Recovery Time Research Articles

Incisionless Otoplasty: Current State of the Art.

Prominent ears, also known as prominauris, inflict psychological distress and suffering on both children and adults. Otoplasty has become one of the most common aesthetic operations due to its high prevalence and significant impact on patients. Various surgical techniques for otoplasty have been documented and developed over time. While complications are rare, open and cartilage-resection techniques may result in hemorrhage, hematomas, contour deformities, hypertrophic scarring, and keloid formation. Incisionless otoplasty has been demonstrated in the literature to be an effective method, when correctly indicated, to correct prominauris with a shorter recovery time and reduced morbidity. A thorough preoperative evaluation, awareness of the different techniques, and assessment of their appropriate application minimize potential risks and unpleasant results.

In Vivo Mapping of Human Ventricular Fibrillation in Brugada Syndrome: The Role of Repolarization Heterogeneity.

Brugada syndrome (BrS) is associated with ventricular fibrillation (VF). Different VF mechanisms have been described, and repolarization gradients were associated with VF in a BrS model. The aim of this study is to map VF in BrS with ECG imaging. Furthermore, spatial correlation between sinus rhythm maps and VF maps was evaluated. Inclusion criteria were (1) BrS diagnosis and (2) VF mapped with ECG imaging during right ventricle outflow tract ablation. VF mechanism was classified into (1) rotational, (2) focal, and (3) irregular. For comparison, 6 controls were enrolled. The following sinus rhythm maps were performed: activation, recovery time, and activation-recovery interval time. Spatial overlap between steep repolarization gradients (cliffs) at recovery time and activation-recovery interval time maps and initiating VF rotational activity was evaluated with photogrammetry. A total of 28 VF maps in 21 patients with BrS were analyzed. In the first ≈7 seconds of VF, rotational, focal, and irregular mechanisms were found. In 19 patients with BrS (90.5%) and none of the controls, a right ventricle outflow tract repolarization cliff only was found. In all these patients, the singularity point of the first initiating rotational VF activity spatially overlapped with the right ventricle outflow tract cliff. Abolition of right ventricle outflow tract repolarization cliffs was confirmed in all but 2 patients (94.3%). In one patient with recurrence, VF was mapped on the anterior right ventricle over a cliff that was not targeted at the first ablation procedure. In patients with BrS, repolarization heterogeneity has a critical role in VF. Repolarization cliffs might be a therapeutic target in VF ablation.

Exploring Similarities and Differences in Water Level Response to Earthquakes in Two Neighboring Wells Using Numerical Simulation

The seismic effect of well water level is complex and variable, and even if both wells are located in an area with similar tectonic and hydrogeological conditions, they exhibit slightly varying response characteristics to the same earthquake. Wells BB and RC, located about 100 km apart in the southwest of the Huayingshan fault zone in the Sichuan and Chongqing regions, exhibited obvious similarities and differences in their co-seismically response and sustained recovery characteristics during the Wenchuan Ms8.0 earthquake. Based on the dislocation theory and fluid–solid coupling theory, this study developed the seismic stress–strain model and the response model of pore pressure to seismic stress using Coulomb 3.3 and COMSOL 6.3, respectively. Simulation findings indicate that both BB and RC are located in the expansion zone, where their water levels show a co-seismic step-down. The amplitudes of BB and RC water levels are 83 cm and 81 cm, which are approximately 10 cm smaller than the actual values. The recovery times are 60 d for BB and 3 h for RC, closely resembling the actual values. Furthermore, the numerical results from different scenarios show that the recovery time of pore pressure is reduced by several times when the permeability of the confining layer overlying the observed aquifer increases by one order of magnitude or the thickness decreases, and this change is more sensitive to the permeability. It is clear that the confining condition has an important impact in the response time of sustained changes in well water levels, which may also help to explain the variations in the characteristics of sustained changes in wells BB and RC.

