejudice and discrimination

AbstractThe legal treatment of and attitudes toward sexual minorities has changed considerably over recent decades in the United States, highlighting the role of historical context in the unfolding of human lives. Yet, a full application of the life course perspective to the topic of structural inequalities faced by sexual minorities is missing from the scholarly literature. Through synthesizing and analyzing research findings from the past 15 years, we explain how the five tenets of the life course framework apply to sexual minorities, including (1) the interplay of history and human lives, (2) the timing of lives, (3) linked lives, (4) human development and aging as lifelong processes, and (5) human agency. In doing so, we argue that a life course perspective is crucial for understanding the nature and consequences of prejudice and discrimination faced by sexual minorities. We end with discussion of the need for additional research and methodological innovations regarding distinctive aging experiences, cumulative inequality, and intersectionality.

Family and developmental correlates of adolescent involvement in decision making about screen use

ObjectiveAssess how child involvement in making rules about screen time relates to age, child prosocial functioning, and amount of screen use. MethodsNORC’s AmeriSpeak Panel was used to recruit a nationally representative sample of parents or guardians of school-aged children (age 5–17) in the United States (n = 2084). Parents completed survey that included measures of screen time, child involvement in rule making about screen use, family functioning, and dimensions of child psychosocial functioning. ResultsAcross all age categories, most families had some form of rules about the allowable amount of screen-based digital media for uses other than schoolwork: 86% of elementary school-aged children (ages 5 to 10), 81% of middle school-aged children (ages 11–13), and 61% of high school aged children (ages 14–17). Across all age groups, having rules was associated with fewer hours of screen time (elementary school: B = -1.31, 95% CI = -1.80 to −0.81, p < 0.001; middle school: B = -1.40, 95% CI = -2.20 to −0.59, p < 0.001; high school: B = -0.97, 95% CI = -1.68 to −0.27, p = 0.007). Child involvement in making rules was significantly greater for high school students as compared to elementary school students (ß=0.12, p < 0.001), and not associated with high school- or middle-school aged child screen time. Across all age groups, child involvement in making rules was associated with higher levels of prosocial functioning (elementary school: ß=0.07, p < 0.001; middle school: ß=0.19, p = 0.001; high school: ß=0.21, p < 0.001). ConclusionsChild involvement in making rules about screen use may be an opportunity to strengthen developmentally important competencies, as part of a broader autonomy-supportive approach to parenting.

Behavioral and Functional Changes Due to Smartphone Overusage among Under-five Children in Rural Puducherry: A Community-based Cross-sectional Study

Abstract Context: Smartphones have revolutionized, and become an integral part of a child’s life. The child’s interaction with these modern devices needs to be assessed because it could have an enormous effect on their behavior, sleep habits, and psychological addiction. Aims: The aim of this study is to determine the pattern of exposure to smartphone, and the association between the exposure and behavioral, functional changes among under-five children in rural Puducherry. Settings and Design: This community-based cross-sectional study was done in the field practice area of a private medical college in Puducherry. A multistage sampling technique was used to select 340 eligible participants. Subjects and Methods: A semi-structured questionnaire was used to assess the pattern of exposure and physical, social, and behavioral changes among study participants. Statistical Analysis Used: The data were analyzed using SPSS software, and P &lt; 0.05 was considered statistically significant. Results: Among 340 children, more than half of participants 180 (52.9%) were female. Interestingly, around half of the study participants’ parents 181 (53.2%) accepted that their children were exposed to smartphone for entertainment purposes, and around one-tenth 35 (10.3%) of the participants viewed screen for more than the recommended screen time for age. Increased smartphone exposure was statistically associated with behavioral and functional changes. Conclusions: Measures must be undertaken to prevent deleterious behavioral and functional changes in under-five children due to excessive smartphone usage. Health education sessions and social behavioral change communication should be planned for the parents to protect the budding generation from the negative effects of smartphone usage.