Initial Response Time Research Articles

Stroop task and practice effects demonstrate cognitive dysfunction in long COVID and myalgic encephalomyelitis / chronic fatigue syndrome.

The Stroop task was used to investigate differences in cognitive function between Long COVID (LC), Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) and healthy control subjects. Subjects viewed four color words or neutral (XXXX) stimuli with the same (congruent) or different color ink (incongruent). Cognitive conflict was inferred from response times for pairings of prestimuli and subsequent stimuli. Overall effects were assessed by univariate analysis with time courses determined for binned response times. LC and ME/CFS had significantly longer response times than controls indicating cognitive dysfunction. Initial response times were ranked LC > ME > HC, and decreased according to power functions. At the end of the task (900s), times were ranked LC = ME > HC. Response times were significantly slower for stimuli following an incongruent prestimulus. Time series for Stroop effect, facilitation, interference, surprise index and practice power law parameters were generally similar in LC, ME/CFS and HC suggesting comparable patterns for recruitment of cognitive resources. The prestimulus data were analyzed and generated positive Stroop and interference effects that were distinct from stimulus effects. LC and ME/CFS have global slowing of response times that cannot be overcome by practice suggesting impaired communications between network nodes during problem solving. Analysis of matched prestimulus - stimulus effects adds a new dimension for understanding cognitive conflict. Cognitive dysfunction in Long COVID and ME/CFS was demonstrated using the Stroop task which found global slowing of response times and limitations of practice effects.

Long-term evaluation of the initial response to therapy in 60 dogs with chronic inflammatory enteropathy.

Dogs with chronic inflammatory enteropathy (CIE) are typically classified into food-responsive enteropathy (FRE), antibiotic-responsive enteropathy (ARE), immunomodulator-responsive enteropathy (IRE), and nonresponsive enteropathy (NRE) based on response to therapy(ies). Reassessment of initial categorization (especially IRE and NRE) is lacking. Investigate validity of categorization scheme when reassessed at least 1 year after diagnosis. Sixty client-owned dogs with CIE. Retrospective study. Clinical information was gathered from records and owners from time of diagnosis (TD), time of initial response (TIR), and at least 1 year after diagnosis (T≥1y). Category change was defined as a switch between groups. Median disease activity index (CIBDAI) at TD was 9 and reduced significantly to 1 at T≥1y (P < .0001). At TIR, dogs were categorized as: FRE 27/60 (45%, 95% binomial confidence intervals [CI], 0.32-0.58), IRE 30/60 (50%, CI 0.37-0.63), ARE 0/60 (0%), NRE 3/60 (5%, CI -0.01 to 0.11). Seventeen of 27 (63%) FRE dogs had previously had at least 1 unsuccessful diet trial. At T≥1y, categorization changed to FRE 44/60 (73%, CI 0.62-0.85), IRE 14/60 (23%, CI 0.13-0.34), ARE 0/60 (0%), NRE 2/60 (3%, CI -0.01 to 0.08). Group changes were found for 24/60 (40%) dogs, largest change was from IRE to FRE (19/24, 79%). Immunosuppressive dosages were administered as sole treatment in 1/30 (3%) IRE dogs at TIR. Chronic inflammatory enteropathy categorization based on initial response to therapy needs reassessment after 1 year. Frequent change from IRE to FRE suggests that dogs initially categorized as IRE might have been initially categorized as FRE if multiple dietary trials had been performed. In our study, antibiotics were not needed to achieve satisfying clinical responses.