Drought characteristics and propagation under anthropogenic impacts: A regional-scale modelling analysis in four Large Basins of China

Study regionThe Songhua River Basin, the Yellow River basin, the Yangtze River basin, and the Pearl River Basin in China. Study focusUnderstanding the drought evolution under changing environment is crucial to sustainable water management, especially for China where there are increasing anthropogenic activities. We employ a national-scale land surface-hydrological model (CLHMS v1.1) with representations of human water management and enhance it with dynamic land use setting to investigate the impact of human activities on the drought regime. We first identify the meteorological droughts and hydrological droughts using Standardized Precipitation Index (SPI) and Standardized Streamflow Index (SSI), respectively. Then, two controlled simulation experiments, namely the human altered scenario and the natural scenario, are designed to analyze the human impact on the drought characterisics and propagation. New hydrological insights for the regionThe model accurately simulates the SSI under human impacts, with a correlation coefficient ranging from 0.78 to 0.93. In northern basins, human activities decrease the number of hydrological drought events by 50 %, while increasing their severity, duration, and recovery time. Additionally, human activities have prolonged the average propagation time from meteorological to hydrological droughts by approximately 3.4 months. For southern basins, the impact of human activities on the drought regime is similar to that in northern basins but to a lesser extent.

Ammonia and ethanol detection via an electronic nose utilizing a bionic chamber and a sparrow search algorithm-optimized backpropagation neural network.

Ammonia is widely acknowledged to be a stressor and one of the most detrimental gases in animal enclosures. In livestock- and poultry-breeding facilities, a precise, rapid, and affordable method for detecting ammonia concentrations is essential. We design and develop an electronic nose system containing a bionic chamber that imitates the nasal-cavity structure of humans and canines. The sensors are positioned based on fluid simulation results. Response data for ammonia and ethanol gases and the response/ recovery times of an ammonia sensor under three concentrations are collected using the electronic nose system. Response data are classified and regressed using a sparrow search algorithm (SSA)-optimized backpropagation neural network (BPNN). The results show that the sensor has a relative mean deviation of 1.45%. The ammonia sensor's output voltage is 1.3-2.05 V when the ammonia concentration ranges from 15 to 300 ppm. The ethanol gas sensor's output voltage is 1.89-3.15 V when the ethanol gas concentration ranges from 8 to 200 ppm. The average response time of the ammonia sensor in the chamber is 13 s slower than that of the sensor directly exposed to the gas being measured, while the average recovery time is 19 s faster. In tests comparing the performance of the SSA-BPNN, support vector machine (SVM), and random forest (RF) models, the SSA-BPNN achieves a 99.1% classification accuracy, better than the SVM and RF models. It also outperforms the other models at regression prediction, with smaller absolute, mean absolute, and root mean square errors. Its coefficient of determination (R2) is greater than 0.99, surpassing those of the SVM and RF models. The theoretical and experimental results both indicate that the proposed electronic nose system containing a bionic chamber, when used with the SSA-BPNN, offers a promising approach for detecting ammonia in livestock- and poultry-breeding facilities.

Modulatory effects of aerobic exercise on the autonomic nervous system in healthy subjects: A review.

Physical exercise is a practice of the physical activity programmed, periodized and timed. Thus, it can be subdivided into 2 specific types of practice, anaerobic and aerobic exercises. Resistance or aerobic exercises are the most practiced and easily accessible to the population. In this sense, the regular practice of exercise is capable of promoting modulations in several systems such as the autonomic system, in which sympathetic and parasympathetic reflexes are essential for homeostatic control. Thus, the objective of this study was to carry out, through a review, an investigation into the modulatory effects of aerobic exercise on the autonomic nervous system in healthy people. To carry out this work, articles were searched in the PUBMED database, with the descriptors "autonomic nervous system " and “aerobic exercise". We found 193 articles in the first search with the descriptors, but 9 articles were selected for this review. In this context, physical exercise produces modulatory effects on the post-exercise heart rate recovery time and modulates the levels of catecholamines that act on this autonomic system. Further investigations with a greater variety of physical exercises should be carried out, for future understanding of the modulatory effects in healthy individuals.

Engineering an Ultrafast Ambient NO2 Gas Sensor Using Cotton-Modified LaFeO3/MXene Composites.

