Description of alarm symptoms in women with gynecologic cancer

An international multicenter retrospective analysis of repeated anti-ENA testing in ANA-associated rheumatic diseases, a data-driven proposal to increase testing efficacy.

Removal of uranium from aqueous solution using cellulose extracted from the leaves of Musa paradisiaca.

Pre- versus post-COVID-19 pandemic comparison of kindergarten teacher-reported child development in multiple Canadian jurisdictions.

Rectal cancer surgery timing after neoadjuvant therapy: balancing downstaging and perioperative outcomes.

Inducible differentiation of buffalo (Bubalus bubalis) embryonic stem cells towards male and female germ cell-like lineages under ex vivo BMP4-mediated stimulation.

Camera trap assessment of bushpig (Potamochoerus larvatus)-domestic animal interactions and implications for pathogen transmission in rural habitats of Madagascar.

Timing matters: Surgery-to-chemotherapy interval and outcomes in ovarian cancer.

A model research study on persistence, recovery and analysis of trace DNA under fingernails of drowned bodies.

Silicon (Si) is a relatively novel element that has found widespread application in various fields. Gibberellic acid (GA3) is known to induce different physiological traits in a variety of plants. While Si and GA₃ independently improve plant performance, their interactive mechanisms and potential synergy are poorly understood. In the present study, different treatments of GA3 (0, 10, 20, 50, 75 and 100ppm) and Si (50ppm) were applied as foliar and soil irrigation on sugarcane (Saccharum officinarum L. cv. GT55) plants at specific time intervals, such as 60 and 90days. The result findings indicated that the application of foliar and soil irrigation containing GA3 and Si notably enhanced and/ or stabilized enzymatic and non-enzymatic activities, i.e., soluble protein, catalase, peroxidase, ascorbate peroxidase, superoxide dismutase, glutathione reductase, hydrogen peroxide, lipid peroxidation, proline, ascorbate, glutathione, oxidized glutathione, glutathione-S-transferase, dehydroascorbate, and plant hormones, such as indole-3-acetic acid, abscissic acid, and gibberellic acid in sugarcane plant leaves and roots after foliar and soil irrigation application. The results showed that the interactive applications of GA3 and Si were not harmful to sugarcane plants, and positively affected their growth and development. The simultaneous application of Si and GA₃ is a safe and highly effective strategy to upregulate sugarcane growth and metabolic regulation. This innovative approach presents sustainable technology to enhance crop productivity and contribute to global food security goals without relying on conventional chemical inputs.

Delayed coloanal anastomosis for rectovaginal fistulas: Insights from a multicenter cohort (GRECCAR).

Critical care transfers of ventilator-dependent patients from operating theatres to Critical Care Units in a South African Metropole.

Optimal driving strategies for trains on level track with bounds on energy consumption during specified intermediate time intervals

Phase resetting with temporal template explains complexity matching in finger tapping to fractal rhythms.

A majority of the human genome codes for genes that do not produce proteins. Many of these long non-coding RNA (lncRNA) transcripts have evolved at a faster rate than genes that code for proteins, have critical regulatory and structural roles, and have important roles in higher-level brain functioning and diseases. We have shown selective time and cell-type stability of RNA transcripts in human brain during the postmortem interval. Here, we have extended these studies to examine the stability of lncRNAs in a simulated human postmortem interval. We found that lncRNA stability is variable and cell-type specific. While some lncRNAs are stable for up to 24 hours, those expressed in neurons decline rapidly and those expressed in glial cells such as astrocytes and microglia increase dramatically during this same time interval. The lncRNAs are less stable than protein-coding RNAs, and microRNAs were highly unstable in the simulated postmortem interval. Knowing the stability of human brain protein-coding and non-coding genes in the postmortem interval is critical to interpret studies of all human brain disorders ranging from Alzheimer's disease to schizophrenia.