Emergency Medical Service Transport Time in Rural Farm and Non-Farm Pediatric Trauma

ABSTRACT Objectives Pediatric farm injuries tend to be more severe and have poorer outcomes compared to injuries sustained in non-farm settings. Timely emergency medical service (EMS) response and transport to definitive care is crucial for optimizing outcomes for trauma patients. We aimed to determine if pediatric farm injuries were associated with longer EMS response and transport times compared to pediatric non-farm injuries in rural communities. Methods The 2021 National EMS Information System (NEMSIS) database was used to identify rural EMS activations where injured pediatric patients who were transported to a hospital. Median transport times for farm and non-farm injuries, as well as other components of prehospital time and use of air EMS transport, were compared between injuries on farms and injuries in non-farm rural settings. Results The analytic sample included 22,248 rural EMS activations for pediatric injuries, of which 156 (1%) were for pediatric farm injuries. For non-farm and farm injuries, the median transport times were 20 minutes and 28 minutes, respectively. Median total prehospital time was 50 minutes compared to 62 minutes, and 9.8% of patients with non-farm injuries versus 20.5% of those with farm injuries were transported to a hospital by air EMS units. After multivariable adjustment, farm vs. non-farm injury location was associated with a 4 minute increase in EMS transport time, but no difference in initial EMS response time, EMS time on scene, or use of air EMS units. Conclusion Among children sustaining an injury that resulted in rural EMS activation, farm injuries were associated with prolonged transport time compared to non-farm injuries, which may contribute to worse in-hospital outcomes described to pediatric farm injuries in prior research.

Epileptic spasms relapse is associated with response latency but not conventional attributes of post-treatment EEG.

Relapse of epileptic spasms after initial treatment of infantile epileptic spasms syndrome (IESS) is common. However, past studies of small cohorts have inconsistently linked relapse risk to etiology, treatment modality, and EEG features upon response. Using a large single-center IESS cohort, we set out to quantify the risk of epileptic spasms relapse and identify specific risk factors. We identified all children with epileptic spasms at our center using a clinical EEG database. Using the electronic medical record, we confirmed IESS syndrome classification and ascertained treatment, response, time to relapse, etiology, EEG features, and other demographic factors. Relapse-free survival analysis was carried out using Cox proportional hazards regression. Among 599 children with IESS, 197 specifically responded to hormonal therapy and/or vigabatrin (as opposed to surgery or other second-line treatments). In this study, 41 (21%) subjects exhibited relapse of epileptic spasms within 12 months of response. Longer duration of IESS prior to response (>3 months) was strongly associated with shorter latency to relapse (hazard ratio = 3.11; 95% CI 1.59-6.10; p = 0.001). Relapse was not associated with etiology, developmental status, or any post-treatment EEG feature. This study suggests that long duration of IESS before response is the single largest clinical predictor of relapse risk, and therefore underscores the importance of prompt and successful initial treatment. Further study is needed to evaluate candidate biomarkers of epileptic spasms relapse and identify treatments to mitigate this risk. Relapse of infantile spasms is common after initially successful treatment. With study of a large group of children with infantile spasms, we determined that relapse is linked to long duration of infantile spasms. In contrast, relapse was not associated with the cause of infantile spasms, developmental measures, or EEG features at the time of initial response. Further study is needed to identify tools to predict impending relapse of infantile spasms.

K2Cr2O7-induced DNA damage in HT1080 cells: Electrochemical signal response mechanism

The existing DNA damage detection technology cannot meet the current detection requirements. It is critical to build new methods and discover novel biomarkers. In this study, alkaline comet and 8-OHDG ELISA assays were used to identify DNA damage in HT-1080 cells exposed to K2Cr2O7, and electrochemical behaviors of HT-1080 cells with DNA damage was studied. With an increase in K2Cr2O7 exposure time, two electrochemical signals from HT-1080 cells at 0.69 and 1.01 V steadily grew before decreasing after reaching their highest values. The electrochemical signal's initial response time and peak time decreased as the concentration of K2Cr2O7 increased. The duration of the high dose group was 0.5 and 1 h, while the low dose group was 1.5 and 6 h. Western blotting analysis revealed that DNA damage increased the expression of proteins involved in catabolism and de novo purine synthesis, particularly de novo purine synthesis. Expressions of PRPP amidotransferase, IMPDH, and ADA were all higher than those of ADSS, XOD, and GDA, which resulted in larger concentrations of hypoxanthine, guanine, and xanthine, and in turn improved electrochemical signaling. These findings suggest that intracellular purine identified by linear scan voltammetry is predicted to evolve as a marker of early DNA damage.