This work presents a room-temperature (RT) NO2 gas sensor based on cotton-modified LaFeO3 (CLFO) combined with MXene. LaFeO3 (LFO), CLFO, and CLFO/MXene composites were synthesized via a hydrothermal method. The fabricated sensor, utilizing MXene/CLFO, exhibits a p-type behavior and fully recoverable sensing capabilities for low concentrations of NO2, achieving a higher response of 14.2 times at 5 ppm. The sensor demonstrates excellent performance with a response time of 2.7 s and a recovery time of 6.2 s, along with notable stability. The sensor's sensitivity is attributed to gas interactions on the material's surface, adsorption energy, and charge-transfer mechanisms. Techniques such as in situ FTIR (Fourier transform infrared) spectroscopy, GC-MS (gas chromatography-mass spectroscopy), and near-ambient pressure X-ray photoelectron spectroscopy were employed to verify gas interactions and their byproducts. Additionally, finite-difference time-domain simulations were used to model the electromagnetic field distribution and provide insight into the interaction between NO2 molecules and the sensor surface at the nanoscale. A prototype wireless IoT (Internet of Things)-based NO2 gas leakage detection system was also developed, showcasing the sensor's practical application. This study offers valuable insight into the development of room-temperature NO2 sensors with a low detection limit.

Midterm Effects of SARS-CoV-2 on Respiratory Function in Judokas With and Without Exercise-Induced Bronchoconstriction: A Retrospective Study.

The clinical consequences of coronavirus infection in elite judokas with exercise-induced bronchoconstriction (EIB) are unclear. We aimed to determine potential respiratory function abnormalities and recovery in athletes with and without EIB after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Retrospective cohort study. Türkiye Olympic Preparation Centre. This retrospective study analyzed data collected from 25 consecutive elite judokas diagnosed with and without EIB and SARS-CoV-2 infection, routinely followed at an Olympic Sports Center between September 2020 and 2021. Respiratory muscle strength and pulmonary function data were collected before and up to 90 days after SARS-CoV-2 infection. Measurements included maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, and peak expiratory flow (PEF). Infected athletes with EIB had more markedly reduced respiratory muscle strength and pulmonary function than those without EIB. Maximal inspiratory pressure was decreased by 14% and MEP by 8% from baseline in infected athletes with EIB during follow-up. Likewise, FEV1 and FVC decreased by 4%. Maximal inspiratory pressure, MEP, FEV1, and FVC remained abnormal after 90 days of SARS-CoV-2 infection in EIB athletes but normalized rapidly in non-EIB athletes. Peak expiratory flow seemed unaffected during follow-up. Exercise-induced bronchoconstriction severity was moderately correlated with the maximum fall in MEP during follow-up. Severe acute respiratory syndrome coronavirus-2 infection notably decreases respiratory muscle strength and pulmonary function in judokas, especially those with pre-existing EIB, thereby prolonging spontaneous recovery time.

Fault Tolerance Management Implementation from Medium-to-Large-Scale Networks

As network infrastructures grow in complexity, ensuring high availability and resilience becomes critical, especially for medium-to-large scale networks. This study focuses on the development and implementation of fault tolerance management within Software-defined networking (SDN) environments, aimed at minimizing downtime and enhancing network reliability. SDN’s centralized control and dynamic programmability provide an ideal framework for implementing efficient fault detection and recovery mechanisms. The proposed model leverages real-time monitoring, redundancy protocols, and adaptive rerouting strategies to mitigate the impact of node or link failures. Key components of the model include failover mechanisms, load balancing, and traffic rerouting algorithms, designed to maintain seamless network operations during failures. Through simulation and testing, the model demonstrates significant improvements in network resilience, reducing recovery time and ensuring uninterrupted service delivery. This research provides a comprehensive guide to implementing fault-tolerant networks using SDN, offering scalable solutions that can be adapted to various network sizes and configurations. The findings emphasize the potential of SDN to revolutionize fault management in modern network infrastructures, making it a crucial consideration for future network design and operations.

Autonomic nervous system dysfunction in idiopathic REM sleep behavior disorder as a short-term risk for a synucleinopathy.