It is estimated that, need for food will surge by 60 to 98% in the coming years. To meet the escalating demand for food in our densely inhabited world, safeguarding grains from insect pests has become a trending subject. To overcome these issues, there is an urgent need to develop green, environment friendly, cost effective and long-lasting techniques to protect grains from insect pests. The main objective of the current investigation is to analyse phytochemical constituents, and to evaluate bioefficacy and repellent activity of Parmelia perlata against Sitophilus species. Different concentrations of ethanol and methanol extracts are investigated for its insecticidal and repellent activity. The phytochemicals found include phytosterol in ethanol extract, saponins and phytosterols in the methanol extract. The mortality rate rose proportionally with the extension of the time interval following the treatment. The LC50 value of ethanol extract after 72 hours of exposure is 153.152 mg/L and LC50 Value of methanol extract after 72 hours of exposure is 194.919mg/L. The ethanol extract appears to be more potent when compared to the methanol extracts. The average repellent percentage of Parmelia perlata ethanol extract is 51.85% at 500mg/L concentration. The P-Value of ethanol extract is 1.1971 X 10-192 and for methanol extract the P-Value is 2.5349 X 10-169 which is less than 0.01 which shows the results obtained are significant. The bioactive compounds in the extract are likely responsible for its effectiveness. Thus, Parmelia perlata is a promising grain protectant, ensuring seed viability.

Wartime injuries contribute to the global burden of mortality as a major public health threat. Early access to healthcare improves the quality of life of war-injured patients. The patterns of trauma care and its outcomes in war-injured patients have not been documented in conflict-affected regions of the Democratic Republic of Congo, where political crisis and civil unrest lasted more than two decades. This paper describes the pathway to care, referral patterns and treatment outcomes of war-injured patients treated at the Provincial Hospital of North Kivu (PHNK) during the January 2025 crisis in Goma. This retrospective observational study identified 239 war-injured patients admitted at the PHNK between 25th January and 31st March 2025. The study gathered information on patient demographics (age, sex, marital status, and religion), time interval between trauma occurrence and hospital admission, mode of admission, injury patterns (mechanism, site, and type), first medical aid at the trauma site, severity of injury and outcomes (mortality, length of hospital stay, and postoperative infection). Descriptive analyses performed with Stata 15.0 were summarized as proportions, medians or means and standard deviation. Most war-injured patients admitted at the PHNK were male (82.3%), single (52.2%), and aged 18-49 years (76.3%). These patients were self-referred (87.1%), did not benefit from first medical aid at trauma sites (86.7%), and had a time interval ranging from 6 to 24h between trauma occurrence and hospital admission (37.4%). Debridement was performed in 54.4% of cases. Tetanus immunization was administered to 15.9% of war-injured patients, whereas 13% benefited from physiotherapy. Only 7.1% of cases benefited from psychological management. The overall mortality rate was 4.4% (11 patients), with 9 deaths occurring within 48h from admission. The mean length of hospital stay was 14 days, whereas 8% of war-injured patients had a postoperative infection. These results show the delays in care, self-referral and mortality in war-injured patients in the context of limited resources and conflict. The results call for feasible interventions within a context of high violence such as that of the Democratic Republic of Congo, aiming at strengthening the health system and enhancing community-level capacities to improve the quality of life of war-wounded individuals in conflict zones. This study also shows that a robust health system can deliver an effective response to acute crises if it is equipped with sufficient technical capacity, well-trained staff, essential medicines, and strong organizational structures.

BackgroundLate-onset Pompe’s disease (LOPD) is a progressive treatable metabolic myopathy due to partial acid α-glucosidase (GAA) deficiency, with potential onset during the pediatric age. To date, Pompe’s disease is not widely included in newborn screening panels, so that clinical suspect remains essential for timely diagnosis and management. Clinical identification of LOPD was shown to be challenging in adult patients, whereas data in children and adolescents are scanty. We conducted an Italian nationwide multicentric survey in order to delineate the characteristics of LOPD in the pediatric population. This prompted us to propose a diagnostic algorithm to facilitate the identification of LOPD in pediatrics.ResultsThe survey provided information on 38 Italian pediatric patients with a definite biochemical and molecular diagnosis of LOPD firstly suspected based on clinical approach. Nineteen patients (50%) reached medical attention because of clinical symptoms of LOPD (79% within 3 years of age; 21% at 3–18 years of age) and 19 (50%) because of incidental finding of asymptomatic hyperCKemia. All the 38 LOPD patients showed hyperCKemia (56%: range 500–1000 U/l; 18%; range 250–500 U/l; 18% range 1000–2000 U/l; 8% >2000 U/l), almost invariably accompained by concomitant hypertransaminasemia (91%). Main clinical symptoms before 3 years of age were inability to (1) sit at 8 months, (2) walk indipendently at 18 months, and (3) climb stairs at 30 months. Later pediatric presentations (3–18 years of age) were limitation to (1) get up from supine position, (2) perform sport activity, and (3) run. In symptomatic patients, diagnostic latency (i.e. the time interval between clinical onset and diagnosis of LOPD) ranged from < 1 year (58%) to 2–12 years (42%).ConclusionsClinical diagnosis of LOPD in pediatrics is challenging in spite of its frequent presentation within 3 years of age. A selective screening by measuring GAA activity on dried blood spot in the two main clinical diagnostic contexts of LOPD in pediatrics – namely (1) age-related myopathic symptoms or (2) asymptomatic hyperCKemia (and hypertransaminasemia) – will likely ensure diagnostic anticipation for those patients not screened for Pompe’s disease in the neonatal period.