Association Between Initial Corticosteroid Regimen and Treatment Response Time in Acetylcholine Receptor Antibody–Positive Myasthenia Gravis

Background: Corticosteroids remain the cornerstone in the management of myasthenia gravis (MG). Initiation of corticosteroid treatment at a high dose and subsequently decreasing the dose or gradual escalation from a low dose is recommended. We aimed to investigate the association between the initial corticosteroid regimen and treatment response.Methods: A retrospective study was conducted on 234 acetylcholine receptor (AChR) antibody (Ab)–positive MG patients who visited our institution between January 2010 and February 2023. Patients were grouped based on prednisolone dosages received: initial high (IH, ≥50 mg/day) or initial low (IL, ≤20 mg/day). Time to initial improvement and the achievement of minimal manifestation (MM) status were the main outcomes.Results: Of the 234 patients, 135 were classified as IH and 99 as IL group. The IH group demonstrated a faster onset of improvement compared with the IL group (20.0 [16.0–29.0] vs. 40.0 [27.0–84.0] days), with the IH group being a significant prognostic factor for initial improvement (HR, 2.44; 95% CI, 1.76–3.39). However, the IH group had a higher incidence of steroid‐induced exacerbation (51.9% vs. 2.0%, p &lt; 0.001). No significant difference between the IH and IL groups was found in terms of the proportion of patients achieving MM or the time to achieve MM within the first year after treatment initiation.Conclusion: While an initial high dose of corticosteroid treatment accelerated the onset of therapeutic responses in patients with AChR Ab–positive MG, it was associated with a higher cumulative steroid dose and an increased risk of steroid‐induced exacerbations.

Immune thrombocytopenia (ITP) with corticosteroids: “Evaluation of Response”

Objective: to evaluate the response of corticosteroids in newly persistent ITP patients. Methodology: Descriptive Case series conducted from 30th October 20202 to 29th April 2021 at Armed Forces Bone Marrow Transplant Centre Rawalpindi. A total of 74 individuals with ITP who were both males and females of various ages. Prednisolone was administered orally to patients in maximal dose of 1mg/kg. The initial reaction of platelets count was assessed on day 5 and subsequently every two weeks until the full response was attained. An informed consent was obtained. Results: Age was 32.0±19.1 years on average. Twenty-four (32.4%) of the patients were over the age of 40 while the majority (n=50, 67.6%) of the patients were under the age of 40 years. There were 1:1.1 patients that were male and female with 36 (48.6%) men and 38(51.4%) women. Twenty (27.0%) individuals had persistent ITP compared to 54 (73.0%) patients who had just been diagnosed. 34 (45.9%) patients had an initial response whereas 43 patients (58.1%) showed a full response. The average initial response time was 5.47±2.39 days and 11.79±6.73 days for full response. The frequency of first didn’t differ statistically significantly by patient age, gender or other subgroups. Conclusion: Regardless of age, gender, or ITP type, steroids were associated with an initial and complete response in a significant majority of patients with immune thrombocytopenia. Keeping in view with their affordability accessibility favors the use of steroids as first line in these patients.

Parameters and indicators selection of clinical centers in predicting the patients enrollment for clinical trials