Idiopathic REM sleep behavior disorder (iRBD) is a prodromal marker of the alpha-synucleinopathies, in which autonomic nervous system (ANS) involvement may occur. We aimed to characterize the presence and severity of subjective and objective ANS dysfunction in iRBD and assess its capacity to predict short-term clinical progression to a synucleinopathy. Prospective study of patients with polysomnography-confirmed iRBD in whom symptomatic ANS involvement was assessed using the Composite Autonomic Symptom Score (COMPASS-31) and objective dysfunction with the Composite Autonomic Severity Score (CASS). Baseline ANS data were compared between those who later developed a synucleinopathy and those who did not. We evaluated 25 subjects with iRBD without risk factors for autonomic neuropathy and at least 6months of follow-up (mean: 19months). At the end of the study, seven (28%) patients developed a synucleinopathy, namely Parkinson's disease (n = 5) and dementia with Lewy bodies (n = 2). 73.7% of patients had COMPASS-31 scores above the normal cut-off, while no score differences regarding phenoconversion status were observed. At baseline, 85.7% of the subjects who phenoconverted exhibited at least one abnormal result in the CASS score, compared to 38.9% of subjects who remained disease-free (p = 0.035). Adrenergic dysfunction evaluated by an impaired overshoot in Valsalva phase IV and by pressure recovery time was associated with the development of overt synucleinopathy (p = 0.032 and 0.033, respectively). Symptomatic and subclinical ANS dysfunctions are common in iRBD. ANS dysfunction affecting mainly the adrenergic system seems to be a short-term risk for the development of a synucleinopathy.

The Effect of Intraset Rest Periods on External and Internal Load During Small-Sided Games in Soccer

The purpose of this study was to compare the internal and external load in continuous and intermittent small-sided games (SSG) formats. Eight semi-professional soccer players participated in the study, and they completed three protocols: (a) I-intermittent SSG protocol (Int-I, 4 sets of 4 min with a 3 min recovery); (b) Continuous SSG protocol (Con, 2 sets of 8 min with a 3 min recovery); (c) II-SSG protocol (Int-II, 4 sets of 4 min, where each set includes 1 min of exercise with varying recovery periods (10, 20, 30 s), with a 3 min recovery period between sets). A one-way analysis of variance (ANOVA) was used to analyze the dependent variables, with significance determined at p < 0.05. The three protocols differed in total distance covered and in distance covered at speeds >19 km/h, with the Int-II protocol resulting in the greatest distance covered (p < 0.05). Additionally, players in the Con protocol exercised at a higher percentage of their maximum heart rate (%HRmax) (p < 0.05), while the highest RPE value was observed in the Int-I interval protocol (p < 0.05). The external load experienced by players in intermittent SSG protocols is higher, while internal load (%HRmax) remains relatively low. This effect is especially notable in the new intermittent exercise model proposed in this study, which incorporates progressively increasing recovery times within each exercise set. Coaches can use this model to increase players’ external load without causing a heightened perception of fatigue.

Recovery capital profiles among a heterogeneous sample of individuals in recovery from alcohol problems.

Recovery capital (RC) is a framework for conceptualizing the resources individuals use to support alcohol and other drug recovery across social, physical, human, and cultural domains. The goal of this study was to identify subgroups of individuals in recovery with distinct combinations of RC across domains and characteristics of individuals with unique RC patterns. Latent profile analyses investigated patterns in both within-domain amount and variability of RC across each of the four domains using the Multidimensional Inventory of Recovery Capital, a theoretically and psychometrically sound RC measure. The sample included U.S. participants closely reflecting 2020 Census demographics (n = 482, 49% female, 38% racial/ethnic minority, Mage = 42.57) identifying as having resolved a prior problem with alcohol (alone or with other drugs). Latent profile analyses distinguished four RC profiles: Low/Inconsistent (23%), Moderate/Consistent (43%), Moderate/Inconsistent (12%), and High/Consistent (22%). Females and individuals who were unemployed, nonabstinent, and had greater alcohol problem severity were more likely to belong to the Low/Inconsistent profile. Individuals in unassisted recovery were more likely to belong to the Moderate/Inconsistent profile. Older age and more time in recovery were associated with High/Consistent profile membership. Race/ethnicity was not associated with profile membership. These person-oriented analyses elucidate complex patterns of resources that individuals utilize during recovery and individual characteristics underpinning differences across RC patterns. The empirically derived subgroups in this heterogeneous sample highlight multiple combinations of resources that individuals leverage to achieve recovery and indicate characteristics of individuals who may need greater amounts and/or consistency of RC to continue sustaining recovery. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Ecological indicators for restoration success: Development of fish diversity in a large restored floodplain over twelve years