To obtain the state information of multiple targets in a fiber optic sensing network, we improve the target state recognition probability. A target state recognition algorithm based on data mining is proposed. An orthogonally distributed FBG sensing network is designed based on the characteristics of fiber optic sensing. The clustering weights and clustering degree for multi-target state classification are derived. A target state recognition model based on data mining is constructed. The time interval between peak-to-peak tip positions in an aliased signal containing a faster-moving target is narrower. The more targets are aliased, the greater the time width of the overall echo response. The average test speeds for target A, target B, and target C are 0.99 m/s, 2.86 m/s, and 4.87 m/s, with relative errors of 1.3%, 4.7%, and 2.5%, respectively. The experimental comparison of target recognition probabilities before and after data mining shows that the recognition rate is significantly improved after applying this algorithm. It is especially effective for overlapping signals of state-similar targets. Moreover, this algorithm also suppresses the system’s false judgment rate to a certain extent.

IntroductionAlthough opioids remain the standard of care for managing postsurgical pain, concerns persist regarding their safety, tolerability, and potential for addiction. Intravenous (IV) formulations of ketoprofen and tramadol have been widely available in numerous countries outside the United States and Canada.MethodsThis single-dose, single-center, double-blind, randomized study (n=185) evaluated the analgesic efficacy, dose-response relationship, duration of action, and safety of IV ketoprofen 50 mg (n=33) and 100 mg (n=31), IV tramadol 100 mg (n=33) and 150 mg (n=22), IV morphine 4 mg (n=33), and placebo (n=33) administered over two minutes upon the first occurrence of moderate-to-severe pain following surgical extraction of bony impacted mandibular third molars. Pain intensity and pain relief were assessed over eight hours. The primary efficacy endpoint was total pain relief over the first four hours (TOTPAR 0-4). Secondary efficacy endpoints included TOTPAR at additional time intervals, summed pain intensity difference (SPID), peak pain relief, peak pain intensity difference, time to rescue analgesia, patient global evaluation, and time to confirmed perceptible and meaningful pain relief. Safety assessments included volunteered and observed adverse events (AEs).ResultsFor TOTPAR 0-4 and all other efficacy endpoints, IV ketoprofen 50 mg and 100 mg, and IV tramadol 100 mg and 150 mg were significantly superior to IV morphine 4 mg and placebo. IV ketoprofen at both doses also outperformed IV tramadol at both doses across the majority of outcome measures. No significant differences in efficacy were observed between IV morphine 4 mg and placebo. The proportion of subjects experiencing one or more AEs was comparable among the placebo, IV ketoprofen 50 mg, and IV ketoprofen 100 mg groups. In contrast, higher AE rates were reported in the IV tramadol and IV morphine groups relative to placebo. Dosing in the IV tramadol 150 mg group was discontinued early due to the occurrence of seizures in two patients (9%) immediately following administration.ConclusionsBoth IV ketoprofen and IV tramadol demonstrated superior analgesic efficacy compared to IV morphine and placebo in the management of postsurgical pain. Notably, IV ketoprofen consistently outperformed tramadol across efficacy endpoints. The lack of efficacy observed with IV morphine 4 mg raises concerns about potential analgesic assay insensitivity in postsurgical dental pain. The occurrence of seizures in subjects without known seizure risk factors highlights a potentially insufficient safety margin for tramadol in unselected patient populations.