Relevance. Recruitment of patients and its compliance with the clinical trial protocol is one of the main goals of conducting a feasibility study before starting any clinical trial. Study feasibility is a must before starting any international multicentre clinical trial, and one of the main goals of feasibility is to find clinical centers with a suitable pool of patients for their subsequent selection and prediction of patient recruitment according to protocol requirements. Well-conducted fitness is clinical centers that recruit eligible patients in compliance with the protocol framework and the recruitment numbers proposed by the centers. After conducting fability, the patient recruitment prediction coincides with the protocol patient recruitment prediction. However, more than half of international multicenter clinical trials fail due to unsuccessful patient recruitment. A widely used method in the study of feasibility is a questionnaire and the reasons for subsequent failures in a clinical trial can be both an underestimation of the information provided in the questionnaires, and the lack of appropriate parameters and indicators, and, as a result, the selection of inappropriate clinical centers. Exposure to the subjectivity of opinion in the selection of sites also leads to poor selection of sites and, therefore, relevance in an objective and independent assessment remains. The aim of the study was to analyze the set of patients in selected clinical trials, identify set-related parameters and measures, and find a statistically significant relationship with a successful set of analyzed parameters and measures. Materials and Methods: A retrospective analysis of 4 international multicenter clinical trials of II-III phases was carried out for the recruitment of patients. The selection criterion is a successful recruitment of patients. Statistical analysis: descriptive statistics, multivariate analysis, correlation analysis. Results and Discussion. Parameters and indicators were found that showed a strong statistical correlation with successful recruitment of patients in clinical centers. As a result of the study, conclusions were drawn about the need to expand the use of parameters and the ratio of parameters: instead of indicators of one parameter - the expected set of patients before inclusion in the mandatory assessment of sites is a calculated parameter, it is also necessary to additionally take into account the following parameters: type of site and initial response time in days. Conclusions. Using the proposed parameters and metrics will reduce the likelihood of failure in patient recruitment. These parameters will make it possible to evaluate clinical centers with a prediction of the number of patients and to select more qualitative clinical centers.

Patient Outcomes after Initial High Dose Versus Low Dose Romiplostim for Inpatient Management of Immune Thrombocytopenia

Introduction: Romiplostim is a thrombopoietin receptor agonist approved by the US FDA for chronic immune thrombocytopenia (ITP) in patients who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. The recommended dose is 1 mcg/kg/week subcutaneously, escalated weekly by increments of 1 mcg/kg to achieve and maintain a platelet count of 50 x 10 9 /L g ( Kuter et al 2021). It has been postulated that starting at the maximum recommended dose of 10 mcg/kg/week in patients with severe bleeding may swiftly increase platelets and minimize bleeding ( Roumier et al 2021). However, this approach may also increase the risk of major thrombotic events (TE). It is unclear if the more aggressive dosing strategy results in more rapid, robust responses and a tolerable safety profile compared to the FDA approved approach. Methods: This retrospective chart review included adult patients who initiated romiplostim while admitted for ITP at a Mayo Clinic Enterprise site from May 2018 to May 2022. Outcomes included rate of TE at 30 days and 90 days and time to first TE in patients receiving initial romiplostim doses of &amp;lt; 5 mcg/kg (low dose, LD) and &amp;gt; 5 mcg/kg (high dose, HD), median time to platelet response (defined as platelets &amp;gt; 30 x10 9/L and &amp;gt; 50 x10 9/L on 2 separate checks) in LD vs HD, and cost to the institution comparing LD to HD. Outcomes were summarized using descriptive statistics. Statistical analysis was done using BlueSky. Fischer's exact test and chi-squared were performed for categorical data, and Wilcoxon rank sum test were done for continuous variables. Results: Forty-five patients met eligibility criteria: 33 (73%) received initial romiplostim doses &amp;lt; 5 mcg/kg and 12 (27%) received doses &amp;gt; 5 mcg/kg. The majority of patients (43/45 (96%)) presented with platelets &amp;lt; 50 x 10 9/L. The median age was 65 years (68 in LD vs 57 HD). There were 24 (73%) males in the LD group vs five (42%) in the HD group. At baseline, 64% (n = 21) of LD patients and 75% (n = 9) of HD patients presented with bleeding. Major bleeding (defined by 2019 ASH ITP guidelines) was present in 21% (n= 7) vs 17% (n = 2) of patients, LD versus HD, respectively ( Neunert et al 2019). The overall incidence of TE in this study was 24% (n = 11): LD 5 (15%) and HD 6 (50%) (p = 0.044) at 90 days. Median days to TE was 21 days, 12 days in LD group (range 5-21) vs 24.5 days (range 14-58) in HD group (p = 0.067). TE included deep vein thrombosis (DVT, n = 6), DVT with pulmonary embolism (n = 1), portal vein thrombus (n = 1), multiple brain infarcts (n = 1), splenic vein thrombus (n = 1), and left atrial appendage thrombus (n = 1). The median platelet count at the time of TE was 304 x 10 9/L, 415 x 10 9/L (range 58-900) in the LD group vs 323 x 10 8/L (range 33-1427) in the HD group (p = 0.79). Thirty-two (71%) out of 45 patients had a response to romiplostim: 22 in the LD group (71%) vs 10 (83.3%) in the HD group (p = 0.698). Of the patients that responded, the median time to response was 6 days in the LD group vs 11.5 days in the HD group (p = 0.09) The median dose at time of initial response was 2 mcg/kg in the LD group and 6 mcg/kg in the HD group. Wholesale Acquisition Cost (WAC) was used to determine the cost per dose, rounded to the nearest vial size. The average WAC for the initial dose in LD patients was $1806.80 compared to $6061.79 in HD patients. Conclusion:There was a significantly increased incidence of thrombosis in patients admitted with ITP that received initial romiplostim doses &amp;gt; 5 mcg/kg, with no differences in the time to platelet response. Careful consideration of risks versus benefits should be given prior to initiating romiplostim at doses higher than recommended doses.