The restoration of rivers and their floodplains is complex, requires substantial financial efforts, intensive stakeholder involvement and long recovery times, making the identification of appropriate ecological indicators for restoration success a key challenge. Herein, one of the largest floodplain restorations along the European Danube was repeatedly assessed over a 12-year period. Changes in the fish community composition in relation to chemical and morphological habitat variables were assessed in all three restored habitat types free-flowing rivers (RS), reconnected oxbows (OS), and small floodplain ponds (FP) which are only temporarily connected to the main stem Danube. Fish species composition of RS, OS, FP and the Danube differed significantly. Species numbers (34 detected in 2022) remained largely constant since the last monitoring in 2013, whereas abundance increased by 15%. Small-bodied target species with short generation times were able to establish populations comprising all size classes shortly after restoration, whilst large-bodied species needed a decade after the restoration for full demographic representation. Highly specialised species such as the rheophilic Chondrostoma nasus used restored RS only during the life stages spawning and juvenile growth. Restoration increased habitat heterogeneity and the initialized hydromorphological processes are still ongoing, supporting the high species diversity. The observed differences in colonization patterns can be explained by species-specific life histories, resulting in diverse short and long-term responses of different fish species and life stages following restoration. Consequently, a comprehensive assessment of restoration success only becomes possible if multiple fish species as ecological indicators are combined in a long-term monitoring.

Traditional Chinese medicine application and evidence analysis of 1426 cases of long COVID: A retrospective study

BackgroundIn recent years, with the increase in COVID-19 infection cases, the focus of treatment and rehabilitation has shifted to symptoms and complications that arise during the recovery period. Traditional Chinese medicine (TCM) has certain advantages in treatment and rehabilitation, but there is currently a lack of systematic clinical research. ObjectiveTo preliminarily evaluate the clinical efficacy of integrated Chinese and Western medical treatment plans and to describe the characteristics of "long COVID'' syndromes. MethodsEligible "long COVID'' patients diagnosed between December 2022 and June 2023 at the Third Affiliated Hospital of Zhejiang Chinese Medical University were identified through electronic medical records. Baseline demographic information was collected, and patients were divided into a TCM group and a Western medicine group based on their treatment methods. The primary outcome for efficacy evaluation was TCM syndrome scores and symptom improvement time, with secondary outcomes including symptom improvement rates. Survival curve analysis was used to assess symptom improvement time, and a Cox regression model was employed to identify potential risk factors affecting symptom prognosis. Chi-square tests were used to compare binary data between or among groups. The Jaccard method was applied for systematic clustering of TCM syndromes, and clinical characteristics at the start and end of treatment were reported. ResultsAnalysis showed that younger patients, those with underweight, and those receiving TCM treatment had shorter recovery times (P < 0.0001). Systematic clustering of the main symptom elements (33 elements with a frequency ≥ 5 %) identified six core combinations. The main symptoms of long COVID included cough, excessive sputum, nasal congestion, chest tightness, sore throat, and fatigue. Notably, symptoms such as fatigue, shortness of breath, and loss of appetite, classified as deficiency syndromes in TCM, had longer recovery times. ConclusionElderly, obesity, underlying diseases, and exclusive Western medicine treatment were associated with poorer prognosis. The early recovery period is characterized by a mix of deficiency and excess syndromes, whereas the later period is dominated by deficiency syndromes. TCM treatment can effectively improve clinical symptoms and shorten symptom duration, but further research is needed.

Yttrium-encapsulated fullerene (Y@C80) mono-doping with As, Bi, Sb, and P for the enhanced sensing of methylmalonic acid (MMA) as a biomarker for vitamin B12 deficiency: A DFT study