A Self-Sustained CPS Design for Reliable Wildfire Monitoring

Continuous monitoring of areas nearby the electric grid is critical for preventing and early detection of devastating wildfires. Existing wildfire monitoring systems are intermittent and oblivious to local ambient risk factors, resulting in poor wildfire awareness. Ambient sensor suites deployed near the gridlines can increase the monitoring granularity and detection accuracy. However, these sensors must address two challenging and competing objectives at the same time. First, they must remain powered for years without manual maintenance due to their remote locations. Second, they must provide and transmit reliable information if and when a wildfire starts. The first objective requires aggressive energy savings and ambient energy harvesting, while the second requires continuous operation of a range of sensors. To the best of our knowledge, this paper presents the first self-sustained cyber-physical system that dynamically co-optimizes the wildfire detection accuracy and active time of sensors. The proposed approach employs reinforcement learning to train a policy that controls the sensor operations as a function of the environment (i.e., current sensor readings), harvested energy, and battery level. The proposed cyber-physical system is evaluated extensively using real-life temperature, wind, and solar energy harvesting datasets and an open-source wildfire simulator. In long-term (5 years) evaluations, the proposed framework achieves 89% uptime, which is 46% higher than a carefully tuned heuristic approach. At the same time, it averages a 2-minute initial response time, which is at least 2.5× faster than the same heuristic approach. Furthermore, the policy network consumes 0.6 mJ per day on the TI CC2652R microcontroller using TensorFlow Lite for Micro, which is negligible compared to the daily sensor suite energy consumption.

Development of Measuring System using CSI on ITIL V3 for Improvement at Oil Palm Plantation Company

Many information technology services firms now offer services and consider software availability to be a critical component of achieving excellence and competing in the industry. The most crucial factor for customers is the quality of service, consumer needs, the state of the organization/company, and the present market should all be considered when improving their service. In this study, an ITSM analysis will be carried out at an oil palm plantation company based in West Kalimantan Province using ITIL framework V3 by focusing on continual service improvement, which largely relies on service measurement because a process must be measurable to be regulated and improved. To achieve continuous service improvement (CSI) throughout the service life cycle, we use the 7-step process to improve is used to establish and take care of the stages involved in identifying, defining, collecting, processing, analyzing, presenting, and implementing changes. The result of this analysis is CSF and KPI analysis that produce metrics, such as the average resolution time, the percentage of events allocated more than once, and the initial response time, then create a measurement system that is in accordance with the needs and can be used as a reference for the company's system assessment.

Association Between Door-to-Doctor Time and Discharge Against Medical Advice in Patients with COVID-19 from the ED

The cause of Discharge Against Medical Advice (DAMA) is a long response time/doorto- doctor time, which is not according to the recommendation of 5 minutes. This study aimed to determine the association between Door to Doctor Time and DAMA incidence in patients with COVID-19 from the ED. The research design used is a cross-sectional study. This study used a purposive sampling technique (n = 414) in patients with COVID-19 symptoms who came or were referred to the ED in December 2020-April 2021. The data analysis used the Spearman correlation test. The results of this study indicate that most response times with response time indicators arrive until the initial action is not according to recommendations, namely 75 patients (18.1%). In contrast, the response time (response time for initial treatment to supporting laboratory examinations) is dominated by the same response time as many as 54 patients (13.0%). The results of the Spearman correlation show a positive correlation between the two waiting times / Door to Doctor time with an indicator (response time to achieve initial action) with the incidence of DAMA in COVID-19 patients. The correlation value is 0.000 (sig &lt; 0.05), which is 0.436, and (the response to initial handling time until laboratory examination) has a correlation value of 0.413 with the same relationship, namely positive and unidirectional. At the same time, the strength of associations was moderate. The door to Doctor Time / Response time with indicators (response time from arrival to initial action and response time to initial treatment to supporting laboratory tests) is associated with the incidence of DAMA in patients with Covid-19 in the ED. The longer the response time will affect the incidence of DAMA in COVID-19 patients.&#x0D; Keywords: discharge against medical advice, door to the doctor time, COVID-19, ED

Soil loss through fissures and its responses to rainfall based on drip water monitoring in karst caves

Owing to the binary geologic structure, soil loss in the karst region is characterized as a combination of surface erosion and underground soil loss. However, we know little about the process and amount of underground soil loss by now due to the difficulty in observation and identification. To predict soil loss accurately and control rocky desertification effectively, it is urgent to collect data of underground soil loss directly by new ways. In this study, 137Cs tracer technique, high frequency online monitoring and UAV survey were used to investigate soil loss through fissures. The soil samples were collected in five karst caves of Guizhou Province for determining 137Cs activity. In two of these caves, the improved monitoring devices were adopted to monitor drip water online, and the sediment content in drip water was measured once a month. Furthermore, depending on 5 exposed karst sections, the distribution density of fissures was surveyed with UAV to calculate the average underground soil loss modulus in the watershed. The results showed that (1) the soil materials deposited in caves were mainly transported by runoff from the cave entrance, rather than through fissures above the caves. (2) The initial response time and duration of drip water in caves to rainfall were controlled by surface land coverage and the process of precipitation. And the variation of sediment content in drip water kept almost constant with rainfall except at the beginning of the rainy season. (3) The directly measured underground soil loss rate monitored through the fissure above a cave with high bedrock exposure rate and a cave with high vegetation coverage was 2.42 g·yr−1 and 0.36 g·yr−1, respectively. (4) The average underground soil loss modulus in the area with high bedrock exposure rate and with high vegetation coverage was 0.35 t·km−2·yr−1 and 0.05 t·km−2·yr−1, respectively. This study is helpful for understanding the process and intensity of underground soil loss.

Exploring groundwater drought responsiveness in lowland post-glacial environments

Groundwater drought response to meteorological forcing depends on initial hydrological conditions. This makes it difficult to characterise groundwater droughts and identify the drought vulnerability of aquifers. The objective is to increase the understanding of groundwater memory and response to meteorological forcing in lowland post-glacial environments. Eighty-one groundwater hydrographs are analysed, using the standardised groundwater level index (SGI) and the precipitation index. Memory and response times are assessed using auto- and cross-correlation functions. Response time is estimated by comparing two approaches: (1) the traditional use of the maximum cross-correlation, and (2) the alternative use of the cross-correlation slope. Results are interpreted for different hydrogeological settings. The analysis showed that sand aquifers have the longest memory and response times, particularly in confined settings where the memory could be over 4 years. Silts and tills have relatively short memories and response times, at less than 1 year, though median values for silt are higher than for unconfined sand aquifers. In this study, estimating response time using the correlation slope is superior at capturing the initial response time of groundwater to precipitation. However, the results showed that groundwater anomalies in lowland post-glacial environments are sometimes more influenced by climate teleconnections than concurrent forcing. This emphasises the need for a holistic approach for the characterisation and projection of groundwater drought, as it develops in simultaneous response to meteorological forcing at different timescales.