The development of new approaches or approaches for the detection of methylmalonic acid from biological samples is now necessary for early diagnosis of vitamin B12 deficiency and appropriate treatment. In this study, Yttrium-encapsulated fullerene (Y@C80) doped with arsenic (As), bismuth (Bi), phosphorous (P), and antimony (Sb) was investigated for its ability to sense methylmalonic acid (MMA) as a biomarker using M06-2X/GenECP/def2svp/LanL2DZ method. The nanostructural analysis showed a marginal deviation in the bond lengths between atoms of the structure upon optimization of the structures interacting with the MMA biomarker, which demonstrated the stability of the system for sensing. The HOMO-LUMO reactivity descriptor revealed that the compound was reactive toward the sensing of the MMA biomarker, as the various systems MMA_As_Y@C80, MMA_Bi_Y@C80, MMA_P_Y@C80, and MMA_Sb_Y@C80 demonstrated relatively short energy gaps of 2.039 eV, 2.025 eV, 2.135 eV, and 2.023 eV, respectively. The nanomaterial strongly adsorbed the biomarker, as indicated by the negative adsorption energies of −0.47075 eV, −0.70478 eV, 0.9034 eV, and −0.5388 eV corresponding to MMA_As_Y@C80, MMA_Bi_Y@C80, MMA_P_Y@C80, and MMA_Sb_Y@C80, respectively; however, MMA-P-Y@C80 showed a weaker ability to sense the biomarker. Additionally, the recovery time after the detection of the biomarker was relatively short, comparable to the increase in the adsorption strength, with MMA-Bi-Y@C80 having the shortest recovery time (3.829 × 10−37). This is significant for the development of a highly sensitive and efficient technique for methylmalonic acid (MMA) biomarker sensing.

The prophylactic application of low-dose rabbit antithymocyte globulin in matched siblings HSCT with high-risk factors for graft-versus-host disease

Relapse and graft-versus-host disease (GVHD) are currently the predominant causes of mortality post allogeneic hematopoietic stem cell transplantation (allo-HSCT). The contentious use of antithymocyte globulin (ATG) for preventing GVHD in matched sibling HSCT scenarios has been a topic of significant debate. A retrospective analysis was conducted on matched sibling HSCT cases with high-risk factors for GVHD in our center from January 2018 to June 2023. Our assessment revealed that the group administered with ATG exhibited a 30 % incidence of acute GVHD (aGVHD), in contrast to 81.8 % in the non-ATG cohort (P = 0.037) among matched sibling HSCT cases with high GVHD risk factors. Furthermore, chronic GVHD (cGVHD) occurred in 20 % of the ATG group and 72.7 % of the non-ATG group (P = 0.03). Notably, the administration of ATG did not significantly impact disease relapse (p = 0.149), infection rates (p = 0.64), granulocyte recovery time (p = 0.15), platelet recovery time (p = 0.12), overall survival (p = 0.889), or disease-free survival time (p = 0.787). The use of rabbit antithymocyte globulin (r-ATG) at a 5 mg/kg dosage demonstrated a notable reduction in aGVHD and cGVHD incidences within sibling matched HSCT cases with high-risk factors for GVHD, without increasing rates of disease recurrence or infections. These findings highlight the potential benefit of using low-dose r-ATG in high-risk of GVHD sibling matched allogeneic HSCTs, although further validation with a larger cohort is necessary.

Study of the Sensitivity of Carbon Quantum Dots for NO2 Gas Sensor and improve it using Graphene

Gas sensors are essential for detecting noxious gases that have a detrimental effect on people's health and welfare. Carbon quantum dots (CQDs) are the fundamental component of gas detectors. CQDs and graphene (Gr) were prepared using the electrochemical method. The gas sensitivity of these materials was evaluated at different temperatures (150, 200, 250 °C) to assess their effectiveness. Subsequently, experiments were conducted at different temperatures to ascertain that the combination of CQDs and Gr, with various percentages of Gr and CQDs, exhibited superior gas sensitization properties compared to CQDs alone. This was evaluated based on criteria such as sensitivity, recovery time, and reaction time. Interestingly, the combination was highly responsive. The quantum dots on glass substrates could detect NO2 gas at the abovementioned temperatures. Experimental evidence showed that the gas sensor can only detect graphene at low temperatures.