Global Good Open Source Software Development in Response to the COVID-19 Pandemic - Perspectives from SORMAS Implementation in Europe.

In recent years, software has evolved from being static, closed source, proprietary products to being dynamic, open source, ecosystems contributing to the global good. To this end, the open source software (OSS) solution and global good, Surveillance Outbreak Response Management and Analysis System (SORMAS), rapidly adjusted to the demands of the Coronavirus disease 2019 (COVID-19) outbreak by introducing a COVID-19 module. This allowed countries that were already making use of the software as part of their public health surveillance infrastructure to make use of the new module in order to respond to the pandemic. New countries in continental Europe, most notably Germany, Switzerland, Liechtenstein and France subsequently chose to adopt the software for public health surveillance purposes for the first time during 2020, requiring additional adaptations to meet local needs. As a result, in this paper, we aim to gain a better understanding of how rapidly SORMAS was adapted to meet global needs by analyzing the SORMAS COVID-19 module introduction timeline, as well as the overall development activity of the software during 2020 and 2021 in response to the pandemic. Favorable initial feature response times in combination with development scale-up possibilities speak to some of the potential advantages of implementing global good OSS tools such as SORMAS for public health surveillance, in response to an emergency. Overall, SORMAS serves as proof of concept for developing a global good OSS solution on an international scale.

Evaluation of Labuhanbatu Regency Government Website based on Performance Variables

Since the establishment of the Labuhanbatu Regency Government website, no efforts have been made to evaluate its performance. This is important to do considering that the Labuhanbatu Regency Government website is a medium of public information needed by the community. The website is also an indicator of the quality assessment of the government as an effort to improve services to the community. This study aims to analyze the website of the Labuhanbatu Regency Government using the evaluation method. The evaluation process is carried out with the help of the GTmetrix measuring tool by measuring website performance through performance metrics such as: First Contentful Paint (FCP), Speed ​​Index (SI), Large Contenful Paint (LCP), Time to Interactive (TTI), Total Blocking Time ( TBT), and Cumulative Layout Shift (CLS). The test results show that the Grade of the website is at level D, with 61% Performance, and 78% Structure. The test results on performance metrics at two test times show a downward trend, where the best FCP is achieved within 2100 milliseconds, SI 6500 milliseconds, LCP 4300 milliseconds, TTI 2100 milliseconds, and TBT 0 milliseconds, although the FCP, SI, and LCP metrics are still in the non-recommended category. The results showed that the GTmetrix measuring instrument could be used to evaluate the website of the Labuhanbatu Regency Government with comprehensive evaluation results. The thing that must be evaluated is the “Reduce initial server response time” aspect which makes the website's initial page load slow. As a solution to these problems, the Labuhanbatu Regency website manager must make improvements to the program code and database queries, implement caching on the server, and perform periodic upgrades to Server hardware, CPU, and Memory.

Photorefractive Response Enhancement in Poly(triarylamine)-Based Polymer Composites by a Second Electron Trap Chromophore.

Photorefractive (PR) performances are affected by the components of the photoconductor, sensitizer, nonlinear optical dye, and plasticizer. A photoconductor with high hole mobility promises a faster response time, whereas it induces higher photoconductivity, which leads to easy dielectric breakdown. Adding a second electron trap is effective in controlling photoconductivity. In this study, the role of a second electron trap 1,3,5-tri[(3-pyridyl)-phen-3-yl]benzene (TmPyPB) was investigated in a PR composite consisting of a photoconductor of poly[bis(4-phenyl)(2,4,6-trimethylphenyl)amine] with a high hole mobility, a nonlinear optical chromophore of piperidinodicyanostyrene, a plasticizer of (2,4,6-trimethylphenyl)diphenylamine, and a sensitizer of [6,6]-phenyl C61 butyric acid-methyl ester. The minimum time response with the maximum optical diffraction efficiency and sensitivity was measured at a 1 wt % content of TmPyPB. These results were consistent with the number of charge carriers trapped per unit volume and per unit time Nc (cm–3 s–1), which is defined as the ratio between the initial trap density Ti (cm–3) and response time τ (s), at a 1 wt % content of TmPyPB. A faster response time of 149 μs, optical diffraction of 24.1% (external diffraction of 4.8%), and a sensitivity of 2746 cm2 J–1 were measured at 50 V μm–1 for the sample with 1 wt % TmPyPB. High loading of 5 wt % TmPyPB led to a large decrease in photoconductivity and effectively suppressed the dielectric breakdown under a stronger electric field, whereas a slower response time with lower diffraction efficiency was observed for optical diffraction.

Managing Increased Cognitive Load in a Guided Search.

In the Sternberg item recognition task and its variants, an individual’s mean reaction time increases with the number of items to be retained in the memory set. An increase in reaction time has also been seen when a secondary task was added. The usual interpretation for this increased reaction time is that adding cognitive load makes tasks more difficult. In a series of three experiments, we manipulated cognitive load through increases in the memory set or through a second task. In each experiment, high cognitive load was associated with higher mean response times but a reduced slope, based on the target position in a series of probes. Thus, in a Sternberg task with multiple word targets and multiple word probes, participants searched more efficiently per probe under high load than under low load. This pattern was replicated with the addition of a working memory task requiring participants to calculate a cumulative price based on the price per target word item. By considering both initial response times and reaction time slopes in large memory sets, this study provides a challenge to the traditional interpretation of cognitive load effects on search performance.

Late vs Early Response and Depth of Response Are Associated with Improved Outcomes in Newly Diagnosed Multiple Myeloma (NDMM) Patients (pts) Treated with Ixazomib-Lenalidomide-Dexamethasone (IRd) or Placebo-Lenalidomide-Dexamethasone (pbo-Rd) in the Phase 3 TOURMALINE-MM2 Trial

Late vs Early Response and Depth of Response Are Associated with Improved Outcomes in Newly Diagnosed Multiple Myeloma (NDMM) Patients (pts) Treated with Ixazomib-Lenalidomide-Dexamethasone (IRd) or Placebo-Lenalidomide-Dexamethasone (pbo-Rd) in the Phase 3 TOURMALINE-MM2 Trial

Development of a Monitoring and Management System for Nonheritage Tourist Attractions Based on Mobile GIS and Multisensor Technology

With the rapid development of the tourism industry, how to monitor scenic spots and tourists in real time has become an issue. This paper mainly describes the development of a monitoring and management system for scenic spots of intangible cultural heritage based on Mobile GIS and multisensor technology. The monitoring system adopts the idea of structured programming, which reduces the coupling degree of various components and promotes the expansion of system functions. The shortest path module uses the scenic spot management subsystem on the PC. The scenic spot manager enters the distance between adjacent scenic spots that can be directly reached into the system database and then uses the shortest path algorithm, Dijkstra algorithm, to calculate. Asynchronous Socket programming mechanisms are used to implement communication capabilities, the XML markup language is selected as the system’s data exchange protocol, and the DHT11 digital temperature and humidity sensor is used to obtain humidity information around ancient buildings. A Mobile GIS reader of an ancient building in a scenic spot sends a request to connect to a server. The listener is the communication interface between the server software and the reader. It is responsible for parsing the transmitted data and storing it in the database. The CC2430 chip is used to wear on tourists. When tourist nodes and guide nodes enter the scenic spot, they join the network to query the density of the entire scenic spot and upload real-time information. In terminal query, the average response time of real-time location query is 2S. The average initial response time for historical location queries is about 3S. The results show that the visualization services provided by software development can intuitively and accurately display the flow and density of scenic spots, providing a scientific reference for carrying capacity and flow management of scenic spots.