Effects of Melatonin on Ginseng Leaf Phenotypic and Photosynthetic Properties Following Chilling and Freezing Stress

Spring frost damage is a significant natural disaster, which can lead to large-scale ginseng (Panax ginseng C. A. Mey) yield reduction. To determine chilling and freezing stress damage to ginseng, we designed an experiment using three-year-old potted ginseng plants. We simulated chilling (0±0.3 ℃) and freezing (-2.5±0.3 ℃, -5±0.3 ℃) in an artificial room, with 16±2 ℃ of the room temperature at night as the control, to evaluate their physiological effects on ginseng leaf spectral reflectance, photosynthetic characteristics, and chlorophyll fluorescence parameters. We also investigated the mitigating effects of exogenous melatonin on ginseng leaves exposed to chilling and freezing stress. All ginseng leaves died under -5 ℃ freezing stress and the mortality rate reached 25∼57% under -2.5 ℃ freezing stress, while no plants died under 0 ℃ chilling stress. After -2.5 ℃ and 0 ℃ stress, leaf spectral reflectance in the 750∼1000 nm band was significantly lower than the control; transpiration rate, net photosynthetic rate, intercellular CO2 concentration, and stomatal conductance decreased significantly compared with the control, and there was no significant change in recovery time. The Fv/Fm ratio and qp decreased after low-temperature stress, while NPQ increased. After one week of melatonin application, leaf spectral reflectance in the 600∼650 and 750∼1000 nm bands reflected significant differences between the effects of melatonin application and no application on ginseng leaf chlorophyll content and structure under freezing stress. Ginseng leaf net photosynthetic rate increased by 23.79% and 4.48%, while intercellular CO2 concentration increased by 33.49 and 11.83% under stress at -2.5°C and 0°C. The ginseng leaf chlorophyll fluorescence parameter (Fv/Fm) recovered to 0.8 and above in one week after melatonin application, and qp decreased under -2.5°C and 0°C stress after melatonin application. Additionally, the NPQ values were 11.44% and 4.6% lower in -2.5+MT and 0+MT, respectively, compared to the treatment without MT applied. A sudden drop in temperature to 0 ℃ or even below caused ginseng plant growth inhibition, but melatonin application at a concentration of 100 nmol L−1 had certain mitigating effects on ginseng growth, which provides a theoretical basis and technical support for ginseng production.

Short-Term Results of Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery (ALCAPA) Repair: A Single Centre Study

This retrospective case series reviews outcomes for 12 patients who underwent Anomalous Left Coronary Artery from the Pulmonary Artery (ALCAPA) repair at our hospital from July 2018 to June 2023, following ethical approval. Diagnoses were confirmed via echocardiography, angiography, or CT angiography, excluding those with additional anomalies or prior surgeries. Data collected included patient demographics, preoperative symptoms, left ventricular ejection fraction, and mitral regurgitation severity. Surgeries involved median sternotomy with modified left coronary perfusion and cardioplegia. Key outcomes assessed were success rates, recovery times, early complications, and improvements in cardiac function. Results showed a mean age of 8.5 ± 2.1 months and a mean weight of 8.41 ± 1.2 kg, with 75.9% male patients. Preoperative symptoms included tachypnea, growth failure, and irritability, with an initial left ventricular ejection fraction of 28%. Post-surgery, the success rate was 100%, with significant improvements in left ventricular ejection fraction to 45% and reduced mitral regurgitation. The study highlights the importance of early diagnosis and effective surgical management of ALCAPA, especially in cases involving non-facing coronary origins. Keywords: ALCAPA, Congenital Heart Defect, Coronary Artery Anomalies, Echocardiography Left coronary artery

Clinical efficacy of endoscopic plasma resection of juvenile nasopharyngeal angiofibroma

Objective:To investigate the clinical effect of plasma resection of juvenile nasopharyngeal angiofibroma（JNA） under nasal endoscope. Methods:The clinical data of 12 cases with JNA treated in the Department of Otorhinolaryngology and head and neck surgery of the 940th Hospital from 2015.01 to 2020.01 were analyzed retrospectively. All of them were young males. Imaging examination, digital subtraction angiography（DSA） and selective blood supply artery embolization were performed before operation, and then plasma was used to remove the tumor under nasal endoscope. The patients were followed up for at least 30 months. During the follow-up, the nasal cavity was observed under nasal endoscope and the tumor recurrence was observed by imaging examination. Results:In 12 cases, the vision was clear, the amount of bleeding was less, the operation time was within 2 h, and the postoperative recovery time was short. 12 cases were followed up and no tumor recurrence was found by nasal endoscopy and imaging examination. Conclusion:Selective external carotid artery embolization before operation and plasma resection of JNA under nasal endoscope during operation is a safe and effective treatment, which can effectively improve the cure rate and reduce the recurrence rate.